| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the GSK1059615_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GDA | guanine deaminase | 0.128316 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0873543 |
| KYNU | kynureninase | 0.0797728 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0584109 |
| NTN4 | netrin 4 | 0.0560258 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0537745 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.051312 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0503597 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0491617 |
| RPS2 | ribosomal protein S2 | 0.0467157 |
| SMYD3 | SET and MYND domain containing 3 | 0.0413891 |
| SQSTM1 | sequestosome 1 | 0.0392068 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0389373 |
| RPS12 | ribosomal protein S12 | 0.0384518 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0366412 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0346953 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0346103 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0337566 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0332274 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0330516 |
| GRAMD1B | GRAM domain containing 1B | 0.0312311 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0311059 |
| CD44 | CD44 molecule (Indian blood group) | 0.0310941 |
| CD109 | CD109 molecule | 0.0301874 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0300648 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0294462 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0291786 |
| BPTF | bromodomain PHD finger transcription factor | 0.0278283 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0270638 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0261935 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0260303 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0259725 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0259449 |
| RPS27 | ribosomal protein S27 | 0.0258375 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0252047 |
| RACK1 | receptor for activated C kinase 1 | 0.024865 |
| SMAD2 | SMAD family member 2 | 0.0248016 |
| RPL39 | ribosomal protein L39 | 0.0243832 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0243797 |
| RPS8 | ribosomal protein S8 | 0.0239921 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0235132 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0235074 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0231528 |
| NFX1 | nuclear transcription factor, X-box binding 1 | 0.0229871 |
| PHF14 | PHD finger protein 14 | 0.0226097 |
| COL5A2 | collagen, type V, alpha 2 | 0.022446 |
| TUSC3 | tumor suppressor candidate 3 | 0.0223033 |
| RANBP17 | RAN binding protein 17 | 0.0222248 |
| MAP7 | microtubule-associated protein 7 | 0.0219465 |
| PTEN | phosphatase and tensin homolog | 0.0219157 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.021741 |
| FNIP1 | folliculin interacting protein 1 | 0.0209562 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0206905 |
| PCBP2 | poly(rC) binding protein 2 | 0.0204318 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0199221 |
| JMJD1C | jumonji domain containing 1C | 0.0198117 |
| RPL37 | ribosomal protein L37 | 0.0198101 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0197976 |
| BMP6 | bone morphogenetic protein 6 | 0.0197467 |
| RPL26 | ribosomal protein L26 | 0.0196693 |
| RPS17 | ribosomal protein S17 | 0.0196369 |
| MT2A | metallothionein 2A | 0.0188436 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0186695 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0183552 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0182712 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0181904 |
| RPS7 | ribosomal protein S7 | 0.018025 |
| SVIL | supervillin | 0.0176146 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0175943 |
| RPL36A | ribosomal protein L36a | 0.0175858 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0173781 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0173338 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0173232 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0173185 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0172966 |
| FAM107B | family with sequence similarity 107, member B | 0.0170855 |
| ASTN2 | astrotactin 2 | 0.0165757 |
| ATXN1 | ataxin 1 | 0.0165626 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0165095 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0164636 |
| R3HDM2 | R3H domain containing 2 | 0.0164146 |
| RASAL2 | RAS protein activator like 2 | 0.0163353 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0160041 |
| VMP1 | vacuole membrane protein 1 | 0.0159633 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.015899 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0158857 |
| GOLGB1 | golgin B1 | 0.0158822 |
| GPC5 | glypican 5 | 0.0157947 |
| RPL31 | ribosomal protein L31 | 0.0157373 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0156591 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0156323 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0155437 |
| CDK13 | cyclin-dependent kinase 13 | 0.0154011 |
| RAB31 | RAB31, member RAS oncogene family | 0.0152919 |
| RPL7 | ribosomal protein L7 | 0.0152718 |
| FAT1 | FAT atypical cadherin 1 | 0.0152117 |
| EXOC6B | exocyst complex component 6B | 0.0152074 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0151454 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0151373 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.014896 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.233864 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.170302 |
| FN1 | fibronectin 1 | -0.147524 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.136573 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.136489 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0920989 |
| TMSB10 | thymosin beta 10 | -0.0817501 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0792741 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0769039 |
| VIM | vimentin | -0.0728546 |
| SPAG9 | sperm associated antigen 9 | -0.0715518 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0672141 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0666721 |
| OGA | O-GlcNAcase | -0.0643652 |
| EFNA5 | ephrin-A5 | -0.0619047 |
| PTMA | prothymosin, alpha | -0.058811 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.05873 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0576285 |
| PGK1 | phosphoglycerate kinase 1 | -0.0533612 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0529595 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0525829 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0518663 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0518503 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0516894 |
| NRCAM | neuronal cell adhesion molecule | -0.0512281 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0499445 |
| ASPH | aspartate beta-hydroxylase | -0.0486838 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0475637 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0470507 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.046641 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0460719 |
| PRELID2 | PRELI domain containing 2 | -0.0458067 |
| FAM13A | family with sequence similarity 13, member A | -0.0455236 |
| GNAS | GNAS complex locus | -0.0439841 |
| WDR45B | WD repeat domain 45B | -0.0434232 |
| LSAMP | limbic system-associated membrane protein | -0.043414 |
| NDRG1 | N-myc downstream regulated 1 | -0.0431709 |
| RGS2 | regulator of G-protein signaling 2 | -0.042435 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0420527 |
| RBM39 | RNA binding motif protein 39 | -0.0413845 |
| PCBP3 | poly(rC) binding protein 3 | -0.0410649 |
| FTL | ferritin, light polypeptide | -0.0401167 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0399897 |
| HELZ | helicase with zinc finger | -0.0399534 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.039612 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0388976 |
| USP3 | ubiquitin specific peptidase 3 | -0.0387852 |
| ZNF292 | zinc finger protein 292 | -0.0387758 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0385337 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0375721 |
| PDE10A | phosphodiesterase 10A | -0.0375246 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.034819 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0343408 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0342943 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0340195 |
| NCKAP5 | NCK-associated protein 5 | -0.0339086 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0335499 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0334616 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0332407 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0326638 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0321946 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0320939 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0318459 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0317846 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.031748 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0316751 |
| RTN4 | reticulon 4 | -0.0315213 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0314793 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0314756 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0313499 |
| MYOF | myoferlin | -0.0310617 |
| DENND1A | DENN/MADD domain containing 1A | -0.0309733 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0300216 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0298389 |
| SRPK2 | SRSF protein kinase 2 | -0.0296773 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0296708 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.029347 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0293336 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.029202 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0291611 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0290405 |
| NUP58 | nucleoporin 58 | -0.0289612 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0288062 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0287837 |
| PHF21A | PHD finger protein 21A | -0.0286999 |
| RPS24 | ribosomal protein S24 | -0.0283641 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0281163 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0280514 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0279833 |
| CDC73 | cell division cycle 73 | -0.0278726 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0277695 |
| S100A10 | S100 calcium binding protein A10 | -0.0277104 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0275891 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0274976 |
| GPC6 | glypican 6 | -0.0273167 |
| TPD52 | tumor protein D52 | -0.0272397 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0272248 |
| ANXA1 | annexin A1 | -0.0270989 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0269367 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0269357 |
