GSK1059615_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.22325
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.103223
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0908629
PTMA prothymosin, alpha 0.0760901
EIF1 eukaryotic translation initiation factor 1 0.0643927
H3-3B H3.3 histone B 0.0544248
RPS6 ribosomal protein S6 0.0526167
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0515868
RPLP1 ribosomal protein, large, P1 0.0475613
CENPF centromere protein F, 350/400kDa 0.0440442
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0426152
RPL35A ribosomal protein L35a 0.0425507
GOLGA4 golgin A4 0.0417789
RPS12 ribosomal protein S12 0.039794
RPL12 ribosomal protein L12 0.0348133
PCBP2 poly(rC) binding protein 2 0.0334287
RPL23 ribosomal protein L23 0.0334007
PRRC2C proline-rich coiled-coil 2C 0.0310679
RPS23 ribosomal protein S23 0.030704
RPLP0 ribosomal protein, large, P0 0.0293641
RPL7 ribosomal protein L7 0.0286021
FTL ferritin, light polypeptide 0.0278582
MAP1B microtubule-associated protein 1B 0.0272798
RPS2 ribosomal protein S2 0.0266698
SET SET nuclear proto-oncogene 0.0265222
FN1 fibronectin 1 0.0258834
EEF2 eukaryotic translation elongation factor 2 0.0253818
ANXA2 annexin A2 0.025004
B2M beta-2-microglobulin 0.0248642
TPR translocated promoter region, nuclear basket protein 0.0246055
RPL34 ribosomal protein L34 0.024415
RPL37A ribosomal protein L37a 0.0242484
APP amyloid beta (A4) precursor protein 0.0241616
RPS27 ribosomal protein S27 0.0234646
PKM pyruvate kinase, muscle 0.0234177
CD36 CD36 molecule (thrombospondin receptor) 0.0233396
MATR3 matrin 3 0.0232703
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0232351
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0232184
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0230643
KPNB1 karyopherin (importin) beta 1 0.0229086
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0227084
POTEF POTE ankyrin domain family, member F 0.0224391
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0224112
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0223463
RTN4 reticulon 4 0.0220823
RPS29 ribosomal protein S29 0.0220404
BIRC6 baculoviral IAP repeat containing 6 0.0217166
RAD21 RAD21 homolog (S. pombe) 0.0215798
JMJD1C jumonji domain containing 1C 0.0215726
CARD16 caspase recruitment domain family, member 16 0.0212534
RPL19 ribosomal protein L19 0.0212093
SRRM2 serine/arginine repetitive matrix 2 0.0210282
RPL4 ribosomal protein L4 0.0209213
CBX3 chromobox homolog 3 0.0204955
LDHA lactate dehydrogenase A 0.02032
RPS3 ribosomal protein S3 0.0203066
UBC ubiquitin C 0.0202995
RPS8 ribosomal protein S8 0.020294
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0202403
GNAS GNAS complex locus 0.0202168
SON SON DNA binding protein 0.02016
TPT1 tumor protein, translationally-controlled 1 0.0200937
PTEN phosphatase and tensin homolog 0.0198117
BRD2 bromodomain containing 2 0.0194336
RO60 Ro60, Y RNA binding protein 0.019426
MKI67 marker of proliferation Ki-67 0.019132
NFE2L1 nuclear factor, erythroid 2-like 1 0.0190319
SLMAP sarcolemma associated protein 0.0188872
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0185199
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0184993
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0182689
NUP58 nucleoporin 58 0.0182016
RSRC2 arginine/serine-rich coiled-coil 2 0.0181628
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0181244
CDK19 cyclin-dependent kinase 19 0.0180576
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0180187
VIM vimentin 0.0179332
DSCAM Down syndrome cell adhesion molecule 0.0177662
RPL31 ribosomal protein L31 0.0176976
S100A9 S100 calcium binding protein A9 0.0176548
TXNRD1 thioredoxin reductase 1 0.0176059
GPC5 glypican 5 0.0176028
CSDE1 cold shock domain containing E1, RNA-binding 0.0175417
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0175257
SCAF11 SR-related CTD-associated factor 11 0.0174948
S100A6 S100 calcium binding protein A6 0.017413
PA2G4 proliferation-associated 2G4, 38kDa 0.0173649
RPL37 ribosomal protein L37 0.017128
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0169978
YBX1 Y box binding protein 1 0.0169521
TNPO1 transportin 1 0.0167254
SFTPA2 surfactant protein A2 0.0167106
RPL26 ribosomal protein L26 0.0165675
DSTN destrin (actin depolymerizing factor) 0.0164838
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.016448
ZNF292 zinc finger protein 292 0.0163904
KMT2E lysine (K)-specific methyltransferase 2E 0.0163453
RSL1D1 ribosomal L1 domain containing 1 0.0163127
RPS19 ribosomal protein S19 0.01627

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.271374
LSAMP limbic system-associated membrane protein -0.224588
NRG1 neuregulin 1 -0.205233
PTPRD protein tyrosine phosphatase, receptor type, D -0.144101
NALF1 NALCN channel auxiliary factor 1 -0.142189
EXT1 exostosin glycosyltransferase 1 -0.126469
PRKCA protein kinase C, alpha -0.122993
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.122532
VCL vinculin -0.107268
NREP neuronal regeneration related protein -0.0796971
THSD4 thrombospondin, type I, domain containing 4 -0.0796108
ANTXR1 anthrax toxin receptor 1 -0.0790348
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0778577
RPTOR regulatory associated protein of MTOR, complex 1 -0.0759448
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0694864
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0673879
MAPK10 mitogen-activated protein kinase 10 -0.0629866
MSI2 musashi RNA-binding protein 2 -0.0608963
TRIB2 tribbles pseudokinase 2 -0.0597395
SMYD3 SET and MYND domain containing 3 -0.0580193
FRMD4A FERM domain containing 4A -0.0578535
NPAS2 neuronal PAS domain protein 2 -0.0578273
FNDC3B fibronectin type III domain containing 3B -0.0566208
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.052818
BCAS3 breast carcinoma amplified sequence 3 -0.0513397
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0471626
ZNF804A zinc finger protein 804A -0.047102
RAD51B RAD51 paralog B -0.0469104
RNF213 ring finger protein 213 -0.0457912
MAML2 mastermind-like 2 (Drosophila) -0.0452991
COL1A1 collagen, type I, alpha 1 -0.0443248
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0433041
TPM1 tropomyosin 1 (alpha) -0.0432784
DNAH14 dynein, axonemal, heavy chain 14 -0.041731
BICD1 bicaudal D homolog 1 (Drosophila) -0.0414981
PTPRM protein tyrosine phosphatase, receptor type, M -0.0408873
ZBTB20 zinc finger and BTB domain containing 20 -0.0403767
CUX1 cut-like homeobox 1 -0.0402072
KLHL13 kelch-like family member 13 -0.0399342
DACH2 dachshund family transcription factor 2 -0.0398367
LPP LIM domain containing preferred translocation partner in lipoma -0.039676
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0390404
IGFBP3 insulin-like growth factor binding protein 3 -0.0389327
PLAT plasminogen activator, tissue -0.0387556
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0387443
GSE1 Gse1 coiled-coil protein -0.0373437
UNC5C unc-5 homolog C (C. elegans) -0.0370223
GREM2 gremlin 2, DAN family BMP antagonist -0.0367142
PBX1 pre-B-cell leukemia homeobox 1 -0.0361929
PDZRN3 PDZ domain containing ring finger 3 -0.0352013
IGF1R insulin-like growth factor 1 receptor -0.0347469
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0343165
BPTF bromodomain PHD finger transcription factor -0.033819
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0335952
PCDH9 protocadherin 9 -0.0333043
TRPS1 trichorhinophalangeal syndrome I -0.0331794
RNF150 ring finger protein 150 -0.0329241
FNDC3A fibronectin type III domain containing 3A -0.0327331
AEBP2 AE binding protein 2 -0.0326226
TRIO trio Rho guanine nucleotide exchange factor -0.0322956
DIAPH2 diaphanous-related formin 2 -0.0320872
CADM1 cell adhesion molecule 1 -0.0320022
COL4A6 collagen, type IV, alpha 6 -0.0318878
AHR aryl hydrocarbon receptor -0.0317396
COL3A1 collagen, type III, alpha 1 -0.0315143
NBEA neurobeachin -0.0310133
TLE4 transducin-like enhancer of split 4 -0.0309431
AKAP12 A kinase (PRKA) anchor protein 12 -0.0308682
ATRNL1 attractin-like 1 -0.030666
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0306302
PRKG1 protein kinase, cGMP-dependent, type I -0.0305836
PRKCE protein kinase C, epsilon -0.0305635
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0305574
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0303277
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0302617
COL4A5 collagen, type IV, alpha 5 -0.0301285
COL18A1 collagen, type XVIII, alpha 1 -0.0301203
KCTD16 potassium channel tetramerization domain containing 16 -0.0301171
CADM2 cell adhesion molecule 2 -0.0298277
DTNA dystrobrevin, alpha -0.0297777
MACF1 microtubule-actin crosslinking factor 1 -0.0292501
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.028947
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.028696
COL4A2 collagen, type IV, alpha 2 -0.0278223
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.027467
LIMCH1 LIM and calponin homology domains 1 -0.0274271
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0273651
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0272198
SLIT2 slit homolog 2 (Drosophila) -0.027195
LDB2 LIM domain binding 2 -0.027193
CNTN4 contactin 4 -0.0271634
THBS1 thrombospondin 1 -0.0271545
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0270818
MYH9 myosin, heavy chain 9, non-muscle -0.0269868
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0263913
AFF3 AF4/FMR2 family, member 3 -0.0262955
KIAA1217 KIAA1217 -0.0261481
INTS6 integrator complex subunit 6 -0.0260972
IGFBP5 insulin-like growth factor binding protein 5 -0.0257495
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0254198