GTEx Heart 20-29 vs 40-49 Gene Set

Dataset GTEx Tissue-Specific Aging Signatures
Category transcriptomics
Type tissue sample
Description aging signature described by "GTEx [Tissue] [Background Age] vs [Sample Age]" (Genotype Tissue Expression)
Similar Terms
Downloads & Tools

Genes

257 genes with high or low expression in GTEx Heart 20-29 vs 40-49 relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.

increased expression

Symbol Name Standardized Value
EPOR erythropoietin receptor 4.71801
ING5 inhibitor of growth family, member 5 4.28505
SYCE2 synaptonemal complex central element protein 2 4.28505
RGL3 ral guanine nucleotide dissociation stimulator-like 3 4.19211
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 3.69113
DDB2 damage-specific DNA binding protein 2, 48kDa 3.50432
SPATA6L spermatogenesis associated 6-like 3.23423
DHRS3 dehydrogenase/reductase (SDR family) member 3 3.23423
EDA2R ectodysplasin A2 receptor 3.23423
SRRM1 serine/arginine repetitive matrix 1 3.18699
PAAF1 proteasomal ATPase-associated factor 1 3.18699
NPC1L1 NPC1-like 1 3.18699
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 3.17646
RPL13P12 ribosomal protein L13 pseudogene 12 3.13941
IGSF1 immunoglobulin superfamily, member 1 3.13941
LRRC56 leucine rich repeat containing 56 3.13941
C2ORF92 chromosome 2 open reading frame 92 3.13941
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 3.13941
TBX19 T-box 19 3.1135
RBM5 RNA binding motif protein 5 3.1135
TMEM63A transmembrane protein 63A 3.1135
TTLL3 tubulin tyrosine ligase-like family member 3 3.1135
PIPOX pipecolic acid oxidase 3.1135
PTCHD4 patched domain containing 4 3.1135
SOCS2-AS1 SOCS2 antisense RNA 1 3.1135
CFAP57 cilia and flagella associated protein 57 3.1135
LIPH lipase, member H 3.1135
ANXA2R-AS1 ANXA2R antisense RNA 1 3.1135
RPH3AL-AS1 RPH3AL antisense RNA 1 3.1135
SAXO4 stabilizer of axonemal microtubules 4 3.1135
PJVK pejvakin 3.1135
CFAP91 cilia and flagella associated protein 91 3.1135
SPACA9 sperm acrosome associated 9 3.1135
MNMIP1 manchette microtubule inner protein 1 3.1135
CCDC102A coiled-coil domain containing 102A 3.1135
TLR9 toll-like receptor 9 3.1135
VIT vitrin 3.1135
B4GAT1-DT B4GAT1 divergent transcript 3.1135
LINC00304 long intergenic non-protein coding RNA 304 3.1135
NPHP3 nephronophthisis 3 (adolescent) 3.1135
TSSK3 testis-specific serine kinase 3 3.1135
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.1135
WASH8P WAS protein family homolog 8, pseudogene 3.1135
RBM33 RNA binding motif protein 33 3.1135
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.1135
ENO2 enolase 2 (gamma, neuronal) 3.1135
EBF4 early B-cell factor 4 3.1135
ADAMTS9-AS2 ADAMTS9 antisense RNA 2 3.1135
TNN tenascin N 3.1135
UBQLNL ubiquilin-like 3.1135
CXCR1 chemokine (C-X-C motif) receptor 1 3.1135
LINC00294 long intergenic non-protein coding RNA 294 3.1135
SNX33 sorting nexin 33 3.1135
MRNIP MRN complex interacting protein 3.1135
LMCD1-AS1 LMCD1 antisense RNA 1 (head to head) 3.1135
SPATA18 spermatogenesis associated 18 3.1135
ALOX12-AS1 ALOX12 antisense RNA 1 3.1135
ADCY2 adenylate cyclase 2 (brain) 3.1135
PLA2G5 phospholipase A2, group V 3.1135
CLK1 CDC-like kinase 1 3.1135
TLDC2 TBC/LysM-associated domain containing 2 3.1135
PRCD progressive rod-cone degeneration 3.1135
NMRK1 nicotinamide riboside kinase 1 3.1135
SPIN4 spindlin family, member 4 3.1135
TTC28-AS1 TTC28 antisense RNA 1 3.1064
NXF3 nuclear RNA export factor 3 3.08919
NISCH nischarin 3.08919
ZNF337 zinc finger protein 337 3.08919
BMP4 bone morphogenetic protein 4 3.08919
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 3.0687
DPH7 diphthamide biosynthesis 7 3.05745
RFX3-DT RFX3 divergent transcript 3.05745
MYO15A myosin XVA 3.05745
BAIAP2 BAI1-associated protein 2 3.05715
LOC102723566 uncharacterized LOC102723566 3.05715
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 3.05652
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha 3.05652
LOC100506235 uncharacterized LOC100506235 3.0562
NBR2 neighbor of BRCA1 gene 2 (non-protein coding) 3.05227
TMEM91 transmembrane protein 91 3.04787
PODNL1 podocan-like 1 3.04787
PLEKHA6 pleckstrin homology domain containing, family A member 6 3.04787
NPIPB14P nuclear pore complex interacting protein family member B14, pseudogene 3.04787
CLK3 CDC-like kinase 3 3.04787
PARP15 poly (ADP-ribose) polymerase family, member 15 3.04787
SYTL1 synaptotagmin-like 1 3.04787
PROCA1 protein interacting with cyclin A1 3.04787
FBXL2 F-box and leucine-rich repeat protein 2 3.04723
DNASE1L3 deoxyribonuclease I-like 3 3.04723
NPIPB12 nuclear pore complex interacting protein family member B12 3.04723
HAUS7 HAUS augmin-like complex, subunit 7 3.04723
LZTS3 leucine zipper, putative tumor suppressor family member 3 3.04723
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 3.03403
FTX FTX transcript, XIST regulator (non-protein coding) 3.03403
TMEM100 transmembrane protein 100 3.03403
ARMCX4 armadillo repeat containing, X-linked 4 3.03403
KAT2A K(lysine) acetyltransferase 2A 3.01883
HOXC6 homeobox C6 3.01883
CENATAC centrosomal AT-AC splicing factor 3.01883
COL24A1 collagen, type XXIV, alpha 1 3.01794
ESPN espin 3.00914
SRSF5 serine/arginine-rich splicing factor 5 3.00914
EOLA2-DT EOLA2 divergent transcript 3.00538
NLRP1 NLR family, pyrin domain containing 1 3.00308

decreased expression

Symbol Name Standardized Value
IER3IP1 immediate early response 3 interacting protein 1 -3.23423
PPA1 pyrophosphatase (inorganic) 1 -3.18699
CXADR coxsackie virus and adenovirus receptor -3.18699
SEPHS2 selenophosphate synthetase 2 -3.18699
RCAN3 RCAN family member 3 -3.18699
ICA1 islet cell autoantigen 1, 69kDa -3.18699
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.18623
MRPL15 mitochondrial ribosomal protein L15 -3.17646
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -3.17646
ETNPPL ethanolamine-phosphate phospho-lyase -3.13941
CDC42 cell division cycle 42 -3.13941
RAB2A RAB2A, member RAS oncogene family -3.13941
CALM2 calmodulin 2 (phosphorylase kinase, delta) -3.13941
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -3.1135
UBE2N ubiquitin-conjugating enzyme E2N -3.1135
PDE3A phosphodiesterase 3A, cGMP-inhibited -3.1135
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -3.1135
RAMAC RNA guanine-7 methyltransferase activating subunit -3.1135
STRIP2 striatin interacting protein 2 -3.1135
RAB10 RAB10, member RAS oncogene family -3.1135
DMAC2L distal membrane arm assembly component 2 like -3.1135
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 -3.1135
PRMT6 protein arginine methyltransferase 6 -3.1135
POLR1F RNA polymerase I subunit F -3.1135
PPP1R8 protein phosphatase 1, regulatory subunit 8 -3.1135
ATF6 activating transcription factor 6 -3.1135
EIF3M eukaryotic translation initiation factor 3, subunit M -3.1135
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -3.1135
DCAF13 DDB1 and CUL4 associated factor 13 -3.1135
MED6 mediator complex subunit 6 -3.1135
LYPLA1 lysophospholipase I -3.1135
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -3.1135
AGFG1 ArfGAP with FG repeats 1 -3.1135
ELOC elongin C -3.1135
TMEM70 transmembrane protein 70 -3.1135
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -3.1135
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -3.1135
VTA1 vesicle (multivesicular body) trafficking 1 -3.1135
MACROH2A2 macroH2A.2 histone -3.1135
EID2 EP300 interacting inhibitor of differentiation 2 -3.1135
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -3.1135
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -3.1135
SERBP1 SERPINE1 mRNA binding protein 1 -3.1135
FCMR Fc fragment of IgM receptor -3.1135
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -3.1135
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -3.1135
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -3.1135
CCDC43 coiled-coil domain containing 43 -3.1135
TOMM70 translocase of outer mitochondrial membrane 70 -3.1135
UXS1 UDP-glucuronate decarboxylase 1 -3.1135
HPF1 histone PARylation factor 1 -3.1135
WDR82 WD repeat domain 82 -3.1135
HRH2 histamine receptor H2 -3.1135
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -3.1135
BCAP29 B-cell receptor-associated protein 29 -3.1135
ELOA elongin A -3.1135
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -3.1135
RAB11A RAB11A, member RAS oncogene family -3.1135
MRPL3 mitochondrial ribosomal protein L3 -3.1135
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -3.1135
MTMR9 myotubularin related protein 9 -3.1135
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -3.1135
REEP5 receptor accessory protein 5 -3.1135
GAR1 GAR1 ribonucleoprotein -3.1135
BRD7 bromodomain containing 7 -3.1135
RNASEH2B ribonuclease H2, subunit B -3.1135
SMIM13 small integral membrane protein 13 -3.1135
TSPYL5 TSPY-like 5 -3.1135
PDPN podoplanin -3.1135
MET MET proto-oncogene, receptor tyrosine kinase -3.1135
CTSL cathepsin L -3.1135
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli) -3.1135
OCIAD2 OCIA domain containing 2 -3.1135
SH3GLB1 SH3-domain GRB2-like endophilin B1 -3.1135
CDH13 cadherin 13 -3.1135
GLRX3 glutaredoxin 3 -3.1135
RABGGTB Rab geranylgeranyltransferase, beta subunit -3.1135
TIPRL TOR signaling pathway regulator -3.1135
CLIC4 chloride intracellular channel 4 -3.1135
PREP prolyl endopeptidase -3.1135
DSC2 desmocollin 2 -3.1135
MIEF1 mitochondrial elongation factor 1 -3.1135
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -3.1135
PFN2 profilin 2 -3.1135
CHMP4B charged multivesicular body protein 4B -3.1135
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -3.1135
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -3.1135
TSN translin -3.1135
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -3.1135
CALM3 calmodulin 3 (phosphorylase kinase, delta) -3.1135
SAAL1 serum amyloid A-like 1 -3.1135
GSK3B glycogen synthase kinase 3 beta -3.1135
ATXN10 ataxin 10 -3.1135
AGPS alkylglycerone phosphate synthase -3.1135
TTC27 tetratricopeptide repeat domain 27 -3.1135
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -3.1135
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -3.1135
SLC35F5 solute carrier family 35, member F5 -3.1135
RABL3 RAB, member of RAS oncogene family-like 3 -3.1135
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -3.1135
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -3.1135
VAMP7 vesicle-associated membrane protein 7 -3.10517
MRPS22 mitochondrial ribosomal protein S22 -3.10517
LPCAT3 lysophosphatidylcholine acyltransferase 3 -3.08919
TXNDC15 thioredoxin domain containing 15 -3.08919
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -3.08919
PEX13 peroxisomal biogenesis factor 13 -3.08919
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -3.08439
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -3.08439
C6ORF120 chromosome 6 open reading frame 120 -3.08212
GBE1 glucan (1,4-alpha-), branching enzyme 1 -3.07451
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -3.07191
RTRAF RNA transcription, translation and transport factor -3.05745
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -3.05745
GTPBP8 GTP-binding protein 8 (putative) -3.05715
PDCD10 programmed cell death 10 -3.05652
CSNK2A1 casein kinase 2, alpha 1 polypeptide -3.05652
CENPL centromere protein L -3.05652
ANXA7 annexin A7 -3.05652
FARSB phenylalanyl-tRNA synthetase, beta subunit -3.05652
UBE2A ubiquitin-conjugating enzyme E2A -3.05652
SRP72 signal recognition particle 72kDa -3.05652
DCTN4 dynactin 4 (p62) -3.0562
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -3.05201
MOB4 MOB family member 4, phocein -3.04787
MTX2 metaxin 2 -3.04787
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -3.04787
MRPL47 mitochondrial ribosomal protein L47 -3.04787
BTF3L4 basic transcription factor 3-like 4 -3.04787
SSBP1 single-stranded DNA binding protein 1, mitochondrial -3.04787
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -3.04787
SYAP1 synapse associated protein 1 -3.04787
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -3.04723
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -3.04723
THSD4 thrombospondin, type I, domain containing 4 -3.04723
FDX1 ferredoxin 1 -3.04723
RPP40 ribonuclease P/MRP 40kDa subunit -3.04723
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog -3.04723
GCLM glutamate-cysteine ligase, modifier subunit -3.04723
ATXN7L3B ataxin 7-like 3B -3.04723
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -3.04723
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -3.04723
KLHL41 kelch-like family member 41 -3.04723
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.04046
NDC1 NDC1 transmembrane nucleoporin -3.03403
FAM120A family with sequence similarity 120A -3.03403
MSX2 msh homeobox 2 -3.01883
OLA1 Obg-like ATPase 1 -3.01883
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -3.00914
HBS1L HBS1-like translational GTPase -3.00914
NSF N-ethylmaleimide-sensitive factor -3.00308
SSB Sjogren syndrome antigen B (autoantigen La) -3.00308
EIF5A eukaryotic translation initiation factor 5A -2.99985