GSK1059615_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description GSK1059615 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the GSK1059615_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0948134
KYNU kynureninase 0.0887023
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0784232
SOD2 superoxide dismutase 2, mitochondrial 0.0703579
ELL2 elongation factor, RNA polymerase II, 2 0.0626825
FNIP1 folliculin interacting protein 1 0.0495904
MATR3 matrin 3 0.0491719
FTH1 ferritin, heavy polypeptide 1 0.0491278
AKAP9 A kinase (PRKA) anchor protein 9 0.0486626
NAMPT nicotinamide phosphoribosyltransferase 0.0456726
FNDC3B fibronectin type III domain containing 3B 0.0427159
RND3 Rho family GTPase 3 0.0411632
GOLGB1 golgin B1 0.0397325
VEGFC vascular endothelial growth factor C 0.0394387
DPYD dihydropyrimidine dehydrogenase 0.0378356
WNT5A wingless-type MMTV integration site family, member 5A 0.0376495
ANXA5 annexin A5 0.0352717
CDK13 cyclin-dependent kinase 13 0.035095
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0347658
UBE2H ubiquitin-conjugating enzyme E2H 0.0346267
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0342703
CD44 CD44 molecule (Indian blood group) 0.0339243
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0335213
EXOC4 exocyst complex component 4 0.0330692
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.03306
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0319039
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0315948
SEC31A SEC31 homolog A (S. cerevisiae) 0.0315838
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0311092
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0301842
ZCCHC7 zinc finger, CCHC domain containing 7 0.0299187
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0298363
ACTN1 actinin, alpha 1 0.029445
AGO3 argonaute RISC catalytic component 3 0.0294098
UBC ubiquitin C 0.0291914
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0290759
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0289127
VEGFA vascular endothelial growth factor A 0.0284725
USP34 ubiquitin specific peptidase 34 0.0283829
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0283529
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0280072
SEM1 SEM1 26S proteasome subunit 0.0276889
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0275382
ANKRD17 ankyrin repeat domain 17 0.0270966
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0268867
ARB2A ARB2 cotranscriptional regulator A 0.0268606
TFG TRK-fused gene 0.0268328
RBM39 RNA binding motif protein 39 0.026818
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0265617
MAML2 mastermind-like 2 (Drosophila) 0.0264664
RNF216 ring finger protein 216 0.0258242
COL7A1 collagen, type VII, alpha 1 0.0258054
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0254501
TPST1 tyrosylprotein sulfotransferase 1 0.0253232
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0251659
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0251116
TNS3 tensin 3 0.0250683
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0249282
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0248082
KLC1 kinesin light chain 1 0.024666
BBS9 Bardet-Biedl syndrome 9 0.0243451
FTO fat mass and obesity associated 0.0242193
ESYT2 extended synaptotagmin-like protein 2 0.0241295
SDC4 syndecan 4 0.024067
IGFBP7 insulin-like growth factor binding protein 7 0.0239171
CCNG2 cyclin G2 0.0237384
RNF24 ring finger protein 24 0.0235744
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0235072
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0234421
DSCAM Down syndrome cell adhesion molecule 0.0232915
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0228631
SUCO SUN domain containing ossification factor 0.022795
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0225714
CALR calreticulin 0.0225349
SEC24A SEC24 family member A 0.0224959
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0224551
ZBTB20 zinc finger and BTB domain containing 20 0.0223152
GOLGA4 golgin A4 0.0220403
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0220113
TMEM14B transmembrane protein 14B 0.0219264
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0215158
AVL9 AVL9 homolog (S. cerevisiase) 0.0213444
RNF145 ring finger protein 145 0.0213179
FMNL2 formin-like 2 0.0211438
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0211124
KAZN kazrin, periplakin interacting protein 0.0210964
LIMS1 LIM and senescent cell antigen-like domains 1 0.0210563
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0209331
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0209294
SRRM2 serine/arginine repetitive matrix 2 0.0209274
MYO10 myosin X 0.0208526
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0206823
COPA coatomer protein complex, subunit alpha 0.0206701
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0205925
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0205829
WWOX WW domain containing oxidoreductase 0.0205711
NAV1 neuron navigator 1 0.0205279
IPO7 importin 7 0.0203856
PSD3 pleckstrin and Sec7 domain containing 3 0.0203498
LAMB1 laminin, beta 1 0.0202099

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.154815
FN1 fibronectin 1 -0.105596
COL1A1 collagen, type I, alpha 1 -0.102418
LOX lysyl oxidase -0.096515
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0946736
MT2A metallothionein 2A -0.0884494
COL1A2 collagen, type I, alpha 2 -0.0791891
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0763839
TMSB10 thymosin beta 10 -0.0673509
NDRG1 N-myc downstream regulated 1 -0.0670163
IGFBP3 insulin-like growth factor binding protein 3 -0.0614239
CDK6 cyclin-dependent kinase 6 -0.0539381
HLA-A major histocompatibility complex, class I, A -0.0476717
VIM vimentin -0.0459998
RPS3 ribosomal protein S3 -0.0454262
CADM1 cell adhesion molecule 1 -0.0438313
HLA-B major histocompatibility complex, class I, B -0.0435754
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0433747
PGK1 phosphoglycerate kinase 1 -0.0395587
COL3A1 collagen, type III, alpha 1 -0.0383182
PRSS23 protease, serine, 23 -0.0373915
ENO2 enolase 2 (gamma, neuronal) -0.0364176
GNAS GNAS complex locus -0.0361804
DLG1 discs, large homolog 1 (Drosophila) -0.035789
HLA-C major histocompatibility complex, class I, C -0.0355961
ACTG1 actin gamma 1 -0.0346976
COL6A1 collagen, type VI, alpha 1 -0.0336465
SCARB2 scavenger receptor class B, member 2 -0.0326253
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0322862
CA12 carbonic anhydrase XII -0.0317273
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0311886
PUM2 pumilio RNA-binding family member 2 -0.0307784
ANKRD28 ankyrin repeat domain 28 -0.0299465
PLCB4 phospholipase C, beta 4 -0.0298952
MEF2A myocyte enhancer factor 2A -0.0298773
CDH13 cadherin 13 -0.0296158
PDIA3 protein disulfide isomerase family A, member 3 -0.0294919
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0288911
CTSB cathepsin B -0.0278133
COL5A2 collagen, type V, alpha 2 -0.0275077
RASAL2 RAS protein activator like 2 -0.027061
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0270388
FTL ferritin, light polypeptide -0.0269747
LSAMP limbic system-associated membrane protein -0.026602
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0260945
RPL9 ribosomal protein L9 -0.0260708
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0247295
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.024398
TPT1 tumor protein, translationally-controlled 1 -0.0241193
LMAN1 lectin, mannose-binding, 1 -0.0240197
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0238001
RPL37A ribosomal protein L37a -0.023713
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0236298
LOXL2 lysyl oxidase-like 2 -0.0231674
TENT5A terminal nucleotidyltransferase 5A -0.0229391
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0227919
KLHL5 kelch-like family member 5 -0.0223105
DSTN destrin (actin depolymerizing factor) -0.0220534
CTSD cathepsin D -0.0217732
RPS27A ribosomal protein S27a -0.0216522
SEC24D SEC24 family member D -0.0213041
DTNA dystrobrevin, alpha -0.0211736
CSMD2 CUB and Sushi multiple domains 2 -0.021121
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0208616
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0207332
SSR1 signal sequence receptor, alpha -0.0206128
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0203489
CALU calumenin -0.0200686
PTN pleiotrophin -0.0200667
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0200235
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0199717
RREB1 ras responsive element binding protein 1 -0.0197277
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0197221
RBM25 RNA binding motif protein 25 -0.0195663
FGFR1 fibroblast growth factor receptor 1 -0.0193767
LDHA lactate dehydrogenase A -0.0193016
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0192386
WSB1 WD repeat and SOCS box containing 1 -0.0192171
GLIS3 GLIS family zinc finger 3 -0.0191512
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0189402
TNNC1 troponin C type 1 (slow) -0.0189047
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0188909
IFI44 interferon-induced protein 44 -0.018805
PFN1 profilin 1 -0.0187119
ZFHX3 zinc finger homeobox 3 -0.0184573
FKBP1A FK506 binding protein 1A, 12kDa -0.0180255
GJA1 gap junction protein, alpha 1, 43kDa -0.0178412
VCL vinculin -0.017756
STK10 serine/threonine kinase 10 -0.0176904
FRMD4A FERM domain containing 4A -0.0176376
TUBA1B tubulin, alpha 1b -0.0175444
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0174143
SYT1 synaptotagmin I -0.0172063
TENM3 teneurin transmembrane protein 3 -0.017202
TM9SF3 transmembrane 9 superfamily member 3 -0.017186
RPS8 ribosomal protein S8 -0.0171491
MRPS6 mitochondrial ribosomal protein S6 -0.0170779
CD99 CD99 molecule -0.0169697
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0169014
PTBP3 polypyrimidine tract binding protein 3 -0.0168034