GSK1059615_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.121789
DSCAM Down syndrome cell adhesion molecule 0.110426
LMO7 LIM domain 7 0.0942855
USP34 ubiquitin specific peptidase 34 0.0908774
PDE4D phosphodiesterase 4D, cAMP-specific 0.0908709
MYO1E myosin IE 0.0774952
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0744838
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0730919
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0725249
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0719927
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0708175
SBF2 SET binding factor 2 0.0685291
SQSTM1 sequestosome 1 0.0667009
FBXO11 F-box protein 11 0.0657248
EXT1 exostosin glycosyltransferase 1 0.0655355
AHNAK AHNAK nucleoprotein 0.0586077
FNIP1 folliculin interacting protein 1 0.0571851
TAS2R14 taste receptor, type 2, member 14 0.0511717
EEF2 eukaryotic translation elongation factor 2 0.0510856
DSPP dentin sialophosphoprotein 0.0502811
MED13L mediator complex subunit 13-like 0.0501148
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0497232
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0490309
RAB7A RAB7A, member RAS oncogene family 0.0489616
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0477071
PNISR PNN-interacting serine/arginine-rich protein 0.0474453
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0465092
KMT2E lysine (K)-specific methyltransferase 2E 0.0453465
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0448604
FUS FUS RNA binding protein 0.0446494
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0444761
ZNF292 zinc finger protein 292 0.0439917
TXNIP thioredoxin interacting protein 0.0435676
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0433545
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.043241
SPAG9 sperm associated antigen 9 0.0427047
TRIO trio Rho guanine nucleotide exchange factor 0.0423328
ANKRD17 ankyrin repeat domain 17 0.0417889
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0407297
EPS8 epidermal growth factor receptor pathway substrate 8 0.0404575
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0391866
SLTM SAFB-like, transcription modulator 0.0373328
RBM39 RNA binding motif protein 39 0.0373069
KDM7A lysine (K)-specific demethylase 7A 0.0368517
EGFR epidermal growth factor receptor 0.0360236
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0359399
ATXN1 ataxin 1 0.0359219
STK24 serine/threonine kinase 24 0.0346241
ARHGAP5 Rho GTPase activating protein 5 0.0345068
KMT2C lysine (K)-specific methyltransferase 2C 0.0327484
CSNK1A1 casein kinase 1, alpha 1 0.0326943
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.03243
RPL11 ribosomal protein L11 0.0313839
RAB2A RAB2A, member RAS oncogene family 0.0308272
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.030199
GPBP1 GC-rich promoter binding protein 1 0.0298312
VCL vinculin 0.0297174
KIF5B kinesin family member 5B 0.0291423
CDC73 cell division cycle 73 0.0279261
MORF4L2 mortality factor 4 like 2 0.0277816
JMJD1C jumonji domain containing 1C 0.0276099
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0273359
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0268374
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0260523
ZSWIM6 zinc finger, SWIM-type containing 6 0.0257599
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0247984
RPS6 ribosomal protein S6 0.0242309
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0238238
ADAM10 ADAM metallopeptidase domain 10 0.0233168
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0231213
KTN1 kinectin 1 (kinesin receptor) 0.0222838
TPR translocated promoter region, nuclear basket protein 0.0219653
MPHOSPH8 M-phase phosphoprotein 8 0.0218801
NCOR1 nuclear receptor corepressor 1 0.0205017
FTH1 ferritin, heavy polypeptide 1 0.0200107
KANSL1 KAT8 regulatory NSL complex subunit 1 0.019567
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0191906
CDK13 cyclin-dependent kinase 13 0.0189723
SLC38A2 solute carrier family 38, member 2 0.0188119
SP100 SP100 nuclear antigen 0.0188065
ANKRD11 ankyrin repeat domain 11 0.0174911
VMP1 vacuole membrane protein 1 0.0173336
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0172821
CALR calreticulin 0.0170546
SLC38A1 solute carrier family 38, member 1 0.0169738
SPDYA speedy/RINGO cell cycle regulator family member A 0.0159695
MAML2 mastermind-like 2 (Drosophila) 0.0157495
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0149644
RBM25 RNA binding motif protein 25 0.0148937
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.014442
KDM3A lysine (K)-specific demethylase 3A 0.0141602
ARHGAP26 Rho GTPase activating protein 26 0.0132596
PRKCA protein kinase C, alpha 0.0131684
TSC22D2 TSC22 domain family, member 2 0.0130221
GOLGB1 golgin B1 0.0127856
MATR3 matrin 3 0.0127808
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0127737
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0122898
PRELID2 PRELI domain containing 2 0.0119106
RPL26 ribosomal protein L26 0.0115547

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.443473
TMSB10 thymosin beta 10 -0.151277
VIM vimentin -0.149461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.10699
NDRG1 N-myc downstream regulated 1 -0.100217
FNDC3B fibronectin type III domain containing 3B -0.0961869
FTL ferritin, light polypeptide -0.0927334
ELL2 elongation factor, RNA polymerase II, 2 -0.0880955
NAMPT nicotinamide phosphoribosyltransferase -0.0842511
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0820399
TPT1 tumor protein, translationally-controlled 1 -0.081851
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.08116
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0807592
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0794906
EFNA5 ephrin-A5 -0.0721507
PTMA prothymosin, alpha -0.0675368
MT2A metallothionein 2A -0.0650979
IGFBP3 insulin-like growth factor binding protein 3 -0.0635864
FLNB filamin B, beta -0.0633285
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0627519
MYO10 myosin X -0.0623247
RPL32 ribosomal protein L32 -0.0601407
FN1 fibronectin 1 -0.0577249
FAM13A family with sequence similarity 13, member A -0.0566491
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.055443
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0553084
RPS13 ribosomal protein S13 -0.0541688
RPL15 ribosomal protein L15 -0.0539469
RPL35A ribosomal protein L35a -0.05336
RPL23 ribosomal protein L23 -0.0532949
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0528009
ACTG1 actin gamma 1 -0.0484061
RPLP0 ribosomal protein, large, P0 -0.0468388
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0467214
ALCAM activated leukocyte cell adhesion molecule -0.0466778
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0453423
PDIA3 protein disulfide isomerase family A, member 3 -0.0452485
EIF1 eukaryotic translation initiation factor 1 -0.0451545
S100A10 S100 calcium binding protein A10 -0.044183
ANXA2 annexin A2 -0.0424307
RPS19 ribosomal protein S19 -0.0406685
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0403892
ZBTB20 zinc finger and BTB domain containing 20 -0.039921
HDAC9 histone deacetylase 9 -0.0391031
CANX calnexin -0.039073
RPL12 ribosomal protein L12 -0.0373806
MTDH metadherin -0.0369554
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0352382
CDH13 cadherin 13 -0.0345593
GARS1 glycyl-tRNA synthetase 1 -0.0337967
WSB1 WD repeat and SOCS box containing 1 -0.0329123
RPS16 ribosomal protein S16 -0.0325168
HOOK2 hook microtubule-tethering protein 2 -0.0313192
RRBP1 ribosome binding protein 1 -0.0312499
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0306606
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0305109
OGA O-GlcNAcase -0.0294347
RAD51B RAD51 paralog B -0.0290165
RPL7A ribosomal protein L7a -0.0282375
RPL34 ribosomal protein L34 -0.0278418
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.027834
PDE8A phosphodiesterase 8A -0.0276073
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0268
SRRM2 serine/arginine repetitive matrix 2 -0.0267051
TM9SF3 transmembrane 9 superfamily member 3 -0.0264283
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0262623
YAP1 Yes-associated protein 1 -0.0254374
FHIT fragile histidine triad -0.0250746
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0250719
CCNI cyclin I -0.0243044
RPL37 ribosomal protein L37 -0.0240679
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0235905
BPTF bromodomain PHD finger transcription factor -0.0235447
RPL31 ribosomal protein L31 -0.0231418
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0227638
RPS3 ribosomal protein S3 -0.0225014
AFF4 AF4/FMR2 family, member 4 -0.0216119
BIRC6 baculoviral IAP repeat containing 6 -0.0212117
LDHA lactate dehydrogenase A -0.0211187
LAMC2 laminin, gamma 2 -0.0199684
LAMA4 laminin, alpha 4 -0.019223
ENO1 enolase 1, (alpha) -0.0189192
RPL36 ribosomal protein L36 -0.0178373
CD44 CD44 molecule (Indian blood group) -0.0175845
CHD9 chromodomain helicase DNA binding protein 9 -0.0167574
AKAP13 A kinase (PRKA) anchor protein 13 -0.0166869
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0160472
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0160036
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0159966
HELZ helicase with zinc finger -0.0159188
RTN4 reticulon 4 -0.0156212
FNDC3A fibronectin type III domain containing 3A -0.0139723
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0138942
RPS14 ribosomal protein S14 -0.013825
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0130873
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0128424
PARD3 par-3 family cell polarity regulator -0.0126683
ANKRD12 ankyrin repeat domain 12 -0.0115027
MED13 mediator complex subunit 13 -0.0113906
POTEF POTE ankyrin domain family, member F -0.0109291