GSK1059615_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
WAC WW domain containing adaptor with coiled-coil 0.064023
ANKRD11 ankyrin repeat domain 11 0.0412718
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0369275
EIF1 eukaryotic translation initiation factor 1 0.0367568
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0337781
WWOX WW domain containing oxidoreductase 0.0323357
USP34 ubiquitin specific peptidase 34 0.0314226
RBM39 RNA binding motif protein 39 0.0295946
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0293005
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.0286857
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0255459
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0245199
BIRC6 baculoviral IAP repeat containing 6 0.0244588
EIF5 eukaryotic translation initiation factor 5 0.0240747
PHF3 PHD finger protein 3 0.0230198
CDK13 cyclin-dependent kinase 13 0.0226145
DSCAM Down syndrome cell adhesion molecule 0.0225644
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0211852
ARB2A ARB2 cotranscriptional regulator A 0.0205042
CHD1 chromodomain helicase DNA binding protein 1 0.0198655
NIPBL Nipped-B homolog (Drosophila) 0.0197574
SOS2 son of sevenless homolog 2 (Drosophila) 0.0197507
TNRC6B trinucleotide repeat containing 6B 0.0196357
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0193434
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0193408
PUM2 pumilio RNA-binding family member 2 0.0191727
CCNG2 cyclin G2 0.0190393
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0186928
TPR translocated promoter region, nuclear basket protein 0.0184149
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0181637
KAZN kazrin, periplakin interacting protein 0.0181398
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0179879
SMOC1 SPARC related modular calcium binding 1 0.0179301
FTO fat mass and obesity associated 0.017769
CFLAR CASP8 and FADD-like apoptosis regulator 0.0177494
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0176986
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0175436
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0170014
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0168267
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0166902
GOLGB1 golgin B1 0.0163005
LARP4B La ribonucleoprotein domain family, member 4B 0.0161803
OGA O-GlcNAcase 0.0160644
DOCK3 dedicator of cytokinesis 3 0.0157219
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0157161
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0156544
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0155946
MED13 mediator complex subunit 13 0.0155624
ATF4 activating transcription factor 4 0.0154527
NCKAP1 NCK-associated protein 1 0.0154216
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.0154189
BRD2 bromodomain containing 2 0.0153356
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0148979
JMJD1C jumonji domain containing 1C 0.0148531
FUS FUS RNA binding protein 0.0148292
EXOC6B exocyst complex component 6B 0.0146285
FNIP1 folliculin interacting protein 1 0.0143907
AFF4 AF4/FMR2 family, member 4 0.0142992
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0142469
AATF apoptosis antagonizing transcription factor 0.0142196
KMT2C lysine (K)-specific methyltransferase 2C 0.0140108
FNBP4 formin binding protein 4 0.0139869
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0139749
ANKHD1 ankyrin repeat and KH domain containing 1 0.0137452
AKAP9 A kinase (PRKA) anchor protein 9 0.0134911
MATR3 matrin 3 0.0134618
CUX1 cut-like homeobox 1 0.0133478
CDK19 cyclin-dependent kinase 19 0.0133439
BBS9 Bardet-Biedl syndrome 9 0.0133289
GGNBP2 gametogenetin binding protein 2 0.0132898
TTLL10 tubulin tyrosine ligase-like family member 10 0.0132845
CAMKMT calmodulin-lysine N-methyltransferase 0.0132625
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0131064
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0131044
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0130144
TMEM135 transmembrane protein 135 0.012838
SQSTM1 sequestosome 1 0.0128016
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.012737
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0127362
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0127029
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.012695
PHIP pleckstrin homology domain interacting protein 0.0126718
RB1CC1 RB1-inducible coiled-coil 1 0.0126052
CAMTA1 calmodulin binding transcription activator 1 0.012551
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0125405
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0125369
HSPA8 heat shock 70kDa protein 8 0.012521
NUP153 nucleoporin 153kDa 0.0124695
ZNF451 zinc finger protein 451 0.0124447
HLA-E major histocompatibility complex, class I, E 0.0123013
WDR70 WD repeat domain 70 0.0121044
NCOA2 nuclear receptor coactivator 2 0.0119715
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0119135
RNF145 ring finger protein 145 0.0118029
WDFY3 WD repeat and FYVE domain containing 3 0.0117902
WDR49 WD repeat domain 49 0.0117874
TP53BP1 tumor protein p53 binding protein 1 0.0116878
WAPL WAPL cohesin release factor 0.0115937
ZC3H11A zinc finger CCCH-type containing 11A 0.0115794
VIRMA vir like m6A methyltransferase associated 0.0115749

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.243302
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157149
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100283
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.071458
VIM vimentin -0.0707004
TMSB10 thymosin beta 10 -0.0706934
AKAP12 A kinase (PRKA) anchor protein 12 -0.0691062
TM4SF1 transmembrane 4 L six family member 1 -0.0684443
GRAMD1B GRAM domain containing 1B -0.0572258
TFPI2 tissue factor pathway inhibitor 2 -0.0538675
ACTG1 actin gamma 1 -0.0491295
IGF2 insulin-like growth factor 2 -0.0482259
IER3 immediate early response 3 -0.0479163
PM20D1 peptidase M20 domain containing 1 -0.0471851
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0452515
POTEF POTE ankyrin domain family, member F -0.0436713
TXNRD1 thioredoxin reductase 1 -0.0432663
CMIP c-Maf inducing protein -0.0417214
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0395086
S100A6 S100 calcium binding protein A6 -0.0389789
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0382076
PTMA prothymosin, alpha -0.0380004
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0374256
FTH1 ferritin, heavy polypeptide 1 -0.0354126
FTL ferritin, light polypeptide -0.0348051
FGB fibrinogen beta chain -0.0341373
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0331339
STC1 stanniocalcin 1 -0.0323677
C15ORF48 chromosome 15 open reading frame 48 -0.0308873
BIRC3 baculoviral IAP repeat containing 3 -0.0305784
LDHA lactate dehydrogenase A -0.0296032
SAMD4A sterile alpha motif domain containing 4A -0.028228
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0281596
ASPH aspartate beta-hydroxylase -0.0277599
PKM pyruvate kinase, muscle -0.0275316
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0263093
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.025632
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.025626
RPL23 ribosomal protein L23 -0.0255983
EGR1 early growth response 1 -0.0254956
S100A10 S100 calcium binding protein A10 -0.0243874
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.024346
BICC1 BicC family RNA binding protein 1 -0.023704
DOCK5 dedicator of cytokinesis 5 -0.0234584
PYGL phosphorylase, glycogen, liver -0.0226962
THSD4 thrombospondin, type I, domain containing 4 -0.0226551
FAM107B family with sequence similarity 107, member B -0.0225963
DOCK4 dedicator of cytokinesis 4 -0.022557
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0214475
EGFR epidermal growth factor receptor -0.0214239
ACTN1 actinin, alpha 1 -0.021316
NCEH1 neutral cholesterol ester hydrolase 1 -0.0209321
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0200822
RPLP1 ribosomal protein, large, P1 -0.0195698
HDAC9 histone deacetylase 9 -0.0195483
PFN1 profilin 1 -0.019459
RPL19 ribosomal protein L19 -0.0192478
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0191055
MYOF myoferlin -0.0190045
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0189698
TPD52 tumor protein D52 -0.0189624
RPS21 ribosomal protein S21 -0.0188281
RAD51B RAD51 paralog B -0.0187802
MCL1 myeloid cell leukemia 1 -0.0185884
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0184042
HMGA1 high mobility group AT-hook 1 -0.0184014
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0182835
OSMR oncostatin M receptor -0.0179854
PDIA6 protein disulfide isomerase family A, member 6 -0.0179324
ANXA2 annexin A2 -0.0178264
PDLIM5 PDZ and LIM domain 5 -0.0177872
ERBIN erbb2 interacting protein -0.0177512
IGFBP4 insulin-like growth factor binding protein 4 -0.017585
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0175825
IGFBP3 insulin-like growth factor binding protein 3 -0.0174337
UBASH3B ubiquitin associated and SH3 domain containing B -0.0170016
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0167717
RTN4 reticulon 4 -0.0167017
ANGPTL4 angiopoietin-like 4 -0.0166158
NAV3 neuron navigator 3 -0.0165037
ENO1 enolase 1, (alpha) -0.01639
PLS3 plastin 3 -0.016135
IL6 interleukin 6 -0.0159446
PDIA3 protein disulfide isomerase family A, member 3 -0.0159272
RPS6 ribosomal protein S6 -0.015781
GLIS3 GLIS family zinc finger 3 -0.0157543
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0156922
FLNB filamin B, beta -0.0156356
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0155126
LAMB1 laminin, beta 1 -0.0153467
EFNA5 ephrin-A5 -0.0152217
ZMYND8 zinc finger, MYND-type containing 8 -0.0150807
PRDX1 peroxiredoxin 1 -0.0149614
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0149335
USP3 ubiquitin specific peptidase 3 -0.0149104
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0148724
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0148366
S100A11 S100 calcium binding protein A11 -0.0147598
NEBL nebulette -0.0147036
NNMT nicotinamide N-methyltransferase -0.0146745