Gallic acid (hydrate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 0.322453
NCOA3 nuclear receptor coactivator 3 0.0784211
INTS6 integrator complex subunit 6 0.0719477
CDK12 cyclin-dependent kinase 12 0.0621253
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0614153
LPP LIM domain containing preferred translocation partner in lipoma 0.0603804
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0580181
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.057076
CEP250 centrosomal protein 250kDa 0.0554603
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0512667
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0507062
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0475918
PTPRK protein tyrosine phosphatase, receptor type, K 0.0457275
CATSPERB catsper channel auxiliary subunit beta 0.0436758
GMDS GDP-mannose 4,6-dehydratase 0.0432141
PDLIM5 PDZ and LIM domain 5 0.0411531
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.0399605
ZSWIM6 zinc finger, SWIM-type containing 6 0.0395988
STXBP4 syntaxin binding protein 4 0.0395056
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0394675
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0392216
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0388766
IFI6 interferon, alpha-inducible protein 6 0.0378714
DENND1A DENN/MADD domain containing 1A 0.037078
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.0367535
PLSCR2 phospholipid scramblase 2 0.0365672
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.0358987
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0349582
RPL37A ribosomal protein L37a 0.0348689
TRIO trio Rho guanine nucleotide exchange factor 0.0348563
DNAH14 dynein, axonemal, heavy chain 14 0.034538
THSD4 thrombospondin, type I, domain containing 4 0.03437
PTK2 protein tyrosine kinase 2 0.0343012
SP100 SP100 nuclear antigen 0.0341481
DTNA dystrobrevin, alpha 0.0341231
FNDC3A fibronectin type III domain containing 3A 0.0335549
TPT1 tumor protein, translationally-controlled 1 0.0329113
VCL vinculin 0.0328801
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0328211
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0322823
RAB7A RAB7A, member RAS oncogene family 0.0318948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0315157
EXOC4 exocyst complex component 4 0.031374
SMYD3 SET and MYND domain containing 3 0.031107
EXT1 exostosin glycosyltransferase 1 0.0309836
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0306043
KRT86 keratin 86, type II 0.0296623
RPS3 ribosomal protein S3 0.0292132
ATAD2 ATPase family, AAA domain containing 2 0.0288451
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.028748
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0287239
ANKHD1 ankyrin repeat and KH domain containing 1 0.028552
MAPK8 mitogen-activated protein kinase 8 0.0284954
CLTC clathrin, heavy chain (Hc) 0.0284335
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0283207
FAF1 Fas (TNFRSF6) associated factor 1 0.0281679
RCOR1 REST corepressor 1 0.0278082
UBAP2 ubiquitin associated protein 2 0.0272762
ATF6 activating transcription factor 6 0.0272512
VMP1 vacuole membrane protein 1 0.0272364
VCP valosin containing protein 0.0271364
MYO1D myosin ID 0.027087
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0269853
LARP4B La ribonucleoprotein domain family, member 4B 0.0269316
NAP1L1 nucleosome assembly protein 1-like 1 0.0269254
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0266981
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0265456
ADIPOR2 adiponectin receptor 2 0.0264767
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0262728
ZFAND3 zinc finger, AN1-type domain 3 0.0261461
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0260689
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0259956
PUM1 pumilio RNA-binding family member 1 0.0256701
EFNA5 ephrin-A5 0.0254659
ANKRD11 ankyrin repeat domain 11 0.0254395
ANKRD17 ankyrin repeat domain 17 0.0246927
NABP1 nucleic acid binding protein 1 0.0246335
MCU mitochondrial calcium uniporter 0.024325
AEBP2 AE binding protein 2 0.0242789
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0241651
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0238097
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0238
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0236857
PATJ PATJ crumbs cell polarity complex component 0.0236222
MIPOL1 mirror-image polydactyly 1 0.0232653
NEBL nebulette 0.023173
IGF1R insulin-like growth factor 1 receptor 0.0231507
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.0231428
SAMD12 sterile alpha motif domain containing 12 0.0230089
RNASE7 ribonuclease, RNase A family, 7 0.022805
FNDC3B fibronectin type III domain containing 3B 0.0227955
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0227112
ITCH itchy E3 ubiquitin protein ligase 0.0226934
RAD51B RAD51 paralog B 0.0225252
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0224545
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0224486
PUM2 pumilio RNA-binding family member 2 0.0223252
MSI2 musashi RNA-binding protein 2 0.0219615
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0217362
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0216467

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.181012
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.138631
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.071589
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0681609
ZMYND8 zinc finger, MYND-type containing 8 -0.0571114
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0567761
SLC38A1 solute carrier family 38, member 1 -0.0507981
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0503183
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0498144
NDRG1 N-myc downstream regulated 1 -0.0460929
GRB7 growth factor receptor-bound protein 7 -0.0446783
ACTG1 actin gamma 1 -0.0438528
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0435335
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0431282
LASP1 LIM and SH3 protein 1 -0.0400742
POTEF POTE ankyrin domain family, member F -0.0396386
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0394255
PKM pyruvate kinase, muscle -0.038805
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0379125
KRT19 keratin 19, type I -0.0375751
TMEM165 transmembrane protein 165 -0.0369673
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0362077
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0340702
LMAN1 lectin, mannose-binding, 1 -0.0331601
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.03283
PRR11 proline rich 11 -0.032822
CCND1 cyclin D1 -0.0325866
LOC102724023 ES1 protein homolog, mitochondrial -0.032257
EEF2 eukaryotic translation elongation factor 2 -0.0322532
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0320766
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0317567
FADS2 fatty acid desaturase 2 -0.0307493
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0307323
RAB6A RAB6A, member RAS oncogene family -0.0305652
ASPH aspartate beta-hydroxylase -0.0304604
ZNF652 zinc finger protein 652 -0.0304544
TMEM123 transmembrane protein 123 -0.0299595
FASN fatty acid synthase -0.0298792
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0296355
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0280455
TPM4 tropomyosin 4 -0.0277238
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0276598
VAV3 vav 3 guanine nucleotide exchange factor -0.0270691
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.026939
TMC5 transmembrane channel-like 5 -0.0269177
OSMR oncostatin M receptor -0.026814
LDHA lactate dehydrogenase A -0.0257694
DSPP dentin sialophosphoprotein -0.0253858
NCOA6 nuclear receptor coactivator 6 -0.025159
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0251006
CCNI cyclin I -0.025066
ESYT2 extended synaptotagmin-like protein 2 -0.0246508
LOC112694756 uncharaterized LOC112694756 -0.0246383
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0237736
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0237001
RPL8 ribosomal protein L8 -0.0234519
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0234502
MAP1B microtubule-associated protein 1B -0.0232761
KDM2A lysine (K)-specific demethylase 2A -0.0232013
PFN1 profilin 1 -0.0231744
SETD5 SET domain containing 5 -0.022952
DUSP4 dual specificity phosphatase 4 -0.0229265
WDR45B WD repeat domain 45B -0.0229081
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0226951
SRCIN1 SRC kinase signaling inhibitor 1 -0.0224491
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0223726
VEGFA vascular endothelial growth factor A -0.0222406
PCBP2 poly(rC) binding protein 2 -0.0222105
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0221913
SRRM2 serine/arginine repetitive matrix 2 -0.0220557
RAB27B RAB27B, member RAS oncogene family -0.02143
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -0.0211638
NTN4 netrin 4 -0.0211518
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0210773
RAB22A RAB22A, member RAS oncogene family -0.0206674
ARHGAP29 Rho GTPase activating protein 29 -0.0204342
BCL9L B-cell CLL/lymphoma 9-like -0.0203409
PERP PERP, TP53 apoptosis effector -0.0201223
DSTN destrin (actin depolymerizing factor) -0.0200356
MT2A metallothionein 2A -0.0197613
TAPBP TAP binding protein (tapasin) -0.0195124
MDK midkine (neurite growth-promoting factor 2) -0.0193906
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0191983
MYADM myeloid-associated differentiation marker -0.0191481
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.018849
S100A14 S100 calcium binding protein A14 -0.0185942
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0185819
TXNRD1 thioredoxin reductase 1 -0.0185186
TMEM45B transmembrane protein 45B -0.0184348
TRAM1 translocation associated membrane protein 1 -0.0184303
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0179432
UGCG UDP-glucose ceramide glucosyltransferase -0.0179426
CD99 CD99 molecule -0.0178507
ITGB6 integrin, beta 6 -0.0177315
INSIG1 insulin induced gene 1 -0.0176539
UBC ubiquitin C -0.0175929
HILPDA hypoxia inducible lipid droplet-associated -0.0174953
RAI1 retinoic acid induced 1 -0.0174197
S100A9 S100 calcium binding protein A9 -0.0174052
KIF5B kinesin family member 5B -0.0173962