GTF2I Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description general transcription factor IIi|This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 2969)
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Genes

360 genes differentially expressed following the GTF2I gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CASQ2 calsequestrin 2 (cardiac muscle) 3.11252
GFRA3 GDNF family receptor alpha 3 3.11252
SIGLEC15 sialic acid binding Ig-like lectin 15 3.11252
SP100 SP100 nuclear antigen 3.11252
GNLY granulysin 3.11252
SCNN1D sodium channel, non voltage gated 1 delta subunit 3.11252
ZNF467 zinc finger protein 467 3.11252
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.11252
BOLL boule-like RNA-binding protein 3.11252
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.11252
ARSF arylsulfatase F 3.11252
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.11252
VWA3A von Willebrand factor A domain containing 3A 3.11252
DPPA3 developmental pluripotency associated 3 3.11252
PAX7 paired box 7 3.11252
TMEM86B transmembrane protein 86B 3.11252
DNAL1 dynein, axonemal, light chain 1 3.11252
ADAM2 ADAM metallopeptidase domain 2 3.11252
OPRM1 opioid receptor, mu 1 3.11252
APOL6 apolipoprotein L, 6 3.11252
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 3.11252
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 3.11252
TSNAXIP1 translin-associated factor X interacting protein 1 3.11252
ZNF831 zinc finger protein 831 3.11252
CLIC2 chloride intracellular channel 2 3.11252
NPY5R neuropeptide Y receptor Y5 3.11252
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 3.11252
TLE6 transducin-like enhancer of split 6 3.11252
TMEM176A transmembrane protein 176A 3.11252
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 3.04458
SOX1 SRY (sex determining region Y)-box 1 3.04458
AADACL4 arylacetamide deacetylase-like 4 3.04458
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 3.04458
GAL galanin/GMAP prepropeptide 3.04458
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 3.04458
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.04458
FBXL8 F-box and leucine-rich repeat protein 8 3.04458
SSTR1 somatostatin receptor 1 3.04458
FGL2 fibrinogen-like 2 3.04458
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 3.04458
ZNF101 zinc finger protein 101 3.04458
ANKK1 ankyrin repeat and kinase domain containing 1 3.04458
S100A3 S100 calcium binding protein A3 3.04458
S100A1 S100 calcium binding protein A1 3.04458
SETSIP SET-like protein 3.04458
HBM hemoglobin, mu 3.04458
ACKR5 atypical chemokine receptor 5 3.04458
LGALS2 lectin, galactoside-binding, soluble, 2 3.04458
MRC1 mannose receptor, C type 1 3.04458
CPLX4 complexin 4 3.04458
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.04458
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide 3.04458
TRIM42 tripartite motif containing 42 3.04458
KCNU1 potassium channel, subfamily U, member 1 3.04458
DIRAS2 DIRAS family, GTP-binding RAS-like 2 3.04458
HAS1 hyaluronan synthase 1 3.04458
GADL1 glutamate decarboxylase-like 1 3.04458
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 3.04458
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.04458
C1ORF146 chromosome 1 open reading frame 146 3.04458
LCN12 lipocalin 12 3.04458
LCN15 lipocalin 15 3.04458
FABP12 fatty acid binding protein 12 3.04458
GYS2 glycogen synthase 2 (liver) 3.04458
SPMIP11 sperm microtubule inner protein 11 3.04458
PLG plasminogen 3.04458
AVPR1A arginine vasopressin receptor 1A 3.04458
GPX5 glutathione peroxidase 5 3.04458
CAPN9 calpain 9 3.04458
MYH7 myosin, heavy chain 7, cardiac muscle, beta 3.04458
MGAT4D MGAT4 family, member D 3.04458
RHCE Rh blood group, CcEe antigens 3.04458
LMNTD1 lamin tail domain containing 1 3.04458
ADRB1 adrenoceptor beta 1 3.04458
RAB36 RAB36, member RAS oncogene family 3.04458
ALDOB aldolase B, fructose-bisphosphate 3.04458
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 3.04458
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.04458
SPATA31H1 SPATA31 subfamily H member 1 3.04458
TEX53 testis expressed 53 3.04458
IRF2-DT IRF2 divergent transcript 3.04458
CD8B2 CD8b2 molecule 3.04458
CTXND1 cortexin domain containing 1 3.04458
H3C3 H3 clustered histone 3 3.04458
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 3.04458
KASH5 KASH domain containing 5 3.04458
VSIR V-set immunoregulatory receptor 3.04458
STING1 stimulator of interferon response cGAMP interactor 1 3.04458
MYL10 myosin, light chain 10, regulatory 3.04458
SPATA25 spermatogenesis associated 25 3.04458
CLDN5 claudin 5 3.04458
CLDN9 claudin 9 3.04458
POMC proopiomelanocortin 3.04458
IZUMO4 IZUMO family member 4 3.04458
ACTRT1 actin-related protein T1 3.04458
PRB1 proline-rich protein BstNI subfamily 1 3.04458
NRN1 neuritin 1 3.04458
SIX2 SIX homeobox 2 3.04458
HLX H2.0-like homeobox 3.04458
RNF17 ring finger protein 17 3.04458
EDAR ectodysplasin A receptor 3.04458
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.04458
TMEM235 transmembrane protein 235 3.04458
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.04458
ZNF705A zinc finger protein 705A 3.04458
CNTN6 contactin 6 3.04458
ASIC3 acid sensing (proton gated) ion channel 3 3.04458
WNT9B wingless-type MMTV integration site family, member 9B 3.04458
TAS1R1 taste receptor, type 1, member 1 3.04458
FMR1NB fragile X mental retardation 1 neighbor 3.04458
OOSP2 oocyte secreted protein 2 3.04458
C6ORF118 chromosome 6 open reading frame 118 3.04458
TMEM236 transmembrane protein 236 3.04458
LY86 lymphocyte antigen 86 3.04458
PAQR6 progestin and adipoQ receptor family member VI 3.04458
GOLGA6D golgin A6 family, member D 3.04458
SERINC4 serine incorporator 4 3.04458
C11ORF16 chromosome 11 open reading frame 16 3.04458
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.04458
CPA3 carboxypeptidase A3 (mast cell) 3.04458
FIBIN fin bud initiation factor homolog (zebrafish) 3.04458
CLEC18C C-type lectin domain family 18, member C 3.04458
FBXO40 F-box protein 40 3.04458
C20ORF144 chromosome 20 open reading frame 144 3.04458
KLF1 Kruppel-like factor 1 (erythroid) 3.04458
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 3.04458
FZD6 frizzled class receptor 6 3.04458
DMTN dematin actin binding protein 3.04458
PRSS54 protease, serine, 54 3.04458
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 3.04458
TBPL2 TATA box binding protein like 2 3.04458
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.04458
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 3.04458
APOB apolipoprotein B 3.04458
AQP7 aquaporin 7 3.04458
RELN reelin 3.04458
FSHR follicle stimulating hormone receptor 3.04458
LY9 lymphocyte antigen 9 3.04458
OR4D2 olfactory receptor, family 4, subfamily D, member 2 3.04458
NOBOX NOBOX oogenesis homeobox 3.04458
LHX2 LIM homeobox 2 3.04458
C1ORF105 chromosome 1 open reading frame 105 3.04458
MYADML2 myeloid-associated differentiation marker-like 2 3.04458
GOLGA8N golgin A8 family, member N 3.04458
GOLGA8Q golgin A8 family, member Q 3.04458
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.04458
PRSS33 protease, serine, 33 3.04458
GSTA2 glutathione S-transferase alpha 2 3.04458
EPHA10 EPH receptor A10 3.04458
CHIT1 chitinase 1 (chitotriosidase) 3.04458
PTPN20 protein tyrosine phosphatase, non-receptor type 20 3.04458
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.04458
PGR progesterone receptor 3.04458
TG thyroglobulin 3.04458
ZC3H12D zinc finger CCCH-type containing 12D 3.04458
PTHLH parathyroid hormone-like hormone 3.04458
SIGLEC11 sialic acid binding Ig-like lectin 11 3.04458
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.04458
LST1 leukocyte specific transcript 1 3.04458
SHISA3 shisa family member 3 3.04458
CIB3 calcium and integrin binding family member 3 3.04458
FGF6 fibroblast growth factor 6 3.04458
PRSS22 protease, serine, 22 3.04458
GPR78 G protein-coupled receptor 78 3.04458
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.04458
NR2F2 nuclear receptor subfamily 2, group F, member 2 3.04458
GHRH growth hormone releasing hormone 3.04458
IFNK interferon, kappa 3.04458
IFNE interferon, epsilon 3.04458
RBP3 retinol binding protein 3, interstitial 3.04458
TTC36 tetratricopeptide repeat domain 36 3.04458
BPIFC BPI fold containing family C 3.04458
CLEC2A C-type lectin domain family 2, member A 3.04458
TGM5 transglutaminase 5 3.04458
ANXA8 annexin A8 3.04458
POU5F2 POU domain class 5, transcription factor 2 3.04458
TEX38 testis expressed 38 3.04458
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 3.04458
BIN2 bridging integrator 2 3.04458
DEFB134 defensin, beta 134 3.04458
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 3.04458
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 3.04458
STAP1 signal transducing adaptor family member 1 3.04458
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 3.02734
TMEM196 transmembrane protein 196 2.91715
LHX6 LIM homeobox 6 2.91715
RUNDC3A RUN domain containing 3A 2.91715
MUC19 mucin 19, oligomeric 2.91715
C11ORF96 chromosome 11 open reading frame 96 2.91715
LONP2 lon peptidase 2, peroxisomal 2.79223
TNIP1 TNFAIP3 interacting protein 1 2.77895
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.66959
S100B S100 calcium binding protein B 2.58161
BCAR1 breast cancer anti-estrogen resistance 1 2.54537
PXK PX domain containing serine/threonine kinase 2.53914
AS3MT arsenite methyltransferase 2.53104
PTPRN protein tyrosine phosphatase, receptor type, N 2.5098
ANKH ANKH inorganic pyrophosphate transport regulator 2.5063
SYT1 synaptotagmin I 2.49425
JADE3 jade family PHD finger 3 2.48999
CDH13 cadherin 13 2.48594
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 2.47985
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.43849
MRPL37 mitochondrial ribosomal protein L37 2.41419
SERTM1 serine-rich and transmembrane domain containing 1 2.38141
NPB neuropeptide B 2.36299
SHLD2 shieldin complex subunit 2 2.35912
SPAG17 sperm associated antigen 17 2.35348
FDXR ferredoxin reductase 2.3416
CLYBL citrate lyase beta like 2.32779
TPPP2 tubulin polymerization-promoting protein family member 2 2.30984
SCN1B sodium channel, voltage gated, type I beta subunit 2.30881
CCNF cyclin F 2.30881
TTC16 tetratricopeptide repeat domain 16 2.30674
GFAP glial fibrillary acidic protein 2.30674
USH1G Usher syndrome 1G (autosomal recessive) 2.30674
C17ORF107 chromosome 17 open reading frame 107 2.30674
CFAP96 cilia and flagella associated protein 96 2.29955
ITM2A integral membrane protein 2A 2.28644
PHF21A PHD finger protein 21A 2.28644
ADGRL2 adhesion G protein-coupled receptor L2 2.28644
ZBTB4 zinc finger and BTB domain containing 4 2.24513
AIF1L allograft inflammatory factor 1-like 2.24513
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.2156
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 2.21337
LYG1 lysozyme G-like 1 2.18574
PRDM14 PR domain containing 14 2.18503
ZNF626 zinc finger protein 626 2.18014
SLC48A1 solute carrier family 48 (heme transporter), member 1 2.16709
CARF calcium responsive transcription factor 2.16017
TMEM255B transmembrane protein 255B 2.15614
TDRP testis development related protein 2.15211
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 2.12376
ARMH4 armadillo like helical domain containing 4 2.12376
NHSL1 NHS-like 1 2.10115
SAMD12 sterile alpha motif domain containing 12 2.09904
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.09904
GSDMB gasdermin B 2.07143
FBXO28 F-box protein 28 2.07143
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 2.06487
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 2.05327
RAB3C RAB3C, member RAS oncogene family 2.05211
PAK1IP1 PAK1 interacting protein 1 2.0326
CUL2 cullin 2 2.0326
PROS1 protein S (alpha) 2.0326
SNX29 sorting nexin 29 2.02496
KCTD3 potassium channel tetramerization domain containing 3 2.00981
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.00981
FABP7 fatty acid binding protein 7, brain 2.00564
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) 2.00564
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 2.00318

decreased expression

Symbol Name Standardized Value
CCDC170 coiled-coil domain containing 170 -3.11252
CD8B CD8b molecule -3.11252
SIRT2 sirtuin 2 -3.04458
GANAB glucosidase, alpha; neutral AB -3.04458
HMGN2 high mobility group nucleosomal binding domain 2 -3.04458
SLC16A11 solute carrier family 16, member 11 -3.04458
CTPS2 CTP synthase 2 -3.04458
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) -3.04458
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) -3.04458
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 -3.04458
KCNK15 potassium channel, two pore domain subfamily K, member 15 -3.04458
CD86 CD86 molecule -3.04458
CHAD chondroadherin -3.04458
SFXN3 sideroflexin 3 -3.04458
PDYN prodynorphin -3.04458
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) -3.04458
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.04458
AANAT aralkylamine N-acetyltransferase -3.04458
TSPAN8 tetraspanin 8 -3.04458
CCDC42 coiled-coil domain containing 42 -3.04458
PCDHGC3 protocadherin gamma subfamily C, 3 -3.04458
HSPB6 heat shock protein, alpha-crystallin-related, B6 -3.04458
THPO thrombopoietin -3.04458
TSGA10IP testis specific, 10 interacting protein -3.04458
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.04458
ATP13A4 ATPase type 13A4 -3.04458
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 -3.04458
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime -3.04458
TBC1D28 TBC1 domain family, member 28 -3.04458
KISS1 KiSS-1 metastasis-suppressor -3.04458
CDHR4 cadherin-related family member 4 -3.04458
ANKRD63 ankyrin repeat domain 63 -3.04458
TRIM55 tripartite motif containing 55 -3.04458
ODC1 ornithine decarboxylase 1 -3.04458
OCM oncomodulin -3.04458
RRH retinal pigment epithelium-derived rhodopsin homolog -3.04458
SSC5D scavenger receptor cysteine rich family, 5 domains -3.03878
MCF2 MCF.2 cell line derived transforming sequence -2.80432
RAI1 retinoic acid induced 1 -2.80432
BCAP29 B-cell receptor-associated protein 29 -2.78399
RBX1 ring-box 1, E3 ubiquitin protein ligase -2.76557
PDE4C phosphodiesterase 4C, cAMP-specific -2.68586
EPCAM epithelial cell adhesion molecule -2.63904
GPC6 glypican 6 -2.59298
ETF1 eukaryotic translation termination factor 1 -2.57173
SYT15B synaptotagmin 15B -2.54951
GLIS1 GLIS family zinc finger 1 -2.54951
SLCO2A1 solute carrier organic anion transporter family, member 2A1 -2.53884
GPR162 G protein-coupled receptor 162 -2.53821
CASC3 cancer susceptibility candidate 3 -2.50674
NHSL3 NHS like 3 -2.48281
NT5C3A 5'-nucleotidase, cytosolic IIIA -2.46892
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa -2.4542
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -2.43152
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.43141
EMP2 epithelial membrane protein 2 -2.41002
SANBR SANT and BTB domain regulator of CSR -2.35912
ZNF587 zinc finger protein 587 -2.34173
TTC31 tetratricopeptide repeat domain 31 -2.3073
IFIH1 interferon induced with helicase C domain 1 -2.28644
FZD9 frizzled class receptor 9 -2.28644
PRXL2A peroxiredoxin like 2A -2.2861
GFRA1 GDNF family receptor alpha 1 -2.2861
RNF181 ring finger protein 181 -2.27843
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.25221
SFRP2 secreted frizzled-related protein 2 -2.21079
CRBN cereblon -2.20995
LMF2 lipase maturation factor 2 -2.20262
MRAP2 melanocortin 2 receptor accessory protein 2 -2.19817
ZNF232 zinc finger protein 232 -2.19571
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 -2.18829
GTF2I general transcription factor IIi -2.18829
MARVELD3 MARVEL domain containing 3 -2.18574
ATL2 atlastin GTPase 2 -2.18574
TRERF1 transcriptional regulating factor 1 -2.18503
STAG2 stromal antigen 2 -2.18398
KATNAL1 katanin p60 subunit A-like 1 -2.18052
PI4K2A phosphatidylinositol 4-kinase type 2 alpha -2.17991
EIF4E eukaryotic translation initiation factor 4E -2.17991
RHOXF1 Rhox homeobox family, member 1 -2.17991
KDM3A lysine (K)-specific demethylase 3A -2.17136
SPMIP6 sperm microtubule inner protein 6 -2.16709
SPMIP8 sperm microtubule inner protein 8 -2.16709
ADAM11 ADAM metallopeptidase domain 11 -2.16709
DLG4 discs, large homolog 4 (Drosophila) -2.1449
ZIC5 Zic family member 5 -2.1333
FAM162A family with sequence similarity 162, member A -2.12376
CD248 CD248 molecule, endosialin -2.12376
TMEM221 transmembrane protein 221 -2.12376
GLIPR1L1 GLI pathogenesis-related 1 like 1 -2.12376
ECE2 endothelin converting enzyme 2 -2.12376
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -2.1215
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -2.1111
RHBDL3 rhomboid, veinlet-like 3 (Drosophila) -2.10358
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 -2.10028
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.10028
RAB32 RAB32, member RAS oncogene family -2.09904
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B -2.08734
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.0817
SUB1 SUB1 homolog (S. cerevisiae) -2.07128
PFDN1 prefoldin subunit 1 -2.06222
ZNF559 zinc finger protein 559 -2.05866
LPAR6 lysophosphatidic acid receptor 6 -2.05331
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 -2.05327
SLC38A1 solute carrier family 38, member 1 -2.05327
SOX3 SRY (sex determining region Y)-box 3 -2.05327
FAM117A family with sequence similarity 117, member A -2.04091
PNPLA3 patatin-like phospholipase domain containing 3 -2.04091
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.03214