GSK3B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description glycogen synthase kinase 3 beta|The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 2932)
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Genes

325 genes differentially expressed following the GSK3B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ACKR2 atypical chemokine receptor 2 2.45151
FRMPD1 FERM and PDZ domain containing 1 2.45151
ASCL5 achaete-scute family bHLH transcription factor 5 2.45151
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.45151
LMO1 LIM domain only 1 (rhombotin 1) 2.45151
NME5 NME/NM23 family member 5 2.45151
CRHR1 corticotropin releasing hormone receptor 1 2.45151
FAM186A family with sequence similarity 186, member A 2.45151
CCK cholecystokinin 2.45151
NPFFR1 neuropeptide FF receptor 1 2.45151
CLPSL1 colipase-like 1 2.45151
CELF6 CUGBP, Elav-like family member 6 2.45151
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 2.45151
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 2.45151
PDCD1LG2 programmed cell death 1 ligand 2 2.45151
SPMAP1 sperm microtubule associated protein 1 2.45151
MYO1G myosin IG 2.45151
BMP5 bone morphogenetic protein 5 2.45151
TXLNB taxilin beta 2.45151
CCDC170 coiled-coil domain containing 170 2.45151
NECTIN4 nectin cell adhesion molecule 4 2.45151
GNLY granulysin 2.40894
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.40894
MC4R melanocortin 4 receptor 2.40894
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.40894
NPPB natriuretic peptide B 2.40894
USP26 ubiquitin specific peptidase 26 2.40894
FAM180A family with sequence similarity 180, member A 2.40894
NECAB1 N-terminal EF-hand calcium binding protein 1 2.40894
PARP3 poly (ADP-ribose) polymerase family, member 3 2.40894
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.40894
ZNF503 zinc finger protein 503 2.40894
COLEC10 collectin sub-family member 10 (C-type lectin) 2.40894
SP6 Sp6 transcription factor 2.40894
ATOH7 atonal homolog 7 (Drosophila) 2.40894
ZIC4 Zic family member 4 2.40894
ANAPC13 anaphase promoting complex subunit 13 2.40894
MUC1 mucin 1, cell surface associated 2.40894
RAB17 RAB17, member RAS oncogene family 2.40894
C9ORF152 chromosome 9 open reading frame 152 2.40894
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.40894
ACVRL1 activin A receptor type II-like 1 2.40894
TRIM77 tripartite motif containing 77 2.40894
HCRTR2 hypocretin (orexin) receptor 2 2.40894
SMC1B structural maintenance of chromosomes 1B 2.40894
LRG1 leucine-rich alpha-2-glycoprotein 1 2.40894
DLL4 delta-like 4 (Drosophila) 2.40894
BMP8A bone morphogenetic protein 8a 2.40894
DSG3 desmoglein 3 2.40894
PNOC prepronociceptin 2.40894
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.40894
GLYAT glycine-N-acyltransferase 2.40894
PTCD1 pentatricopeptide repeat domain 1 2.40894
SOX14 SRY (sex determining region Y)-box 14 2.40894
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.40894
OFD1 oral-facial-digital syndrome 1 2.40894
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.40894
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 2.40894
CLDN16 claudin 16 2.40894
SRGN serglycin 2.40894
ABHD14B abhydrolase domain containing 14B 2.40894
PICALM phosphatidylinositol binding clathrin assembly protein 2.40894
DLK2 delta-like 2 homolog (Drosophila) 2.40894
NPIPB8 nuclear pore complex interacting protein family, member B8 2.40894
GDF7 growth differentiation factor 7 2.40894
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.40894
OOSP1 oocyte secreted protein 1, pseudogene 2.40894
MCHR2 melanin-concentrating hormone receptor 2 2.40894
ARX aristaless related homeobox 2.40894
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.40894
H2BK1 H2B.K variant histone 1 2.40894
MINDY4B MINDY family member 4B 2.40894
TEX13D TEX13 family member D 2.40894
CFAP107 cilia and flagella associated protein 107 2.40894
SOFU1 sperm-oocyte fusion factor 1 2.40894
JAML junction adhesion molecule like 2.40894
DNAAF8 dynein axonemal assembly factor 8 2.40894
TBXT T-box transcription factor T 2.40894
CFAP65 cilia and flagella associated protein 65 2.40894
OPN5 opsin 5 2.40894
RGS22 regulator of G-protein signaling 22 2.40894
CCR3 chemokine (C-C motif) receptor 3 2.40894
GDA guanine deaminase 2.40894
CAPN14 calpain 14 2.40894
SCRG1 stimulator of chondrogenesis 1 2.40894
FER1L6 fer-1-like family member 6 2.40894
TMPRSS11D transmembrane protease, serine 11D 2.40894
UPK3B uroplakin 3B 2.40894
IL4I1 interleukin 4 induced 1 2.40894
ZACN zinc activated ligand-gated ion channel 2.40894
SSX4B synovial sarcoma, X breakpoint 4B 2.40894
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 2.40894
TUBA3E tubulin, alpha 3e 2.40894
NXPE1 neurexophilin and PC-esterase domain family, member 1 2.40894
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.40894
RASAL3 RAS protein activator like 3 2.40894
RNF113B ring finger protein 113B 2.40894
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.40894
TFEC transcription factor EC 2.40894
TLR7 toll-like receptor 7 2.40894
CIDEB cell death-inducing DFFA-like effector b 2.40894
THPO thrombopoietin 2.40894
AMBP alpha-1-microglobulin/bikunin precursor 2.40894
OR11H4 olfactory receptor, family 11, subfamily H, member 4 2.40894
IL36R interleukin 36 receptor 2.40894
FNDC1 fibronectin type III domain containing 1 2.40894
C17ORF99 chromosome 17 open reading frame 99 2.40894
C6ORF15 chromosome 6 open reading frame 15 2.40894
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.40894
CALML6 calmodulin-like 6 2.40894
POTEF POTE ankyrin domain family, member F 2.40894
LRRC74B leucine rich repeat containing 74B 2.40894
ZC3H12D zinc finger CCCH-type containing 12D 2.40894
DUOXA1 dual oxidase maturation factor 1 2.40894
GRAP2 GRB2-related adaptor protein 2 2.40894
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.40894
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 2.40894
SMIM17 small integral membrane protein 17 2.40894
LRRC3 leucine rich repeat containing 3 2.40894
C10ORF90 chromosome 10 open reading frame 90 2.40894
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.40894
FNDC8 fibronectin type III domain containing 8 2.40894
BRDT bromodomain, testis-specific 2.40894
RAD21L1 RAD21-like 1 (S. pombe) 2.40894
PAGE4 P antigen family, member 4 (prostate associated) 2.40894
CD52 CD52 molecule 2.40894
RPS28 ribosomal protein S28 2.40894
BAHCC1 BAH domain and coiled-coil containing 1 2.40894
TMEM64 transmembrane protein 64 2.40894
TMEM130 transmembrane protein 130 2.40894
TIGD3 tigger transposable element derived 3 2.40894
DGCR6 DiGeorge syndrome critical region gene 6 2.40894
NOX1 NADPH oxidase 1 2.40894
ANKRD61 ankyrin repeat domain 61 2.40894
AQP6 aquaporin 6, kidney specific 2.40894
TESPA1 thymocyte expressed, positive selection associated 1 2.40894
ZNF541 zinc finger protein 541 2.40894
WNT7A wingless-type MMTV integration site family, member 7A 2.40894
PRMT2 protein arginine methyltransferase 2 2.40894
OR52K1 olfactory receptor, family 52, subfamily K, member 1 2.40894
TMPRSS13 transmembrane protease, serine 13 2.40894
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 2.40894
KAT2B K(lysine) acetyltransferase 2B 2.40894
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.40894
TRIML1 tripartite motif family-like 1 2.40894
GOLGA8K golgin A8 family, member K 2.40894
SPDEF SAM pointed domain containing ETS transcription factor 2.40894
EBI3 Epstein-Barr virus induced 3 2.40894
METTL21C methyltransferase like 21C 2.40894
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 2.40894
CCDC83 coiled-coil domain containing 83 2.40894
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.40894
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.40894
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 2.40894
FAM9B family with sequence similarity 9, member B 2.40894
TMEM132C transmembrane protein 132C 2.40894
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.40894
NMUR1 neuromedin U receptor 1 2.40894
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.40894
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.40894
BOD1L2 biorientation of chromosomes in cell division 1-like 2 2.40894
WNT2 wingless-type MMTV integration site family member 2 2.40894
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 2.40894
SYNGR4 synaptogyrin 4 2.40894
DLX3 distal-less homeobox 3 2.40894
GPR68 G protein-coupled receptor 68 2.40894
PRND prion protein 2 (dublet) 2.40894
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.40894
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.40894
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.40894
AOC1 amine oxidase, copper containing 1 2.40894
PCDHB6 protocadherin beta 6 2.40894
LRRN4 leucine rich repeat neuronal 4 2.40894
CLDN23 claudin 23 2.40578
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.40578
LCN10 lipocalin 10 2.40578
ANGPT1 angiopoietin 1 2.40289
RBPMS RNA binding protein with multiple splicing 2.38553
PTPRG protein tyrosine phosphatase, receptor type, G 2.36959
HYPK huntingtin interacting protein K 2.36505
ARL13A ADP-ribosylation factor-like 13A 2.36505
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.36505
PNMA8A PNMA family member 8A 2.36284
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.34178
CCDC17 coiled-coil domain containing 17 2.30996
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.30321
COL16A1 collagen, type XVI, alpha 1 2.29817
ATP5PO ATP synthase peripheral stalk subunit OSCP 2.29366
RORC RAR-related orphan receptor C 2.29296
COL10A1 collagen, type X, alpha 1 2.28918
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 2.26594
WDR41 WD repeat domain 41 2.26379
FKBP1A FK506 binding protein 1A, 12kDa 2.25423
C1ORF35 chromosome 1 open reading frame 35 2.23745
RAB39B RAB39B, member RAS oncogene family 2.23677
UBIAD1 UbiA prenyltransferase domain containing 1 2.23225
RPL28 ribosomal protein L28 2.2144
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 2.19662
THAP11 THAP domain containing 11 2.19662
TROAP trophinin associated protein 2.17083
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.16342
RPL13A ribosomal protein L13a 2.16288
PHACTR1 phosphatase and actin regulator 1 2.16288
VMP1 vacuole membrane protein 1 2.16288
DEPTOR DEP domain containing MTOR-interacting protein 2.15551
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.15343
GRIK2 glutamate receptor, ionotropic, kainate 2 2.15132
ZSCAN26 zinc finger and SCAN domain containing 26 2.15083
PHAX phosphorylated adaptor for RNA export 2.15083
CPT2 carnitine palmitoyltransferase 2 2.1405
WNT5A wingless-type MMTV integration site family, member 5A 2.11888
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 2.11674
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 2.10716
TSPOAP1 TSPO associated protein 1 2.09917
ETHE1 ethylmalonic encephalopathy 1 2.08221
SLC60A2 solute carrier family 60 member 2 2.06828
CCDC85A coiled-coil domain containing 85A 2.06023
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 2.05655
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.0502
PCED1B PC-esterase domain containing 1B 2.04748
CCDC117 coiled-coil domain containing 117 2.04748
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 2.04508
RYBP RING1 and YY1 binding protein 2.0308
NCOA3 nuclear receptor coactivator 3 2.02037
PHF20L1 PHD finger protein 20-like 1 2.01206
SMAD9 SMAD family member 9 2.01057
PGM2 phosphoglucomutase 2 2.00998
TBC1D24 TBC1 domain family, member 24 2.004
CROCC ciliary rootlet coiled-coil, rootletin 2.00279

decreased expression

Symbol Name Standardized Value
CFAP58 cilia and flagella associated protein 58 -2.45151
KIN Kin17 DNA and RNA binding protein -2.45151
TJP1 tight junction protein 1 -2.45151
GSK3B glycogen synthase kinase 3 beta -2.45151
CCDC178 coiled-coil domain containing 178 -2.45151
CHL1 cell adhesion molecule L1-like -2.40977
IL32 interleukin 32 -2.40977
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa -2.40894
MAGED4 melanoma antigen family D4 -2.40894
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C -2.40894
AVPR1A arginine vasopressin receptor 1A -2.40894
HARBI1 harbinger transposase derived 1 -2.40894
EXOC2 exocyst complex component 2 -2.40894
PCDHGA11 protocadherin gamma subfamily A, 11 -2.40894
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -2.40894
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.40894
DDAH2 dimethylarginine dimethylaminohydrolase 2 -2.40894
PDE3A phosphodiesterase 3A, cGMP-inhibited -2.40894
TFPI2 tissue factor pathway inhibitor 2 -2.40894
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.40894
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.40894
MYZAP myocardial zonula adherens protein -2.40894
PIRT phosphoinositide-interacting regulator of transient receptor potential channels -2.40894
DOK7 docking protein 7 -2.40894
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.40894
CETN2 centrin, EF-hand protein, 2 -2.40894
WDR62 WD repeat domain 62 -2.40894
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) -2.40894
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -2.40894
STKLD1 serine/threonine kinase-like domain containing 1 -2.40894
C7ORF25 chromosome 7 open reading frame 25 -2.40894
CARD14 caspase recruitment domain family, member 14 -2.40894
ZBTB45 zinc finger and BTB domain containing 45 -2.40894
RIOK3 RIO kinase 3 -2.40894
PPP1R37 protein phosphatase 1, regulatory subunit 37 -2.40894
SNTN sentan, cilia apical structure protein -2.40894
PCDH20 protocadherin 20 -2.40894
LRRC32 leucine rich repeat containing 32 -2.40894
AAGAB alpha- and gamma-adaptin binding protein -2.40894
IDI2 isopentenyl-diphosphate delta isomerase 2 -2.40894
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.40894
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -2.40894
EGR2 early growth response 2 -2.40894
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.40894
ISL2 ISL LIM homeobox 2 -2.40894
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 -2.40894
DBF4 DBF4 zinc finger -2.40364
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -2.36284
FAM47E family with sequence similarity 47, member E -2.35352
ZNF331 zinc finger protein 331 -2.34908
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.34093
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -2.34093
BOK BCL2-related ovarian killer -2.29887
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -2.29837
MZF1 myeloid zinc finger 1 -2.29817
ADM5 adrenomedullin 5 (putative) -2.29296
TMEM253 transmembrane protein 253 -2.28917
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.28917
JOSD2 Josephin domain containing 2 -2.28917
RNF217 ring finger protein 217 -2.26823
LIMA1 LIM domain and actin binding 1 -2.26705
LAD1 ladinin 1 -2.25999
ZNF721 zinc finger protein 721 -2.25423
OPHN1 oligophrenin 1 -2.24933
SSBP4 single stranded DNA binding protein 4 -2.23745
CREBZF CREB/ATF bZIP transcription factor -2.23028
ZNF709 zinc finger protein 709 -2.22039
GPR143 G protein-coupled receptor 143 -2.2183
PNPLA8 patatin-like phospholipase domain containing 8 -2.2003
ARRDC1 arrestin domain containing 1 -2.19662
TCEAL5 transcription elongation factor A (SII)-like 5 -2.18668
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -2.18591
LINGO1 leucine rich repeat and Ig domain containing 1 -2.1857
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 -2.17726
ICE2 interactor of little elongation complex ELL subunit 2 -2.16342
PGLS 6-phosphogluconolactonase -2.16171
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.15376
DAB2IP DAB2 interacting protein -2.15343
TBX19 T-box 19 -2.14337
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 -2.12075
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.10681
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.07658
BACE2 beta-site APP-cleaving enzyme 2 -2.06828
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.05803
USP18 ubiquitin specific peptidase 18 -2.05705
RUNX1 runt-related transcription factor 1 -2.05618
DIAPH3 diaphanous-related formin 3 -2.0502
LPIN3 lipin 3 -2.0502
PLD1 phospholipase D1, phosphatidylcholine-specific -2.0502
RAB40A RAB40A, member RAS oncogene family -2.0502
RGPD6 RANBP2-like and GRIP domain containing 6 -2.0502
MYO5C myosin VC -2.04911
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase -2.04615
PICK1 protein interacting with PRKCA 1 -2.04212
TMPRSS2 transmembrane protease, serine 2 -2.04212
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 -2.04133