Gallic acid (hydrate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.20551
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.165917
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.14339
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.112441
VIM vimentin 0.0989164
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0962177
KTN1 kinectin 1 (kinesin receptor) 0.0859556
FTL ferritin, light polypeptide 0.0765668
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0690207
IGFBP3 insulin-like growth factor binding protein 3 0.0685913
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0612785
PDIA3 protein disulfide isomerase family A, member 3 0.0612525
RPL23 ribosomal protein L23 0.061135
KIF5B kinesin family member 5B 0.0591302
EIF1 eukaryotic translation initiation factor 1 0.0571895
WAC WW domain containing adaptor with coiled-coil 0.0570795
ZSWIM6 zinc finger, SWIM-type containing 6 0.0549185
ENO1 enolase 1, (alpha) 0.0517648
ZFAND3 zinc finger, AN1-type domain 3 0.0517003
AKAP12 A kinase (PRKA) anchor protein 12 0.0513625
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0501267
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.048014
S100A6 S100 calcium binding protein A6 0.0479124
RPS8 ribosomal protein S8 0.0455828
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0449861
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0433255
S100A10 S100 calcium binding protein A10 0.0429823
UGCG UDP-glucose ceramide glucosyltransferase 0.0405891
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0394141
CXCL8 chemokine (C-X-C motif) ligand 8 0.0391175
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0378586
RPLP1 ribosomal protein, large, P1 0.0370101
ASPH aspartate beta-hydroxylase 0.0336612
RNF145 ring finger protein 145 0.0332376
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0325133
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0308922
FOXO3 forkhead box O3 0.0307769
CSNK1A1 casein kinase 1, alpha 1 0.0307474
GOLGA4 golgin A4 0.0305992
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0304247
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0303934
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0302398
RPS6 ribosomal protein S6 0.0298707
PDIA6 protein disulfide isomerase family A, member 6 0.0296841
LGALS1 lectin, galactoside-binding, soluble, 1 0.0292796
SAMD4A sterile alpha motif domain containing 4A 0.0289812
PUM2 pumilio RNA-binding family member 2 0.0288458
FTH1 ferritin, heavy polypeptide 1 0.0286816
ITCH itchy E3 ubiquitin protein ligase 0.0278337
TRA2A transformer 2 alpha homolog (Drosophila) 0.0272423
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0270677
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0268459
HELZ helicase with zinc finger 0.0268256
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0265948
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0265869
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0265837
C15ORF48 chromosome 15 open reading frame 48 0.0265162
LDHA lactate dehydrogenase A 0.0264838
TOP1 topoisomerase (DNA) I 0.0263835
CCPG1 cell cycle progression 1 0.0263487
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0262284
TPD52 tumor protein D52 0.0260974
S100A9 S100 calcium binding protein A9 0.0257594
RPS17 ribosomal protein S17 0.0256359
TPM3 tropomyosin 3 0.0251986
TRIO trio Rho guanine nucleotide exchange factor 0.0248038
COPA coatomer protein complex, subunit alpha 0.0247975
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0247909
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0246478
EEF2 eukaryotic translation elongation factor 2 0.0246421
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0245546
RPS25 ribosomal protein S25 0.0243982
CTBP2 C-terminal binding protein 2 0.0243755
PUM1 pumilio RNA-binding family member 1 0.0242562
BIRC6 baculoviral IAP repeat containing 6 0.0241909
APLP2 amyloid beta (A4) precursor-like protein 2 0.0241309
PRELID2 PRELI domain containing 2 0.023999
BIRC3 baculoviral IAP repeat containing 3 0.0233811
CAVIN1 caveolae associated protein 1 0.023288
CDC73 cell division cycle 73 0.0232746
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0231986
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0230563
MACF1 microtubule-actin crosslinking factor 1 0.0224105
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0222936
ZFR zinc finger RNA binding protein 0.0222924
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0221804
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0221193
TPR translocated promoter region, nuclear basket protein 0.0216579
NAP1L1 nucleosome assembly protein 1-like 1 0.0215728
RPS29 ribosomal protein S29 0.0215114
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0213547
BAIAP2L1 BAI1-associated protein 2-like 1 0.0212325
RPS20 ribosomal protein S20 0.0212208
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0210463
ELL2 elongation factor, RNA polymerase II, 2 0.0209935
CLU clusterin 0.0209616
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0209152
RAB18 RAB18, member RAS oncogene family 0.0208488
KIF13A kinesin family member 13A 0.0208158
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0207033

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.198736
IGF2 insulin-like growth factor 2 -0.152482
TXNRD1 thioredoxin reductase 1 -0.141305
THSD4 thrombospondin, type I, domain containing 4 -0.124549
MT2A metallothionein 2A -0.123945
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.089517
TM4SF1 transmembrane 4 L six family member 1 -0.0894185
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0805167
BICC1 BicC family RNA binding protein 1 -0.0643799
PDE4D phosphodiesterase 4D, cAMP-specific -0.0583171
OSMR oncostatin M receptor -0.0578784
TMSB10 thymosin beta 10 -0.0529269
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0525195
CMIP c-Maf inducing protein -0.0492298
HDAC9 histone deacetylase 9 -0.0487763
DGKD diacylglycerol kinase, delta 130kDa -0.0413418
EGR1 early growth response 1 -0.0403444
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0393538
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0386372
MCL1 myeloid cell leukemia 1 -0.037507
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0365465
PYGL phosphorylase, glycogen, liver -0.0360751
TTC28 tetratricopeptide repeat domain 28 -0.0356173
BABAM2 BRISC and BRCA1 A complex member 2 -0.035283
DOCK4 dedicator of cytokinesis 4 -0.0351026
NAMPT nicotinamide phosphoribosyltransferase -0.0339301
RTN4 reticulon 4 -0.0337282
ACTN1 actinin, alpha 1 -0.0334727
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0329851
GLIS3 GLIS family zinc finger 3 -0.032626
ZBTB20 zinc finger and BTB domain containing 20 -0.0320704
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0304808
KLF6 Kruppel-like factor 6 -0.0303971
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.029172
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0284249
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.027943
SMAD3 SMAD family member 3 -0.0276049
RPS21 ribosomal protein S21 -0.0270304
NPC1 Niemann-Pick disease, type C1 -0.0269024
DENND4A DENN/MADD domain containing 4A -0.0268667
TFPI2 tissue factor pathway inhibitor 2 -0.026849
MAML3 mastermind-like 3 (Drosophila) -0.026457
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0258555
ZFHX3 zinc finger homeobox 3 -0.0258166
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0250618
RFWD3 ring finger and WD repeat domain 3 -0.0248033
AK1 adenylate kinase 1 -0.024736
IGFBP4 insulin-like growth factor binding protein 4 -0.0245777
DOCK5 dedicator of cytokinesis 5 -0.0243626
NAV3 neuron navigator 3 -0.0243206
IGF1R insulin-like growth factor 1 receptor -0.024271
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0240494
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.02366
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0229252
ZMYND8 zinc finger, MYND-type containing 8 -0.0227667
RPS2 ribosomal protein S2 -0.022715
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0225785
NTN4 netrin 4 -0.0223083
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0222454
ATP5F1B ATP synthase F1 subunit beta -0.0221127
TBC1D5 TBC1 domain family, member 5 -0.0220768
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0214625
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0214507
RIN2 Ras and Rab interactor 2 -0.0212268
EFNA5 ephrin-A5 -0.0205491
SOX4 SRY (sex determining region Y)-box 4 -0.0205232
LAMB1 laminin, beta 1 -0.0204521
FLNB filamin B, beta -0.0201882
LMNA lamin A/C -0.0200893
FOXP1 forkhead box P1 -0.0198783
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0196767
CLTC clathrin, heavy chain (Hc) -0.0195321
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0194897
EGFR epidermal growth factor receptor -0.0194566
NRG1 neuregulin 1 -0.0190346
NSUN6 NOP2/Sun domain family, member 6 -0.019005
ATG7 autophagy related 7 -0.0189411
ANKRD28 ankyrin repeat domain 28 -0.0189365
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0187816
NCOA7 nuclear receptor coactivator 7 -0.01878
PDE8A phosphodiesterase 8A -0.0186263
SP3 Sp3 transcription factor -0.0183792
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0183269
MSRB3 methionine sulfoxide reductase B3 -0.0182865
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0182697
CBX5 chromobox homolog 5 -0.0181052
FLNA filamin A, alpha -0.0180061
FLOT1 flotillin 1 -0.0177902
STC1 stanniocalcin 1 -0.0177704
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0177494
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0172734
ACACA acetyl-CoA carboxylase alpha -0.017188
KIFC3 kinesin family member C3 -0.0171067
MKI67 marker of proliferation Ki-67 -0.0169462
DENND1A DENN/MADD domain containing 1A -0.01693
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0167044
FDPS farnesyl diphosphate synthase -0.0165706
NABP1 nucleic acid binding protein 1 -0.0165164
PM20D1 peptidase M20 domain containing 1 -0.0164811
NCEH1 neutral cholesterol ester hydrolase 1 -0.0163601