Gallic acid (hydrate)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRKG1 protein kinase, cGMP-dependent, type I 0.22243
VIM vimentin 0.153497
CADM2 cell adhesion molecule 2 0.126995
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0976468
HMGA2 high mobility group AT-hook 2 0.0920625
PDE4D phosphodiesterase 4D, cAMP-specific 0.0835783
TSHZ2 teashirt zinc finger homeobox 2 0.0817094
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0731108
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0625549
JMJD1C jumonji domain containing 1C 0.0544798
FGFR1 fibroblast growth factor receptor 1 0.0542719
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0535203
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0510732
PEG10 paternally expressed 10 0.0497414
MGP matrix Gla protein 0.0464467
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0463457
TRIO trio Rho guanine nucleotide exchange factor 0.0453769
CTBP2 C-terminal binding protein 2 0.0395201
AFF4 AF4/FMR2 family, member 4 0.0368579
GMDS GDP-mannose 4,6-dehydratase 0.035623
FNDC3B fibronectin type III domain containing 3B 0.0345204
NBEA neurobeachin 0.032687
KAZN kazrin, periplakin interacting protein 0.0323015
NFIB nuclear factor I/B 0.0319468
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0316482
SOX4 SRY (sex determining region Y)-box 4 0.0315192
MYOF myoferlin 0.0313161
LPP LIM domain containing preferred translocation partner in lipoma 0.0297253
ACTG1 actin gamma 1 0.0292926
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0288906
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0288595
ATP11A ATPase, class VI, type 11A 0.0274043
UTRN utrophin 0.0260335
THSD4 thrombospondin, type I, domain containing 4 0.0258418
SENP6 SUMO1/sentrin specific peptidase 6 0.0254849
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0253695
IGF2R insulin-like growth factor 2 receptor 0.0253208
CUX1 cut-like homeobox 1 0.0246054
KDM4C lysine (K)-specific demethylase 4C 0.0244961
COL1A2 collagen, type I, alpha 2 0.024451
ZMIZ1 zinc finger, MIZ-type containing 1 0.0243341
KMT2C lysine (K)-specific methyltransferase 2C 0.0235938
PDE10A phosphodiesterase 10A 0.0231285
SLC38A2 solute carrier family 38, member 2 0.0230471
USP9X ubiquitin specific peptidase 9, X-linked 0.0229971
COL5A2 collagen, type V, alpha 2 0.0223829
MSRB3 methionine sulfoxide reductase B3 0.0223085
ARB2A ARB2 cotranscriptional regulator A 0.0222696
KMT2E lysine (K)-specific methyltransferase 2E 0.0221101
EXOC4 exocyst complex component 4 0.0220886
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.022041
TULP4 tubby like protein 4 0.0218424
DLG1 discs, large homolog 1 (Drosophila) 0.0216358
ZBTB20 zinc finger and BTB domain containing 20 0.0214654
PHF3 PHD finger protein 3 0.0212899
CANX calnexin 0.0210315
TPK1 thiamin pyrophosphokinase 1 0.0208061
EGFR epidermal growth factor receptor 0.0205926
FRMD6 FERM domain containing 6 0.0205223
MICU1 mitochondrial calcium uptake 1 0.0203641
TET1 tet methylcytosine dioxygenase 1 0.0200568
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0200102
FLNB filamin B, beta 0.0198663
PCM1 pericentriolar material 1 0.019765
MAP1B microtubule-associated protein 1B 0.0197446
SOX6 SRY (sex determining region Y)-box 6 0.0196038
MTUS1 microtubule associated tumor suppressor 1 0.0194871
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0192406
SIK3 SIK family kinase 3 0.0191975
ZFAND3 zinc finger, AN1-type domain 3 0.0190654
ANO6 anoctamin 6 0.0189114
ANKRD12 ankyrin repeat domain 12 0.0187479
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0186995
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0186635
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0185092
TTC28 tetratricopeptide repeat domain 28 0.0184308
RAD51B RAD51 paralog B 0.018111
CDK6 cyclin-dependent kinase 6 0.0180976
RAI1 retinoic acid induced 1 0.018077
ZFHX3 zinc finger homeobox 3 0.0180597
PARD3 par-3 family cell polarity regulator 0.0180367
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0179789
LINGO2 leucine rich repeat and Ig domain containing 2 0.0179776
TPM4 tropomyosin 4 0.0178779
PDE4B phosphodiesterase 4B, cAMP-specific 0.0178552
FBXO11 F-box protein 11 0.0178269
KANK1 KN motif and ankyrin repeat domains 1 0.0175618
ATXN2 ataxin 2 0.0174965
CSNK1A1 casein kinase 1, alpha 1 0.0174345
HDAC8 histone deacetylase 8 0.0174225
VEGFA vascular endothelial growth factor A 0.0173844
RAB7A RAB7A, member RAS oncogene family 0.0172988
ADIPOR2 adiponectin receptor 2 0.0172834
PLS3 plastin 3 0.0172346
RSU1 Ras suppressor protein 1 0.017192
DENND5A DENN/MADD domain containing 5A 0.0171616
GOLGA4 golgin A4 0.0170983
TSC22D1 TSC22 domain family, member 1 0.0170184
TTC3 tetratricopeptide repeat domain 3 0.0169825
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.016888

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0573803
MT2A metallothionein 2A -0.0471812
RPS2 ribosomal protein S2 -0.0327902
MEST mesoderm specific transcript -0.0299228
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0289942
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.024963
MKI67 marker of proliferation Ki-67 -0.0241688
CENPF centromere protein F, 350/400kDa -0.0228062
HMGB2 high mobility group box 2 -0.0203109
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0197159
RAD21 RAD21 homolog (S. pombe) -0.0191736
H1-4 H1.4 linker histone, cluster member -0.0187659
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0186697
NAMPT nicotinamide phosphoribosyltransferase -0.0166605
CKAP2 cytoskeleton associated protein 2 -0.0155901
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0155865
ITGAV integrin, alpha V -0.0155575
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0155116
TPX2 TPX2, microtubule-associated -0.0151505
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.014954
USP3 ubiquitin specific peptidase 3 -0.0147696
CAMTA1 calmodulin binding transcription activator 1 -0.0145268
MIS18BP1 MIS18 binding protein 1 -0.0144986
CAPRIN1 cell cycle associated protein 1 -0.0141803
ANLN anillin, actin binding protein -0.0139974
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0136777
SCLT1 sodium channel and clathrin linker 1 -0.0131448
ECT2 epithelial cell transforming 2 -0.0131208
GAS2L3 growth arrest-specific 2 like 3 -0.0126507
ATP5F1B ATP synthase F1 subunit beta -0.0122347
WTAP Wilms tumor 1 associated protein -0.0121196
CALR calreticulin -0.0119862
RPS18 ribosomal protein S18 -0.0119808
CCNL1 cyclin L1 -0.0110896
SQSTM1 sequestosome 1 -0.0110036
P4HB prolyl 4-hydroxylase, beta polypeptide -0.010778
KIF2C kinesin family member 2C -0.0107299
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0106602
KIF23 kinesin family member 23 -0.0105423
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0105278
MED13L mediator complex subunit 13-like -0.0105101
CCNG1 cyclin G1 -0.0104047
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0103631
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0103172
PTMA prothymosin, alpha -0.0101303
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0100193
ELL2 elongation factor, RNA polymerase II, 2 -0.00986128
RBM39 RNA binding motif protein 39 -0.00986121
CXCL8 chemokine (C-X-C motif) ligand 8 -0.00979822
NCKAP1 NCK-associated protein 1 -0.0097448
KIF18B kinesin family member 18B -0.00949279
CENPE centromere protein E, 312kDa -0.00939607
MORF4L2 mortality factor 4 like 2 -0.00938086
ADM adrenomedullin -0.00937924
RPS29 ribosomal protein S29 -0.0093716
SUCO SUN domain containing ossification factor -0.00935654
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.00935433
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -0.0093459
KIF20A kinesin family member 20A -0.00934063
EPS15 epidermal growth factor receptor pathway substrate 15 -0.00930215
MALSU1 mitochondrial assembly of ribosomal large subunit 1 -0.00915362
PFN1 profilin 1 -0.00914121
CCNA2 cyclin A2 -0.00905384
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -0.00897629
TUBA1B tubulin, alpha 1b -0.00889613
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.00882969
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -0.00882194
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0088003
CLTC clathrin, heavy chain (Hc) -0.00879795
ASPH aspartate beta-hydroxylase -0.00876499
MED14 mediator complex subunit 14 -0.00875886
ITGA6 integrin, alpha 6 -0.00869703
RTN4 reticulon 4 -0.00869438
KIAA1958 KIAA1958 -0.0086534
ARHGAP11A Rho GTPase activating protein 11A -0.00865182
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -0.00859046
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.00857032
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00856191
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.00854734
RPS3 ribosomal protein S3 -0.00852024
NCAPD2 non-SMC condensin I complex, subunit D2 -0.00839928
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.00835934
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00835753
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -0.00835305
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.00834573
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.00828368
ZC3H6 zinc finger CCCH-type containing 6 -0.00824832
TXNRD1 thioredoxin reductase 1 -0.00820926
USP1 ubiquitin specific peptidase 1 -0.0081842
TAPBP TAP binding protein (tapasin) -0.00812192
IGF2 insulin-like growth factor 2 -0.00806091
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.00802093
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.00801631
TTK TTK protein kinase -0.00793842
TMPO thymopoietin -0.00790472
MTF2 metal response element binding transcription factor 2 -0.00789977
TDG thymine-DNA glycosylase -0.00786146
SP3 Sp3 transcription factor -0.00782307
TLK1 tousled-like kinase 1 -0.00773939
HOXA9 homeobox A9 -0.00773401