Gallic acid (hydrate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.121377
PCLO piccolo presynaptic cytomatrix protein 0.10054
GPC3 glypican 3 0.0838496
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0834206
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.083194
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0782135
VIM vimentin 0.0774216
COL3A1 collagen, type III, alpha 1 0.0764779
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0713948
ENO1 enolase 1, (alpha) 0.0541794
PCDH9 protocadherin 9 0.0522995
AKAP12 A kinase (PRKA) anchor protein 12 0.0500456
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0493738
RPL26 ribosomal protein L26 0.0480293
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0465556
FN1 fibronectin 1 0.0463522
TPT1 tumor protein, translationally-controlled 1 0.0462444
MT2A metallothionein 2A 0.0459858
PTMA prothymosin, alpha 0.0455452
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0452681
RPL23 ribosomal protein L23 0.0434612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0431887
RAD21 RAD21 homolog (S. pombe) 0.0430622
HMGB2 high mobility group box 2 0.0428599
GOLGB1 golgin B1 0.0376688
CSDE1 cold shock domain containing E1, RNA-binding 0.037436
LDHA lactate dehydrogenase A 0.0371669
PHF3 PHD finger protein 3 0.0370268
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0357414
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0354537
NAP1L1 nucleosome assembly protein 1-like 1 0.0348501
CANX calnexin 0.034204
RPS12 ribosomal protein S12 0.032514
DDIT4 DNA-damage-inducible transcript 4 0.0323834
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0318827
RPL37 ribosomal protein L37 0.0318689
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0318046
SET SET nuclear proto-oncogene 0.031447
SQSTM1 sequestosome 1 0.03142
RPL31 ribosomal protein L31 0.0313015
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0308711
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0307388
RPS19 ribosomal protein S19 0.0305171
NPAS3 neuronal PAS domain protein 3 0.0302171
ASPH aspartate beta-hydroxylase 0.0293779
CEP350 centrosomal protein 350kDa 0.0291954
TRPS1 trichorhinophalangeal syndrome I 0.0288261
LMO7 LIM domain 7 0.0275893
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0275569
PCDH17 protocadherin 17 0.0274033
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0271579
ARHGAP5 Rho GTPase activating protein 5 0.026907
ZSWIM6 zinc finger, SWIM-type containing 6 0.0268144
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.026679
MKI67 marker of proliferation Ki-67 0.0263657
NFE2L2 nuclear factor, erythroid 2-like 2 0.0262705
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261136
RPL9 ribosomal protein L9 0.0258099
RASAL2 RAS protein activator like 2 0.0257964
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0257684
ZNF608 zinc finger protein 608 0.0256365
SRRM2 serine/arginine repetitive matrix 2 0.0250532
STMN1 stathmin 1 0.0250087
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0246792
RPS17 ribosomal protein S17 0.0244934
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0244808
RPLP0 ribosomal protein, large, P0 0.0244497
RPL10A ribosomal protein L10a 0.0240957
PDS5A PDS5 cohesin associated factor A 0.0239744
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0239594
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0239192
SFRP4 secreted frizzled-related protein 4 0.0238916
CUL4B cullin 4B 0.0235652
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0234355
RPL7 ribosomal protein L7 0.0231222
PDE4D phosphodiesterase 4D, cAMP-specific 0.0229808
RPS3 ribosomal protein S3 0.0229417
RSRC2 arginine/serine-rich coiled-coil 2 0.0226195
SERINC1 serine incorporator 1 0.0226083
WDPCP WD repeat containing planar cell polarity effector 0.0224253
TMSB4X thymosin beta 4, X-linked 0.0222579
CALCR calcitonin receptor 0.0222396
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0221367
ITSN2 intersectin 2 0.0218403
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0217921
EZR ezrin 0.0217485
PRKD1 protein kinase D1 0.0215497
RPL37A ribosomal protein L37a 0.0215178
MRPS30 mitochondrial ribosomal protein S30 0.0214953
EGFR epidermal growth factor receptor 0.0214513
NRIP1 nuclear receptor interacting protein 1 0.02139
USP53 ubiquitin specific peptidase 53 0.0210979
KTN1 kinectin 1 (kinesin receptor) 0.0210644
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0210513
MPG N-methylpurine-DNA glycosylase 0.0210403
EFNA5 ephrin-A5 0.0207976
RACK1 receptor for activated C kinase 1 0.0207771
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0205309
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0205166
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0204366

decreased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B -0.104554
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.100493
TSC22D2 TSC22 domain family, member 2 -0.100265
ITGAV integrin, alpha V -0.0967722
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0914923
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.091405
ATP5F1B ATP synthase F1 subunit beta -0.0887171
ZFAND3 zinc finger, AN1-type domain 3 -0.0871266
PARD3B par-3 family cell polarity regulator beta -0.0800502
MDK midkine (neurite growth-promoting factor 2) -0.0726493
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0719136
PRTG protogenin -0.0682773
PFN1 profilin 1 -0.0637831
WASF2 WAS protein family, member 2 -0.0596339
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.058683
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0572151
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0543852
PLPP1 phospholipid phosphatase 1 -0.0536697
CADM2 cell adhesion molecule 2 -0.0524369
KDM5B lysine (K)-specific demethylase 5B -0.0523919
STRN3 striatin, calmodulin binding protein 3 -0.051577
THOC2 THO complex 2 -0.0513468
TMSB10 thymosin beta 10 -0.050778
PEG10 paternally expressed 10 -0.0492605
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0476562
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0474602
POTEF POTE ankyrin domain family, member F -0.0456506
PCBP2 poly(rC) binding protein 2 -0.0445552
SRPK2 SRSF protein kinase 2 -0.0445173
ANK2 ankyrin 2, neuronal -0.0444468
ACTN4 actinin, alpha 4 -0.0440089
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0436365
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.042635
PUM1 pumilio RNA-binding family member 1 -0.0423405
MRPS6 mitochondrial ribosomal protein S6 -0.0413982
PICALM phosphatidylinositol binding clathrin assembly protein -0.0411706
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0410882
PGAP1 post-GPI attachment to proteins 1 -0.0404899
MED13L mediator complex subunit 13-like -0.0400428
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.040012
KPNB1 karyopherin (importin) beta 1 -0.0399983
SRP54 signal recognition particle 54kDa -0.0393784
PBX3 pre-B-cell leukemia homeobox 3 -0.0393105
RAD51B RAD51 paralog B -0.0385703
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0385333
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0384593
NOP58 NOP58 ribonucleoprotein -0.0382069
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0375919
GARS1 glycyl-tRNA synthetase 1 -0.0375898
CLTC clathrin, heavy chain (Hc) -0.0375068
MEIS2 Meis homeobox 2 -0.0364889
TOX thymocyte selection-associated high mobility group box -0.0360727
KMT2C lysine (K)-specific methyltransferase 2C -0.0360229
ADGRL3 adhesion G protein-coupled receptor L3 -0.0355818
ARID4B AT rich interactive domain 4B (RBP1-like) -0.035569
RAB7A RAB7A, member RAS oncogene family -0.0355487
UPP1 uridine phosphorylase 1 -0.0354255
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0351896
RBM39 RNA binding motif protein 39 -0.034326
TENM3 teneurin transmembrane protein 3 -0.0339717
ZBTB35 zinc finger and BTB domain containing 35 -0.0334362
SMYD3 SET and MYND domain containing 3 -0.0330667
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0330291
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0325319
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0324942
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0324643
MAP4 microtubule-associated protein 4 -0.0316512
RAB6A RAB6A, member RAS oncogene family -0.0315861
CAMTA1 calmodulin binding transcription activator 1 -0.0314477
JMJD1C jumonji domain containing 1C -0.0309273
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0308736
ADAM9 ADAM metallopeptidase domain 9 -0.0306773
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0301439
PRR16 proline rich 16 -0.0298502
NCOR2 nuclear receptor corepressor 2 -0.0295602
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0292669
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0290446
ATXN2 ataxin 2 -0.0289494
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0286222
KMT2A lysine (K)-specific methyltransferase 2A -0.0285111
TCF12 transcription factor 12 -0.0278226
BRWD1 bromodomain and WD repeat domain containing 1 -0.0276641
PPP4R1 protein phosphatase 4, regulatory subunit 1 -0.0275709
GLS2 glutaminase 2 (liver, mitochondrial) -0.0275444
ANKRD33B ankyrin repeat domain 33B -0.0274469
R3HDM1 R3H domain containing 1 -0.0273503
ZCCHC7 zinc finger, CCHC domain containing 7 -0.027161
SLC44A5 solute carrier family 44, member 5 -0.0270061
ZFR zinc finger RNA binding protein -0.0268327
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0264129
GRB2 growth factor receptor-bound protein 2 -0.0264108
SIK3 SIK family kinase 3 -0.0262648
UBE4B ubiquitination factor E4B -0.0262623
GPC4 glypican 4 -0.0262569
CCNL1 cyclin L1 -0.026118
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0258656
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0256229
NRG1 neuregulin 1 -0.0256149
EVI5 ecotropic viral integration site 5 -0.0254006
ECT2 epithelial cell transforming 2 -0.0253773