GTEx Blood 20-29 vs 70-79 Gene Set

Dataset GTEx Tissue-Specific Aging Signatures
Category transcriptomics
Type tissue sample
Description aging signature described by "GTEx [Tissue] [Background Age] vs [Sample Age]" (Genotype Tissue Expression)
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Genes

219 genes with high or low expression in GTEx Blood 20-29 vs 70-79 relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.

increased expression

Symbol Name Standardized Value
HSPA7 heat shock 70kDa protein 7 (HSP70B) 3.78883
GADD45B growth arrest and DNA-damage-inducible, beta 3.78883
CXCL12 chemokine (C-X-C motif) ligand 12 3.78883
AASS aminoadipate-semialdehyde synthase 3.78883
CYTIP cytohesin 1 interacting protein 3.78883
PPDPF pancreatic progenitor cell differentiation and proliferation factor 3.78883
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 3.78883
PHLDA2 pleckstrin homology-like domain, family A, member 2 3.78883
TGFBR3 transforming growth factor, beta receptor III 3.78883
PLIN2 perilipin 2 3.78883
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 3.78883
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.78883
ABI3 ABI family, member 3 3.78883
RGS9 regulator of G-protein signaling 9 3.78883
GTPBP1 GTP binding protein 1 3.78883
CALR calreticulin 3.78883
DDIT4 DNA-damage-inducible transcript 4 3.77177
HSPA1B heat shock 70kDa protein 1B 3.77177
RRN3P2 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2 3.77177
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 3.75239
SNORD10 small nucleolar RNA, C/D box 10 3.6926
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 3.6926
EMD emerin 3.66913
NFYA nuclear transcription factor Y, alpha 3.63679
PDGFRB platelet-derived growth factor receptor, beta polypeptide 3.63679
PDIA3 protein disulfide isomerase family A, member 3 3.63679
NR4A1 nuclear receptor subfamily 4, group A, member 1 3.63679
PHF8 PHD finger protein 8 3.63679
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 3.63679
EVC2 Ellis van Creveld syndrome 2 3.63679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 3.59883
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 3.58759
HSPH1 heat shock 105kDa/110kDa protein 1 3.58759
ATF3 activating transcription factor 3 3.54293
GPR183 G protein-coupled receptor 183 3.42454
F2R coagulation factor II (thrombin) receptor 3.42454
JUN jun proto-oncogene 3.42454
CCL4 chemokine (C-C motif) ligand 4 3.42454
LINC-PINT long intergenic non-protein coding RNA, p53 induced transcript 3.42454
PDE4A phosphodiesterase 4A, cAMP-specific 3.42454
CSRNP1 cysteine-serine-rich nuclear protein 1 3.42454
GZF1 GDNF-inducible zinc finger protein 1 3.42454
STIP1 stress-induced phosphoprotein 1 3.42454
CMKLR1 chemerin chemokine-like receptor 1 3.42454
AVPI1 arginine vasopressin-induced 1 3.42454
DTHD1 death domain containing 1 3.42454
STX1A syntaxin 1A (brain) 3.34227
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 3.34227
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.34227
H2BC18 H2B clustered histone 18 3.34227
H2BC8 H2B clustered histone 8 3.34227
PPP1R15A protein phosphatase 1, regulatory subunit 15A 3.34227
SRSF3 serine/arginine-rich splicing factor 3 3.34227
NGFR nerve growth factor receptor 3.34227
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 3.34227
ERRFI1 ERBB receptor feedback inhibitor 1 3.33067
COPZ2 coatomer protein complex, subunit zeta 2 3.32774
FKBP4 FK506 binding protein 4, 59kDa 3.32774
PER1 period circadian clock 1 3.32774
L3MBTL4 l(3)mbt-like 4 (Drosophila) 3.32774
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 3.32774
RALGDS ral guanine nucleotide dissociation stimulator 3.32774
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 3.32774
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 3.32774
HK2 hexokinase 2 3.32774
SETBP1 SET binding protein 1 3.32774
RHOC ras homolog family member C 3.32774
FKBP10 FK506 binding protein 10, 65 kDa 3.32774
BRD4 bromodomain containing 4 3.32774
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 3.30961
RHOB ras homolog family member B 3.30847
TBX21 T-box 21 3.30847
DUSP10 dual specificity phosphatase 10 3.30783
JAG2 jagged 2 3.30546
SPON2 spondin 2, extracellular matrix protein 3.30546
UBAP2L ubiquitin associated protein 2-like 3.29638
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6 3.29079
IRF6 interferon regulatory factor 6 3.25752
FAM50A family with sequence similarity 50, member A 3.25752
TPRG1 tumor protein p63 regulated 1 3.22634
ZBTB20 zinc finger and BTB domain containing 20 3.21829
BHLHE40 basic helix-loop-helix family, member e40 3.21829
HNRNPM heterogeneous nuclear ribonucleoprotein M 3.21829
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 3.21829
KAT6A K(lysine) acetyltransferase 6A 3.21478
EAF1 ELL associated factor 1 3.20963
ADGRB1 adhesion G protein-coupled receptor B1 3.19409
APOC1 apolipoprotein C-I 3.18485
ARF6 ADP-ribosylation factor 6 3.15358
DHCR7 7-dehydrocholesterol reductase 3.15358
DDIT3 DNA-damage-inducible transcript 3 3.15358
H2BC9 H2B clustered histone 9 3.15358
TPM4 tropomyosin 4 3.15358
YBX1 Y box binding protein 1 3.15358
H2BC26 H2B clustered histone 26 3.15358
GATAD2B GATA zinc finger domain containing 2B 3.15358
JMJD6 jumonji domain containing 6 3.15358
HBEGF heparin-binding EGF-like growth factor 3.15358
DLG5 discs, large homolog 5 (Drosophila) 3.15358
IL18BP interleukin 18 binding protein 3.13886
TBC1D7 TBC1 domain family, member 7 3.13886
MVD mevalonate (diphospho) decarboxylase 3.13482
EIF1 eukaryotic translation initiation factor 1 3.13482
HSF1 heat shock transcription factor 1 3.13482
ADORA2A-AS1 ADORA2A antisense RNA 1 3.13482
RLF rearranged L-myc fusion 3.13482
HSPB1 heat shock 27kDa protein 1 3.12216
ETF1 eukaryotic translation termination factor 1 3.10916
SF3A1 splicing factor 3a, subunit 1, 120kDa 3.10908
JAKMIP1 janus kinase and microtubule interacting protein 1 3.10908
H2BC5 H2B clustered histone 5 3.10908
HILPDA hypoxia inducible lipid droplet-associated 3.09547
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.09313
RMC1 regulator of MON1-CCZ1 3.09313
GK5 glycerol kinase 5 (putative) 3.08919
SRSF4 serine/arginine-rich splicing factor 4 3.08919
NR4A2 nuclear receptor subfamily 4, group A, member 2 3.08919
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 3.07761
PLEK pleckstrin 3.07761
SYAP1 synapse associated protein 1 3.07761
ING1 inhibitor of growth family, member 1 3.07761
PDE4D phosphodiesterase 4D, cAMP-specific 3.07761
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 3.07761
CCDC85C coiled-coil domain containing 85C 3.07761
TRIB1 tribbles pseudokinase 1 3.07282
LOC102724428 serine/threonine-protein kinase SIK1 3.07282
GUK1 guanylate kinase 1 3.06947
SCD5 stearoyl-CoA desaturase 5 3.06947
PATL1 protein associated with topoisomerase II homolog 1 (yeast) 3.06947
PLAU plasminogen activator, urokinase 3.06947
AUTS2 autism susceptibility candidate 2 3.0667
ZFP36 ZFP36 ring finger protein 3.0667
HES4 hes family bHLH transcription factor 4 3.0667
ACP6 acid phosphatase 6, lysophosphatidic 3.06019
STAU1 staufen double-stranded RNA binding protein 1 3.04209
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 3.03211

decreased expression

Symbol Name Standardized Value
LINC01003 long intergenic non-protein coding RNA 1003 -3.78883
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -3.78883
ZSWIM1 zinc finger, SWIM-type containing 1 -3.78883
ZNF174 zinc finger protein 174 -3.78883
SDCBP2-AS1 SDCBP2 antisense RNA 1 -3.78883
KIAA1614 KIAA1614 -3.78883
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta -3.78883
POU5F1 POU class 5 homeobox 1 -3.78883
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -3.78883
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 -3.78883
ZNF768 zinc finger protein 768 -3.78883
CCR7 chemokine (C-C motif) receptor 7 -3.78883
LRRN3 leucine rich repeat neuronal 3 -3.77177
LOC105370941 uncharacterized LOC105370941 -3.77177
LINC01963 long intergenic non-protein coding RNA 1963 -3.77177
GLIS2 GLIS family zinc finger 2 -3.63679
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -3.63679
ILRUN-AS1 ILRUN antisense RNA 1 -3.63679
ASTE1 asteroid homolog 1 (Drosophila) -3.63679
ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2 -3.59883
MBD4 methyl-CpG binding domain protein 4 -3.59883
OXLD1 oxidoreductase-like domain containing 1 -3.58759
ZNF425 zinc finger protein 425 -3.58759
RTL10 retrotransposon Gag like 10 -3.58759
KLC4 kinesin light chain 4 -3.42454
GPC1-AS1 GPC1 antisense RNA 1 -3.42454
SLC35E3 solute carrier family 35, member E3 -3.42454
MED9 mediator complex subunit 9 -3.34227
ZNF763 zinc finger protein 763 -3.34227
NLRX1 NLR family member X1 -3.34227
STK35 serine/threonine kinase 35 -3.32774
CES2 carboxylesterase 2 -3.32774
TMEM119 transmembrane protein 119 -3.32774
FBXL19 F-box and leucine-rich repeat protein 19 -3.32774
ZNF747 zinc finger protein 747 -3.32774
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -3.32669
ZNF740 zinc finger protein 740 -3.30847
RHOQ-AS1 RHOQ antisense RNA 1 -3.30546
ING4 inhibitor of growth family, member 4 -3.25752
ZNF540 zinc finger protein 540 -3.25752
PDCD6 programmed cell death 6 -3.21478
DNAL4 dynein, axonemal, light chain 4 -3.20963
PAGR1 PAXIP1 associated glutamate-rich protein 1 -3.20963
ORAI3 ORAI calcium release-activated calcium modulator 3 -3.18485
ZNF606 zinc finger protein 606 -3.18485
ZBED1 zinc finger, BED-type containing 1 -3.16877
CLN5 ceroid-lipofuscinosis, neuronal 5 -3.16877
NCBP2AS2 NCBP2 antisense 2 (head to head) -3.15358
ZNF576 zinc finger protein 576 -3.15358
MRPL20-AS1 MRPL20 antisense RNA 1 -3.15358
RNF170 ring finger protein 170 -3.15358
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -3.15358
PRDM2 PR domain containing 2, with ZNF domain -3.15358
SPRING1 SREBF pathway regulator in golgi 1 -3.15358
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor -3.13482
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -3.13482
AMACR alpha-methylacyl-CoA racemase -3.13482
TUBD1 tubulin, delta 1 -3.13482
CYB561D1 cytochrome b561 family, member D1 -3.12732
UNC119B unc-119 homolog B (C. elegans) -3.12732
TBCC tubulin folding cofactor C -3.12216
MOCS3 molybdenum cofactor synthesis 3 -3.09547
ZNF689 zinc finger protein 689 -3.09547
FAAP24 FA core complex associated protein 24 -3.09313
PEX11B peroxisomal biogenesis factor 11 beta -3.09313
MSS51 MSS51 mitochondrial translational activator -3.08919
MED18 mediator complex subunit 18 -3.08919
SPMIP8 sperm microtubule inner protein 8 -3.08919
LRRC61 leucine rich repeat containing 61 -3.07761
SPOP speckle-type POZ protein -3.07761
ZNF671 zinc finger protein 671 -3.07761
IFT70B intraflagellar transport 70B -3.07375
PYGO2 pygopus family PHD finger 2 -3.07375
GOLPH3L golgi phosphoprotein 3-like -3.07375
ZSWIM3 zinc finger, SWIM-type containing 3 -3.07282
LINC01089 long intergenic non-protein coding RNA 1089 -3.06947
TSSK6 testis-specific serine kinase 6 -3.06947
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) -3.06946
PIGX phosphatidylinositol glycan anchor biosynthesis, class X -3.05821
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -3.05494
ZNF33A zinc finger protein 33A -3.02595
ZNF20 zinc finger protein 20 -2.9987
ZNF408 zinc finger protein 408 -2.99756