GSK1059615_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 0.118276
COL11A1 collagen, type XI, alpha 1 0.112776
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0961328
COL5A2 collagen, type V, alpha 2 0.0839142
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0557731
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0480899
DSCAM Down syndrome cell adhesion molecule 0.0469616
DNAH14 dynein, axonemal, heavy chain 14 0.0461424
ITGAV integrin, alpha V 0.0459928
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0415748
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0395419
TAS2R14 taste receptor, type 2, member 14 0.0373714
PARD3B par-3 family cell polarity regulator beta 0.0358452
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0347708
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0344153
CCNG2 cyclin G2 0.0332476
HMCN1 hemicentin 1 0.0317941
USP34 ubiquitin specific peptidase 34 0.0317272
ADGRL2 adhesion G protein-coupled receptor L2 0.0316822
CSMD3 CUB and Sushi multiple domains 3 0.0315941
RIMS2 regulating synaptic membrane exocytosis 2 0.0315445
TRPS1 trichorhinophalangeal syndrome I 0.03152
TP63 tumor protein p63 0.0313736
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0312189
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0292512
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0291433
BIRC6 baculoviral IAP repeat containing 6 0.0290361
EPHA5 EPH receptor A5 0.028645
AKAP9 A kinase (PRKA) anchor protein 9 0.0283249
VMP1 vacuole membrane protein 1 0.0275804
PEG10 paternally expressed 10 0.0270865
WWOX WW domain containing oxidoreductase 0.0269967
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0268909
RBM33 RNA binding motif protein 33 0.0266515
RABGAP1L RAB GTPase activating protein 1-like 0.0254328
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0252069
FOXP2 forkhead box P2 0.0242938
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0238099
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0234648
ADAM32 ADAM metallopeptidase domain 32 0.0233369
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0232059
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0229912
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0227594
TPR translocated promoter region, nuclear basket protein 0.0227216
KAZN kazrin, periplakin interacting protein 0.0224948
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0224387
TBC1D32 TBC1 domain family, member 32 0.0223288
APP amyloid beta (A4) precursor protein 0.0222968
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0221197
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) 0.0217206
CDK13 cyclin-dependent kinase 13 0.0216913
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0216853
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0216647
FAM177A1 family with sequence similarity 177, member A1 0.0214829
COL26A1 collagen, type XXVI, alpha 1 0.0213802
USP53 ubiquitin specific peptidase 53 0.0212774
CDH19 cadherin 19, type 2 0.0212253
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0207511
MSRB3 methionine sulfoxide reductase B3 0.0206563
RBM39 RNA binding motif protein 39 0.0206141
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.02053
PLCB4 phospholipase C, beta 4 0.0205259
CLIC4 chloride intracellular channel 4 0.0200757
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.0199671
BRD2 bromodomain containing 2 0.0199378
ADGRV1 adhesion G protein-coupled receptor V1 0.0198873
PHF3 PHD finger protein 3 0.0198774
ZNF638 zinc finger protein 638 0.0198548
ABI2 abl-interactor 2 0.0197407
AGO3 argonaute RISC catalytic component 3 0.0194843
RFC3 replication factor C (activator 1) 3, 38kDa 0.0194554
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0194111
MATR3 matrin 3 0.0193597
BRMS1L breast cancer metastasis-suppressor 1-like 0.0193178
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0193076
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0192212
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0191057
BBS9 Bardet-Biedl syndrome 9 0.019096
SFPQ splicing factor proline/glutamine-rich 0.0190324
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.0186811
SPIDR scaffolding protein involved in DNA repair 0.0186698
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.018593
NUP160 nucleoporin 160kDa 0.0183303
ATM ATM serine/threonine kinase 0.0182458
FNDC3B fibronectin type III domain containing 3B 0.0181517
GLS2 glutaminase 2 (liver, mitochondrial) 0.018053
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) 0.0180207
NCKAP1 NCK-associated protein 1 0.0180197
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0180161
CENPF centromere protein F, 350/400kDa 0.0179977
FOXP1 forkhead box P1 0.0179809
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0179469
SYT1 synaptotagmin I 0.0179424
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0179201
CFLAR CASP8 and FADD-like apoptosis regulator 0.0179113
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0178917
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0177954
ZNF568 zinc finger protein 568 0.0176225
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0175868
INTS6 integrator complex subunit 6 0.0175749

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.174884
PTMA prothymosin, alpha -0.171461
TMSB10 thymosin beta 10 -0.135422
CADM2 cell adhesion molecule 2 -0.118952
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104263
WSB1 WD repeat and SOCS box containing 1 -0.100472
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0713922
MDK midkine (neurite growth-promoting factor 2) -0.0654732
GPC3 glypican 3 -0.0648503
PGK1 phosphoglycerate kinase 1 -0.0643902
PCDH9 protocadherin 9 -0.0603389
RPS16 ribosomal protein S16 -0.0598732
RPS6 ribosomal protein S6 -0.0572129
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0549852
RPL35A ribosomal protein L35a -0.0543165
ISG15 ISG15 ubiquitin-like modifier -0.0530804
RPS8 ribosomal protein S8 -0.0525594
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0521257
PLPP1 phospholipid phosphatase 1 -0.051558
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0512451
B2M beta-2-microglobulin -0.0482064
NEBL nebulette -0.0472676
TSC22D2 TSC22 domain family, member 2 -0.045665
COL1A2 collagen, type I, alpha 2 -0.0449914
AKAP12 A kinase (PRKA) anchor protein 12 -0.0446873
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0435851
RBM20 RNA binding motif protein 20 -0.0429091
SPAG9 sperm associated antigen 9 -0.0427433
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0424997
ACTG1 actin gamma 1 -0.0421626
RPL11 ribosomal protein L11 -0.0419221
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0418829
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0409045
NPAS3 neuronal PAS domain protein 3 -0.0399266
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0399056
ZNF292 zinc finger protein 292 -0.038312
THBS1 thrombospondin 1 -0.037956
NTM neurotrimin -0.0378336
ZNF217 zinc finger protein 217 -0.0376382
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0376088
H1-0 H1.0 linker histone -0.0375784
TMSB4X thymosin beta 4, X-linked -0.0370693
RPS19 ribosomal protein S19 -0.0367029
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0363549
CALR calreticulin -0.0363152
RAD51B RAD51 paralog B -0.035679
ANKRD33B ankyrin repeat domain 33B -0.0350954
RPL23 ribosomal protein L23 -0.0348867
GSE1 Gse1 coiled-coil protein -0.0347588
RPL31 ribosomal protein L31 -0.0345137
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0344142
SFRP4 secreted frizzled-related protein 4 -0.0342756
APOE apolipoprotein E -0.0338904
CNRIP1 cannabinoid receptor interacting protein 1 -0.0335504
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0334707
RPLP1 ribosomal protein, large, P1 -0.0333786
ENO1 enolase 1, (alpha) -0.0329478
ATP5F1B ATP synthase F1 subunit beta -0.0328402
TPT1 tumor protein, translationally-controlled 1 -0.0320368
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0314245
S100A10 S100 calcium binding protein A10 -0.0310784
LRRC4C leucine rich repeat containing 4C -0.0308097
MYL12B myosin, light chain 12B, regulatory -0.030207
RPL34 ribosomal protein L34 -0.0300353
RPS21 ribosomal protein S21 -0.0300114
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0299124
LDHA lactate dehydrogenase A -0.0296059
RPS12 ribosomal protein S12 -0.0289213
RPLP2 ribosomal protein, large, P2 -0.0287711
RPL12 ribosomal protein L12 -0.0281021
ANXA2 annexin A2 -0.0278043
HSPB1 heat shock 27kDa protein 1 -0.02755
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0273779
RAI1 retinoic acid induced 1 -0.0273772
TBCA tubulin folding cofactor A -0.0269704
S100A9 S100 calcium binding protein A9 -0.0266463
RPS27A ribosomal protein S27a -0.026096
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0258997
RPS13 ribosomal protein S13 -0.02542
ZEB2 zinc finger E-box binding homeobox 2 -0.0253486
SERF2 small EDRK-rich factor 2 -0.0253386
RPL9 ribosomal protein L9 -0.0247279
SAMD4A sterile alpha motif domain containing 4A -0.0247089
HMGB1 high mobility group box 1 -0.0246945
MT2A metallothionein 2A -0.0246185
POTEF POTE ankyrin domain family, member F -0.024617
LOC102724023 ES1 protein homolog, mitochondrial -0.0242547
RPL5 ribosomal protein L5 -0.0241874
ZMYND8 zinc finger, MYND-type containing 8 -0.0240027
AHNAK AHNAK nucleoprotein -0.023945
RPL19 ribosomal protein L19 -0.0236059
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.023458
BEX3 brain expressed X-linked 3 -0.0232964
RSL1D1 ribosomal L1 domain containing 1 -0.0230931
NXN nucleoredoxin -0.0230313
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0228494
PGAP1 post-GPI attachment to proteins 1 -0.022665
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.022654
FTL ferritin, light polypeptide -0.0225587
TOX thymocyte selection-associated high mobility group box -0.0225496