| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the GSK1059615_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.231697 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.11936 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.117664 |
| ANXA1 | annexin A1 | 0.0845752 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0792146 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0785787 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0770238 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0715844 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.068448 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0683915 |
| AHNAK | AHNAK nucleoprotein | 0.0641937 |
| EHBP1 | EH domain binding protein 1 | 0.0600169 |
| RPS8 | ribosomal protein S8 | 0.0592111 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0572497 |
| LPIN1 | lipin 1 | 0.0543984 |
| TXNRD1 | thioredoxin reductase 1 | 0.0543117 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0518235 |
| RAI1 | retinoic acid induced 1 | 0.051304 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0498556 |
| CANX | calnexin | 0.04879 |
| TMEM41B | transmembrane protein 41B | 0.0468879 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.045977 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0453047 |
| EREG | epiregulin | 0.0443087 |
| RPS6 | ribosomal protein S6 | 0.0434527 |
| ENO1 | enolase 1, (alpha) | 0.042175 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0420646 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0420367 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0412279 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0409206 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0407332 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0406693 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0405461 |
| GOLGB1 | golgin B1 | 0.0395895 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0392146 |
| RACK1 | receptor for activated C kinase 1 | 0.0380328 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0379359 |
| HDLBP | high density lipoprotein binding protein | 0.0362497 |
| ANK2 | ankyrin 2, neuronal | 0.0354539 |
| RPL37 | ribosomal protein L37 | 0.0348765 |
| COL5A2 | collagen, type V, alpha 2 | 0.0339871 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0333341 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0329895 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0326951 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0318234 |
| TPM4 | tropomyosin 4 | 0.0318166 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0313617 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0311388 |
| RPS23 | ribosomal protein S23 | 0.0311007 |
| RPLP0 | ribosomal protein, large, P0 | 0.0308943 |
| MAP4 | microtubule-associated protein 4 | 0.0301595 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0300684 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0299965 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0299438 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.029924 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0298012 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.029728 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0293109 |
| RPL12 | ribosomal protein L12 | 0.0289686 |
| RPS25 | ribosomal protein S25 | 0.0289174 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0281365 |
| IPO7 | importin 7 | 0.0279593 |
| KLF6 | Kruppel-like factor 6 | 0.0279002 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0278902 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0276637 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0272536 |
| UBC | ubiquitin C | 0.0272128 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0267554 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0265981 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0263749 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0263276 |
| SNX9 | sorting nexin 9 | 0.0262665 |
| RPL39 | ribosomal protein L39 | 0.0262618 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0261688 |
| VMP1 | vacuole membrane protein 1 | 0.0259717 |
| RPL26 | ribosomal protein L26 | 0.0255723 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0253283 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.0252901 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 0.0252176 |
| PLK2 | polo-like kinase 2 | 0.0248931 |
| RPS12 | ribosomal protein S12 | 0.0248884 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0248851 |
| TMF1 | TATA element modulatory factor 1 | 0.0245868 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0245693 |
| SLC38A1 | solute carrier family 38, member 1 | 0.024552 |
| XPOT | exportin, tRNA | 0.024143 |
| SFTPA2 | surfactant protein A2 | 0.0241003 |
| PDGFC | platelet derived growth factor C | 0.0238412 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0238089 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0234496 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0233097 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0231175 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0228725 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0227868 |
| RPS13 | ribosomal protein S13 | 0.0226378 |
| ACTG1 | actin gamma 1 | 0.0224907 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0224762 |
| ANKRD50 | ankyrin repeat domain 50 | 0.0223417 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0220136 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0220096 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.152055 |
| RAD51B | RAD51 paralog B | -0.10369 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.100809 |
| PRELID2 | PRELI domain containing 2 | -0.0981523 |
| TMSB10 | thymosin beta 10 | -0.0981323 |
| TP63 | tumor protein p63 | -0.0898298 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0842255 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0840863 |
| CADM2 | cell adhesion molecule 2 | -0.0807159 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0737702 |
| ZNF292 | zinc finger protein 292 | -0.0717355 |
| FMNL2 | formin-like 2 | -0.0710082 |
| MT2A | metallothionein 2A | -0.0696536 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0694889 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0654324 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0611088 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0588837 |
| PTMA | prothymosin, alpha | -0.0584553 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0569354 |
| PTK2 | protein tyrosine kinase 2 | -0.0558701 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.055269 |
| DPH6 | diphthamine biosynthesis 6 | -0.0518545 |
| TMSB4X | thymosin beta 4, X-linked | -0.0502865 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0487425 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0484885 |
| DENND1A | DENN/MADD domain containing 1A | -0.0475638 |
| FNIP1 | folliculin interacting protein 1 | -0.0468569 |
| LOXL2 | lysyl oxidase-like 2 | -0.0455891 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0452571 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0448756 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0446046 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0438613 |
| RUNX1 | runt-related transcription factor 1 | -0.042968 |
| SMYD3 | SET and MYND domain containing 3 | -0.0418766 |
| EXOC4 | exocyst complex component 4 | -0.0415411 |
| NEK10 | NIMA-related kinase 10 | -0.0413822 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0412847 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0408227 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0402829 |
| VIM | vimentin | -0.0401978 |
| PARD3 | par-3 family cell polarity regulator | -0.0398785 |
| MT1X | metallothionein 1X | -0.0395343 |
| DST | dystonin | -0.0394851 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0393998 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.039122 |
| EFNA5 | ephrin-A5 | -0.038861 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0384646 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0373421 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0366832 |
| ECE1 | endothelin converting enzyme 1 | -0.0366063 |
| RCOR1 | REST corepressor 1 | -0.0365904 |
| PDE8A | phosphodiesterase 8A | -0.0361595 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0357507 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0353102 |
| SRPK2 | SRSF protein kinase 2 | -0.0351161 |
| CAPRIN2 | caprin family member 2 | -0.0341913 |
| FUS | FUS RNA binding protein | -0.0341604 |
| RNF213 | ring finger protein 213 | -0.0339222 |
| POU2F1 | POU class 2 homeobox 1 | -0.0335621 |
| SMAD3 | SMAD family member 3 | -0.0334749 |
| WDR45B | WD repeat domain 45B | -0.0334057 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0331685 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | -0.0331452 |
| RTTN | rotatin | -0.0330595 |
| CEP128 | centrosomal protein 128kDa | -0.0326009 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0322277 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0321697 |
| VCL | vinculin | -0.0320821 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0320552 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0320175 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0319541 |
| OGA | O-GlcNAcase | -0.0318678 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0317477 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.031349 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0308208 |
| NF1 | neurofibromin 1 | -0.0308082 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0307128 |
| TFRC | transferrin receptor | -0.0306571 |
| HDAC9 | histone deacetylase 9 | -0.0306342 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0305025 |
| ZNF217 | zinc finger protein 217 | -0.0297438 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0291603 |
| INTS6 | integrator complex subunit 6 | -0.0291145 |
| PDE10A | phosphodiesterase 10A | -0.0289295 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0288105 |
| RBM39 | RNA binding motif protein 39 | -0.0284129 |
| PRKCE | protein kinase C, epsilon | -0.0283234 |
| FHIT | fragile histidine triad | -0.0282301 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0282255 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0281194 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0280809 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0280585 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0278319 |
| PHIP | pleckstrin homology domain interacting protein | -0.027796 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0275844 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0273854 |
| TNS3 | tensin 3 | -0.0273453 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0268995 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0268157 |
| GNAS | GNAS complex locus | -0.0267264 |
