| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the GSK1059615_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0668164 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0666394 |
| VCAN | versican | 0.0499357 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0435818 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.04144 |
| JMJD1C | jumonji domain containing 1C | 0.0399019 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.038205 |
| CENPF | centromere protein F, 350/400kDa | 0.0368422 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0360235 |
| RPS2 | ribosomal protein S2 | 0.0351093 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0323036 |
| PCBP2 | poly(rC) binding protein 2 | 0.0314081 |
| RPL37 | ribosomal protein L37 | 0.0307156 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0287693 |
| NAV2 | neuron navigator 2 | 0.0286578 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0286533 |
| AHR | aryl hydrocarbon receptor | 0.028332 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0281655 |
| MKI67 | marker of proliferation Ki-67 | 0.0265875 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0261425 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0260094 |
| NRP1 | neuropilin 1 | 0.0256284 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0255458 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0250525 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0247523 |
| KYNU | kynureninase | 0.0245105 |
| RND3 | Rho family GTPase 3 | 0.0244817 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0244209 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0241982 |
| VMP1 | vacuole membrane protein 1 | 0.023501 |
| CDK19 | cyclin-dependent kinase 19 | 0.0234173 |
| HMGA2 | high mobility group AT-hook 2 | 0.0232318 |
| BICC1 | BicC family RNA binding protein 1 | 0.0229414 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0228433 |
| APP | amyloid beta (A4) precursor protein | 0.022738 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0223922 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0219932 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0215749 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0214215 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0213809 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0212242 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0210072 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0205061 |
| MATR3 | matrin 3 | 0.0201751 |
| NONO | non-POU domain containing, octamer-binding | 0.0200268 |
| FLOT1 | flotillin 1 | 0.0200235 |
| SVIL | supervillin | 0.0190849 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0187734 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.01876 |
| HDAC9 | histone deacetylase 9 | 0.0185696 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0184524 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.01834 |
| RPL39 | ribosomal protein L39 | 0.018323 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0179806 |
| SQSTM1 | sequestosome 1 | 0.0179556 |
| FNIP1 | folliculin interacting protein 1 | 0.0178574 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0174575 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0171085 |
| IPO7 | importin 7 | 0.0170165 |
| MCL1 | myeloid cell leukemia 1 | 0.0166452 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.016512 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0165026 |
| MYO10 | myosin X | 0.0162761 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0160179 |
| TUSC3 | tumor suppressor candidate 3 | 0.015728 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0156055 |
| MSN | moesin | 0.0153624 |
| DIAPH3 | diaphanous-related formin 3 | 0.0152291 |
| TPM3 | tropomyosin 3 | 0.0151446 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0150197 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0147265 |
| DUSP10 | dual specificity phosphatase 10 | 0.0147216 |
| FOXP1 | forkhead box P1 | 0.0146359 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.014607 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0145492 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0143502 |
| TPX2 | TPX2, microtubule-associated | 0.0142003 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0141736 |
| RPS18 | ribosomal protein S18 | 0.0138518 |
| KIF4A | kinesin family member 4A | 0.0138104 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0136976 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0134991 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0133887 |
| NOTCH2 | notch 2 | 0.0133708 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0132493 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.0132187 |
| ZNF638 | zinc finger protein 638 | 0.0131475 |
| CREBRF | CREB3 regulatory factor | 0.0129092 |
| OPTN | optineurin | 0.0128015 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0126171 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0126038 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0126029 |
| TCP1 | t-complex 1 | 0.0125774 |
| DNAJC13 | DnaJ (Hsp40) homolog, subfamily C, member 13 | 0.0125497 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.012472 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0124451 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0124313 |
| GOLGB1 | golgin B1 | 0.0124004 |
| BRD2 | bromodomain containing 2 | 0.012365 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0122929 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.310354 |
| HLA-B | major histocompatibility complex, class I, B | -0.0934456 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0928669 |
| FRMD4A | FERM domain containing 4A | -0.0919745 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0905556 |
| IER3 | immediate early response 3 | -0.0876942 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0860749 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0778737 |
| TMSB10 | thymosin beta 10 | -0.075126 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0744288 |
| FTL | ferritin, light polypeptide | -0.0743557 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0727402 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0710683 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0685044 |
| NDRG1 | N-myc downstream regulated 1 | -0.0630016 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0605649 |
| MT2A | metallothionein 2A | -0.0564134 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0562499 |
| PDE10A | phosphodiesterase 10A | -0.0535926 |
| PGK1 | phosphoglycerate kinase 1 | -0.0522095 |
| CADM1 | cell adhesion molecule 1 | -0.0519684 |
| FN1 | fibronectin 1 | -0.0512668 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0486105 |
| LDHA | lactate dehydrogenase A | -0.0478881 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0475647 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0468784 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0460676 |
| STC1 | stanniocalcin 1 | -0.0457834 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0441383 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0434331 |
| ADM | adrenomedullin | -0.042044 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.041881 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0413726 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0405406 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.039188 |
| PTMA | prothymosin, alpha | -0.0391605 |
| HLA-A | major histocompatibility complex, class I, A | -0.0391259 |
| GNAS | GNAS complex locus | -0.0383084 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0367174 |
| CALR | calreticulin | -0.0364985 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0349809 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0330095 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0323231 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0320139 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0318167 |
| PLIN2 | perilipin 2 | -0.0311705 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0301965 |
| MYOF | myoferlin | -0.0298226 |
| LOX | lysyl oxidase | -0.0294189 |
| CTSD | cathepsin D | -0.0294153 |
| C3 | complement component 3 | -0.0293822 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0291455 |
| VEGFA | vascular endothelial growth factor A | -0.0290322 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0289816 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0289513 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0289047 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.028723 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0287129 |
| GLIS3 | GLIS family zinc finger 3 | -0.0286869 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0283956 |
| RPLP2 | ribosomal protein, large, P2 | -0.0283816 |
| RRBP1 | ribosome binding protein 1 | -0.0268553 |
| VCL | vinculin | -0.0267556 |
| TPM4 | tropomyosin 4 | -0.0265933 |
| TMSB4X | thymosin beta 4, X-linked | -0.0264081 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0261788 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0254576 |
| COL1A1 | collagen, type I, alpha 1 | -0.0253848 |
| NAV1 | neuron navigator 1 | -0.0243188 |
| NRN1 | neuritin 1 | -0.0243057 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0236732 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0228622 |
| BNC2 | basonuclin 2 | -0.0227278 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0225698 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0215202 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0211554 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0210166 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0206777 |
| EGFR | epidermal growth factor receptor | -0.02065 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0200588 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0199574 |
| MMP12 | matrix metallopeptidase 12 | -0.0198879 |
| RPS19 | ribosomal protein S19 | -0.0196502 |
| GOLGA4 | golgin A4 | -0.0195134 |
| SP100 | SP100 nuclear antigen | -0.0195125 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0194364 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0194214 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0192153 |
| CLMP | CXADR-like membrane protein | -0.0190467 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0188058 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0187692 |
| ARFGEF3 | ARFGEF family member 3 | -0.0186934 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0186216 |
| RAD51B | RAD51 paralog B | -0.0185101 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0183933 |
| HMGA1 | high mobility group AT-hook 1 | -0.0182558 |
| KRT19 | keratin 19, type I | -0.0182369 |
| WFDC10B | WAP four-disulfide core domain 10B | -0.0181259 |
| RPS24 | ribosomal protein S24 | -0.0180837 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0180701 |
