| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | glutathione S-transferase alpha 2|Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2939) |
| External Link | https://ncbi.nlm.nih.gov/gene/2939 |
| Similar Terms | |
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499 genes differentially expressed following the GSTA2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GNAS | GNAS complex locus | 0.0168233 |
| FEZ1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.015461 |
| DIPK1A | divergent protein kinase domain 1A | 0.0146447 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0141233 |
| PCNA | proliferating cell nuclear antigen | 0.0134142 |
| XIC | X chromosome inactivation center | 0.012982 |
| NLRP2 | NLR family, pyrin domain containing 2 | 0.011971 |
| TRIM22 | tripartite motif containing 22 | 0.0119066 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.0117495 |
| CHP1 | calcineurin-like EF-hand protein 1 | 0.011746 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.0117222 |
| FXYD5 | FXYD domain containing ion transport regulator 5 | 0.0117157 |
| LAMB1 | laminin, beta 1 | 0.0104683 |
| MAN1C1 | mannosidase, alpha, class 1C, member 1 | 0.0104472 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | 0.0104315 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.0103939 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0103849 |
| SCPEP1 | serine carboxypeptidase 1 | 0.0102401 |
| CTSB | cathepsin B | 0.00986956 |
| S100A10 | S100 calcium binding protein A10 | 0.00981969 |
| NID1 | nidogen 1 | 0.00981907 |
| GPX1 | glutathione peroxidase 1 | 0.00973959 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00967258 |
| C3 | complement component 3 | 0.00966356 |
| PRKCA | protein kinase C, alpha | 0.00950334 |
| TNS3 | tensin 3 | 0.00942181 |
| TLCD3A | TLC domain containing 3A | 0.00911569 |
| FBLN1 | fibulin 1 | 0.00905021 |
| RBPMS | RNA binding protein with multiple splicing | 0.00903178 |
| SMC1A | structural maintenance of chromosomes 1A | 0.00893879 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.00887718 |
| GSTP1 | glutathione S-transferase pi 1 | 0.00847186 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0084188 |
| RGS1 | regulator of G-protein signaling 1 | 0.00836391 |
| SCD5 | stearoyl-CoA desaturase 5 | 0.00836118 |
| COL6A1 | collagen, type VI, alpha 1 | 0.00823859 |
| GSPT2 | G1 to S phase transition 2 | 0.00823748 |
| WASHC4 | WASH complex subunit 4 | 0.00822784 |
| LOXL2 | lysyl oxidase-like 2 | 0.00821882 |
| SIRT3 | sirtuin 3 | 0.00816489 |
| ISL1 | ISL LIM homeobox 1 | 0.00814776 |
| MSLN | mesothelin | 0.00814224 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00814151 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.00813087 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00809966 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.00807675 |
| KRT7 | keratin 7, type II | 0.00807549 |
| OLFM4 | olfactomedin 4 | 0.00795716 |
| SRGN | serglycin | 0.0079275 |
| PRDX2 | peroxiredoxin 2 | 0.00789267 |
| PDE4A | phosphodiesterase 4A, cAMP-specific | 0.00786698 |
| PSCA | prostate stem cell antigen | 0.0078386 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00783133 |
| TOX | thymocyte selection-associated high mobility group box | 0.00776234 |
| GABRE | gamma-aminobutyric acid (GABA) A receptor, epsilon | 0.00766269 |
| ICOS | inducible T-cell co-stimulator | 0.00764123 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00763493 |
| RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | 0.00761386 |
| JAG1 | jagged 1 | 0.00761265 |
| CTSC | cathepsin C | 0.00758056 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 0.00747911 |
| FN1 | fibronectin 1 | 0.00743346 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00739369 |
| HOXB2 | homeobox B2 | 0.00733939 |
| FAM13A | family with sequence similarity 13, member A | 0.00732003 |
| RGS13 | regulator of G-protein signaling 13 | 0.00730324 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | 0.00729694 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00727341 |
| CAVIN3 | caveolae associated protein 3 | 0.00724525 |
| LUM | lumican | 0.00724168 |
| MSMB | microseminoprotein, beta- | 0.00722236 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00719436 |
| TMEM35 | transmembrane protein 35 | 0.00718692 |
| COL9A3 | collagen, type IX, alpha 3 | 0.00716806 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0071575 |
| LIMA1 | LIM domain and actin binding 1 | 0.00713988 |
| CD53 | CD53 molecule | 0.00712201 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00710549 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00709454 |
| GPNMB | glycoprotein (transmembrane) nmb | 0.00704633 |
| TGM2 | transglutaminase 2 | 0.00702463 |
| GBP1 | guanylate binding protein 1, interferon-inducible | 0.00691533 |
| LTF | lactotransferrin | 0.00689858 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.00685537 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | 0.00681612 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00679374 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00675989 |
| PDZD2 | PDZ domain containing 2 | 0.00675648 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.00675442 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00671299 |
| HK2 | hexokinase 2 | 0.00666252 |
| MX1 | MX dynamin-like GTPase 1 | 0.00664841 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00662801 |
| MAL | mal, T-cell differentiation protein | 0.0066278 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.00660441 |
| RGS4 | regulator of G-protein signaling 4 | 0.00658483 |
| ZFAND5 | zinc finger, AN1-type domain 5 | 0.00654967 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00654378 |
| HEY1 | hes-related family bHLH transcription factor with YRPW motif 1 | 0.00652419 |
| RPS27L | ribosomal protein S27-like | 0.00651272 |
| SMCO4 | single-pass membrane protein with coiled-coil domains 4 | 0.00650671 |
| HLA-F | major histocompatibility complex, class I, F | 0.00650592 |
| POU2AF1 | POU class 2 associating factor 1 | 0.00648405 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.00647215 |
| DMD | dystrophin | 0.00646697 |
| PLLP | plasmolipin | 0.00644829 |
| XPO7 | exportin 7 | 0.00642944 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | 0.00641311 |
| CLDN10 | claudin 10 | 0.006381 |
| TFCP2 | transcription factor CP2 | 0.0063402 |
| MAGEA3 | melanoma antigen family A3 | 0.00633006 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.00632749 |
| KRT15 | keratin 15, type I | 0.00629325 |
| PDE8B | phosphodiesterase 8B | 0.00626573 |
| JAM3 | junctional adhesion molecule 3 | 0.00624265 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.00622704 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.0062133 |
| ATP9A | ATPase, class II, type 9A | 0.00621063 |
| KRT13 | keratin 13, type I | 0.00620474 |
| MCAM | melanoma cell adhesion molecule | 0.00620023 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | 0.00619774 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00619058 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.00618774 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00617733 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.00617488 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00617275 |
| STOM | stomatin | 0.00616386 |
| GM2A | GM2 ganglioside activator | 0.00612172 |
| KRT18 | keratin 18, type I | 0.0061197 |
| PRNP | prion protein | 0.00611917 |
| MEIS2 | Meis homeobox 2 | 0.00606821 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.00606436 |
| PGBD5 | piggyBac transposable element derived 5 | 0.00605845 |
| TMEM255A | transmembrane protein 255A | 0.00605507 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00603859 |
| AVPI1 | arginine vasopressin-induced 1 | 0.00601528 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00600929 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00599329 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | 0.00597836 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.0059773 |
| MID1 | midline 1 | 0.00597453 |
| SAMSN1 | SAM domain, SH3 domain and nuclear localization signals 1 | 0.00597052 |
| SLC16A4 | solute carrier family 16, member 4 | 0.00596219 |
| PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | 0.00594103 |
| METTL7A | methyltransferase like 7A | 0.00593967 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.00593755 |
| OCRL | oculocerebrorenal syndrome of Lowe | 0.00593092 |
| STXBP6 | syntaxin binding protein 6 (amisyn) | 0.00592306 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.00589105 |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.00585769 |
| NANOG | Nanog homeobox | 0.00585247 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.00584037 |
| PLTP | phospholipid transfer protein | 0.00583181 |
| PLS3 | plastin 3 | 0.00580488 |
| MAF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog | 0.00578107 |
| MSN | moesin | 0.00577138 |
| CNN2 | calponin 2 | 0.00575735 |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.00575697 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.005749 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.00571682 |
| L1CAM | L1 cell adhesion molecule | 0.00571316 |
| IGSF3 | immunoglobulin superfamily, member 3 | 0.00570762 |
| LRRN3 | leucine rich repeat neuronal 3 | 0.00568573 |
| ACD | adrenocortical dysplasia homolog (mouse) | 0.00567916 |
| UTP14A | UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) | 0.00567472 |
| RBM34 | RNA binding motif protein 34 | 0.00565571 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.00565512 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00565052 |
| IFI44L | interferon-induced protein 44-like | 0.00562732 |
| TLE4 | transducin-like enhancer of split 4 | 0.00561687 |
| CHEK1 | checkpoint kinase 1 | 0.00560225 |
| DCHS1 | dachsous cadherin-related 1 | 0.00559149 |
| PNMA8A | PNMA family member 8A | 0.00558516 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.00558019 |
| PMP22 | peripheral myelin protein 22 | 0.00557466 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | 0.00556997 |
| MMD | monocyte to macrophage differentiation-associated | 0.00554343 |
| BTG3 | BTG family, member 3 | 0.00554199 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00553004 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00550812 |
| AXL | AXL receptor tyrosine kinase | 0.00549698 |
| MET | MET proto-oncogene, receptor tyrosine kinase | 0.00549076 |
| MAGED1 | melanoma antigen family D1 | 0.00547143 |
| CETN2 | centrin, EF-hand protein, 2 | 0.00546643 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.00546409 |
| KIF20A | kinesin family member 20A | 0.00546256 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | 0.00545951 |
| LPXN | leupaxin | 0.00544469 |
| MXRA7 | matrix-remodelling associated 7 | 0.00543426 |
| SPRR3 | small proline-rich protein 3 | 0.00540094 |
| CFB | complement factor B | 0.00539658 |
| MAMLD1 | mastermind-like domain containing 1 | 0.00538722 |
| MIA | melanoma inhibitory activity | 0.00537738 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.00536558 |
| ALDH9A1 | aldehyde dehydrogenase 9 family, member A1 | 0.00534735 |
| GPI | glucose-6-phosphate isomerase | 0.00534459 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.00533776 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.00531928 |
| EHBP1 | EH domain binding protein 1 | 0.00529964 |
| BSG | basigin (Ok blood group) | 0.00529392 |
| ENGASE | endo-beta-N-acetylglucosaminidase | 0.00529275 |
| ORC1 | origin recognition complex, subunit 1 | 0.00528997 |
| UXT | ubiquitously-expressed, prefoldin-like chaperone | 0.00528909 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00528856 |
| DSTN | destrin (actin depolymerizing factor) | 0.00527898 |
| RFX5 | regulatory factor X, 5 (influences HLA class II expression) | 0.00527371 |
| PNMA2 | paraneoplastic Ma antigen 2 | 0.00525906 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 0.0052577 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.00525463 |
| PHC1 | polyhomeotic homolog 1 (Drosophila) | 0.00525042 |
| C7 | complement component 7 | 0.0052409 |
| MTMR11 | myotubularin related protein 11 | 0.00522363 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.00520149 |
| CTSE | cathepsin E | 0.00517082 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | 0.00516499 |
| FGA | fibrinogen alpha chain | 0.00515344 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | 0.00515239 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00511784 |
| CD70 | CD70 molecule | 0.00509887 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.00508907 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00508464 |
| WFDC1 | WAP four-disulfide core domain 1 | 0.0050838 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.00507744 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.00506336 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00503624 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | 0.00501816 |
| COL5A2 | collagen, type V, alpha 2 | 0.00501552 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | 0.00500906 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00500319 |
| PAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 | 0.00500302 |
| SLC25A46 | solute carrier family 25, member 46 | 0.00499776 |
| GPX4 | glutathione peroxidase 4 | 0.00499273 |
| CIAPIN1 | cytokine induced apoptosis inhibitor 1 | 0.00498281 |
| MICAL1 | microtubule associated monooxygenase, calponin and LIM domain containing 1 | 0.0049775 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 0.00495816 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.00495195 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.00494052 |
| MDFIC | MyoD family inhibitor domain containing | 0.00493473 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00493146 |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | 0.00492966 |
| ADI1 | acireductone dioxygenase 1 | 0.00492626 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | 0.00490498 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.00490157 |
| ADD3 | adducin 3 (gamma) | 0.00489964 |
| PTN | pleiotrophin | 0.00489225 |
| PARN | poly(A)-specific ribonuclease | 0.00488714 |
| HLA-B | major histocompatibility complex, class I, B | 0.00488366 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.0048755 |
| FDX1 | ferredoxin 1 | 0.00487522 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MAP7 | microtubule-associated protein 7 | -0.0176881 |
| PRR7 | proline rich 7 (synaptic) | -0.0128065 |
| KIAA0100 | KIAA0100 | -0.0127729 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.0118275 |
| TNNT1 | troponin T type 1 (skeletal, slow) | -0.0115348 |
| PDLIM3 | PDZ and LIM domain 3 | -0.0113768 |
| TSPYL5 | TSPY-like 5 | -0.0112937 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | -0.0106085 |
| ACTA1 | actin, alpha 1, skeletal muscle | -0.0103361 |
| SLC39A6 | solute carrier family 39 (zinc transporter), member 6 | -0.010253 |
| SLN | sarcolipin | -0.00989395 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00966816 |
| GUCY1A3 | guanylate cyclase 1, soluble, alpha 3 | -0.00965222 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | -0.00926907 |
| MMP3 | matrix metallopeptidase 3 | -0.00919572 |
| TNNI2 | troponin I type 2 (skeletal, fast) | -0.00901316 |
| TTN | titin | -0.00894057 |
| OXTR | oxytocin receptor | -0.0089043 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00886032 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00883597 |
| TNNC1 | troponin C type 1 (slow) | -0.00880045 |
| MB | myoglobin | -0.0087256 |
| ENO3 | enolase 3 (beta, muscle) | -0.00864655 |
| PTP4A3 | protein tyrosine phosphatase type IVA, member 3 | -0.00854658 |
| MYL2 | myosin, light chain 2, regulatory, cardiac, slow | -0.00853769 |
| TXNIP | thioredoxin interacting protein | -0.00848192 |
| PPBP | pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | -0.00847404 |
| ABHD6 | abhydrolase domain containing 6 | -0.00844831 |
| ESR1 | estrogen receptor 1 | -0.00844677 |
| SCUBE2 | signal peptide, CUB domain, EGF-like 2 | -0.00838797 |
| CLGN | calmegin | -0.00819888 |
| MYH2 | myosin, heavy chain 2, skeletal muscle, adult | -0.00803579 |
| IRX5 | iroquois homeobox 5 | -0.00797562 |
| MYBPC1 | myosin binding protein C, slow type | -0.00796987 |
| SPARCL1 | SPARC-like 1 (hevin) | -0.00791275 |
| TNNC2 | troponin C type 2 (fast) | -0.00779203 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.00776403 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | -0.00774598 |
| TNNI1 | troponin I type 1 (skeletal, slow) | -0.00770403 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.00761101 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -0.0076073 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00755874 |
| KIAA0125 | KIAA0125 | -0.00755059 |
| CKM | creatine kinase, muscle | -0.00749966 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00749403 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.00740595 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00740537 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00739418 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.00736777 |
| COQ8A | coenzyme Q8A | -0.00732257 |
| DKFZP586I1420 | uncharacterized protein DKFZp586I1420 | -0.00731079 |
| KLHL41 | kelch-like family member 41 | -0.00724837 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00722905 |
| MYL1 | myosin, light chain 1, alkali; skeletal, fast | -0.00713579 |
| TFF3 | trefoil factor 3 (intestinal) | -0.00704254 |
| IRS1 | insulin receptor substrate 1 | -0.00699111 |
| PF4 | platelet factor 4 | -0.00696634 |
| MYBPC2 | myosin binding protein C, fast type | -0.00694652 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.00693286 |
| HSPA2 | heat shock 70kDa protein 2 | -0.0069318 |
| SMPX | small muscle protein, X-linked | -0.00691184 |
| AMDHD2 | amidohydrolase domain containing 2 | -0.00690835 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00689163 |
| CD300A | CD300a molecule | -0.00688232 |
| LPCAT1 | lysophosphatidylcholine acyltransferase 1 | -0.0068729 |
| RAB25 | RAB25, member RAS oncogene family | -0.00686026 |
| CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | -0.00680006 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00677105 |
| NOTCH2NL | notch 2 N-terminal like | -0.00676962 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00674403 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -0.00670862 |
| EMX2 | empty spiracles homeobox 2 | -0.0066451 |
| YBX3 | Y box binding protein 3 | -0.00662816 |
| AQP1 | aquaporin 1 (Colton blood group) | -0.00660309 |
| HBS1L | HBS1-like translational GTPase | -0.00659996 |
| KLK5 | kallikrein-related peptidase 5 | -0.00658633 |
| MLF1 | myeloid leukemia factor 1 | -0.00658144 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | -0.00657546 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00655684 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) | -0.00655494 |
| EMP2 | epithelial membrane protein 2 | -0.0064723 |
| ACTN2 | actinin, alpha 2 | -0.0064547 |
| ENPEP | glutamyl aminopeptidase (aminopeptidase A) | -0.00640004 |
| ASCL1 | achaete-scute family bHLH transcription factor 1 | -0.00635227 |
| EPHA4 | EPH receptor A4 | -0.00628286 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | -0.00624165 |
| HMGB1 | high mobility group box 1 | -0.00622509 |
| CD1E | CD1e molecule | -0.00621092 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.00620996 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.00620128 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.00619663 |
| MYLPF | myosin light chain, phosphorylatable, fast skeletal muscle | -0.00616916 |
| NOTCH3 | notch 3 | -0.00615208 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00615177 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00614044 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.00611492 |
| IKZF1 | IKAROS family zinc finger 1 (Ikaros) | -0.00610637 |
| ARG1 | arginase 1 | -0.0060917 |
| EREG | epiregulin | -0.00607795 |
| TFF1 | trefoil factor 1 | -0.00605679 |
| BID | BH3 interacting domain death agonist | -0.00601674 |
| FLNC | filamin C, gamma | -0.00598774 |
| GUCY1B3 | guanylate cyclase 1, soluble, beta 3 | -0.00597506 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00597095 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.00596559 |
| PERP | PERP, TP53 apoptosis effector | -0.00596482 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.00593348 |
| RCAN1 | regulator of calcineurin 1 | -0.00592477 |
| HOPX | HOP homeobox | -0.00590184 |
| CHRNA1 | cholinergic receptor, nicotinic, alpha 1 (muscle) | -0.00589499 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -0.00589087 |
| ZIC1 | Zic family member 1 | -0.00588374 |
| DSP | desmoplakin | -0.00587482 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | -0.00586367 |
| AGTR1 | angiotensin II receptor, type 1 | -0.0058582 |
| KLK6 | kallikrein-related peptidase 6 | -0.00585363 |
| MYOT | myotilin | -0.00584705 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.00578115 |
| MAPT | microtubule-associated protein tau | -0.00569095 |
| MEF2C | myocyte enhancer factor 2C | -0.00568472 |
| AIF1 | allograft inflammatory factor 1 | -0.00566392 |
| H2AFV | H2A histone family, member V | -0.00564841 |
| FCN1 | ficolin (collagen/fibrinogen domain containing) 1 | -0.00561822 |
| CALML3 | calmodulin-like 3 | -0.00561525 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.00561106 |
| CPE | carboxypeptidase E | -0.0055915 |
| F12 | coagulation factor XII (Hageman factor) | -0.00558414 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | -0.00558054 |
| LST1 | leukocyte specific transcript 1 | -0.00557872 |
| TNNT3 | troponin T type 3 (skeletal, fast) | -0.00557635 |
| G0S2 | G0/G1 switch 2 | -0.00557579 |
| PKP2 | plakophilin 2 | -0.00557095 |
| HBB | hemoglobin, beta | -0.00557025 |
| CLEC3B | C-type lectin domain family 3, member B | -0.00556651 |
| THBS4 | thrombospondin 4 | -0.00554784 |
| CLIC5 | chloride intracellular channel 5 | -0.00552444 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | -0.00548426 |
| NKG7 | natural killer cell granule protein 7 | -0.00545616 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.00544959 |
| ACTC1 | actin, alpha, cardiac muscle 1 | -0.0054346 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.00540977 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.00540761 |
| CALML5 | calmodulin-like 5 | -0.00537618 |
| EFNB2 | ephrin-B2 | -0.00537139 |
| CPVL | carboxypeptidase, vitellogenic-like | -0.00533761 |
| WIF1 | WNT inhibitory factor 1 | -0.00532842 |
| PALLD | palladin, cytoskeletal associated protein | -0.00532721 |
| PYGM | phosphorylase, glycogen, muscle | -0.00531709 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.00530593 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00528072 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.00527856 |
| S100A9 | S100 calcium binding protein A9 | -0.00527407 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide | -0.00526899 |
| TEX30 | testis expressed 30 | -0.00526166 |
| SRSF10 | serine/arginine-rich splicing factor 10 | -0.00525772 |
| SVIL | supervillin | -0.00524496 |
| CLIC2 | chloride intracellular channel 2 | -0.00524256 |
| NAV3 | neuron navigator 3 | -0.00523823 |
| HOMER1 | homer scaffolding protein 1 | -0.00523643 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.00523117 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | -0.0052127 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) | -0.00520342 |
| DKK4 | dickkopf WNT signaling pathway inhibitor 4 | -0.00519394 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00519039 |
| JUP | junction plakoglobin | -0.00518512 |
| OLFM1 | olfactomedin 1 | -0.00518091 |
| RB1 | retinoblastoma 1 | -0.00517216 |
| PDCD2 | programmed cell death 2 | -0.00516991 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.00516422 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00515934 |
| MYH1 | myosin, heavy chain 1, skeletal muscle, adult | -0.00513902 |
| CLIC1 | chloride intracellular channel 1 | -0.00513582 |
| ECI2 | enoyl-CoA delta isomerase 2 | -0.00512253 |
| CYB5R1 | cytochrome b5 reductase 1 | -0.00511979 |
| NUP107 | nucleoporin 107kDa | -0.00511411 |
| PON3 | paraoxonase 3 | -0.00511256 |
| TMEM14B | transmembrane protein 14B | -0.00509921 |
| CLDN3 | claudin 3 | -0.0050969 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00508582 |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | -0.00507826 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.00507197 |
| TYROBP | TYRO protein tyrosine kinase binding protein | -0.00506915 |
| HSPA4L | heat shock 70kDa protein 4-like | -0.00506372 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00505806 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.00505408 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.00505153 |
| HP | haptoglobin | -0.00504006 |
| TPM3 | tropomyosin 3 | -0.00503062 |
| TRAPPC8 | trafficking protein particle complex 8 | -0.00502307 |
| COX6A2 | cytochrome c oxidase subunit VIa polypeptide 2 | -0.00501191 |
| ATP2A3 | ATPase, Ca++ transporting, ubiquitous | -0.00500685 |
| TMEM38B | transmembrane protein 38B | -0.00499957 |
| FBXO3 | F-box protein 3 | -0.00498222 |
| AREG | amphiregulin | -0.00498022 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.00497282 |
| HSF2 | heat shock transcription factor 2 | -0.00496943 |
| PPM1A | protein phosphatase, Mg2+/Mn2+ dependent, 1A | -0.00496768 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.00496623 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00491481 |
| TOM1L1 | target of myb1 (chicken)-like 1 | -0.00491465 |
| YEATS4 | YEATS domain containing 4 | -0.00490114 |
| TPBG | trophoblast glycoprotein | -0.00488945 |
| MGAT4A | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A | -0.00488507 |
| FOXA1 | forkhead box A1 | -0.00488137 |
| DSC1 | desmocollin 1 | -0.00487482 |
| KLF3-AS1 | KLF3 antisense RNA 1 | -0.00486552 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | -0.00485643 |
| AHNAK | AHNAK nucleoprotein | -0.0048525 |
| CMTR1 | cap methyltransferase 1 | -0.00485095 |
| MED13L | mediator complex subunit 13-like | -0.0048471 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | -0.00484309 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.004839 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.00483251 |
| CALCRL | calcitonin receptor-like | -0.00479416 |
| IFRD2 | interferon-related developmental regulator 2 | -0.0047928 |
| C11ORF21 | chromosome 11 open reading frame 21 | -0.00479242 |
| TSPAN7 | tetraspanin 7 | -0.00479232 |
| GLB1L2 | galactosidase, beta 1-like 2 | -0.00478189 |
| AP1M2 | adaptor-related protein complex 1, mu 2 subunit | -0.00477541 |
| KRT23 | keratin 23, type I | -0.00477405 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.00476935 |
| HCK | HCK proto-oncogene, Src family tyrosine kinase | -0.00476073 |
| DUSP13 | dual specificity phosphatase 13 | -0.00475001 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00474602 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0047367 |
| MYH7 | myosin, heavy chain 7, cardiac muscle, beta | -0.00472543 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.00470878 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00470486 |
| MACROD1 | MACRO domain containing 1 | -0.00470315 |
| RAPSN | receptor-associated protein of the synapse | -0.00470163 |
| HRASLS | HRAS-like suppressor | -0.00469413 |
| MYOZ2 | myozenin 2 | -0.00469041 |
| ACKR3 | atypical chemokine receptor 3 | -0.00468108 |
| FERMT2 | fermitin family member 2 | -0.00466964 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | -0.00466886 |
| CLU | clusterin | -0.00466194 |
| DHCR7 | 7-dehydrocholesterol reductase | -0.00465894 |
| RRAGD | Ras-related GTP binding D | -0.00465603 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | -0.00465384 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.00465024 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.00464872 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | -0.00464238 |
| DDAH2 | dimethylarginine dimethylaminohydrolase 2 | -0.00464022 |
| LAT2 | linker for activation of T cells family, member 2 | -0.00462622 |
| PLA2G4C | phospholipase A2, group IVC (cytosolic, calcium-independent) | -0.00462251 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | -0.00461277 |
| RNF146 | ring finger protein 146 | -0.00461213 |
| ADGRF5 | adhesion G protein-coupled receptor F5 | -0.00460801 |
| TXNDC9 | thioredoxin domain containing 9 | -0.00458998 |
| TSPAN12 | tetraspanin 12 | -0.00458916 |
