Gallic acid (hydrate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.128703
TPT1 tumor protein, translationally-controlled 1 0.126383
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.12227
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.114045
CANX calnexin 0.0829584
ERRFI1 ERBB receptor feedback inhibitor 1 0.074466
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0728652
ENO1 enolase 1, (alpha) 0.072546
KRT18 keratin 18, type I 0.0640972
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0616547
PGK1 phosphoglycerate kinase 1 0.0608905
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0592425
AHNAK AHNAK nucleoprotein 0.0558471
MT2A metallothionein 2A 0.0554792
EZR ezrin 0.0549497
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.050488
CCDC47 coiled-coil domain containing 47 0.0478005
ARHGAP5 Rho GTPase activating protein 5 0.0455809
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0439549
RPL26 ribosomal protein L26 0.0429958
AKAP12 A kinase (PRKA) anchor protein 12 0.0424387
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0401577
BZW1 basic leucine zipper and W2 domains 1 0.0392225
RSL1D1 ribosomal L1 domain containing 1 0.0387338
PHF3 PHD finger protein 3 0.0379115
FTL ferritin, light polypeptide 0.0377018
PLAUR plasminogen activator, urokinase receptor 0.037417
EPCAM epithelial cell adhesion molecule 0.0367591
RPL23 ribosomal protein L23 0.0353503
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0330006
SERINC1 serine incorporator 1 0.0328926
TMF1 TATA element modulatory factor 1 0.0316763
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0313808
LDHA lactate dehydrogenase A 0.0310457
RPL4 ribosomal protein L4 0.0306429
COPB1 coatomer protein complex, subunit beta 1 0.0306023
RAD21 RAD21 homolog (S. pombe) 0.0304084
CSDE1 cold shock domain containing E1, RNA-binding 0.0300894
ITPRID2 ITPR interacting domain containing 2 0.0290953
PRRC2C proline-rich coiled-coil 2C 0.0280503
CENPF centromere protein F, 350/400kDa 0.0277613
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0275074
RPS3 ribosomal protein S3 0.0274256
RAD50 RAD50 homolog (S. cerevisiae) 0.0274144
HMGB2 high mobility group box 2 0.0272437
GOLGB1 golgin B1 0.027208
CALR calreticulin 0.0271863
LMAN1 lectin, mannose-binding, 1 0.0269933
PDIA4 protein disulfide isomerase family A, member 4 0.0268699
KIF5B kinesin family member 5B 0.0268233
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0264975
ITSN2 intersectin 2 0.0256555
RRBP1 ribosome binding protein 1 0.0250347
HSPA8 heat shock 70kDa protein 8 0.0249157
PAPOLA poly(A) polymerase alpha 0.0240489
CEP350 centrosomal protein 350kDa 0.0239031
CLIP1 CAP-GLY domain containing linker protein 1 0.0234615
CAVIN1 caveolae associated protein 1 0.0229697
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0228607
TPR translocated promoter region, nuclear basket protein 0.0228162
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0220093
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0219357
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0219183
ANKRD36 ankyrin repeat domain 36 0.0218921
MCFD2 multiple coagulation factor deficiency 2 0.0217936
NUSAP1 nucleolar and spindle associated protein 1 0.0217693
SET SET nuclear proto-oncogene 0.0214739
KDM3A lysine (K)-specific demethylase 3A 0.0213993
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0213715
CALCOCO2 calcium binding and coiled-coil domain 2 0.0213214
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0212865
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0210701
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0210481
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0210177
TMED2 transmembrane emp24 domain trafficking protein 2 0.0209723
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0209423
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.0208274
DPEP2 dipeptidase 2 0.0207858
RPL37A ribosomal protein L37a 0.0207055
NAMPT nicotinamide phosphoribosyltransferase 0.0205888
SMIM14 small integral membrane protein 14 0.0205236
FN1 fibronectin 1 0.020238
IRF3 interferon regulatory factor 3 0.0197141
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.019555
YBX3 Y box binding protein 3 0.0195432
LMO7 LIM domain 7 0.0194888
ARF1 ADP-ribosylation factor 1 0.019486
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.019389
GRSF1 G-rich RNA sequence binding factor 1 0.0193261
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0189572
THRAP3 thyroid hormone receptor associated protein 3 0.0188907
ZC3H11A zinc finger CCCH-type containing 11A 0.0188404
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0185273
RPL7L1 ribosomal protein L7-like 1 0.0184162
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0183798
ZNF106 zinc finger protein 106 0.018367
MYSM1 Myb-like, SWIRM and MPN domains 1 0.0182813
ZMYND8 zinc finger, MYND-type containing 8 0.0181977
RPL12 ribosomal protein L12 0.0181964
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.0180968

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.37286
FAT1 FAT atypical cadherin 1 -0.141279
NDRG1 N-myc downstream regulated 1 -0.13631
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.112747
PKM pyruvate kinase, muscle -0.10865
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.105348
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0997623
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0959924
EGR1 early growth response 1 -0.0913012
POTEF POTE ankyrin domain family, member F -0.0819762
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0657997
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0649026
FTH1 ferritin, heavy polypeptide 1 -0.0630691
RPS6 ribosomal protein S6 -0.0596522
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0569989
PCBP2 poly(rC) binding protein 2 -0.0568935
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0554926
FHIT fragile histidine triad -0.0551123
KDM4C lysine (K)-specific demethylase 4C -0.0540897
PTMA prothymosin, alpha -0.0507178
VEGFA vascular endothelial growth factor A -0.049218
MCL1 myeloid cell leukemia 1 -0.0469433
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0468501
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0464959
CADPS Ca++-dependent secretion activator -0.0460176
RAD51B RAD51 paralog B -0.0455124
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0448647
ACTG1 actin gamma 1 -0.0446997
TBC1D22A TBC1 domain family, member 22A -0.0439992
EEF2 eukaryotic translation elongation factor 2 -0.0434806
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0417369
LOC112694756 uncharaterized LOC112694756 -0.0417052
PFN1 profilin 1 -0.0413621
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0410554
ATXN1 ataxin 1 -0.0397969
HMGA1 high mobility group AT-hook 1 -0.0394534
FUS FUS RNA binding protein -0.0394078
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0377947
SBF2 SET binding factor 2 -0.0374012
SCARB1 scavenger receptor class B, member 1 -0.0371982
PRRC2B proline-rich coiled-coil 2B -0.0370479
SRSF3 serine/arginine-rich splicing factor 3 -0.0369153
BRD4 bromodomain containing 4 -0.036677
CTBP2 C-terminal binding protein 2 -0.0361061
BRD2 bromodomain containing 2 -0.0360968
HLA-A major histocompatibility complex, class I, A -0.0360234
TAPBP TAP binding protein (tapasin) -0.0358451
SLC38A2 solute carrier family 38, member 2 -0.0355963
DIAPH1 diaphanous-related formin 1 -0.0353906
DLG1 discs, large homolog 1 (Drosophila) -0.0344926
WWOX WW domain containing oxidoreductase -0.0342007
RPS15 ribosomal protein S15 -0.0341603
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0339205
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0338943
RHOA ras homolog family member A -0.0337112
ARF4 ADP-ribosylation factor 4 -0.0334568
YEATS2 YEATS domain containing 2 -0.0330791
INTS6 integrator complex subunit 6 -0.0328957
RPS11 ribosomal protein S11 -0.0322296
PATJ PATJ crumbs cell polarity complex component -0.0314022
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.03125
PARD3 par-3 family cell polarity regulator -0.0310864
HOXB3 homeobox B3 -0.0307192
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.0303856
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0298548
ZNF207 zinc finger protein 207 -0.0295606
PTEN phosphatase and tensin homolog -0.0293096
RPL8 ribosomal protein L8 -0.0292212
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0289591
PRELID2 PRELI domain containing 2 -0.0286087
VCL vinculin -0.0283438
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0283012
CCND1 cyclin D1 -0.0282695
ANKRD17 ankyrin repeat domain 17 -0.0281663
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0278377
ITGB4 integrin, beta 4 -0.0271209
WAC WW domain containing adaptor with coiled-coil -0.0270945
MED13L mediator complex subunit 13-like -0.0269097
FLNA filamin A, alpha -0.0266971
WASF2 WAS protein family, member 2 -0.0263292
METTL15 methyltransferase like 15 -0.0261606
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0260862
BIRC6 baculoviral IAP repeat containing 6 -0.0259851
CYB5R3 cytochrome b5 reductase 3 -0.0258501
BBX bobby sox homolog (Drosophila) -0.0257894
CCNL1 cyclin L1 -0.0257636
LCOR ligand dependent nuclear receptor corepressor -0.0257533
ANKRD11 ankyrin repeat domain 11 -0.0252961
ACTN4 actinin, alpha 4 -0.0250205
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0249625
AGRN agrin -0.0249419
FAF1 Fas (TNFRSF6) associated factor 1 -0.024738
LAMA5 laminin, alpha 5 -0.0246622
KRT8 keratin 8, type II -0.0244897
WWC2 WW and C2 domain containing 2 -0.024264
SREBF2 sterol regulatory element binding transcription factor 2 -0.0241731
CUX1 cut-like homeobox 1 -0.024032
GSE1 Gse1 coiled-coil protein -0.0238893
ATN1 atrophin 1 -0.0235747
SREBF1 sterol regulatory element binding transcription factor 1 -0.0233709