GSTM1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description glutathione S-transferase mu 1|Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2944)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_GSTM1
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Genes

109 co-expressed genes for GSTM1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACOX2 acyl-CoA oxidase 2, branched chain
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AGXT alanine-glyoxylate aminotransferase
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMBP alpha-1-microglobulin/bikunin precursor
ANG angiogenin, ribonuclease, RNase A family, 5
APCS amyloid P component, serum
APOA1 apolipoprotein A-I
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOC4 apolipoprotein C-IV
APOF apolipoprotein F
ASGR2 asialoglycoprotein receptor 2
ASL argininosuccinate lyase
ATF5 activating transcription factor 5
C19ORF80 chromosome 19 open reading frame 80
C6 complement component 6
C8A complement component 8, alpha polypeptide
C8G complement component 8, gamma polypeptide
CDHR5 cadherin-related family member 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CES2 carboxylesterase 2
CIDEB cell death-inducing DFFA-like effector b
CPN2 carboxypeptidase N, polypeptide 2
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCXR dicarbonyl/L-xylulose reductase
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
F10 coagulation factor X
F12 coagulation factor XII (Hageman factor)
F2 coagulation factor II (thrombin)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FTCD formimidoyltransferase cyclodeaminase
G6PC glucose-6-phosphatase, catalytic subunit
GALK1 galactokinase 1
GAMT guanidinoacetate N-methyltransferase
GJB1 gap junction protein, beta 1, 32kDa
GNMT glycine N-methyltransferase
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTZ1 glutathione S-transferase zeta 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HGFAC HGF activator
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HP haptoglobin
HPD 4-hydroxyphenylpyruvate dioxygenase
HPN hepsin
HPX hemopexin
HRG histidine-rich glycoprotein
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFALS insulin-like growth factor binding protein, acid labile subunit
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KHK ketohexokinase (fructokinase)
LCAT lecithin-cholesterol acyltransferase
MASP2 mannan-binding lectin serine peptidase 2
MAT1A methionine adenosyltransferase I, alpha
NNMT nicotinamide N-methyltransferase
ORM1 orosomucoid 1
ORM2 orosomucoid 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEMT phosphatidylethanolamine N-methyltransferase
PIPOX pipecolic acid oxidase
PON1 paraoxonase 1
PON3 paraoxonase 3
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
RDH16 retinol dehydrogenase 16 (all-trans)
SAA4 serum amyloid A4, constitutive
SARDH sarcosine dehydrogenase
SDS serine dehydratase
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC38A3 solute carrier family 38, member 3
TAT tyrosine aminotransferase
TKFC triokinase/FMN cyclase
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMPRSS6 transmembrane protease, serine 6
TST thiosulfate sulfurtransferase (rhodanese)
UPB1 ureidopropionase, beta
VTN vitronectin
ZGPAT zinc finger, CCCH-type with G patch domain