Gallic acid (hydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.26775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.179664
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.167956
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.111202
ERRFI1 ERBB receptor feedback inhibitor 1 0.103637
KTN1 kinectin 1 (kinesin receptor) 0.0870138
VIM vimentin 0.070064
CANX calnexin 0.0623747
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0602308
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0532425
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0514731
TPM3 tropomyosin 3 0.0488634
RPS8 ribosomal protein S8 0.0481776
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0477433
PDIA3 protein disulfide isomerase family A, member 3 0.0462212
AEBP2 AE binding protein 2 0.0446656
MCL1 myeloid cell leukemia 1 0.0444403
SYNE2 spectrin repeat containing, nuclear envelope 2 0.043891
PDIA6 protein disulfide isomerase family A, member 6 0.0434228
RPL23 ribosomal protein L23 0.0431205
PTMA prothymosin, alpha 0.0427679
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0427521
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0419628
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0395593
PDIA4 protein disulfide isomerase family A, member 4 0.0391547
GOLGB1 golgin B1 0.0389152
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0371071
DSPP dentin sialophosphoprotein 0.0365523
ENO1 enolase 1, (alpha) 0.0363774
CALR calreticulin 0.0363524
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0357272
DST dystonin 0.0347963
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0346815
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0336063
RPS6 ribosomal protein S6 0.0319864
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0314033
SET SET nuclear proto-oncogene 0.0307522
PRELID2 PRELI domain containing 2 0.0295867
ZSWIM6 zinc finger, SWIM-type containing 6 0.0291481
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0290406
PHF3 PHD finger protein 3 0.028856
XPOT exportin, tRNA 0.0287092
HSPA8 heat shock 70kDa protein 8 0.0284781
RPL37A ribosomal protein L37a 0.0279198
HYOU1 hypoxia up-regulated 1 0.0274682
MT2A metallothionein 2A 0.0274223
AKAP9 A kinase (PRKA) anchor protein 9 0.027322
EIF5B eukaryotic translation initiation factor 5B 0.0267952
KRT18 keratin 18, type I 0.0267647
WWOX WW domain containing oxidoreductase 0.0264254
RPL3 ribosomal protein L3 0.0255535
RPS19 ribosomal protein S19 0.0255361
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0252617
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0239885
NAP1L1 nucleosome assembly protein 1-like 1 0.0237418
HOMER1 homer scaffolding protein 1 0.0237088
GARS1 glycyl-tRNA synthetase 1 0.0230859
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0225972
ZCCHC7 zinc finger, CCHC domain containing 7 0.0216003
RPS3 ribosomal protein S3 0.0215346
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0214103
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0209134
INTS6 integrator complex subunit 6 0.0208868
SETX senataxin 0.0204192
MYH9 myosin, heavy chain 9, non-muscle 0.0203844
ASPH aspartate beta-hydroxylase 0.0201081
DDIT3 DNA-damage-inducible transcript 3 0.0199442
BZW1 basic leucine zipper and W2 domains 1 0.0198848
VCP valosin containing protein 0.0198597
BIRC3 baculoviral IAP repeat containing 3 0.0198551
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0198092
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0191712
RPS27 ribosomal protein S27 0.0189812
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0189017
SESN2 sestrin 2 0.0187992
TTC3 tetratricopeptide repeat domain 3 0.018313
CSNK1A1 casein kinase 1, alpha 1 0.01819
RPL26 ribosomal protein L26 0.0179733
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0177087
C6ORF62 chromosome 6 open reading frame 62 0.0176379
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.017522
TOP2B topoisomerase (DNA) II beta 180kDa 0.0173805
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0173143
DCAF10 DDB1 and CUL4 associated factor 10 0.0173012
MAP1B microtubule-associated protein 1B 0.017219
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0171692
ZBTB1 zinc finger and BTB domain containing 1 0.0171311
MSH6 mutS homolog 6 0.0166917
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0166443
WNK1 WNK lysine deficient protein kinase 1 0.0165079
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0164504
ARFGEF3 ARFGEF family member 3 0.0163412
YBX1 Y box binding protein 1 0.0162963
GDI2 GDP dissociation inhibitor 2 0.0162687
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0162215
RPS17 ribosomal protein S17 0.0161105
ZDBF2 zinc finger, DBF-type containing 2 0.0160847
KIF5B kinesin family member 5B 0.0160072
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0159492
ZFC3H1 zinc finger, C3H1-type containing 0.0158941

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.090792
THSD4 thrombospondin, type I, domain containing 4 -0.0761315
TFPI2 tissue factor pathway inhibitor 2 -0.0724375
OSMR oncostatin M receptor -0.0676674
IGF1R insulin-like growth factor 1 receptor -0.0675226
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0665824
EML4 echinoderm microtubule associated protein like 4 -0.0591108
PDE10A phosphodiesterase 10A -0.056092
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0525934
IGF2 insulin-like growth factor 2 -0.0522643
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.051975
LATS2 large tumor suppressor kinase 2 -0.0516546
SMAD3 SMAD family member 3 -0.0514909
NCOA7 nuclear receptor coactivator 7 -0.0502764
TRIO trio Rho guanine nucleotide exchange factor -0.0491731
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0491667
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.048166
NF1 neurofibromin 1 -0.0481117
BASP1 brain abundant, membrane attached signal protein 1 -0.0449119
PTK2 protein tyrosine kinase 2 -0.0445268
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0440543
RAB7A RAB7A, member RAS oncogene family -0.0416042
ADAR adenosine deaminase, RNA-specific -0.0411405
EGR1 early growth response 1 -0.0390201
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0386363
ZBTB20 zinc finger and BTB domain containing 20 -0.0371611
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.037114
SBF2 SET binding factor 2 -0.0367806
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0364972
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0362894
PRRC2B proline-rich coiled-coil 2B -0.0362637
RBM39 RNA binding motif protein 39 -0.0358379
RNF213 ring finger protein 213 -0.0357519
TMSB10 thymosin beta 10 -0.035585
WSB1 WD repeat and SOCS box containing 1 -0.0350069
CDK17 cyclin-dependent kinase 17 -0.0349147
ZFAND3 zinc finger, AN1-type domain 3 -0.0343925
ZMYND8 zinc finger, MYND-type containing 8 -0.0342939
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0342567
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.033466
TAS2R14 taste receptor, type 2, member 14 -0.0334379
KLF6 Kruppel-like factor 6 -0.0330836
PTPRF protein tyrosine phosphatase, receptor type, F -0.0325317
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0324694
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0320876
CLIP1 CAP-GLY domain containing linker protein 1 -0.031077
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0310568
DNAH14 dynein, axonemal, heavy chain 14 -0.0306879
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0300715
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0298611
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0298433
CCND1 cyclin D1 -0.0294324
ZNFX1 zinc finger, NFX1-type containing 1 -0.0288674
KDM3A lysine (K)-specific demethylase 3A -0.0286569
UBE2H ubiquitin-conjugating enzyme E2H -0.0285803
ITSN1 intersectin 1 (SH3 domain protein) -0.0279626
USP34 ubiquitin specific peptidase 34 -0.0277368
RIGI RNA sensor RIG-I -0.0276784
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0276423
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0271368
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0268184
HMGA2 high mobility group AT-hook 2 -0.0264298
TUBB tubulin, beta class I -0.0260888
TAPBP TAP binding protein (tapasin) -0.02591
TXNRD1 thioredoxin reductase 1 -0.0258927
EXOC4 exocyst complex component 4 -0.0257845
PFN1 profilin 1 -0.0256857
ETV6 ets variant 6 -0.0252015
ATP5F1B ATP synthase F1 subunit beta -0.0251841
NABP1 nucleic acid binding protein 1 -0.0249628
RYR3 ryanodine receptor 3 -0.0248599
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0248495
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0248039
PHIP pleckstrin homology domain interacting protein -0.0247939
BIRC6 baculoviral IAP repeat containing 6 -0.0247919
TM4SF1 transmembrane 4 L six family member 1 -0.0247665
ANKRD28 ankyrin repeat domain 28 -0.0242043
RUNX1 runt-related transcription factor 1 -0.0241987
RAD51B RAD51 paralog B -0.0238806
H1-0 H1.0 linker histone -0.0238404
FLNA filamin A, alpha -0.0238172
ADGRG6 adhesion G protein-coupled receptor G6 -0.0234562
YBX3 Y box binding protein 3 -0.0234107
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0233751
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0231618
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0230629
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0230209
ICAM1 intercellular adhesion molecule 1 -0.0227458
R3HDM1 R3H domain containing 1 -0.022732
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0226648
CCDC91 coiled-coil domain containing 91 -0.0223005
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0221957
EXT1 exostosin glycosyltransferase 1 -0.0219414
ATG7 autophagy related 7 -0.0218915
MED13L mediator complex subunit 13-like -0.0218693
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0218312
PCNX1 pecanex 1 -0.0217246
FUS FUS RNA binding protein -0.0216745
PLSCR1 phospholipid scramblase 1 -0.0215801
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0214528