Gallic acid (hydrate)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.283526
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.176554
EXT1 exostosin glycosyltransferase 1 0.103018
RPL23 ribosomal protein L23 0.081353
TXNRD1 thioredoxin reductase 1 0.0788336
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0725159
FTL ferritin, light polypeptide 0.0724104
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0628757
VCL vinculin 0.0615816
TMSB10 thymosin beta 10 0.0611788
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0597191
MYH9 myosin, heavy chain 9, non-muscle 0.0544485
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0533994
TPT1 tumor protein, translationally-controlled 1 0.0496249
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.049235
CANX calnexin 0.0478099
CXCL8 chemokine (C-X-C motif) ligand 8 0.0466457
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0445266
SMAD3 SMAD family member 3 0.0442119
AHNAK AHNAK nucleoprotein 0.0434395
GLIS3 GLIS family zinc finger 3 0.0421352
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0406345
RPL26 ribosomal protein L26 0.0404458
KYNU kynureninase 0.0399108
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.039205
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0390276
RPL12 ribosomal protein L12 0.0377472
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.036665
RPS8 ribosomal protein S8 0.036611
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0364849
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0357489
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0354444
FNDC3B fibronectin type III domain containing 3B 0.0354017
PTMA prothymosin, alpha 0.034878
RPL34 ribosomal protein L34 0.0329973
RPLP2 ribosomal protein, large, P2 0.0329363
APOL1 apolipoprotein L, 1 0.0310429
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0302547
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0300856
RPS24 ribosomal protein S24 0.0300471
RAD21 RAD21 homolog (S. pombe) 0.0299573
RPS4X ribosomal protein S4, X-linked 0.0297619
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0296518
PDE4D phosphodiesterase 4D, cAMP-specific 0.0282855
PDIA4 protein disulfide isomerase family A, member 4 0.0282464
DOCK5 dedicator of cytokinesis 5 0.0280414
NAMPT nicotinamide phosphoribosyltransferase 0.0275451
NAV2 neuron navigator 2 0.0273215
TKT transketolase 0.0268983
PDLIM5 PDZ and LIM domain 5 0.026885
PBX1 pre-B-cell leukemia homeobox 1 0.0264892
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0261573
GPC6 glypican 6 0.0261069
ALCAM activated leukocyte cell adhesion molecule 0.0260577
EHBP1 EH domain binding protein 1 0.0259013
ANXA2 annexin A2 0.0258097
RPLP1 ribosomal protein, large, P1 0.0258091
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 0.0256298
MT2A metallothionein 2A 0.0256179
LOXL2 lysyl oxidase-like 2 0.0252738
RPL19 ribosomal protein L19 0.0247559
RPL7 ribosomal protein L7 0.0247306
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0245393
RPS27A ribosomal protein S27a 0.0242283
RPS19 ribosomal protein S19 0.0241179
ANLN anillin, actin binding protein 0.0239897
EFNA5 ephrin-A5 0.0237035
JAK1 Janus kinase 1 0.0236802
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0233463
RRBP1 ribosome binding protein 1 0.0229415
ZSWIM6 zinc finger, SWIM-type containing 6 0.022725
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0227053
PARP14 poly (ADP-ribose) polymerase family, member 14 0.022616
HMGB2 high mobility group box 2 0.0226044
NFE2L2 nuclear factor, erythroid 2-like 2 0.0225575
MYOF myoferlin 0.0225136
INTS6 integrator complex subunit 6 0.0224846
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0222951
SMYD3 SET and MYND domain containing 3 0.0218255
HDAC9 histone deacetylase 9 0.0216712
MYO1E myosin IE 0.0216283
SLC35F3 solute carrier family 35, member F3 0.0215264
RPLP0 ribosomal protein, large, P0 0.0213082
ERRFI1 ERBB receptor feedback inhibitor 1 0.021306
RPS12 ribosomal protein S12 0.0202937
SPIDR scaffolding protein involved in DNA repair 0.0202581
APP amyloid beta (A4) precursor protein 0.0201449
NIPBL Nipped-B homolog (Drosophila) 0.0198564
OSMR oncostatin M receptor 0.0198143
MTAP methylthioadenosine phosphorylase 0.0197728
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0197681
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0197103
CKAP5 cytoskeleton associated protein 5 0.0195874
EXOC4 exocyst complex component 4 0.0195324
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0194905
NRIP1 nuclear receptor interacting protein 1 0.019304
CAVIN1 caveolae associated protein 1 0.0193019
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0193015
MKI67 marker of proliferation Ki-67 0.0192163
STK17A serine/threonine kinase 17a 0.0191989

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.290453
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.137706
NDRG1 N-myc downstream regulated 1 -0.131619
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0753606
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.058453
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0548565
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0516647
RTN4 reticulon 4 -0.0488788
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0437778
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0429214
PTBP3 polypyrimidine tract binding protein 3 -0.0420624
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.0391186
UGCG UDP-glucose ceramide glucosyltransferase -0.0384784
ATP13A3 ATPase type 13A3 -0.036522
KMT2E lysine (K)-specific methyltransferase 2E -0.0356159
MYADM myeloid-associated differentiation marker -0.0353863
FTH1 ferritin, heavy polypeptide 1 -0.0352092
POTEF POTE ankyrin domain family, member F -0.0349221
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0343045
CADM1 cell adhesion molecule 1 -0.0321032
ICAM1 intercellular adhesion molecule 1 -0.0320331
ACBD3 acyl-CoA binding domain containing 3 -0.0315651
CYB5R3 cytochrome b5 reductase 3 -0.0307496
CTSD cathepsin D -0.0306816
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0301152
NOP58 NOP58 ribonucleoprotein -0.029606
TPM1 tropomyosin 1 (alpha) -0.0295802
SPAG9 sperm associated antigen 9 -0.0293853
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0290033
FMNL2 formin-like 2 -0.0272542
CSF1 colony stimulating factor 1 (macrophage) -0.02651
VEGFA vascular endothelial growth factor A -0.0263275
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0262968
RAB7A RAB7A, member RAS oncogene family -0.0262236
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0259828
PFN1 profilin 1 -0.0257777
PDE8A phosphodiesterase 8A -0.0254409
ADAM9 ADAM metallopeptidase domain 9 -0.0251084
ANPEP alanyl (membrane) aminopeptidase -0.0246596
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0242802
RND3 Rho family GTPase 3 -0.0241997
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0241534
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0234115
ADM adrenomedullin -0.0232235
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0231647
ZEB2 zinc finger E-box binding homeobox 2 -0.0231251
LAMA5 laminin, alpha 5 -0.0231006
MSN moesin -0.0229551
ADGRG1 adhesion G protein-coupled receptor G1 -0.0228001
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0224957
PRRC2C proline-rich coiled-coil 2C -0.0224464
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0223652
TMEM165 transmembrane protein 165 -0.0220478
RB1CC1 RB1-inducible coiled-coil 1 -0.0212978
MTDH metadherin -0.0212571
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0211291
COPA coatomer protein complex, subunit alpha -0.0210724
MRPS6 mitochondrial ribosomal protein S6 -0.0209726
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0207995
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0207934
WAC WW domain containing adaptor with coiled-coil -0.020652
CCNL1 cyclin L1 -0.0205361
PML promyelocytic leukemia -0.0200571
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0196474
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0195601
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0191257
FNBP4 formin binding protein 4 -0.0190683
DENND2B DENN domain containing 2B -0.0190412
HSPG2 heparan sulfate proteoglycan 2 -0.0190333
GGNBP2 gametogenetin binding protein 2 -0.0189924
TBC1D23 TBC1 domain family, member 23 -0.0189416
NAP1L4 nucleosome assembly protein 1-like 4 -0.0188251
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0188224
PCBP2 poly(rC) binding protein 2 -0.0188159
ZCCHC7 zinc finger, CCHC domain containing 7 -0.018484
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0183247
FAM13A family with sequence similarity 13, member A -0.0182601
TNS1 tensin 1 -0.0182328
WDFY1 WD repeat and FYVE domain containing 1 -0.0181949
WDR43 WD repeat domain 43 -0.0179804
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0178802
PKM pyruvate kinase, muscle -0.0178232
USP3 ubiquitin specific peptidase 3 -0.0178036
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.017802
TFG TRK-fused gene -0.0176025
ANKRD33B ankyrin repeat domain 33B -0.0175671
KCMF1 potassium channel modulatory factor 1 -0.0175519
GRB10 growth factor receptor-bound protein 10 -0.0175456
TAPBP TAP binding protein (tapasin) -0.0174957
RBM39 RNA binding motif protein 39 -0.0174433
NCOR2 nuclear receptor corepressor 2 -0.0173741
TPM4 tropomyosin 4 -0.0173388
IARS1 isoleucyl-tRNA synthetase 1 -0.0173039
AGRN agrin -0.0172237
HMGA1 high mobility group AT-hook 1 -0.0171137
QKI QKI, KH domain containing, RNA binding -0.0170992
BRD4 bromodomain containing 4 -0.0170512
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0169103
KCTD3 potassium channel tetramerization domain containing 3 -0.0169084
PLIN2 perilipin 2 -0.0168462