GSK1059615_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.13742
CEMIP cell migration inducing protein, hyaluronan binding 0.0650427
NALF1 NALCN channel auxiliary factor 1 0.0553797
FAT1 FAT atypical cadherin 1 0.0471534
GMDS GDP-mannose 4,6-dehydratase 0.0454263
EZR ezrin 0.0434342
ALCAM activated leukocyte cell adhesion molecule 0.0404327
PELI1 pellino E3 ubiquitin protein ligase 1 0.0398822
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0396583
MED13 mediator complex subunit 13 0.0364413
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0344135
GPHN gephyrin 0.0340096
AFF1 AF4/FMR2 family, member 1 0.0337872
USP6NL USP6 N-terminal like 0.0333789
GREB1L growth regulation by estrogen in breast cancer-like 0.0330932
LMO7 LIM domain 7 0.0326881
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0313376
PRSS3 protease, serine, 3 0.0309817
MBNL1 muscleblind-like splicing regulator 1 0.0307614
UBE2H ubiquitin-conjugating enzyme E2H 0.0303514
VMP1 vacuole membrane protein 1 0.0302363
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0294512
CADPS Ca++-dependent secretion activator 0.0286971
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0283909
EPHB2 EPH receptor B2 0.0258403
ITGA6 integrin, alpha 6 0.0257499
TXNIP thioredoxin interacting protein 0.0256418
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0254809
SIK3 SIK family kinase 3 0.0251614
EHBP1 EH domain binding protein 1 0.0248779
EIF4B eukaryotic translation initiation factor 4B 0.0238617
PTBP3 polypyrimidine tract binding protein 3 0.0236688
SMYD3 SET and MYND domain containing 3 0.0231905
MYOF myoferlin 0.0231423
SHROOM3 shroom family member 3 0.0230291
PARD3B par-3 family cell polarity regulator beta 0.0227483
MSI2 musashi RNA-binding protein 2 0.022553
JMJD1C jumonji domain containing 1C 0.022181
PTK2 protein tyrosine kinase 2 0.021814
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0215967
FOXO1 forkhead box O1 0.0213882
FTH1 ferritin, heavy polypeptide 1 0.0210257
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0209685
ANKRD28 ankyrin repeat domain 28 0.0209442
TGFBR3 transforming growth factor, beta receptor III 0.0208836
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0207335
RNF43 ring finger protein 43 0.0205871
EXT1 exostosin glycosyltransferase 1 0.0202208
APP amyloid beta (A4) precursor protein 0.0199896
KDM7A lysine (K)-specific demethylase 7A 0.0199756
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.019962
WNK1 WNK lysine deficient protein kinase 1 0.0198631
ARHGAP12 Rho GTPase activating protein 12 0.019727
ARHGAP32 Rho GTPase activating protein 32 0.019659
PKP4 plakophilin 4 0.0194981
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0192162
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0192025
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0191985
WWC1 WW and C2 domain containing 1 0.0189749
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0189026
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0188733
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0186697
ABHD17C abhydrolase domain containing 17C 0.0185339
ADGRA3 adhesion G protein-coupled receptor A3 0.0182082
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0181695
PPARG peroxisome proliferator-activated receptor gamma 0.0181542
TJP1 tight junction protein 1 0.0181482
ARHGAP42 Rho GTPase activating protein 42 0.0180522
ERBIN erbb2 interacting protein 0.0180249
TMEM45B transmembrane protein 45B 0.0180073
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0178807
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.017839
HSPA8 heat shock 70kDa protein 8 0.0176836
TBC1D5 TBC1 domain family, member 5 0.0175822
ZNRF3 zinc and ring finger 3 0.0175767
TRIM2 tripartite motif containing 2 0.0175729
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0174947
PDZD8 PDZ domain containing 8 0.0174055
TRAPPC9 trafficking protein particle complex 9 0.0172717
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0172529
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0172504
PTEN phosphatase and tensin homolog 0.0169404
ARHGAP21 Rho GTPase activating protein 21 0.0169061
ANXA11 annexin A11 0.0168393
FRMD5 FERM domain containing 5 0.0168338
SPRED2 sprouty-related, EVH1 domain containing 2 0.016814
SOX9 SRY (sex determining region Y)-box 9 0.0165217
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0164519
SRPK2 SRSF protein kinase 2 0.0163645
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0163438
TPM3 tropomyosin 3 0.0162258
RAD51B RAD51 paralog B 0.0161472
COBL cordon-bleu WH2 repeat protein 0.0161182
METTL15 methyltransferase like 15 0.0160558
CDK6 cyclin-dependent kinase 6 0.0160476
UBAC2 UBA domain containing 2 0.0160052
XPO1 exportin 1 0.0158098
NHSL1 NHS-like 1 0.0156445
ZZZ3 zinc finger, ZZ-type containing 3 0.0154987
PARD3 par-3 family cell polarity regulator 0.0153955

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.204159
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.167622
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.148171
TMSB10 thymosin beta 10 -0.135282
PTMA prothymosin, alpha -0.135204
RPS6 ribosomal protein S6 -0.12176
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.1166
RPS8 ribosomal protein S8 -0.101031
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0988521
RPS19 ribosomal protein S19 -0.0863286
RPL35A ribosomal protein L35a -0.0804415
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0710172
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0695386
RPL34 ribosomal protein L34 -0.0682922
RPL9 ribosomal protein L9 -0.0666884
RPL12 ribosomal protein L12 -0.0654236
RPLP2 ribosomal protein, large, P2 -0.0628609
RPS12 ribosomal protein S12 -0.0592706
NDRG1 N-myc downstream regulated 1 -0.0585837
AGR2 anterior gradient 2 -0.0564334
FTL ferritin, light polypeptide -0.0535968
RPL36 ribosomal protein L36 -0.051935
RPL37A ribosomal protein L37a -0.0515016
RPLP1 ribosomal protein, large, P1 -0.0512705
IER3 immediate early response 3 -0.0512153
S100P S100 calcium binding protein P -0.0499567
KRT18 keratin 18, type I -0.0490448
RPL19 ribosomal protein L19 -0.0485326
RPS25 ribosomal protein S25 -0.0477675
RPL7A ribosomal protein L7a -0.0471057
TFF1 trefoil factor 1 -0.0470628
RPS24 ribosomal protein S24 -0.0465895
RPS3 ribosomal protein S3 -0.0461917
KLF5 Kruppel-like factor 5 (intestinal) -0.0452415
EIF1 eukaryotic translation initiation factor 1 -0.0430095
RPL26 ribosomal protein L26 -0.0429737
RPL31 ribosomal protein L31 -0.0427557
TPM4 tropomyosin 4 -0.042659
RPL7 ribosomal protein L7 -0.0424574
RPLP0 ribosomal protein, large, P0 -0.0423509
RPL5 ribosomal protein L5 -0.0422769
RPS27A ribosomal protein S27a -0.0421217
HMGA1 high mobility group AT-hook 1 -0.0418744
RPS14 ribosomal protein S14 -0.041023
RPL23 ribosomal protein L23 -0.040742
SOX4 SRY (sex determining region Y)-box 4 -0.040458
S100A6 S100 calcium binding protein A6 -0.0399955
LOC102724023 ES1 protein homolog, mitochondrial -0.0389018
RPS16 ribosomal protein S16 -0.0385664
SLC38A2 solute carrier family 38, member 2 -0.0379242
NUPR1 nuclear protein, transcriptional regulator, 1 -0.037347
RPS27 ribosomal protein S27 -0.0371529
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0364013
CALR calreticulin -0.0361511
RPS13 ribosomal protein S13 -0.0349382
RPL18 ribosomal protein L18 -0.0342299
ACTG1 actin gamma 1 -0.0333727
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0331122
VCL vinculin -0.0323817
RACK1 receptor for activated C kinase 1 -0.0319404
RPS29 ribosomal protein S29 -0.0315997
NPSR1 neuropeptide S receptor 1 -0.0314875
RPL13A ribosomal protein L13a -0.0305752
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0301892
RPL8 ribosomal protein L8 -0.0290253
PGK1 phosphoglycerate kinase 1 -0.0288843
RPL38 ribosomal protein L38 -0.0286094
RPS17 ribosomal protein S17 -0.0282778
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0279579
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0278041
GCC2 GRIP and coiled-coil domain containing 2 -0.0276037
RPS5 ribosomal protein S5 -0.0274727
ATF4 activating transcription factor 4 -0.0274372
PTPRB protein tyrosine phosphatase, receptor type, B -0.0272696
RPS11 ribosomal protein S11 -0.0268641
BTG1 B-cell translocation gene 1, anti-proliferative -0.0267656
RPS23 ribosomal protein S23 -0.0261934
RPL15 ribosomal protein L15 -0.0259875
RPL11 ribosomal protein L11 -0.0255944
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0254403
MT2A metallothionein 2A -0.0242341
SRRM2 serine/arginine repetitive matrix 2 -0.0240286
RPL32 ribosomal protein L32 -0.0238611
S100A9 S100 calcium binding protein A9 -0.0237399
GOLGB1 golgin B1 -0.0235833
S100A10 S100 calcium binding protein A10 -0.0234609
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0223252
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0223115
RPL28 ribosomal protein L28 -0.0221001
RPS10 ribosomal protein S10 -0.0217103
WDR45B WD repeat domain 45B -0.021661
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0215408
GDF15 growth differentiation factor 15 -0.0210412
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0208671
EEF2 eukaryotic translation elongation factor 2 -0.0208216
GNAS GNAS complex locus -0.0207851
VDAC1 voltage-dependent anion channel 1 -0.0207146
ANTXR2 anthrax toxin receptor 2 -0.0204668
PKM pyruvate kinase, muscle -0.0203581
RPL10A ribosomal protein L10a -0.0202542