Gallic acid (hydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.162831
ASPH aspartate beta-hydroxylase 0.139602
HMGA2 high mobility group AT-hook 2 0.0983174
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0972608
LIMCH1 LIM and calponin homology domains 1 0.0889737
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0795886
DST dystonin 0.0777591
LMO7 LIM domain 7 0.0765863
FN1 fibronectin 1 0.0758548
EXT1 exostosin glycosyltransferase 1 0.0756274
KYNU kynureninase 0.0741403
GRB10 growth factor receptor-bound protein 10 0.0690311
SMOC1 SPARC related modular calcium binding 1 0.0621328
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0606364
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0563436
AKAP12 A kinase (PRKA) anchor protein 12 0.0547511
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0546013
FNDC3A fibronectin type III domain containing 3A 0.0535257
MYO1E myosin IE 0.0534384
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0514333
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0514176
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0495844
FNDC3B fibronectin type III domain containing 3B 0.0490688
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0480236
NAMPT nicotinamide phosphoribosyltransferase 0.0469192
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0467227
NALF1 NALCN channel auxiliary factor 1 0.0459459
RBM39 RNA binding motif protein 39 0.0456225
EGFR epidermal growth factor receptor 0.0454094
MYO10 myosin X 0.0449916
PDLIM5 PDZ and LIM domain 5 0.0439289
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0435367
CTBP2 C-terminal binding protein 2 0.0426936
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0424971
GRAMD1B GRAM domain containing 1B 0.0422393
MED13L mediator complex subunit 13-like 0.0419149
MBNL1 muscleblind-like splicing regulator 1 0.0418435
IFIH1 interferon induced with helicase C domain 1 0.0416203
ISG15 ISG15 ubiquitin-like modifier 0.0416076
NEK7 NIMA-related kinase 7 0.041412
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0405507
PELI1 pellino E3 ubiquitin protein ligase 1 0.0400797
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0400024
JMJD1C jumonji domain containing 1C 0.0398051
RICTOR RPTOR independent companion of MTOR, complex 2 0.039743
FXR1 fragile X mental retardation, autosomal homolog 1 0.039029
ARHGAP5 Rho GTPase activating protein 5 0.0387823
GOLGA4 golgin A4 0.0385784
GSK3B glycogen synthase kinase 3 beta 0.0383309
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0382346
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0379093
PDE10A phosphodiesterase 10A 0.037739
EHBP1 EH domain binding protein 1 0.0363155
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0360174
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0359234
EFNA5 ephrin-A5 0.0357033
USP15 ubiquitin specific peptidase 15 0.0355193
KMT2E lysine (K)-specific methyltransferase 2E 0.0352675
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0352227
KDM5B lysine (K)-specific demethylase 5B 0.0348751
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0347667
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0347009
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.034572
CDK6 cyclin-dependent kinase 6 0.0343807
TRIO trio Rho guanine nucleotide exchange factor 0.0337444
CNKSR3 CNKSR family member 3 0.033579
MAML3 mastermind-like 3 (Drosophila) 0.0335119
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.033284
TRA2A transformer 2 alpha homolog (Drosophila) 0.0331852
ELL2 elongation factor, RNA polymerase II, 2 0.0330688
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0330542
PRRC2C proline-rich coiled-coil 2C 0.0330398
FAT1 FAT atypical cadherin 1 0.0327418
GPBP1 GC-rich promoter binding protein 1 0.0325762
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0325218
ABLIM1 actin binding LIM protein 1 0.0324938
COL6A3 collagen, type VI, alpha 3 0.0324324
PRELID2 PRELI domain containing 2 0.0324037
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0323896
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0323635
MATR3 matrin 3 0.0322942
RIGI RNA sensor RIG-I 0.0321747
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0319654
NPAS2 neuronal PAS domain protein 2 0.0318328
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0317783
VCL vinculin 0.0314987
OGA O-GlcNAcase 0.0311537
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0311137
LRMDA leucine rich melanocyte differentiation associated 0.0309714
MYOF myoferlin 0.0309494
RNF145 ring finger protein 145 0.0309326
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0309096
PTPRK protein tyrosine phosphatase, receptor type, K 0.0306847
TJP1 tight junction protein 1 0.0305374
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0304415
CLIP2 CAP-GLY domain containing linker protein 2 0.0302478
GPC6 glypican 6 0.0302453
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0300819
CHD1 chromodomain helicase DNA binding protein 1 0.0299074
ARHGAP26 Rho GTPase activating protein 26 0.0291195

decreased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.254102
FTH1 ferritin, heavy polypeptide 1 -0.142044
ATOSA atos homolog A -0.122273
LAMC2 laminin, gamma 2 -0.107438
NDRG1 N-myc downstream regulated 1 -0.100543
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0898875
CEMIP cell migration inducing protein, hyaluronan binding -0.0863498
LAMB3 laminin, beta 3 -0.0853707
IGFBP3 insulin-like growth factor binding protein 3 -0.0846712
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.073349
SAMD4A sterile alpha motif domain containing 4A -0.0727884
SBF2 SET binding factor 2 -0.064274
KRT17 keratin 17, type I -0.0640643
ANTXR2 anthrax toxin receptor 2 -0.0622913
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0612847
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0610323
MCL1 myeloid cell leukemia 1 -0.0599033
FTL ferritin, light polypeptide -0.0593028
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0590966
S100A9 S100 calcium binding protein A9 -0.0556679
SOS2 son of sevenless homolog 2 (Drosophila) -0.0541156
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0538358
BACE2 beta-site APP-cleaving enzyme 2 -0.0499091
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0497174
KDM7A lysine (K)-specific demethylase 7A -0.0491672
FBXL13 F-box and leucine-rich repeat protein 13 -0.0488303
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0461331
RB1CC1 RB1-inducible coiled-coil 1 -0.0456103
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0444882
RPL19 ribosomal protein L19 -0.0444098
ZMYND8 zinc finger, MYND-type containing 8 -0.0443721
SOX4 SRY (sex determining region Y)-box 4 -0.0431414
MXD1 MAX dimerization protein 1 -0.0424309
IGF2 insulin-like growth factor 2 -0.0416284
EIF1 eukaryotic translation initiation factor 1 -0.0409396
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0405534
STC1 stanniocalcin 1 -0.0404963
HLA-B major histocompatibility complex, class I, B -0.0403393
MRPS6 mitochondrial ribosomal protein S6 -0.0400891
DLG1 discs, large homolog 1 (Drosophila) -0.0399652
CSTB cystatin B (stefin B) -0.0398209
CLMP CXADR-like membrane protein -0.0396771
TMPRSS4 transmembrane protease, serine 4 -0.0395654
PRDM1 PR domain containing 1, with ZNF domain -0.0394264
RAI14 retinoic acid induced 14 -0.0392664
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0390205
FNIP1 folliculin interacting protein 1 -0.0381734
MCTP2 multiple C2 domains, transmembrane 2 -0.037829
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0377362
CATSPERB catsper channel auxiliary subunit beta -0.0377308
KPNA1 karyopherin alpha 1 (importin alpha 5) -0.0372749
TMCC3 transmembrane and coiled-coil domain family 3 -0.037243
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0372331
WASF2 WAS protein family, member 2 -0.0368284
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0365461
SMG6 SMG6 nonsense mediated mRNA decay factor -0.0362458
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0360375
THOC2 THO complex 2 -0.035968
SREBF2 sterol regulatory element binding transcription factor 2 -0.0358099
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0351843
TPI1 triosephosphate isomerase 1 -0.0350949
AKAP13 A kinase (PRKA) anchor protein 13 -0.0349158
AHNAK AHNAK nucleoprotein -0.034739
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0344475
PKM pyruvate kinase, muscle -0.0340911
CERS6 ceramide synthase 6 -0.0336539
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0329946
BTBD10 BTB (POZ) domain containing 10 -0.0324278
HLA-A major histocompatibility complex, class I, A -0.0324207
LOC112694756 uncharaterized LOC112694756 -0.0323408
EPSTI1 epithelial stromal interaction 1 (breast) -0.0323375
PTPRE protein tyrosine phosphatase, receptor type, E -0.0321658
ZNF217 zinc finger protein 217 -0.0321057
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0320587
SHB Src homology 2 domain containing adaptor protein B -0.0320359
IRAK2 interleukin-1 receptor-associated kinase 2 -0.0319925
RAB7A RAB7A, member RAS oncogene family -0.0314991
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF -0.0311737
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0311437
SMC5 structural maintenance of chromosomes 5 -0.0305055
SDC4 syndecan 4 -0.0301147
RREB1 ras responsive element binding protein 1 -0.029996
MT2A metallothionein 2A -0.0299417
USP53 ubiquitin specific peptidase 53 -0.0297906
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0295689
STXBP1 syntaxin binding protein 1 -0.0295438
TMOD3 tropomodulin 3 (ubiquitous) -0.0294961
CSNK1E casein kinase 1, epsilon -0.029214
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0291489
BTG1 B-cell translocation gene 1, anti-proliferative -0.0290208
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0290012
TM9SF3 transmembrane 9 superfamily member 3 -0.028873
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0285375
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0285315
PRRC2B proline-rich coiled-coil 2B -0.0285212
B2M beta-2-microglobulin -0.0284839
DENND4C DENN/MADD domain containing 4C -0.0283688
ELOF1 elongation factor 1 homolog (S. cerevisiae) -0.0280199
MBD5 methyl-CpG binding domain protein 5 -0.0279118
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0275116