GTEx Testis 20-29 vs 60-69 Gene Set

Dataset GTEx Tissue-Specific Aging Signatures
Category transcriptomics
Type tissue sample
Description aging signature described by "GTEx [Tissue] [Background Age] vs [Sample Age]" (Genotype Tissue Expression)
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Genes

240 genes with high or low expression in GTEx Testis 20-29 vs 60-69 relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.

increased expression

Symbol Name Standardized Value
PTCHD4 patched domain containing 4 31.3066
GRTP1 growth hormone regulated TBC protein 1 13.1693
EDA2R ectodysplasin A2 receptor 10.2371
SEC24AP1 SEC24 homolog A pseudogene 1 7.5683
LINC02349 long intergenic non-protein coding RNA 2349 7.5683
PHLDA3 pleckstrin homology-like domain, family A, member 3 7.5683
IL15 interleukin 15 7.50761
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 7.44184
DAPK2 death-associated protein kinase 2 7.4139
LMO3 LIM domain only 3 (rhombotin-like 2) 7.31238
MRC2 mannose receptor, C type 2 6.72952
ACTA2-AS1 ACTA2 antisense RNA 1 6.54199
GDF15 growth differentiation factor 15 6.36654
MFAP5 microfibrillar associated protein 5 6.36654
ACP5 acid phosphatase 5, tartrate resistant 6.36654
ADAMTS9-AS2 ADAMTS9 antisense RNA 2 6.36654
COL4A6 collagen, type IV, alpha 6 6.12247
PLXDC1 plexin domain containing 1 5.98487
CD69 CD69 molecule 5.89768
FAM180B family with sequence similarity 180, member B 5.89228
ANGPTL5 angiopoietin-like 5 5.8577
ADAMTSL2 ADAMTS-like 2 5.8577
LOC105377862 uncharacterized LOC105377862 5.8577
ACOT11 acyl-CoA thioesterase 11 5.82838
ZMAT3 zinc finger, matrin-type 3 5.82838
IFITM10 interferon induced transmembrane protein 10 5.7545
NALCN sodium leak channel, non selective 5.7545
CYS1 cystin 1 5.73975
MAP3K7CL MAP3K7 C-terminal like 5.72932
NTM neurotrimin 5.7157
ACSBG1 acyl-CoA synthetase bubblegum family member 1 5.7157
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 5.7157
LINC03135 long intergenic non-protein coding RNA 3135 5.7157
CCL5 chemokine (C-C motif) ligand 5 5.70451
IFI44L interferon-induced protein 44-like 5.52551
LINC02898 long intergenic non-protein coding RNA 2898 5.3871
COL16A1 collagen, type XVI, alpha 1 5.01927
MXD3 MAX dimerization protein 3 5.01927
TPSG1 tryptase gamma 1 4.90441
HPN hepsin 4.7965
MYCT1 myc target 1 4.77214
LTBP2 latent transforming growth factor beta binding protein 2 4.75804
MUSK muscle, skeletal, receptor tyrosine kinase 4.74127
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 4.74127
AKAP17A A kinase (PRKA) anchor protein 17A 4.64532
IFI44 interferon-induced protein 44 4.63163
VWCE von Willebrand factor C and EGF domains 4.62537
NPIPB4 nuclear pore complex interacting protein family, member B4 4.38678
PCBP4 poly(rC) binding protein 4 4.38678
CXCL14 chemokine (C-X-C motif) ligand 14 4.35723
HAUS7 HAUS augmin-like complex, subunit 7 4.33412
B3GAT1 beta-1,3-glucuronyltransferase 1 4.33412
LCNL1 lipocalin-like 1 4.33412
ENTREP2 endosomal transmembrane epsin interactor 2 4.26872
PDE9A phosphodiesterase 9A 4.11739
ZNF33B zinc finger protein 33B 4.11739
ZNF540 zinc finger protein 540 4.09597
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 4.05772
KIAA1755 KIAA1755 4.04632
LOC100131465 peroxisomal biogenesis factor 5 pseudogene 4.04632
XAF1 XIAP associated factor 1 4.02383
SFRP2 secreted frizzled-related protein 2 4.02383
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 4.00628
ANGPTL7 angiopoietin-like 7 4.00628
PRECSIT p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript 3.99563
MEOX1 mesenchyme homeobox 1 3.99563
CEBPB-AS1 CEBPB antisense RNA 1 3.97194
TRIM22 tripartite motif containing 22 3.95444
HRAS Harvey rat sarcoma viral oncogene homolog 3.91443
RSAD2 radical S-adenosyl methionine domain containing 2 3.8993
LAMC3 laminin, gamma 3 3.89555
CHADL chondroadherin-like 3.8254
CTSG cathepsin G 3.8254
TMEM120B transmembrane protein 120B 3.69241
NIN ninein (GSK3B interacting protein) 3.68772
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 3.68772
HRH3 histamine receptor H3 3.6726
RGS13 regulator of G-protein signaling 13 3.6726
BHLHE22 basic helix-loop-helix family, member e22 3.6726
DCLRE1C DNA cross-link repair 1C 3.67012
CMKLR1 chemerin chemokine-like receptor 1 3.67012
TLR7 toll-like receptor 7 3.66995
SELENOO selenoprotein O 3.61485
ERICH1 glutamate-rich 1 3.56421
TMEM138 transmembrane protein 138 3.52108
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 3.52066
DPP9-AS1 DPP9 antisense RNA 1 3.48566
CD84 CD84 molecule 3.47443
ZNF439 zinc finger protein 439 3.47443
PTGDS prostaglandin D2 synthase 21kDa (brain) 3.44632
DDO D-aspartate oxidase 3.43235
CYTIP cytohesin 1 interacting protein 3.43235
NPEPL1 aminopeptidase-like 1 3.43235
AEBP1 AE binding protein 1 3.43235
RPAIN RPA interacting protein 3.36455
TMC6 transmembrane channel-like 6 3.36455
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 3.36455
FBXO17 F-box protein 17 3.36455
COL7A1 collagen, type VII, alpha 1 3.36455
ELAC2 elaC ribonuclease Z 2 3.36455
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 3.36455
ANKRD65 ankyrin repeat domain 65 3.36455
SRSF5 serine/arginine-rich splicing factor 5 3.34899
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.34697
SLC26A5 solute carrier family 26 (anion exchanger), member 5 3.34278
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 3.34278
TMEM150A transmembrane protein 150A 3.33486
POU6F1 POU class 6 homeobox 1 3.33467
CCDC3 coiled-coil domain containing 3 3.32179
ZFPM2 zinc finger protein, FOG family member 2 3.29919
ZNF789 zinc finger protein 789 3.29137
IQSEC1 IQ motif and Sec7 domain 1 3.29137
GASK1A golgi associated kinase 1A 3.29137
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 3.27813
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 3.27573
KRT222 keratin 222, type II 3.27573
PDE5A phosphodiesterase 5A, cGMP-specific 3.27211
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 3.27211
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 3.26886
MACROD2 MACRO domain containing 2 3.24869
FOXS1 forkhead box S1 3.24869
STK19 serine/threonine kinase 19 3.24869
SNHG12 small nucleolar RNA host gene 12 3.24869
FBXO22 F-box protein 22 3.24869
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) 3.24869
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 3.24869
SCN2A sodium channel, voltage gated, type II alpha subunit 3.24869
CYP4X1 cytochrome P450, family 4, subfamily X, polypeptide 1 3.24869
FNDC7 fibronectin type III domain containing 7 3.24869
MTUS2 microtubule associated tumor suppressor candidate 2 3.24869
RILPL1 Rab interacting lysosomal protein-like 1 3.24869
LINC00670 long intergenic non-protein coding RNA 670 3.24869
WDR91 WD repeat domain 91 3.24869
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 3.24869
CPNE7 copine VII 3.24347
LTB4R leukotriene B4 receptor 3.24347
BMS1P3 BMS1 ribosome biogenesis factor pseudogene 3 3.23421
SRGN serglycin 3.23421
KCNT1 potassium channel, sodium activated subfamily T, member 1 3.21611
SPON2 spondin 2, extracellular matrix protein 3.21611
WNT2B wingless-type MMTV integration site family, member 2B 3.21611
AMT aminomethyltransferase 3.20417
TAS2R15P taste receptor, type 2, member 15, pseudogene 3.1885
CACNA2D3-AS1 CACNA2D3 antisense RNA 1 3.1885
C11ORF21 chromosome 11 open reading frame 21 3.1885
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B 3.16968
GPAT4 glycerol-3-phosphate acyltransferase 4 3.16968
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 3.16368
MIR34AHG MIR34A host gene 3.16251
SLC66A1 solute carrier family 66 member 1 3.15926
SLC22A31 solute carrier family 22, member 31 3.14924
AFAP1L2 actin filament associated protein 1-like 2 3.14735
PKP4-AS1 PKP4 antisense RNA 1 3.13575
TSNARE1 t-SNARE domain containing 1 3.13575
ZNF180 zinc finger protein 180 3.11023
AOAH acyloxyacyl hydrolase (neutrophil) 3.10846
ILF3-DT ILF3 divergent transcript 3.10846
IDI2-AS1 IDI2 antisense RNA 1 3.10147
TARBP1 TAR (HIV-1) RNA binding protein 1 3.06136
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 3.05589
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 3.05589
UNC5A unc-5 homolog A (C. elegans) 3.05589
ILRUN-AS1 ILRUN antisense RNA 1 3.05589
KLHDC8A kelch domain containing 8A 3.0284
TAS2R20 taste receptor, type 2, member 20 3.0284
TESPA1 thymocyte expressed, positive selection associated 1 3.0284
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.0284
BATF2 basic leucine zipper transcription factor, ATF-like 2 3.0284
LOC101929270 uncharacterized LOC101929270 3.02806
BISPR BST2 interferon stimulated positive regulator (non-protein coding) 3.02742
MX1 MX dynamin-like GTPase 1 3.02742
EPS8L2 EPS8-like 2 3.02742
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 3.02536

decreased expression

Symbol Name Standardized Value
ZNF93 zinc finger protein 93 -7.99961
LOC102724710 uncharacterized LOC102724710 -7.99961
ILF2 interleukin enhancer binding factor 2 -6.14778
UGT8 UDP glycosyltransferase 8 -6.12247
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -5.7545
RPA2 replication protein A2, 32kDa -5.7157
SEC23B Sec23 homolog B (S. cerevisiae) -5.24376
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -5.18494
AMPH amphiphysin -5.01491
TPX2 TPX2, microtubule-associated -4.95401
EIF3J eukaryotic translation initiation factor 3, subunit J -4.77214
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -4.74127
LINC00911 long intergenic non-protein coding RNA 911 -4.71409
STRA8 stimulated by retinoic acid 8 -4.65265
OXCT1 3-oxoacid CoA transferase 1 -4.63163
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -4.55473
HOXB9 homeobox B9 -4.46411
ARHGAP19 Rho GTPase activating protein 19 -4.33505
TMPRSS11B transmembrane protease, serine 11B -4.33412
WAPL WAPL cohesin release factor -4.26872
BCAS1 breast carcinoma amplified sequence 1 -4.21834
MICB MHC class I polypeptide-related sequence B -4.11739
BEST2 bestrophin 2 -3.99563
DYNLL1 dynein, light chain, LC8-type 1 -3.97564
IRF2-DT IRF2 divergent transcript -3.91443
CTR9 CTR9, Paf1/RNA polymerase II complex component -3.91443
OTUD6A OTU deubiquitinase 6A -3.91443
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa -3.90301
GPN3 GPN-loop GTPase 3 -3.8993
BTBD10 BTB (POZ) domain containing 10 -3.88174
CCT4 chaperonin containing TCP1, subunit 4 (delta) -3.78424
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -3.6939
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 -3.61485
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -3.57185
GDE1 glycerophosphodiester phosphodiesterase 1 -3.57185
GML glycosylphosphatidylinositol anchored molecule like -3.52108
ZNF526 zinc finger protein 526 -3.49042
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 -3.43235
HOXC11 homeobox C11 -3.42522
RBM15 RNA binding motif protein 15 -3.41336
EIF1B eukaryotic translation initiation factor 1B -3.36455
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 -3.27573
UBE2T ubiquitin-conjugating enzyme E2T -3.27211
CLSPN claspin -3.24869
EYA3 EYA transcriptional coactivator and phosphatase 3 -3.24869
IFT46 intraflagellar transport 46 -3.24869
WDR41 WD repeat domain 41 -3.24869
EPHX4 epoxide hydrolase 4 -3.24869
GPBP1 GC-rich promoter binding protein 1 -3.24869
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -3.21611
CRY1 cryptochrome circadian clock 1 -3.21611
HSPH1 heat shock 105kDa/110kDa protein 1 -3.17735
HMGB2 high mobility group box 2 -3.16968
IQCA1 IQ motif containing with AAA domain 1 -3.1633
HOXB5 homeobox B5 -3.16251
METAP2 methionyl aminopeptidase 2 -3.15926
ATP5PB ATP synthase peripheral stalk-membrane subunit b -3.14924
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -3.1348
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -3.13174
HOTAIR HOX transcript antisense RNA -3.10147
KCNK9 potassium channel, two pore domain subfamily K, member 9 -3.02742
RAN RAN, member RAS oncogene family -3.02742
MED31 mediator complex subunit 31 -3.02742
NRBP1 nuclear receptor binding protein 1 -3.02742
CHIC2 cysteine-rich hydrophobic domain 2 -3.00997
CSE1L CSE1 chromosome segregation 1-like (yeast) -3.00442
KIF20A kinesin family member 20A -2.99893