| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the GSK1059615_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.118292 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.114296 |
| MCL1 | myeloid cell leukemia 1 | 0.100316 |
| RPL37 | ribosomal protein L37 | 0.0792521 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.065792 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0623775 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0541907 |
| AEBP2 | AE binding protein 2 | 0.0539483 |
| GOLGB1 | golgin B1 | 0.0519544 |
| KLRD1 | killer cell lectin-like receptor subfamily D, member 1 | 0.0500381 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0484002 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0453688 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0446218 |
| WWOX | WW domain containing oxidoreductase | 0.0445459 |
| ATXN1 | ataxin 1 | 0.0433358 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0420381 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0402609 |
| INTS6 | integrator complex subunit 6 | 0.0396684 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0389337 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0387505 |
| OSMR | oncostatin M receptor | 0.0387394 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0365168 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0361079 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0360387 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0355198 |
| ATF6 | activating transcription factor 6 | 0.0352569 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0334344 |
| RPL37A | ribosomal protein L37a | 0.0333617 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0331088 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0326904 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0325802 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0319683 |
| CDK13 | cyclin-dependent kinase 13 | 0.0316726 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0316045 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0313325 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0310012 |
| HLA-B | major histocompatibility complex, class I, B | 0.0307598 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0294849 |
| PHF3 | PHD finger protein 3 | 0.0289856 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0289686 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0288716 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0285137 |
| MAP4 | microtubule-associated protein 4 | 0.0281417 |
| NBEAL1 | neurobeachin-like 1 | 0.0280444 |
| USP34 | ubiquitin specific peptidase 34 | 0.0277993 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0276848 |
| DST | dystonin | 0.0276432 |
| CUX1 | cut-like homeobox 1 | 0.0271244 |
| GPATCH2L | G patch domain containing 2-like | 0.0263078 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0260939 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0260549 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0260278 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | 0.0259488 |
| SVIL | supervillin | 0.0259343 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0254002 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0251577 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.024872 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0244562 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0243241 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.024207 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0241214 |
| KAZN | kazrin, periplakin interacting protein | 0.0239218 |
| PDE10A | phosphodiesterase 10A | 0.0238133 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.023707 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0235037 |
| DUSP16 | dual specificity phosphatase 16 | 0.0232256 |
| HMGA2 | high mobility group AT-hook 2 | 0.0232241 |
| PCNX4 | pecanex 4 | 0.0230923 |
| C1S | complement component 1, s subcomponent | 0.0230779 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0230467 |
| STYK1 | serine/threonine/tyrosine kinase 1 | 0.0228836 |
| ADIPOR2 | adiponectin receptor 2 | 0.0227863 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0226482 |
| BRD2 | bromodomain containing 2 | 0.022055 |
| MACROD2 | MACRO domain containing 2 | 0.0220475 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0219598 |
| HLA-E | major histocompatibility complex, class I, E | 0.021947 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.02179 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0216388 |
| RYR3 | ryanodine receptor 3 | 0.0215926 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0215734 |
| STPG4 | sperm-tail PG-rich repeat containing 4 | 0.0213717 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0213456 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0213114 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0211808 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0207367 |
| ATG7 | autophagy related 7 | 0.0207183 |
| MFSD4B | major facilitator superfamily domain containing 4B | 0.0204891 |
| AHNAK | AHNAK nucleoprotein | 0.020322 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0202959 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.020139 |
| LRRC23 | leucine rich repeat containing 23 | 0.0200832 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0200784 |
| WDR70 | WD repeat domain 70 | 0.0200742 |
| TRIM59 | tripartite motif containing 59 | 0.01995 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0197313 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0195397 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0194031 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0193974 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | 0.0192982 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.200226 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.115247 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0974509 |
| VIM | vimentin | -0.0762404 |
| TXNRD1 | thioredoxin reductase 1 | -0.071689 |
| RAD51B | RAD51 paralog B | -0.0711321 |
| PFN1 | profilin 1 | -0.0683677 |
| BBX | bobby sox homolog (Drosophila) | -0.0578735 |
| PHIP | pleckstrin homology domain interacting protein | -0.0562096 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0530601 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0489898 |
| TPI1 | triosephosphate isomerase 1 | -0.0478878 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0470312 |
| CCNL1 | cyclin L1 | -0.0440395 |
| RTN4 | reticulon 4 | -0.0435572 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0426888 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0421075 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0392871 |
| TMSB10 | thymosin beta 10 | -0.0387772 |
| LDHB | lactate dehydrogenase B | -0.0383564 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0360297 |
| POTEF | POTE ankyrin domain family, member F | -0.0354 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0350415 |
| HMGA1 | high mobility group AT-hook 1 | -0.0350052 |
| YBX3 | Y box binding protein 3 | -0.034876 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0347634 |
| XPO1 | exportin 1 | -0.0346683 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0340144 |
| EGR1 | early growth response 1 | -0.0339807 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0338266 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0331771 |
| PTMA | prothymosin, alpha | -0.0329497 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0321343 |
| PGK1 | phosphoglycerate kinase 1 | -0.031979 |
| ZNF292 | zinc finger protein 292 | -0.0317047 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0311116 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0310785 |
| TMEM165 | transmembrane protein 165 | -0.0307989 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0295714 |
| GPHN | gephyrin | -0.0293498 |
| LATS2 | large tumor suppressor kinase 2 | -0.0291197 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0284233 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0270457 |
| MORF4L2 | mortality factor 4 like 2 | -0.0264837 |
| YBX1 | Y box binding protein 1 | -0.0261033 |
| MMP12 | matrix metallopeptidase 12 | -0.0260316 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0260229 |
| PCNX1 | pecanex 1 | -0.0258492 |
| SEPTIN7 | septin 7 | -0.0258358 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0256899 |
| ATXN2 | ataxin 2 | -0.0256615 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0256133 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0254878 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0254538 |
| H1-0 | H1.0 linker histone | -0.0254471 |
| LMAN1 | lectin, mannose-binding, 1 | -0.025389 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.025294 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0252679 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0243972 |
| WDR45B | WD repeat domain 45B | -0.0242703 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0241353 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0241103 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.02366 |
| IGF2 | insulin-like growth factor 2 | -0.0235405 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.0234269 |
| RPL8 | ribosomal protein L8 | -0.0231906 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0228068 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0227966 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0227268 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0226217 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0225716 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0224747 |
| ADAR | adenosine deaminase, RNA-specific | -0.0224296 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0222864 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0222811 |
| COG5 | component of oligomeric golgi complex 5 | -0.0222618 |
| ERBIN | erbb2 interacting protein | -0.0221414 |
| BSG | basigin (Ok blood group) | -0.0219672 |
| KRT18 | keratin 18, type I | -0.021927 |
| TUBA1B | tubulin, alpha 1b | -0.0218494 |
| SRPK1 | SRSF protein kinase 1 | -0.0218291 |
| TPM2 | tropomyosin 2 (beta) | -0.0217385 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0210619 |
| SRPK2 | SRSF protein kinase 2 | -0.0205526 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0204774 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0204716 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0203812 |
| SBF2 | SET binding factor 2 | -0.0202978 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0202521 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0201939 |
| OGA | O-GlcNAcase | -0.0201218 |
| TMPO | thymopoietin | -0.0198703 |
| CBX3 | chromobox homolog 3 | -0.0197944 |
| CCDC88A | coiled-coil domain containing 88A | -0.0196652 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0195837 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0193935 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | -0.0193824 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0193419 |
| DEK | DEK proto-oncogene | -0.0192559 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0192155 |
