GSK3B Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description glycogen synthase kinase 3 beta|The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] (NCBI Entrez Gene Database, 2932)
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117 substrates of the kinase GSK3B from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADD2 adducin 2 (beta)
APC adenomatous polyposis coli
ARHGAP31 Rho GTPase activating protein 31
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATXN3 ataxin 3
AXIN1 axin 1
BAX BCL2-associated X protein
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL2L1 BCL2-like 1
BCL2L12 BCL2-like 12 (proline rich)
BCLAF1 BCL2-associated transcription factor 1
BORA bora, aurora kinase A activator
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDX2 caudal type homeobox 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CIITA class II, major histocompatibility complex, transactivator
CLASP2 cytoplasmic linker associated protein 2
CLOCK clock circadian regulator
CREB1 cAMP responsive element binding protein 1
CRY2 cryptochrome circadian clock 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
CTNND2 catenin (cadherin-associated protein), delta 2
DCX doublecortin
DNM1L dynamin 1-like
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DROSHA drosha, ribonuclease type III
DSP desmoplakin
DZIP1 DAZ interacting zinc finger protein 1
E2F1 E2F transcription factor 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ESR1 estrogen receptor 1
FBXO4 F-box protein 4
FOXL2 forkhead box L2
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
GCM1 glial cells missing homolog 1 (Drosophila)
GPHN gephyrin
GSK3B glycogen synthase kinase 3 beta
GYS1 glycogen synthase 1 (muscle)
HDAC4 histone deacetylase 4
HIST1H1B histone cluster 1, H1b
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRAS Harvey rat sarcoma viral oncogene homolog
HSF1 heat shock transcription factor 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
IL1RL1 interleukin 1 receptor-like 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KLC2 kinesin light chain 2
KLF5 Kruppel-like factor 5 (intestinal)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP6 low density lipoprotein receptor-related protein 6
MAP1B microtubule-associated protein 1B
MAPT microtubule-associated protein tau
MARK2 MAP/microtubule affinity-regulating kinase 2
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MITF microphthalmia-associated transcription factor
MNX1 motor neuron and pancreas homeobox 1
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBPC3 myosin binding protein C, cardiac
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYLK myosin light chain kinase
MYOCD myocardin
NACA nascent polypeptide-associated complex alpha subunit
NEFH neurofilament, heavy polypeptide
NEUROG2 neurogenin 2
NFE2L1 nuclear factor, erythroid 2-like 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NIFK nucleolar protein interacting with the FHA domain of MKI67
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAX3 paired box 3
PDX1 pancreatic and duodenal homeobox 1
PGR progesterone receptor
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCE protein kinase C, epsilon
PSEN1 presenilin 1
PTEN phosphatase and tensin homolog
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM38 RNA binding motif protein 38
RCAN1 regulator of calcineurin 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RICTOR RPTOR independent companion of MTOR, complex 2
SFPQ splicing factor proline/glutamine-rich
SMAD1 SMAD family member 1
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SNCAIP synuclein, alpha interacting protein
SPAG5 sperm associated antigen 5
SREBF1 sterol regulatory element binding transcription factor 1
STK38 serine/threonine kinase 38
SUFU suppressor of fused homolog (Drosophila)
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
USF2 upstream transcription factor 2, c-fos interacting
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZBED3 zinc finger, BED-type containing 3