Gallic acid (hydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.108626
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.101781
TF transferrin 0.0807358
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0691724
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0689122
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0628731
C3 complement component 3 0.0604771
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0506311
PCBP2 poly(rC) binding protein 2 0.048802
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0466812
ENO1 enolase 1, (alpha) 0.043693
VEGFA vascular endothelial growth factor A 0.0435014
DSPP dentin sialophosphoprotein 0.0434701
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0428439
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0421631
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0416347
CPE carboxypeptidase E 0.0400873
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0379473
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0371981
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0371755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0370136
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368158
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0331997
APLP2 amyloid beta (A4) precursor-like protein 2 0.0330937
PLIN2 perilipin 2 0.031536
KIF1B kinesin family member 1B 0.0310567
RPL3 ribosomal protein L3 0.0308241
KTN1 kinectin 1 (kinesin receptor) 0.0286844
DDIT4 DNA-damage-inducible transcript 4 0.0281816
FMNL2 formin-like 2 0.0277191
ZNF292 zinc finger protein 292 0.0277035
SESTD1 SEC14 and spectrin domains 1 0.026369
MBNL2 muscleblind-like splicing regulator 2 0.0263517
SRRM1 serine/arginine repetitive matrix 1 0.0263214
INSIG2 insulin induced gene 2 0.0246606
KMT2E lysine (K)-specific methyltransferase 2E 0.0243175
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0242552
QKI QKI, KH domain containing, RNA binding 0.0240347
ADAM9 ADAM metallopeptidase domain 9 0.0235322
ESYT2 extended synaptotagmin-like protein 2 0.0235271
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0235211
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0233738
ERRFI1 ERBB receptor feedback inhibitor 1 0.0233251
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0230116
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0229695
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0227856
LDHA lactate dehydrogenase A 0.0227102
PTPRM protein tyrosine phosphatase, receptor type, M 0.0225177
LYZ lysozyme 0.0223756
PDIA3 protein disulfide isomerase family A, member 3 0.0218684
FAM13A family with sequence similarity 13, member A 0.0217931
TRA2A transformer 2 alpha homolog (Drosophila) 0.0215453
AHSG alpha-2-HS-glycoprotein 0.0214798
PTBP3 polypyrimidine tract binding protein 3 0.0213587
GOLGA4 golgin A4 0.0211583
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.021067
VMP1 vacuole membrane protein 1 0.0206934
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 0.0204554
EEF2 eukaryotic translation elongation factor 2 0.0203174
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.020279
KMT2C lysine (K)-specific methyltransferase 2C 0.020195
PEG10 paternally expressed 10 0.0200215
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 0.0197186
ADGRG6 adhesion G protein-coupled receptor G6 0.0196451
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0196033
EML4 echinoderm microtubule associated protein like 4 0.0195937
MYO1B myosin IB 0.0195708
HELZ helicase with zinc finger 0.0195538
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.019553
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0194314
RPS6 ribosomal protein S6 0.0192208
USP47 ubiquitin specific peptidase 47 0.0188789
RNF145 ring finger protein 145 0.0187597
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0185793
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0185286
GRK3 G protein-coupled receptor kinase 3 0.0185277
FBF1 Fas (TNFRSF6) binding factor 1 0.0184989
TMF1 TATA element modulatory factor 1 0.0183884
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.018343
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0182441
DST dystonin 0.0181138
SPAG9 sperm associated antigen 9 0.0179165
CCNL1 cyclin L1 0.0179051
BIRC3 baculoviral IAP repeat containing 3 0.0178226
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0175955
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0175781
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0175708
NBR1 neighbor of BRCA1 gene 1 0.017384
ARHGAP12 Rho GTPase activating protein 12 0.0173637
EPS8 epidermal growth factor receptor pathway substrate 8 0.0171706
UBA6 ubiquitin-like modifier activating enzyme 6 0.0169607
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.016757
TRAM1 translocation associated membrane protein 1 0.0167203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0165497
DTNA dystrobrevin, alpha 0.0164906
RB1CC1 RB1-inducible coiled-coil 1 0.0164874
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0164723
CYB5R3 cytochrome b5 reductase 3 0.0163886
ZFC3H1 zinc finger, C3H1-type containing 0.0163606
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0161025

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.324449
TPT1 tumor protein, translationally-controlled 1 -0.109008
NKD1 naked cuticle homolog 1 (Drosophila) -0.0923828
APOB apolipoprotein B -0.0905114
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0706495
FN1 fibronectin 1 -0.0705595
GPC3 glypican 3 -0.0682819
VCL vinculin -0.0622051
NPAS2 neuronal PAS domain protein 2 -0.0610608
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0596108
GPC6 glypican 6 -0.0592615
TM4SF1 transmembrane 4 L six family member 1 -0.0574664
ITGAV integrin, alpha V -0.0554285
RPS24 ribosomal protein S24 -0.0541534
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0523117
TMSB10 thymosin beta 10 -0.0476516
RPL34 ribosomal protein L34 -0.0460798
SLC38A2 solute carrier family 38, member 2 -0.0443237
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0439022
DLC1 DLC1 Rho GTPase activating protein -0.0427559
RPLP1 ribosomal protein, large, P1 -0.042097
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0412751
EGR1 early growth response 1 -0.0401037
LOC112694756 uncharaterized LOC112694756 -0.0396548
DNAH17 dynein, axonemal, heavy chain 17 -0.0395992
RPL35A ribosomal protein L35a -0.0395443
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0361203
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0356847
ZMYND8 zinc finger, MYND-type containing 8 -0.0320181
SDC4 syndecan 4 -0.0315997
RIGI RNA sensor RIG-I -0.0314809
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0312573
BCL2L1 BCL2-like 1 -0.0310306
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0307939
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0301747
RPS27A ribosomal protein S27a -0.0299817
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0295757
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0295743
RPS21 ribosomal protein S21 -0.029512
AHNAK AHNAK nucleoprotein -0.029327
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0290895
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0290489
LRMDA leucine rich melanocyte differentiation associated -0.0286331
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0285489
ACTN4 actinin, alpha 4 -0.0280728
PTCHD4 patched domain containing 4 -0.0279248
MRTFA myocardin related transcription factor A -0.0275983
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0271425
RNF213 ring finger protein 213 -0.0270853
RUNX1 runt-related transcription factor 1 -0.0269176
LMCD1 LIM and cysteine-rich domains 1 -0.0268078
NINL ninein-like -0.0264359
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0263342
NCOA7 nuclear receptor coactivator 7 -0.0261734
PLAC8 placenta-specific 8 -0.025968
IFI6 interferon, alpha-inducible protein 6 -0.0258926
OSMR oncostatin M receptor -0.0256992
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0255077
ZBTB20 zinc finger and BTB domain containing 20 -0.025386
ACTG1 actin gamma 1 -0.0252418
RRBP1 ribosome binding protein 1 -0.025105
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0248486
AMBP alpha-1-microglobulin/bikunin precursor -0.0247493
TGFBI transforming growth factor, beta-induced, 68kDa -0.0247227
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0246692
RPL37 ribosomal protein L37 -0.0243818
CP ceruloplasmin (ferroxidase) -0.0242614
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0242528
RPL23 ribosomal protein L23 -0.0240961
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0239864
SMAD3 SMAD family member 3 -0.0234945
IER3 immediate early response 3 -0.02331
RPL11 ribosomal protein L11 -0.0231926
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0230605
PTPRF protein tyrosine phosphatase, receptor type, F -0.0229832
RPS19 ribosomal protein S19 -0.0227375
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0222728
RPL38 ribosomal protein L38 -0.0220871
EXT1 exostosin glycosyltransferase 1 -0.0218322
KRT8 keratin 8, type II -0.0217763
RPL31 ribosomal protein L31 -0.0216691
FAT1 FAT atypical cadherin 1 -0.0213259
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0212885
KLF6 Kruppel-like factor 6 -0.0212805
EHBP1 EH domain binding protein 1 -0.0212277
RPL9 ribosomal protein L9 -0.0210898
ZFHX3 zinc finger homeobox 3 -0.0210678
GNAS GNAS complex locus -0.0208721
ARHGAP5 Rho GTPase activating protein 5 -0.0208095
GRB10 growth factor receptor-bound protein 10 -0.0206041
LPP LIM domain containing preferred translocation partner in lipoma -0.0203223
EPAS1 endothelial PAS domain protein 1 -0.02018
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0200259
ZNF644 zinc finger protein 644 -0.0199826
APOA2 apolipoprotein A-II -0.0198295
ACOX3 acyl-CoA oxidase 3, pristanoyl -0.0198213
FRMD5 FERM domain containing 5 -0.0197388
VIL1 villin 1 -0.0194356
ZNFX1 zinc finger, NFX1-type containing 1 -0.0194105
MYO1E myosin IE -0.0193923