| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the GSK1059615_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.176309 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.11287 |
| EGFR | epidermal growth factor receptor | 0.0928979 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0840212 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0828335 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0820186 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0771206 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0721018 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0701902 |
| CPE | carboxypeptidase E | 0.0701046 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0640053 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0606366 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.05683 |
| PTMA | prothymosin, alpha | 0.0553601 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0552691 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0547412 |
| INTS6 | integrator complex subunit 6 | 0.0541056 |
| ENO1 | enolase 1, (alpha) | 0.0507955 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0495634 |
| TMSB10 | thymosin beta 10 | 0.049018 |
| MCL1 | myeloid cell leukemia 1 | 0.0457669 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0455966 |
| EGR1 | early growth response 1 | 0.0450098 |
| MAP7 | microtubule-associated protein 7 | 0.0438015 |
| CAV2 | caveolin 2 | 0.043522 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0421199 |
| SQSTM1 | sequestosome 1 | 0.0420287 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0419671 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0414608 |
| MSN | moesin | 0.0412371 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0403669 |
| PCBP2 | poly(rC) binding protein 2 | 0.0401882 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0397706 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0382606 |
| SMAD3 | SMAD family member 3 | 0.0380796 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0380176 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0378286 |
| SVIL | supervillin | 0.0369885 |
| RPLP1 | ribosomal protein, large, P1 | 0.0365671 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0361904 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0361368 |
| RPL37 | ribosomal protein L37 | 0.0357004 |
| RPS12 | ribosomal protein S12 | 0.0356114 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0352209 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0346191 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0339172 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0335673 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0329808 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.032756 |
| RPS6 | ribosomal protein S6 | 0.0315551 |
| RPS8 | ribosomal protein S8 | 0.0314172 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0313559 |
| KRT7 | keratin 7, type II | 0.0313338 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0310613 |
| FAM13A | family with sequence similarity 13, member A | 0.030556 |
| S100A10 | S100 calcium binding protein A10 | 0.030387 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0303147 |
| FNIP1 | folliculin interacting protein 1 | 0.0298364 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0296609 |
| VEGFA | vascular endothelial growth factor A | 0.0293946 |
| RPL37A | ribosomal protein L37a | 0.0293039 |
| HOMER1 | homer scaffolding protein 1 | 0.0289038 |
| PDE8A | phosphodiesterase 8A | 0.0283114 |
| GPC5 | glypican 5 | 0.0281024 |
| RPS3 | ribosomal protein S3 | 0.0280637 |
| JUN | jun proto-oncogene | 0.0278158 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0277831 |
| SLK | STE20-like kinase | 0.0277623 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.027662 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0274728 |
| BRD2 | bromodomain containing 2 | 0.0272807 |
| POTEF | POTE ankyrin domain family, member F | 0.0270712 |
| RPS2 | ribosomal protein S2 | 0.0263908 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.026343 |
| IRS2 | insulin receptor substrate 2 | 0.0262696 |
| RPL35A | ribosomal protein L35a | 0.0259102 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0258767 |
| CUX1 | cut-like homeobox 1 | 0.0255002 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0254046 |
| RPS25 | ribosomal protein S25 | 0.0250994 |
| PKM | pyruvate kinase, muscle | 0.0247634 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0246838 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0246114 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0245637 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.024438 |
| MED13L | mediator complex subunit 13-like | 0.0239937 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.023466 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0233608 |
| FAM107B | family with sequence similarity 107, member B | 0.0232529 |
| WWOX | WW domain containing oxidoreductase | 0.0232239 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0229477 |
| RPS17 | ribosomal protein S17 | 0.0229329 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0224716 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0221372 |
| GOLGB1 | golgin B1 | 0.0217511 |
| LMO7 | LIM domain 7 | 0.0217441 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0215815 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0208286 |
| CCNG2 | cyclin G2 | 0.0207804 |
| ATF6 | activating transcription factor 6 | 0.0206655 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.177673 |
| TXNRD1 | thioredoxin reductase 1 | -0.153679 |
| OSMR | oncostatin M receptor | -0.140362 |
| LAMA4 | laminin, alpha 4 | -0.106675 |
| LAMC2 | laminin, gamma 2 | -0.10271 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0872504 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0768562 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0714029 |
| H1-0 | H1.0 linker histone | -0.0712772 |
| MKI67 | marker of proliferation Ki-67 | -0.0627761 |
| CES1 | carboxylesterase 1 | -0.06029 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.056235 |
| AHNAK | AHNAK nucleoprotein | -0.0537707 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0505898 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0500803 |
| PGK1 | phosphoglycerate kinase 1 | -0.0497385 |
| TOP1 | topoisomerase (DNA) I | -0.0496086 |
| ASPH | aspartate beta-hydroxylase | -0.0481694 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.046287 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.046116 |
| TES | testin LIM domain protein | -0.0460908 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0459327 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0447649 |
| GM2A | GM2 ganglioside activator | -0.0445445 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0433792 |
| HDLBP | high density lipoprotein binding protein | -0.0419613 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0408132 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0407242 |
| NABP1 | nucleic acid binding protein 1 | -0.0404697 |
| NGLY1 | N-glycanase 1 | -0.0398122 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0393791 |
| RUNX1 | runt-related transcription factor 1 | -0.0385145 |
| LAMB3 | laminin, beta 3 | -0.0381588 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0380394 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0374365 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0373158 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0365714 |
| ABLIM1 | actin binding LIM protein 1 | -0.0357291 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0351728 |
| VCL | vinculin | -0.034868 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.034572 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0344931 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0343872 |
| EFNA5 | ephrin-A5 | -0.0341218 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0328219 |
| SEPTIN10 | septin 10 | -0.0324395 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0321708 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0317302 |
| ECT2 | epithelial cell transforming 2 | -0.0316641 |
| OGA | O-GlcNAcase | -0.0316297 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0308137 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0307357 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0302047 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0295248 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0293304 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0289847 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0289477 |
| WDR45B | WD repeat domain 45B | -0.0286614 |
| MGAT4C | MGAT4 family, member C | -0.0286392 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0283907 |
| FRY | furry homolog (Drosophila) | -0.0282901 |
| MT2A | metallothionein 2A | -0.0281642 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0280913 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0275624 |
| SCEL | sciellin | -0.0275285 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0274954 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0271815 |
| RASA2 | RAS p21 protein activator 2 | -0.0270905 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0267663 |
| RNF169 | ring finger protein 169 | -0.0266187 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0265192 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0265179 |
| TRIM56 | tripartite motif containing 56 | -0.0263976 |
| RTN4 | reticulon 4 | -0.0263921 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0263673 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0263561 |
| ANXA2 | annexin A2 | -0.0257679 |
| SLTM | SAFB-like, transcription modulator | -0.0256334 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0254855 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.0250668 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0248297 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0246509 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0243212 |
| KIAA0232 | KIAA0232 | -0.0237197 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0234104 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0233458 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0233132 |
| SYAP1 | synapse associated protein 1 | -0.0230225 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0229501 |
| TLK1 | tousled-like kinase 1 | -0.0229446 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0228795 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0228628 |
| FRMD4B | FERM domain containing 4B | -0.022782 |
| MYO1B | myosin IB | -0.0226249 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0225335 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0222509 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0220853 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0218881 |
| NPTN | neuroplastin | -0.0217975 |
| KIAA1328 | KIAA1328 | -0.0217811 |
