| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the GSK1059615_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.292413 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.051695 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0477576 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0412199 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0346391 |
| GPC5 | glypican 5 | 0.0336365 |
| GOLGB1 | golgin B1 | 0.0323734 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0313594 |
| VCAN | versican | 0.0295414 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0284667 |
| MCL1 | myeloid cell leukemia 1 | 0.0268142 |
| SQSTM1 | sequestosome 1 | 0.0265632 |
| GLIS3 | GLIS family zinc finger 3 | 0.0262876 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0242928 |
| RAI14 | retinoic acid induced 14 | 0.024208 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0240558 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0228341 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0223076 |
| BRD2 | bromodomain containing 2 | 0.0221556 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0214593 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0213039 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0212975 |
| CLIC4 | chloride intracellular channel 4 | 0.021198 |
| INTS6 | integrator complex subunit 6 | 0.0208039 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0206474 |
| ZNF638 | zinc finger protein 638 | 0.0200695 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0194694 |
| PCBP2 | poly(rC) binding protein 2 | 0.0194503 |
| KAZN | kazrin, periplakin interacting protein | 0.0193623 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0185414 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0182574 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0182571 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0178039 |
| PLIN2 | perilipin 2 | 0.0176395 |
| RPL37 | ribosomal protein L37 | 0.0173868 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0172449 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0169687 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0167946 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0166975 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.016193 |
| ATF4 | activating transcription factor 4 | 0.015809 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0155398 |
| WWOX | WW domain containing oxidoreductase | 0.015406 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0153796 |
| CANX | calnexin | 0.0152182 |
| NEB | nebulin | 0.0150712 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0149855 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0148913 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0146697 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0146692 |
| RNF213 | ring finger protein 213 | 0.0146644 |
| FST | follistatin | 0.0145252 |
| ANKRD11 | ankyrin repeat domain 11 | 0.014233 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0140019 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0137325 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0137175 |
| HM13 | histocompatibility (minor) 13 | 0.0135608 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0134947 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.013401 |
| BMERB1 | bMERB domain containing 1 | 0.0133536 |
| USP34 | ubiquitin specific peptidase 34 | 0.0131194 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0131083 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0130191 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.0129818 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0129529 |
| ATF3 | activating transcription factor 3 | 0.0127972 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0126351 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0126146 |
| ADIPOR2 | adiponectin receptor 2 | 0.0124575 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0124423 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0124337 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0124048 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0123928 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0123887 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0123654 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0121382 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0120588 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.0119717 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0118395 |
| RPS2 | ribosomal protein S2 | 0.0117561 |
| FAM13A | family with sequence similarity 13, member A | 0.0115441 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.011531 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.0115174 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0115004 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0114456 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0114093 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0114049 |
| SEMA3G | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | 0.0113856 |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 | 0.0113507 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0112535 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0110524 |
| TRIB3 | tribbles pseudokinase 3 | 0.0109607 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0109551 |
| OPTN | optineurin | 0.0109288 |
| XPOT | exportin, tRNA | 0.0109247 |
| CDK13 | cyclin-dependent kinase 13 | 0.0109189 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0109021 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0108789 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0108587 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0108109 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.311747 |
| APOB | apolipoprotein B | -0.218697 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.184921 |
| FN1 | fibronectin 1 | -0.176496 |
| C3 | complement component 3 | -0.112028 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.102083 |
| MT2A | metallothionein 2A | -0.0817533 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0780563 |
| GPC6 | glypican 6 | -0.0768145 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0752023 |
| GPC3 | glypican 3 | -0.073265 |
| SLC38A2 | solute carrier family 38, member 2 | -0.073038 |
| EHBP1 | EH domain binding protein 1 | -0.0645913 |
| A2M | alpha-2-macroglobulin | -0.0614099 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0608412 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0604757 |
| TRIM26 | tripartite motif containing 26 | -0.0599663 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0569813 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0541985 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0532664 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0532065 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0511981 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0488362 |
| DSPP | dentin sialophosphoprotein | -0.0470915 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0459538 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0459035 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0451929 |
| TMEM123 | transmembrane protein 123 | -0.0440043 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0432276 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0427306 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0407093 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0385915 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0384255 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0383819 |
| SDC4 | syndecan 4 | -0.0378672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0372611 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0364053 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0363241 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0342905 |
| MALT1 | MALT1 paracaspase | -0.0339799 |
| CFB | complement factor B | -0.0338416 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0337453 |
| APOA2 | apolipoprotein A-II | -0.0333539 |
| VCL | vinculin | -0.0327753 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0314443 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0303367 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0300952 |
| BCL2L1 | BCL2-like 1 | -0.0300434 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0297487 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0296891 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0296165 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0292267 |
| RRBP1 | ribosome binding protein 1 | -0.0290306 |
| ARHGAP9 | Rho GTPase activating protein 9 | -0.0289941 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0284375 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0281391 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0278993 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0274754 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0270068 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0265211 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0264597 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0263039 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0261385 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0260715 |
| PEG10 | paternally expressed 10 | -0.0258743 |
| FRMD5 | FERM domain containing 5 | -0.0256171 |
| RPS24 | ribosomal protein S24 | -0.0254721 |
| ACTN4 | actinin, alpha 4 | -0.0254698 |
| OSMR | oncostatin M receptor | -0.0254647 |
| ENO1 | enolase 1, (alpha) | -0.0249218 |
| RPL11 | ribosomal protein L11 | -0.0246551 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0246349 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0240996 |
| DENND4A | DENN/MADD domain containing 4A | -0.0240543 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0236674 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0234884 |
| LYZ | lysozyme | -0.0231287 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0228329 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0227564 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0224434 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0224349 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0221855 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0221828 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0221341 |
| CPE | carboxypeptidase E | -0.0219004 |
| APOE | apolipoprotein E | -0.021473 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0210726 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.0210277 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0210256 |
| EGR1 | early growth response 1 | -0.0208783 |
| FAM135A | family with sequence similarity 135, member A | -0.0208556 |
| DST | dystonin | -0.0208038 |
| PEG3 | paternally expressed 3 | -0.020789 |
| RPS19 | ribosomal protein S19 | -0.0206152 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0205956 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.020426 |
| FILIP1L | filamin A interacting protein 1-like | -0.0203035 |
| APOA1 | apolipoprotein A-I | -0.0199857 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0198906 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0197382 |
