GSK1059615_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.131912
RAI14 retinoic acid induced 14 0.116103
TIMP3 TIMP metallopeptidase inhibitor 3 0.0904596
CEMIP cell migration inducing protein, hyaluronan binding 0.0777553
EXT1 exostosin glycosyltransferase 1 0.0771762
LMO7 LIM domain 7 0.0765339
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0759723
SOD2 superoxide dismutase 2, mitochondrial 0.0689456
LRP1B low density lipoprotein receptor-related protein 1B 0.0623824
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0613468
DPYD dihydropyrimidine dehydrogenase 0.0517485
ABI3BP ABI family, member 3 (NESH) binding protein 0.0498484
N4BP2L2 NEDD4 binding protein 2-like 2 0.0451285
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0450541
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.044035
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0410015
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0402964
CFLAR CASP8 and FADD-like apoptosis regulator 0.039963
AOPEP aminopeptidase O (putative) 0.0381016
SULF2 sulfatase 2 0.0377868
EXOC4 exocyst complex component 4 0.0355835
EFNA5 ephrin-A5 0.0338779
CLIC4 chloride intracellular channel 4 0.0328991
OSBPL6 oxysterol binding protein-like 6 0.0311251
SVIL supervillin 0.031038
GBP2 guanylate binding protein 2, interferon-inducible 0.0305955
ZBTB20 zinc finger and BTB domain containing 20 0.0296829
CLU clusterin 0.0296528
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0287623
NBEA neurobeachin 0.0277766
CDK17 cyclin-dependent kinase 17 0.0264533
DSCAM Down syndrome cell adhesion molecule 0.0262174
PDLIM5 PDZ and LIM domain 5 0.0261177
MTSS1 metastasis suppressor 1 0.0256803
UBE2H ubiquitin-conjugating enzyme E2H 0.0255858
ITGB8 integrin, beta 8 0.0249616
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0247044
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0244715
BCAR3 breast cancer anti-estrogen resistance 3 0.0237755
RABGAP1L RAB GTPase activating protein 1-like 0.0235924
RNF217 ring finger protein 217 0.0230899
INTS6 integrator complex subunit 6 0.0227389
LAMC2 laminin, gamma 2 0.0226687
MACF1 microtubule-actin crosslinking factor 1 0.0225606
KCTD12 potassium channel tetramerization domain containing 12 0.0222811
SETX senataxin 0.0213805
FOXP1 forkhead box P1 0.021358
DOCK4 dedicator of cytokinesis 4 0.0213355
SPIRE1 spire-type actin nucleation factor 1 0.0212975
RNF213 ring finger protein 213 0.0212661
TMOD1 tropomodulin 1 0.0209773
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0208149
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0207707
TRIM25 tripartite motif containing 25 0.0205872
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0203333
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.020317
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0202007
EGFR epidermal growth factor receptor 0.0199278
SRRM2 serine/arginine repetitive matrix 2 0.0199113
VMP1 vacuole membrane protein 1 0.0198597
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0197447
KYNU kynureninase 0.0197294
WARS1 tryptophanyl-tRNA synthetase 1 0.0195479
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.019535
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0192731
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0190701
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0190444
SQSTM1 sequestosome 1 0.0189611
BBS9 Bardet-Biedl syndrome 9 0.0188768
FRMD6 FERM domain containing 6 0.0188302
SFPQ splicing factor proline/glutamine-rich 0.0184715
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0182884
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0182351
CDK13 cyclin-dependent kinase 13 0.0182139
ZSWIM6 zinc finger, SWIM-type containing 6 0.0180912
PRSS23 protease, serine, 23 0.0180584
ALCAM activated leukocyte cell adhesion molecule 0.0180355
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0179766
IFI44L interferon-induced protein 44-like 0.0179705
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.017955
FER fer (fps/fes related) tyrosine kinase 0.0175708
KIAA1671 KIAA1671 0.0172107
PLXNA2 plexin A2 0.0169899
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0168966
ANKRD12 ankyrin repeat domain 12 0.0167817
NTN4 netrin 4 0.0167494
ATG7 autophagy related 7 0.0164669
SLC35F3 solute carrier family 35, member F3 0.0163348
TTC28 tetratricopeptide repeat domain 28 0.0163239
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0163105
ZC3H12C zinc finger CCCH-type containing 12C 0.0161855
SIK3 SIK family kinase 3 0.0161274
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0159415
GMDS GDP-mannose 4,6-dehydratase 0.0158189
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0157549
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.0156452
LTBP1 latent transforming growth factor beta binding protein 1 0.0156348
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0156247
THSD4 thrombospondin, type I, domain containing 4 0.0155415
DRAM1 DNA-damage regulated autophagy modulator 1 0.0155231

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.193491
FLNB filamin B, beta -0.192475
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.134671
TMSB10 thymosin beta 10 -0.110703
MT2A metallothionein 2A -0.104489
TRIO trio Rho guanine nucleotide exchange factor -0.0913835
PTMA prothymosin, alpha -0.0828496
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0819188
MYOF myoferlin -0.0803553
ENO1 enolase 1, (alpha) -0.0785723
LMNA lamin A/C -0.0768041
PGK1 phosphoglycerate kinase 1 -0.0760328
KRT17 keratin 17, type I -0.0703325
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0701596
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0698305
EMP1 epithelial membrane protein 1 -0.069212
B2M beta-2-microglobulin -0.0685106
RPS3 ribosomal protein S3 -0.0655021
CAV1 caveolin 1, caveolae protein, 22kDa -0.0621544
STC1 stanniocalcin 1 -0.0617287
IFITM3 interferon induced transmembrane protein 3 -0.0611168
LOC112694756 uncharaterized LOC112694756 -0.0599649
GOLGA4 golgin A4 -0.0586006
MEF2A myocyte enhancer factor 2A -0.0562908
LDHA lactate dehydrogenase A -0.0560071
GNAS GNAS complex locus -0.0551832
EZR ezrin -0.0550662
RPLP2 ribosomal protein, large, P2 -0.054924
TMSB4X thymosin beta 4, X-linked -0.0546088
S100A10 S100 calcium binding protein A10 -0.0534484
NAMPT nicotinamide phosphoribosyltransferase -0.053227
ANXA2 annexin A2 -0.0501547
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0499479
RPS19 ribosomal protein S19 -0.0498881
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0497929
ANXA1 annexin A1 -0.0472407
SQLE squalene epoxidase -0.0458384
RPS8 ribosomal protein S8 -0.0455861
RPLP1 ribosomal protein, large, P1 -0.0447507
RPS21 ribosomal protein S21 -0.0447226
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.04464
TPT1 tumor protein, translationally-controlled 1 -0.0433514
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0433143
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0429774
RPS6 ribosomal protein S6 -0.0418706
MORF4L2 mortality factor 4 like 2 -0.0414376
IFITM1 interferon induced transmembrane protein 1 -0.0414047
ITGA6 integrin, alpha 6 -0.041385
FSCN1 fascin actin-bundling protein 1 -0.0400323
ANKRD33B ankyrin repeat domain 33B -0.0388174
S100A2 S100 calcium binding protein A2 -0.0388069
KDM3A lysine (K)-specific demethylase 3A -0.0376011
S100A6 S100 calcium binding protein A6 -0.0375603
RPL11 ribosomal protein L11 -0.0372593
LMAN1 lectin, mannose-binding, 1 -0.0371172
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0369603
PKM pyruvate kinase, muscle -0.0368602
RPL8 ribosomal protein L8 -0.0366626
KRT6A keratin 6A, type II -0.0366538
CUL4B cullin 4B -0.0356279
ANLN anillin, actin binding protein -0.0351448
OGA O-GlcNAcase -0.0350501
FTL ferritin, light polypeptide -0.0350092
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0348928
DSTN destrin (actin depolymerizing factor) -0.0347149
IGF2 insulin-like growth factor 2 -0.0345525
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0331847
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0330529
DUSP6 dual specificity phosphatase 6 -0.0330011
DLG1 discs, large homolog 1 (Drosophila) -0.0329664
CANX calnexin -0.0329185
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0324717
COPB1 coatomer protein complex, subunit beta 1 -0.0322376
RPL5 ribosomal protein L5 -0.0322054
RPL19 ribosomal protein L19 -0.0321652
ITCH itchy E3 ubiquitin protein ligase -0.0315959
H1-0 H1.0 linker histone -0.0314317
RPL12 ribosomal protein L12 -0.0313622
EFHD2 EF-hand domain family, member D2 -0.0312698
CAVIN1 caveolae associated protein 1 -0.0310032
POTEF POTE ankyrin domain family, member F -0.030878
RPS13 ribosomal protein S13 -0.0308462
PODXL podocalyxin-like -0.0307709
S100A9 S100 calcium binding protein A9 -0.0307285
S100A11 S100 calcium binding protein A11 -0.0304555
MT1X metallothionein 1X -0.0304427
WASF2 WAS protein family, member 2 -0.0300835
BHLHE40 basic helix-loop-helix family, member e40 -0.0298651
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0293011
YBX1 Y box binding protein 1 -0.0285792
RPL36 ribosomal protein L36 -0.0285187
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0284888
WSB1 WD repeat and SOCS box containing 1 -0.0280555
RACK1 receptor for activated C kinase 1 -0.027956
VDAC1 voltage-dependent anion channel 1 -0.0279062
FN1 fibronectin 1 -0.0278452
HLA-B major histocompatibility complex, class I, B -0.0277797
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0274675
RLF rearranged L-myc fusion -0.0274332
YBX3 Y box binding protein 3 -0.0274301