GSK1059615_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.17438
ENO1 enolase 1, (alpha) 0.14116
CDH13 cadherin 13 0.140144
UBC ubiquitin C 0.120939
CXCL8 chemokine (C-X-C motif) ligand 8 0.115939
EEF2 eukaryotic translation elongation factor 2 0.104633
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10095
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0938919
ZBTB20 zinc finger and BTB domain containing 20 0.0907731
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0888848
TMSB10 thymosin beta 10 0.0860132
RPS8 ribosomal protein S8 0.0815321
RACK1 receptor for activated C kinase 1 0.0663516
DPYD dihydropyrimidine dehydrogenase 0.0656194
EIF1 eukaryotic translation initiation factor 1 0.0651582
SOD2 superoxide dismutase 2, mitochondrial 0.0621298
FBN1 fibrillin 1 0.060956
RPL23 ribosomal protein L23 0.0592208
RPL35A ribosomal protein L35a 0.058789
CALR calreticulin 0.0571712
KAZN kazrin, periplakin interacting protein 0.0562492
MT2A metallothionein 2A 0.0556336
SQSTM1 sequestosome 1 0.0553474
AHNAK AHNAK nucleoprotein 0.0540785
CALU calumenin 0.0521048
RPS27A ribosomal protein S27a 0.0519826
TRPS1 trichorhinophalangeal syndrome I 0.0500399
GOLGB1 golgin B1 0.0496446
FTH1 ferritin, heavy polypeptide 1 0.0496048
HLA-E major histocompatibility complex, class I, E 0.0473005
NEK10 NIMA-related kinase 10 0.0454098
RPL37 ribosomal protein L37 0.0453299
FN1 fibronectin 1 0.0444712
RPS3 ribosomal protein S3 0.04355
RPL26 ribosomal protein L26 0.0435372
SPDYA speedy/RINGO cell cycle regulator family member A 0.0435118
PTMA prothymosin, alpha 0.0424271
FOXP1 forkhead box P1 0.0422818
RPS12 ribosomal protein S12 0.0417939
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0408471
RPL37A ribosomal protein L37a 0.0406212
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0405569
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0394781
JUN jun proto-oncogene 0.0389379
RPS20 ribosomal protein S20 0.0378165
PCBP2 poly(rC) binding protein 2 0.0373119
CANX calnexin 0.0363886
AHI1 Abelson helper integration site 1 0.0357933
ATF4 activating transcription factor 4 0.0355894
LDHA lactate dehydrogenase A 0.0355274
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0348651
SFPQ splicing factor proline/glutamine-rich 0.0347424
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0346946
ANKRD28 ankyrin repeat domain 28 0.0346795
TPT1 tumor protein, translationally-controlled 1 0.0346329
RPL12 ribosomal protein L12 0.0345727
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0345546
CSDE1 cold shock domain containing E1, RNA-binding 0.0343848
RPLP0 ribosomal protein, large, P0 0.0342465
EEF1G eukaryotic translation elongation factor 1 gamma 0.0341414
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0338385
NALF1 NALCN channel auxiliary factor 1 0.0334275
RPL11 ribosomal protein L11 0.0334081
RPL30 ribosomal protein L30 0.033162
NAP1L1 nucleosome assembly protein 1-like 1 0.0329769
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0312818
RPL5 ribosomal protein L5 0.0311591
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0305815
VMP1 vacuole membrane protein 1 0.030576
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0301176
RPS5 ribosomal protein S5 0.0300753
RPS19 ribosomal protein S19 0.0297581
MBNL1 muscleblind-like splicing regulator 1 0.0294487
MATR3 matrin 3 0.0290941
PLSCR2 phospholipid scramblase 2 0.028997
LGALS1 lectin, galactoside-binding, soluble, 1 0.0289515
COL3A1 collagen, type III, alpha 1 0.028939
HDLBP high density lipoprotein binding protein 0.0289122
AKAP9 A kinase (PRKA) anchor protein 9 0.0286544
RPL28 ribosomal protein L28 0.028627
RPL13A ribosomal protein L13a 0.0285761
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0285356
RPL19 ribosomal protein L19 0.028497
SLC38A2 solute carrier family 38, member 2 0.0282887
BBS9 Bardet-Biedl syndrome 9 0.0282762
IQGAP1 IQ motif containing GTPase activating protein 1 0.0282604
RPL31 ribosomal protein L31 0.0282111
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0281663
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0280568
FTL ferritin, light polypeptide 0.0277304
RPS14 ribosomal protein S14 0.0274008
RPS25 ribosomal protein S25 0.027387
ANKHD1 ankyrin repeat and KH domain containing 1 0.0273014
SP100 SP100 nuclear antigen 0.0271131
B2M beta-2-microglobulin 0.0269458
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0269425
NRP1 neuropilin 1 0.0268004
THRAP3 thyroid hormone receptor associated protein 3 0.0267518
RPL7 ribosomal protein L7 0.0267292
LOC112694756 uncharaterized LOC112694756 0.0267165

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.237614
TRIO trio Rho guanine nucleotide exchange factor -0.146884
VEGFA vascular endothelial growth factor A -0.0891538
PDE10A phosphodiesterase 10A -0.079906
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0751524
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0616236
ATP13A3 ATPase type 13A3 -0.0609434
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0583223
TGFBI transforming growth factor, beta-induced, 68kDa -0.0561786
LOXL2 lysyl oxidase-like 2 -0.0499999
STC1 stanniocalcin 1 -0.0482078
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0466502
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0459626
DLG1 discs, large homolog 1 (Drosophila) -0.0445124
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0427685
F3 coagulation factor III (thromboplastin, tissue factor) -0.0409671
ELL2 elongation factor, RNA polymerase II, 2 -0.040597
LTBP1 latent transforming growth factor beta binding protein 1 -0.0369501
MAP1B microtubule-associated protein 1B -0.0362737
PRELID2 PRELI domain containing 2 -0.0355428
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0353783
ZNF292 zinc finger protein 292 -0.034905
MTSS1 metastasis suppressor 1 -0.0318778
SMAD3 SMAD family member 3 -0.0308158
ECE1 endothelin converting enzyme 1 -0.029206
IGFBP3 insulin-like growth factor binding protein 3 -0.0285871
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0274151
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0263879
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0262689
NAMPT nicotinamide phosphoribosyltransferase -0.0256552
HAS2 hyaluronan synthase 2 -0.0239396
SPAG9 sperm associated antigen 9 -0.0234399
NAV2 neuron navigator 2 -0.0227997
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0227162
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0224266
POSTN periostin, osteoblast specific factor -0.0223495
ADAM12 ADAM metallopeptidase domain 12 -0.0222711
FCHSD2 FCH and double SH3 domains 2 -0.0222041
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0221671
RUNX1 runt-related transcription factor 1 -0.0220985
RTN4 reticulon 4 -0.0214076
EGFR epidermal growth factor receptor -0.0212314
GOLT1B golgi transport 1B -0.0210766
WSB1 WD repeat and SOCS box containing 1 -0.0209054
ABLIM3 actin binding LIM protein family, member 3 -0.0206946
EFNA5 ephrin-A5 -0.0206035
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0203476
ICAM1 intercellular adhesion molecule 1 -0.0203277
SLC22A23 solute carrier family 22, member 23 -0.0199778
KDM7A lysine (K)-specific demethylase 7A -0.0197481
ARHGAP29 Rho GTPase activating protein 29 -0.0196584
KMT2E lysine (K)-specific methyltransferase 2E -0.0195768
YEATS2 YEATS domain containing 2 -0.0192741
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0190747
ARRDC3 arrestin domain containing 3 -0.018986
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.018925
TMEM165 transmembrane protein 165 -0.0189244
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0187296
TRAM2 translocation associated membrane protein 2 -0.0187071
HIPK2 homeodomain interacting protein kinase 2 -0.0185142
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0182982
RASA2 RAS p21 protein activator 2 -0.0179119
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0178098
MEF2A myocyte enhancer factor 2A -0.0177974
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0176659
USP3 ubiquitin specific peptidase 3 -0.0173126
H1-4 H1.4 linker histone, cluster member -0.0171692
CD109 CD109 molecule -0.0170696
PLAUR plasminogen activator, urokinase receptor -0.0170014
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0169313
TENT5A terminal nucleotidyltransferase 5A -0.0168893
XPO1 exportin 1 -0.0167233
MSN moesin -0.0166169
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0165193
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0164814
SH3PXD2B SH3 and PX domains 2B -0.0164417
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0164225
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -0.015958
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0155566
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0154726
P3H2 prolyl 3-hydroxylase 2 -0.0150497
NAV1 neuron navigator 1 -0.0148763
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0147613
LMAN1 lectin, mannose-binding, 1 -0.0147181
CALD1 caldesmon 1 -0.0146514
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.014506
BCAR3 breast cancer anti-estrogen resistance 3 -0.0144192
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0142964
RLF rearranged L-myc fusion -0.0142843
FAM3C family with sequence similarity 3, member C -0.0141475
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0140948
SHB Src homology 2 domain containing adaptor protein B -0.0139886
TNIP1 TNFAIP3 interacting protein 1 -0.0139132
BBX bobby sox homolog (Drosophila) -0.0138715
FOSL1 FOS-like antigen 1 -0.0138101
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0136162
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0135061
CCDC88A coiled-coil domain containing 88A -0.0134735
NGLY1 N-glycanase 1 -0.0133062
H1-0 H1.0 linker histone -0.0131356