Gallic acid (hydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0888982
RPL23 ribosomal protein L23 0.0816665
RPS12 ribosomal protein S12 0.061717
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0555985
GOLGA4 golgin A4 0.0546105
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0542044
RPS19 ribosomal protein S19 0.0481916
RPLP0 ribosomal protein, large, P0 0.0471055
RPL18 ribosomal protein L18 0.0455045
KTN1 kinectin 1 (kinesin receptor) 0.0441088
GARS1 glycyl-tRNA synthetase 1 0.0428964
AREG amphiregulin 0.0426194
RPS6 ribosomal protein S6 0.0411449
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0391408
RPL21 ribosomal protein L21 0.0383227
KIF5B kinesin family member 5B 0.0364943
PRRC2C proline-rich coiled-coil 2C 0.0335079
SRRM1 serine/arginine repetitive matrix 1 0.0324543
UBA6 ubiquitin-like modifier activating enzyme 6 0.0323072
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03193
DDIT4 DNA-damage-inducible transcript 4 0.0316188
RPL12 ribosomal protein L12 0.0310815
SLTM SAFB-like, transcription modulator 0.030418
YBX3 Y box binding protein 3 0.0295908
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0286117
CSDE1 cold shock domain containing E1, RNA-binding 0.0285986
TXNRD1 thioredoxin reductase 1 0.0280125
EREG epiregulin 0.0278968
LIMA1 LIM domain and actin binding 1 0.0278873
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0277364
RNF145 ring finger protein 145 0.0276322
RPS27 ribosomal protein S27 0.0275518
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0270474
CHD1 chromodomain helicase DNA binding protein 1 0.0269489
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0264818
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0264072
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0262736
PDIA3 protein disulfide isomerase family A, member 3 0.0260425
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.025863
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0258188
ZNF292 zinc finger protein 292 0.0255204
SLK STE20-like kinase 0.0254825
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0253084
SET SET nuclear proto-oncogene 0.0252135
RPL10A ribosomal protein L10a 0.0251694
KDM7A lysine (K)-specific demethylase 7A 0.0251237
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0248925
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0248893
LDHA lactate dehydrogenase A 0.0246627
ESYT2 extended synaptotagmin-like protein 2 0.0244081
MT2A metallothionein 2A 0.0239486
TMEM87A transmembrane protein 87A 0.0237205
SMC4 structural maintenance of chromosomes 4 0.0236584
XPO1 exportin 1 0.0235685
RB1CC1 RB1-inducible coiled-coil 1 0.0235355
ENO1 enolase 1, (alpha) 0.0232962
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0231671
PTBP3 polypyrimidine tract binding protein 3 0.0231024
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0231018
NAP1L1 nucleosome assembly protein 1-like 1 0.0223688
TMSB10 thymosin beta 10 0.0220362
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0220328
TPM3 tropomyosin 3 0.0218996
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0213225
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0211838
FAM13A family with sequence similarity 13, member A 0.0211733
CBX3 chromobox homolog 3 0.0211575
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0206246
NPEPPS aminopeptidase puromycin sensitive 0.0205632
PHIP pleckstrin homology domain interacting protein 0.0205102
UBE3A ubiquitin protein ligase E3A 0.0204159
SCAF11 SR-related CTD-associated factor 11 0.0203031
CENPF centromere protein F, 350/400kDa 0.0202526
NKTR natural killer cell triggering receptor 0.0199545
MKI67 marker of proliferation Ki-67 0.0199348
RPL35 ribosomal protein L35 0.0199062
HMGB2 high mobility group box 2 0.0198862
KMT2E lysine (K)-specific methyltransferase 2E 0.019718
TMF1 TATA element modulatory factor 1 0.0196935
BCLAF1 BCL2-associated transcription factor 1 0.0196382
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0195564
TOP2B topoisomerase (DNA) II beta 180kDa 0.019447
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0193148
TPI1 triosephosphate isomerase 1 0.0192428
SLMAP sarcolemma associated protein 0.0191764
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0190333
PLAUR plasminogen activator, urokinase receptor 0.0189886
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0188285
WAC WW domain containing adaptor with coiled-coil 0.0186689
UBE2K ubiquitin-conjugating enzyme E2K 0.0186567
YBX1 Y box binding protein 1 0.0184993
EIF1 eukaryotic translation initiation factor 1 0.0184794
RPS3 ribosomal protein S3 0.0181596
COX7C cytochrome c oxidase subunit VIIc 0.0180225
GDF15 growth differentiation factor 15 0.018009
EEA1 early endosome antigen 1 0.0179381
NRN1 neuritin 1 0.0178822
SON SON DNA binding protein 0.0177077
ARRDC3 arrestin domain containing 3 0.0176661
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0176275

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.165698
TPT1 tumor protein, translationally-controlled 1 -0.130723
LMO7 LIM domain 7 -0.11774
THSD4 thrombospondin, type I, domain containing 4 -0.11073
GMDS GDP-mannose 4,6-dehydratase -0.0922125
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0918157
PDE4D phosphodiesterase 4D, cAMP-specific -0.0860178
FLNB filamin B, beta -0.0841111
MYO1E myosin IE -0.0805811
PTPRB protein tyrosine phosphatase, receptor type, B -0.0771032
ANXA2 annexin A2 -0.0768742
INTS6 integrator complex subunit 6 -0.0761935
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0758559
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0745926
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0676994
HLA-B major histocompatibility complex, class I, B -0.0667732
RIGI RNA sensor RIG-I -0.066348
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0663375
ACTG1 actin gamma 1 -0.0650406
SP100 SP100 nuclear antigen -0.0633776
PTPRK protein tyrosine phosphatase, receptor type, K -0.0608127
EXT1 exostosin glycosyltransferase 1 -0.0606523
BACE2 beta-site APP-cleaving enzyme 2 -0.0599467
CATSPERB catsper channel auxiliary subunit beta -0.0598329
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0570826
MX1 MX dynamin-like GTPase 1 -0.0560702
ACTN4 actinin, alpha 4 -0.0546714
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.053735
LRRC23 leucine rich repeat containing 23 -0.0532301
RNF213 ring finger protein 213 -0.0519179
FUS FUS RNA binding protein -0.0517616
CCSER1 coiled-coil serine-rich protein 1 -0.0503073
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0502787
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0492205
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0485048
RAD51B RAD51 paralog B -0.0482488
PDLIM5 PDZ and LIM domain 5 -0.0481878
IFI6 interferon, alpha-inducible protein 6 -0.0477071
MPRIP myosin phosphatase Rho interacting protein -0.0472151
RPL38 ribosomal protein L38 -0.0470006
RPS23 ribosomal protein S23 -0.046456
DENND1A DENN/MADD domain containing 1A -0.0456623
RPS29 ribosomal protein S29 -0.045143
MYH14 myosin, heavy chain 14, non-muscle -0.0443771
VCL vinculin -0.0432271
EGFR epidermal growth factor receptor -0.0427721
AOPEP aminopeptidase O (putative) -0.0417463
RPL34 ribosomal protein L34 -0.0412155
LPP LIM domain containing preferred translocation partner in lipoma -0.0409975
FRMD5 FERM domain containing 5 -0.0399375
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0394648
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0393425
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0382714
XAF1 XIAP associated factor 1 -0.0381938
RPLP1 ribosomal protein, large, P1 -0.0379239
FNDC3B fibronectin type III domain containing 3B -0.0376765
CUX1 cut-like homeobox 1 -0.037276
PKM pyruvate kinase, muscle -0.0371672
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.0369993
SQSTM1 sequestosome 1 -0.0367818
IRF1 interferon regulatory factor 1 -0.0367769
SPON1 spondin 1, extracellular matrix protein -0.0361626
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0346445
FBXO11 F-box protein 11 -0.0345131
RPS15 ribosomal protein S15 -0.0337238
EXOC4 exocyst complex component 4 -0.0337055
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0336557
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0331026
PALLD palladin, cytoskeletal associated protein -0.0330419
TAS2R14 taste receptor, type 2, member 14 -0.0330159
NABP1 nucleic acid binding protein 1 -0.0329709
NPSR1 neuropeptide S receptor 1 -0.0327881
TRIM2 tripartite motif containing 2 -0.0327517
IFRD1 interferon-related developmental regulator 1 -0.0324676
MX2 MX dynamin-like GTPase 2 -0.0324195
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0320387
RPL35A ribosomal protein L35a -0.0314063
LAMB3 laminin, beta 3 -0.031318
RPS24 ribosomal protein S24 -0.0312326
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0310117
KRT8 keratin 8, type II -0.0309582
LARP1B La ribonucleoprotein domain family, member 1B -0.0308123
CTBP2 C-terminal binding protein 2 -0.0307643
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0306208
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0305571
PSEN1 presenilin 1 -0.0305138
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0303826
RPS11 ribosomal protein S11 -0.0302278
F3 coagulation factor III (thromboplastin, tissue factor) -0.0295881
PLSCR1 phospholipid scramblase 1 -0.0294591
NCOR2 nuclear receptor corepressor 2 -0.0289007
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0286856
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0285101
PATJ PATJ crumbs cell polarity complex component -0.0282577
UBAP2 ubiquitin associated protein 2 -0.0281138
NPR2 natriuretic peptide receptor 2 -0.0281024
PTPRR protein tyrosine phosphatase, receptor type, R -0.0278069
RCC1 regulator of chromosome condensation 1 -0.027683
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0276712
PCSK6 proprotein convertase subtilisin/kexin type 6 -0.0275801