| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | GSK1059615 perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the GSK1059615_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.102066 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0867845 |
| STC2 | stanniocalcin 2 | 0.0732107 |
| NRG1 | neuregulin 1 | 0.0636787 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0603918 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0501719 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0490107 |
| EFNA5 | ephrin-A5 | 0.0482723 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0476121 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0471484 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0467483 |
| SQSTM1 | sequestosome 1 | 0.0457393 |
| INTS6 | integrator complex subunit 6 | 0.043683 |
| GLIS3 | GLIS family zinc finger 3 | 0.0420155 |
| GOLGB1 | golgin B1 | 0.0368929 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0362586 |
| AEBP2 | AE binding protein 2 | 0.0355043 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0351004 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0343382 |
| RASAL2 | RAS protein activator like 2 | 0.0328712 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0327284 |
| SYT1 | synaptotagmin I | 0.0327167 |
| PALLD | palladin, cytoskeletal associated protein | 0.0325082 |
| PDLIM5 | PDZ and LIM domain 5 | 0.031403 |
| VEGFA | vascular endothelial growth factor A | 0.0305962 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0301062 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0299916 |
| RAI14 | retinoic acid induced 14 | 0.0294611 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0293315 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0289259 |
| USP34 | ubiquitin specific peptidase 34 | 0.0286969 |
| GPATCH2L | G patch domain containing 2-like | 0.0285034 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0281331 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0280089 |
| SFTPA2 | surfactant protein A2 | 0.0279347 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0276174 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0275943 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0271086 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0269402 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0266134 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0264175 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0260443 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0259599 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0258923 |
| NTN4 | netrin 4 | 0.0255049 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0250962 |
| CUX1 | cut-like homeobox 1 | 0.0245243 |
| AHI1 | Abelson helper integration site 1 | 0.024413 |
| FBN1 | fibrillin 1 | 0.024383 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0243567 |
| LRRC23 | leucine rich repeat containing 23 | 0.024182 |
| ADIPOR2 | adiponectin receptor 2 | 0.0241071 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0234806 |
| LOXL2 | lysyl oxidase-like 2 | 0.0229926 |
| ATF6 | activating transcription factor 6 | 0.0225965 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0224976 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0223694 |
| EGFR | epidermal growth factor receptor | 0.0223591 |
| CDK13 | cyclin-dependent kinase 13 | 0.022282 |
| TNS3 | tensin 3 | 0.0221874 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0220542 |
| GPC6 | glypican 6 | 0.0219432 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0217572 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0216959 |
| UBAP2 | ubiquitin associated protein 2 | 0.0215652 |
| FNIP1 | folliculin interacting protein 1 | 0.0215529 |
| UBXN4 | UBX domain protein 4 | 0.0214082 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0213865 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0211784 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.02102 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0209276 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0206749 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0204894 |
| TCIM | transcriptional and immune response regulator | 0.0204186 |
| TMF1 | TATA element modulatory factor 1 | 0.0202151 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0201653 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0201607 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0199214 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0198948 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0198215 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0195508 |
| COG6 | component of oligomeric golgi complex 6 | 0.0195317 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0193788 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0192668 |
| RANBP17 | RAN binding protein 17 | 0.0192594 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0192476 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0189903 |
| DUSP16 | dual specificity phosphatase 16 | 0.0189558 |
| LYST | lysosomal trafficking regulator | 0.0189525 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0189282 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0189004 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.018832 |
| SFPQ | splicing factor proline/glutamine-rich | 0.018629 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0186039 |
| KSR1 | kinase suppressor of ras 1 | 0.0185187 |
| POU2F2 | POU class 2 homeobox 2 | 0.0184681 |
| SIRT1 | sirtuin 1 | 0.0179483 |
| NBEA | neurobeachin | 0.0178564 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0178341 |
| PGM3 | phosphoglucomutase 3 | 0.0177083 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.305149 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.147797 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.134648 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.133029 |
| MT2A | metallothionein 2A | -0.114437 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.112067 |
| PTMA | prothymosin, alpha | -0.101299 |
| VIM | vimentin | -0.0862567 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0748053 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0736535 |
| ZNF292 | zinc finger protein 292 | -0.0668981 |
| IER3 | immediate early response 3 | -0.0652479 |
| H1-0 | H1.0 linker histone | -0.0628929 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0602445 |
| TMSB10 | thymosin beta 10 | -0.0591087 |
| HLA-B | major histocompatibility complex, class I, B | -0.0577466 |
| FTL | ferritin, light polypeptide | -0.0575801 |
| RPS6 | ribosomal protein S6 | -0.0560903 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0535419 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0502933 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0500701 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0500361 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0497509 |
| RPL12 | ribosomal protein L12 | -0.0483414 |
| NDRG1 | N-myc downstream regulated 1 | -0.0479364 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0477846 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0464267 |
| ASPH | aspartate beta-hydroxylase | -0.046207 |
| PTK2 | protein tyrosine kinase 2 | -0.046173 |
| RPL35A | ribosomal protein L35a | -0.0460999 |
| RPS24 | ribosomal protein S24 | -0.0456631 |
| OGA | O-GlcNAcase | -0.045141 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0446813 |
| RNF145 | ring finger protein 145 | -0.0445065 |
| MKI67 | marker of proliferation Ki-67 | -0.0444169 |
| SEPTIN7 | septin 7 | -0.0443492 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0443188 |
| RPLP1 | ribosomal protein, large, P1 | -0.044268 |
| TMSB4X | thymosin beta 4, X-linked | -0.0438139 |
| NEK7 | NIMA-related kinase 7 | -0.0426606 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0426072 |
| RPS19 | ribosomal protein S19 | -0.0421498 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0421484 |
| PELO | pelota homolog (Drosophila) | -0.0416294 |
| S100A10 | S100 calcium binding protein A10 | -0.0416109 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0412538 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0398288 |
| FAM13A | family with sequence similarity 13, member A | -0.0398276 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.038815 |
| RPL26 | ribosomal protein L26 | -0.0377129 |
| RHEB | Ras homolog enriched in brain | -0.0376656 |
| PGK1 | phosphoglycerate kinase 1 | -0.0368036 |
| RPS21 | ribosomal protein S21 | -0.0356836 |
| YBX3 | Y box binding protein 3 | -0.0355768 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0355438 |
| WDR45B | WD repeat domain 45B | -0.0352506 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0348013 |
| RPL34 | ribosomal protein L34 | -0.0341203 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0332886 |
| S100A6 | S100 calcium binding protein A6 | -0.0329697 |
| RPS8 | ribosomal protein S8 | -0.0328063 |
| RPS27A | ribosomal protein S27a | -0.031987 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0319714 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0318676 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0309382 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0306441 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0303212 |
| AHNAK | AHNAK nucleoprotein | -0.0302968 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0302844 |
| FNBP1 | formin binding protein 1 | -0.0301223 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0301097 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0299026 |
| QKI | QKI, KH domain containing, RNA binding | -0.0298384 |
| ANLN | anillin, actin binding protein | -0.0297964 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0296709 |
| TFG | TRK-fused gene | -0.0296516 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0294064 |
| ITGA1 | integrin, alpha 1 | -0.0292572 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0289149 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0284913 |
| RLF | rearranged L-myc fusion | -0.0283657 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0283545 |
| RPL19 | ribosomal protein L19 | -0.028075 |
| RPL23 | ribosomal protein L23 | -0.027644 |
| SPAG9 | sperm associated antigen 9 | -0.0275124 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0274733 |
| RTN4 | reticulon 4 | -0.0273844 |
| RBM39 | RNA binding motif protein 39 | -0.0272846 |
| CENPF | centromere protein F, 350/400kDa | -0.0271081 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0268415 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.026751 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0266197 |
| WTAP | Wilms tumor 1 associated protein | -0.026528 |
| GNAS | GNAS complex locus | -0.0264794 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.026437 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0263756 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.026281 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0262188 |
| USP3 | ubiquitin specific peptidase 3 | -0.0261679 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0261492 |
