GTEx Esophagus 20-29 vs 40-49 Gene Set

Dataset GTEx Tissue-Specific Aging Signatures
Category transcriptomics
Type tissue sample
Description aging signature described by "GTEx [Tissue] [Background Age] vs [Sample Age]" (Genotype Tissue Expression)
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Genes

186 genes with high or low expression in GTEx Esophagus 20-29 vs 40-49 relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.

increased expression

Symbol Name Standardized Value
EYA4 EYA transcriptional coactivator and phosphatase 4 14.9126
KIF23-AS1 KIF23 and PAQR5 antisense RNA 1 5.96276
PTCHD4 patched domain containing 4 5.96276
EDA2R ectodysplasin A2 receptor 5.00334
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial 4.94578
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 4.7245
RPS3AP34 ribosomal protein S3a pseudogene 34 4.51437
SPON2 spondin 2, extracellular matrix protein 4.51437
TMEM260 transmembrane protein 260 4.51437
DNASE1 deoxyribonuclease I 4.47191
TBCK TBC1 domain containing kinase 4.44398
SPDYA speedy/RINGO cell cycle regulator family member A 4.44398
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 4.44398
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 4.44398
DNASE1L2 deoxyribonuclease I-like 2 4.44398
ZNF785 zinc finger protein 785 4.44398
LINC02696 long intergenic non-protein coding RNA 2696 4.44398
FBXL4 F-box and leucine-rich repeat protein 4 4.44398
FOXD2-AS1 FOXD2 antisense RNA 1 (head to head) 4.44398
ELOVL7 ELOVL fatty acid elongase 7 4.44398
ZBTB48 zinc finger and BTB domain containing 48 4.44398
TMC2 transmembrane channel-like 2 4.24729
CEP44 centrosomal protein 44kDa 4.10242
RBM12B RNA binding motif protein 12B 4.10242
RSRP1 arginine/serine-rich protein 1 4.10242
VAX2 ventral anterior homeobox 2 4.10242
LSMEM1 leucine-rich single-pass membrane protein 1 4.10242
MANEA-DT MANEA divergent transcript 4.10242
FOXP1-DT FOXP1 divergent transcript 4.0104
SHROOM1 shroom family member 1 3.98269
CLEC2B C-type lectin domain family 2, member B 3.98269
FAM234B family with sequence similarity 234 member B 3.92582
RPL13AP26 ribosomal protein L13a pseudogene 26 3.92582
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 3.92582
UBN2 ubinuclein 2 3.91283
ASXL3 additional sex combs like transcriptional regulator 3 3.91283
SANBR SANT and BTB domain regulator of CSR 3.91283
RGS17 regulator of G-protein signaling 17 3.91283
PEX6 peroxisomal biogenesis factor 6 3.91283
ATXN3 ataxin 3 3.91283
DISC1 disrupted in schizophrenia 1 3.91283
TBX19 T-box 19 3.91283
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) 3.91283
SNRNP48 small nuclear ribonucleoprotein 48kDa (U11/U12) 3.88478
ZNF808 zinc finger protein 808 3.80373
SFXN5 sideroflexin 5 3.62418
ZNF674 zinc finger protein 674 3.6199
PCDHB2 protocadherin beta 2 3.54858
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.54858
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 3.54858
TRA2A transformer 2 alpha homolog (Drosophila) 3.54858
TMEM81 transmembrane protein 81 3.54858
C12ORF60 chromosome 12 open reading frame 60 3.54858
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.54858
CLDN15 claudin 15 3.54536
ZGLP1 zinc finger, GATA-like protein 1 3.54536
CLK1 CDC-like kinase 1 3.53557
NSUN6 NOP2/Sun domain family, member 6 3.50967
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 3.50967
HAUS3 HAUS augmin-like complex, subunit 3 3.50967
TCP10L t-complex 10-like 3.4797
ZMYM1 zinc finger, MYM-type 1 3.4797
JRKL JRK-like 3.4797
NTAN1P2 N-terminal asparagine amidase pseudogene 2 3.4797
LIPC lipase, hepatic 3.4797
SPMIP8 sperm microtubule inner protein 8 3.4797
MMP17 matrix metallopeptidase 17 (membrane-inserted) 3.4797
NLRP1 NLR family, pyrin domain containing 1 3.4797
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 3.4797
TAS2R20 taste receptor, type 2, member 20 3.47452
LTBP2 latent transforming growth factor beta binding protein 2 3.46842
ACYP1 acylphosphatase 1, erythrocyte (common) type 3.44749
VWCE von Willebrand factor C and EGF domains 3.44749
TMEM116 transmembrane protein 116 3.44749
CTAGE7P CTAGE family, member 7, pseudogene 3.44749
ANKRD23 ankyrin repeat domain 23 3.42595
MDM4 MDM4, p53 regulator 3.42595
RPS3AP38 ribosomal protein S3a pseudogene 38 3.42158
LINC00506 long intergenic non-protein coding RNA 506 3.41486
CCDC154 coiled-coil domain containing 154 3.40637
PTEN phosphatase and tensin homolog 3.40637
ACADL acyl-CoA dehydrogenase, long chain 3.40637
GDF15 growth differentiation factor 15 3.40637
RORB RAR-related orphan receptor B 3.40637
LRRC2 leucine rich repeat containing 2 3.40637
DRD2 dopamine receptor D2 3.3998
GALNS galactosamine (N-acetyl)-6-sulfatase 3.37784
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 3.36536
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 3.36536
BORCS8-MEF2B BORCS8-MEF2B readthrough 3.34675
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 3.34675
LOC107985101 uncharacterized LOC107985101 3.33811
ANO2 anoctamin 2, calcium activated chloride channel 3.31621
INTS6-AS1 INTS6 antisense RNA 1 3.31458
GAL3ST4 galactose-3-O-sulfotransferase 4 3.3098
SEC24B-AS1 SEC24B antisense RNA 1 3.27466
MAFTRR MAF transcriptional regulator RNA 3.24064
ZMYND10 zinc finger, MYND-type containing 10 3.2403
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.22623
PLXDC2 plexin domain containing 2 3.22272
CA5B carbonic anhydrase VB, mitochondrial 3.18838
ADAM23 ADAM metallopeptidase domain 23 3.18838
HAGHL hydroxyacylglutathione hydrolase-like 3.17657
OIP5-AS1 OIP5 antisense RNA 1 3.14624
THAP9 THAP domain containing 9 3.14624
C2ORF42 chromosome 2 open reading frame 42 3.12402
THAP2 THAP domain containing, apoptosis associated protein 2 3.10367
ZNF519 zinc finger protein 519 3.07154
LINC02981 long intergenic non-protein coding RNA 2981 3.07154
ZC2HC1A zinc finger, C2HC-type containing 1A 3.07154
PCNX4 pecanex 4 3.07154
TRPV1 transient receptor potential cation channel, subfamily V, member 1 3.07154
C18ORF54 chromosome 18 open reading frame 54 3.07154
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 3.05025
CAPN10-DT CAPN10 divergent transcript 3.03326
LINC00449 long intergenic non-protein coding RNA 449 3.03326
OMG oligodendrocyte myelin glycoprotein 3.0145
ZFYVE27 zinc finger, FYVE domain containing 27 3.00578
HIF1A-AS3 HIF1A antisense RNA 3 3.00445

decreased expression

Symbol Name Standardized Value
NAGA N-acetylgalactosaminidase, alpha- -7.24042
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -5.77658
ZNF587B zinc finger protein 587B -5.29289
EID2 EP300 interacting inhibitor of differentiation 2 -5.05532
PHETA2 PH domain containing endocytic trafficking adaptor 2 -4.91869
SEPHS2 selenophosphate synthetase 2 -4.7245
PUF60 poly-U binding splicing factor 60KDa -4.43536
PDHB pyruvate dehydrogenase (lipoamide) beta -4.24729
NCBP2AS2 NCBP2 antisense 2 (head to head) -4.24729
RNF139 ring finger protein 139 -4.2283
KBTBD4 kelch repeat and BTB (POZ) domain containing 4 -4.10242
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -4.10161
ZNF229 zinc finger protein 229 -3.92582
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -3.92582
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -3.92582
TRAPPC2B trafficking protein particle complex 2B -3.91283
TUBB6 tubulin, beta 6 class V -3.91283
RBBP7 retinoblastoma binding protein 7 -3.88478
PARP1 poly (ADP-ribose) polymerase 1 -3.86054
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -3.86054
UFSP1 UFM1-specific peptidase 1 (non-functional) -3.8166
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -3.8166
FH fumarate hydratase -3.8166
ZNF304 zinc finger protein 304 -3.8032
ZNF35 zinc finger protein 35 -3.66879
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -3.6199
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -3.54858
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -3.54858
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha -3.50967
TRIB1 tribbles pseudokinase 1 -3.50967
KTI12 KTI12 homolog, chromatin associated (S. cerevisiae) -3.5002
MIR22HG MIR22 host gene -3.48896
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -3.4797
PWP1 PWP1 homolog (S. cerevisiae) -3.47452
POLR1F RNA polymerase I subunit F -3.44749
WBP11 WW domain binding protein 11 -3.42595
MALSU1 mitochondrial assembly of ribosomal large subunit 1 -3.42595
SIPA1L1 signal-induced proliferation-associated 1 like 1 -3.42595
KCTD20 potassium channel tetramerization domain containing 20 -3.41656
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -3.4165
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -3.41013
EPOP elongin BC and polycomb repressive complex 2 associated protein -3.38543
ACTRT3 actin-related protein T3 -3.37784
PARL presenilin associated, rhomboid-like -3.37784
ELAC2 elaC ribonuclease Z 2 -3.36536
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) -3.36536
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -3.27466
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28 -3.24959
STRAP serine/threonine kinase receptor associated protein -3.2403
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -3.20885
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -3.20885
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase -3.18996
KAT5 K(lysine) acetyltransferase 5 -3.18996
TLR1 toll-like receptor 1 -3.18838
METAP2 methionyl aminopeptidase 2 -3.1505
LTV1 LTV1 ribosome biogenesis factor -3.1505
TMEM70 transmembrane protein 70 -3.1505
C14ORF119 chromosome 14 open reading frame 119 -3.1031
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -3.10246
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -3.07453
NUBP1 nucleotide binding protein 1 -3.07154
LRRC42 leucine rich repeat containing 42 -3.07154
MIF4GD MIF4G domain containing -3.07154
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 -3.07154
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -3.04552
CLP1 cleavage and polyadenylation factor I subunit 1 -3.03326
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -3.00578