| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the GSK1059615_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.073779 |
| PCBP2 | poly(rC) binding protein 2 | 0.0427884 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0341735 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0287481 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0281884 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0280151 |
| RPS2 | ribosomal protein S2 | 0.0265692 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0243765 |
| MT2A | metallothionein 2A | 0.0239169 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0236068 |
| MSN | moesin | 0.0235772 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0233178 |
| CCNL1 | cyclin L1 | 0.0231992 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0227986 |
| SGMS2 | sphingomyelin synthase 2 | 0.020532 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0201765 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.020085 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0196139 |
| TXNRD1 | thioredoxin reductase 1 | 0.0187992 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0184475 |
| RPS23 | ribosomal protein S23 | 0.0183373 |
| ANXA5 | annexin A5 | 0.0174685 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0168779 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0167351 |
| TFG | TRK-fused gene | 0.0166825 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0165624 |
| VMP1 | vacuole membrane protein 1 | 0.0163578 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0163306 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0155404 |
| RPL3 | ribosomal protein L3 | 0.0153052 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0152264 |
| MYO10 | myosin X | 0.0151727 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0145331 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0144699 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0144672 |
| NUP58 | nucleoporin 58 | 0.0143747 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0141393 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0139197 |
| MATR3 | matrin 3 | 0.0137378 |
| APP | amyloid beta (A4) precursor protein | 0.0136995 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0136365 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0135579 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0133778 |
| RPLP0 | ribosomal protein, large, P0 | 0.013212 |
| RYBP | RING1 and YY1 binding protein | 0.0131074 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0130241 |
| CENPF | centromere protein F, 350/400kDa | 0.012987 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0129088 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0128704 |
| PPIA | peptidylprolyl isomerase A (cyclophilin A) | 0.0128129 |
| STK24 | serine/threonine kinase 24 | 0.0128017 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0127621 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0127479 |
| RNF145 | ring finger protein 145 | 0.0127428 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0126535 |
| IPO7 | importin 7 | 0.0124968 |
| ARRDC3 | arrestin domain containing 3 | 0.0124508 |
| CENPE | centromere protein E, 312kDa | 0.0124314 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0123246 |
| CD46 | CD46 molecule, complement regulatory protein | 0.012319 |
| TMEM131L | transmembrane 131 like | 0.0122255 |
| PPME1 | protein phosphatase methylesterase 1 | 0.012077 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0119911 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.011732 |
| RPS18 | ribosomal protein S18 | 0.0117063 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0116725 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0116562 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0116468 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0116122 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.011585 |
| RPS20 | ribosomal protein S20 | 0.0115602 |
| CEP70 | centrosomal protein 70kDa | 0.0114004 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0113931 |
| MCL1 | myeloid cell leukemia 1 | 0.0113319 |
| NCKAP1 | NCK-associated protein 1 | 0.0113072 |
| TUSC3 | tumor suppressor candidate 3 | 0.0112895 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0112588 |
| BRD2 | bromodomain containing 2 | 0.0111312 |
| HMGB2 | high mobility group box 2 | 0.0110673 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0109855 |
| DENND4A | DENN/MADD domain containing 4A | 0.010935 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0108637 |
| YAP1 | Yes-associated protein 1 | 0.0107246 |
| AHR | aryl hydrocarbon receptor | 0.0107102 |
| TAPBP | TAP binding protein (tapasin) | 0.0106989 |
| RPL39 | ribosomal protein L39 | 0.0106849 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0105636 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0104735 |
| CD83 | CD83 molecule | 0.0103267 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.010266 |
| MLF1 | myeloid leukemia factor 1 | 0.0102243 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.010168 |
| NUP98 | nucleoporin 98kDa | 0.0101272 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0101195 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.010099 |
| LRRC1 | leucine rich repeat containing 1 | 0.0100125 |
| FOSL1 | FOS-like antigen 1 | 0.00996948 |
| NPTN | neuroplastin | 0.00983941 |
| RLF | rearranged L-myc fusion | 0.00970578 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.00966864 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.166863 |
| ACTG1 | actin gamma 1 | -0.15256 |
| PTMA | prothymosin, alpha | -0.137323 |
| TMSB10 | thymosin beta 10 | -0.114559 |
| FBXO32 | F-box protein 32 | -0.103648 |
| FN1 | fibronectin 1 | -0.0990888 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0964698 |
| FTL | ferritin, light polypeptide | -0.0914475 |
| TMSB4X | thymosin beta 4, X-linked | -0.0893345 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0874784 |
| LAMB3 | laminin, beta 3 | -0.0861814 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0849439 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0811417 |
| TPM4 | tropomyosin 4 | -0.0775311 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0764164 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0753511 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0736638 |
| AHNAK | AHNAK nucleoprotein | -0.0727082 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0713554 |
| LMO7 | LIM domain 7 | -0.0710988 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0675714 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0669484 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0651169 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0649201 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0649167 |
| CCND1 | cyclin D1 | -0.0617456 |
| VIM | vimentin | -0.0608233 |
| CSTB | cystatin B (stefin B) | -0.0589479 |
| PGK1 | phosphoglycerate kinase 1 | -0.0587773 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0578659 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0570695 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0564537 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0550561 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0511422 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0506263 |
| KRT7 | keratin 7, type II | -0.0463039 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0460706 |
| S100A10 | S100 calcium binding protein A10 | -0.0459181 |
| ASPH | aspartate beta-hydroxylase | -0.045483 |
| RAI14 | retinoic acid induced 14 | -0.0451926 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0449713 |
| ENO1 | enolase 1, (alpha) | -0.0449669 |
| DSG2 | desmoglein 2 | -0.0443647 |
| CD2AP | CD2-associated protein | -0.043611 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0432658 |
| GNAS | GNAS complex locus | -0.0427139 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0426525 |
| KRT18 | keratin 18, type I | -0.0425503 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0421717 |
| RPL35A | ribosomal protein L35a | -0.0419254 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0415524 |
| EPCAM | epithelial cell adhesion molecule | -0.040121 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0398981 |
| ANXA2 | annexin A2 | -0.0398692 |
| DSPP | dentin sialophosphoprotein | -0.0388179 |
| H1-0 | H1.0 linker histone | -0.0387057 |
| EFNA5 | ephrin-A5 | -0.0383846 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0382052 |
| FLNB | filamin B, beta | -0.0381259 |
| LAMC2 | laminin, gamma 2 | -0.0379422 |
| RPS8 | ribosomal protein S8 | -0.0376752 |
| NDRG1 | N-myc downstream regulated 1 | -0.0376139 |
| HLA-B | major histocompatibility complex, class I, B | -0.0375245 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0372596 |
| CANX | calnexin | -0.0367612 |
| CAVIN1 | caveolae associated protein 1 | -0.0365783 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0365317 |
| LMNA | lamin A/C | -0.0362871 |
| TMEM123 | transmembrane protein 123 | -0.0362758 |
| RRBP1 | ribosome binding protein 1 | -0.0361071 |
| HLA-A | major histocompatibility complex, class I, A | -0.0354354 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0346391 |
| KRT8 | keratin 8, type II | -0.0345804 |
| MX2 | MX dynamin-like GTPase 2 | -0.034087 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0339544 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0337582 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0333144 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.03314 |
| RPL34 | ribosomal protein L34 | -0.0326804 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0326394 |
| ZNF217 | zinc finger protein 217 | -0.0323939 |
| LDHA | lactate dehydrogenase A | -0.032304 |
| SP100 | SP100 nuclear antigen | -0.0313903 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0312489 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0306946 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0306468 |
| HSPB1 | heat shock 27kDa protein 1 | -0.030533 |
| MYO6 | myosin VI | -0.0301022 |
| TOP1 | topoisomerase (DNA) I | -0.0300322 |
| MAP1B | microtubule-associated protein 1B | -0.0299927 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.029422 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0293219 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0292279 |
| RNF213 | ring finger protein 213 | -0.0290741 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0288631 |
| TMEM263 | transmembrane protein 263 | -0.0284943 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0283624 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0278955 |
| WASF2 | WAS protein family, member 2 | -0.027707 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0268393 |
