GSK1059615_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.073989
IGFBP3 insulin-like growth factor binding protein 3 0.0687534
FN1 fibronectin 1 0.0666186
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0649666
CDH13 cadherin 13 0.0552036
MAML3 mastermind-like 3 (Drosophila) 0.0479077
FTH1 ferritin, heavy polypeptide 1 0.0447855
NRG1 neuregulin 1 0.0433856
GRB10 growth factor receptor-bound protein 10 0.0398897
SQSTM1 sequestosome 1 0.0397068
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0389671
SYT1 synaptotagmin I 0.0351213
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.033659
FBN1 fibrillin 1 0.0330657
INTS6 integrator complex subunit 6 0.031726
WWOX WW domain containing oxidoreductase 0.0313795
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0305422
ZSWIM6 zinc finger, SWIM-type containing 6 0.0296773
AADAC arylacetamide deacetylase 0.0292838
PLIN2 perilipin 2 0.0291378
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0289964
TIMP1 TIMP metallopeptidase inhibitor 1 0.0286131
PCBP2 poly(rC) binding protein 2 0.0271731
RPL37 ribosomal protein L37 0.0269347
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0268663
BTG1 B-cell translocation gene 1, anti-proliferative 0.0267326
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.026551
CUX1 cut-like homeobox 1 0.0262058
RNF213 ring finger protein 213 0.025904
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0253742
IFI44L interferon-induced protein 44-like 0.0252749
HMGA2 high mobility group AT-hook 2 0.0252573
RAI14 retinoic acid induced 14 0.0246225
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0230751
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0230492
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0229061
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0228876
ENO1 enolase 1, (alpha) 0.0228463
NTN4 netrin 4 0.0228333
DDIT3 DNA-damage-inducible transcript 3 0.0211309
BBS9 Bardet-Biedl syndrome 9 0.0210932
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0209553
NEBL nebulette 0.0206463
MTSS1 metastasis suppressor 1 0.0205927
B2M beta-2-microglobulin 0.0204771
CDK14 cyclin-dependent kinase 14 0.0204407
PRH1 proline-rich protein HaeIII subfamily 1 0.0201814
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0201423
RPS12 ribosomal protein S12 0.0198475
RPL35A ribosomal protein L35a 0.0198184
WARS1 tryptophanyl-tRNA synthetase 1 0.0197189
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0195488
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0195365
LRMDA leucine rich melanocyte differentiation associated 0.0193692
RPL31 ribosomal protein L31 0.0193371
PSD3 pleckstrin and Sec7 domain containing 3 0.0193292
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0190859
DPYD dihydropyrimidine dehydrogenase 0.0184842
MEF2A myocyte enhancer factor 2A 0.01839
SKIL SKI-like proto-oncogene 0.0183401
IFI6 interferon, alpha-inducible protein 6 0.0183237
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0180018
RPS27 ribosomal protein S27 0.0177788
SUMF1 sulfatase modifying factor 1 0.0177445
MYADM myeloid-associated differentiation marker 0.0176801
TRPS1 trichorhinophalangeal syndrome I 0.0176303
NIBAN1 niban apoptosis regulator 1 0.0172499
RPS8 ribosomal protein S8 0.0172083
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0171484
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0171146
CLIC4 chloride intracellular channel 4 0.0169724
HLA-E major histocompatibility complex, class I, E 0.0167479
NAV1 neuron navigator 1 0.0166515
DNAH14 dynein, axonemal, heavy chain 14 0.0165206
RPLP0 ribosomal protein, large, P0 0.0163065
PRSS23 protease, serine, 23 0.0161605
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0161114
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0160451
IL1B interleukin 1, beta 0.0159632
LRP1B low density lipoprotein receptor-related protein 1B 0.0159142
DIAPH2 diaphanous-related formin 2 0.0158785
SOS1 son of sevenless homolog 1 (Drosophila) 0.0157921
N4BP2L2 NEDD4 binding protein 2-like 2 0.0155856
NPAS2 neuronal PAS domain protein 2 0.0154757
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0154344
COL7A1 collagen, type VII, alpha 1 0.0154262
KCTD16 potassium channel tetramerization domain containing 16 0.0152757
ZNF804A zinc finger protein 804A 0.0152454
AUTS2 autism susceptibility candidate 2 0.0152336
RIMS2 regulating synaptic membrane exocytosis 2 0.0151795
CLMP CXADR-like membrane protein 0.0150239
EFCAB13 EF-hand calcium binding domain 13 0.0149834
RPL37A ribosomal protein L37a 0.0149518
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0149429
TIMP3 TIMP metallopeptidase inhibitor 3 0.0148617
SVIL supervillin 0.0148558
TMSB10 thymosin beta 10 0.014781
THSD4 thrombospondin, type I, domain containing 4 0.0144272
RPS17 ribosomal protein S17 0.0143886
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0143227

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.258845
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.14472
CD44 CD44 molecule (Indian blood group) -0.12191
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.118218
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0988458
FNDC3B fibronectin type III domain containing 3B -0.0988167
ELL2 elongation factor, RNA polymerase II, 2 -0.0977883
RBM39 RNA binding motif protein 39 -0.0956843
GOLGA4 golgin A4 -0.0932593
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0907166
SMAD3 SMAD family member 3 -0.086077
OSMR oncostatin M receptor -0.0780845
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0773511
KDM2A lysine (K)-specific demethylase 2A -0.0703946
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0671942
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0609138
OGA O-GlcNAcase -0.0603012
BASP1 brain abundant, membrane attached signal protein 1 -0.0600664
NPC1 Niemann-Pick disease, type C1 -0.0577483
PDE4D phosphodiesterase 4D, cAMP-specific -0.0577237
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.053472
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0532712
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0530136
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0519476
ZNF292 zinc finger protein 292 -0.0518005
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0516273
EFNA5 ephrin-A5 -0.0493773
KDM3A lysine (K)-specific demethylase 3A -0.0487739
KMT2C lysine (K)-specific methyltransferase 2C -0.0476909
SBF2 SET binding factor 2 -0.0464833
ATP13A3 ATPase type 13A3 -0.046475
DSCAM Down syndrome cell adhesion molecule -0.0444339
ZEB2 zinc finger E-box binding homeobox 2 -0.043801
AKAP12 A kinase (PRKA) anchor protein 12 -0.0433071
RAB27B RAB27B, member RAS oncogene family -0.0429019
RUNX1 runt-related transcription factor 1 -0.0426142
FAM13A family with sequence similarity 13, member A -0.0425553
NCOA7 nuclear receptor coactivator 7 -0.0415234
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0413666
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0411926
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0404809
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0398571
FBXL13 F-box and leucine-rich repeat protein 13 -0.0397317
NAV2 neuron navigator 2 -0.0391853
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0381622
LMAN1 lectin, mannose-binding, 1 -0.0376451
SPAG9 sperm associated antigen 9 -0.0374506
RAP1B RAP1B, member of RAS oncogene family -0.0368824
JMJD1C jumonji domain containing 1C -0.0366658
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0365575
NDRG1 N-myc downstream regulated 1 -0.0365464
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0362894
SETD5 SET domain containing 5 -0.0360719
UGCG UDP-glucose ceramide glucosyltransferase -0.0357984
RB1CC1 RB1-inducible coiled-coil 1 -0.0355711
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0351456
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0348392
MT2A metallothionein 2A -0.0346792
ZMYND8 zinc finger, MYND-type containing 8 -0.034651
GPC6 glypican 6 -0.0344903
USP34 ubiquitin specific peptidase 34 -0.034232
COG5 component of oligomeric golgi complex 5 -0.0339453
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0338156
SIK3 SIK family kinase 3 -0.033509
PARD3 par-3 family cell polarity regulator -0.0335085
ZEB1 zinc finger E-box binding homeobox 1 -0.0334525
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0334523
WDR45B WD repeat domain 45B -0.0333263
PDIA3 protein disulfide isomerase family A, member 3 -0.0331737
PRRC2C proline-rich coiled-coil 2C -0.0320112
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0317184
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0309338
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0308217
YBX3 Y box binding protein 3 -0.0307181
RNF24 ring finger protein 24 -0.0305533
ETV6 ets variant 6 -0.0304072
ITCH itchy E3 ubiquitin protein ligase -0.0304015
TM4SF1 transmembrane 4 L six family member 1 -0.0303113
DOCK5 dedicator of cytokinesis 5 -0.0302204
USP3 ubiquitin specific peptidase 3 -0.0298224
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0296119
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0296011
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0295937
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0293974
CDK17 cyclin-dependent kinase 17 -0.0291261
NIPBL Nipped-B homolog (Drosophila) -0.0291026
CD109 CD109 molecule -0.0288767
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0287005
SRP54 signal recognition particle 54kDa -0.0285556
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0285337
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0284551
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0280025
TGM2 transglutaminase 2 -0.0278878
FLNB filamin B, beta -0.0278488
MIS18BP1 MIS18 binding protein 1 -0.0276152
BMAL2 basic helix-loop-helix ARNT like 2 -0.0273929
PHIP pleckstrin homology domain interacting protein -0.0270837
MARCHF6 membrane associated ring-CH-type finger 6 -0.0270663
PRELID2 PRELI domain containing 2 -0.0270339
SUCO SUN domain containing ossification factor -0.0269926