Gallic acid (hydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.12939
MT2A metallothionein 2A 0.122478
ZNF438 zinc finger protein 438 0.113255
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.109366
FRMD6 FERM domain containing 6 0.104141
NAV3 neuron navigator 3 0.0987011
RPS6 ribosomal protein S6 0.0853072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.084736
FLNB filamin B, beta 0.0843018
ARHGAP22 Rho GTPase activating protein 22 0.0836881
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0813758
HDAC9 histone deacetylase 9 0.0739355
FRMD4A FERM domain containing 4A 0.0735622
HMGA2 high mobility group AT-hook 2 0.072041
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0656915
DLC1 DLC1 Rho GTPase activating protein 0.0645349
PBX3 pre-B-cell leukemia homeobox 3 0.0637107
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0630243
NAV2 neuron navigator 2 0.0620577
ASPH aspartate beta-hydroxylase 0.0613833
EXT1 exostosin glycosyltransferase 1 0.0600061
RPS12 ribosomal protein S12 0.0575152
RPS8 ribosomal protein S8 0.0573779
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0572473
RPL23 ribosomal protein L23 0.0564198
ENO1 enolase 1, (alpha) 0.0557661
RAD51B RAD51 paralog B 0.0531516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0512736
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.050755
BNC2 basonuclin 2 0.0501291
SET SET nuclear proto-oncogene 0.0490823
RPS3 ribosomal protein S3 0.0471449
DGKI diacylglycerol kinase, iota 0.0454217
RPL35A ribosomal protein L35a 0.043833
RPL37A ribosomal protein L37a 0.043336
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0429776
IFI16 interferon, gamma-inducible protein 16 0.0428972
EEF2 eukaryotic translation elongation factor 2 0.042818
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0425083
RPL7 ribosomal protein L7 0.0420621
MCL1 myeloid cell leukemia 1 0.0414136
NABP1 nucleic acid binding protein 1 0.040576
SLC38A2 solute carrier family 38, member 2 0.0403668
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400328
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0399345
EXOC4 exocyst complex component 4 0.0397356
FHIT fragile histidine triad 0.0396378
AKAP12 A kinase (PRKA) anchor protein 12 0.0391879
RPL12 ribosomal protein L12 0.0391133
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0390818
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0385777
PTMA prothymosin, alpha 0.0385549
SAMD4A sterile alpha motif domain containing 4A 0.03846
RPS17 ribosomal protein S17 0.0383926
RPLP1 ribosomal protein, large, P1 0.0382363
TPM4 tropomyosin 4 0.0371243
RPL7A ribosomal protein L7a 0.0369562
SRRM2 serine/arginine repetitive matrix 2 0.0356004
RPLP2 ribosomal protein, large, P2 0.0354159
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0348649
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0348254
LPP LIM domain containing preferred translocation partner in lipoma 0.0344944
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0342627
ANK2 ankyrin 2, neuronal 0.0336987
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0332196
PTPRG protein tyrosine phosphatase, receptor type, G 0.0330819
TPT1 tumor protein, translationally-controlled 1 0.0330095
RPL26 ribosomal protein L26 0.0326495
RPS19 ribosomal protein S19 0.032553
ZSWIM6 zinc finger, SWIM-type containing 6 0.0323537
MACF1 microtubule-actin crosslinking factor 1 0.0323307
RPL9 ribosomal protein L9 0.0318996
TMSB10 thymosin beta 10 0.0308434
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0305857
RPL35 ribosomal protein L35 0.0301042
MTAP methylthioadenosine phosphorylase 0.0299895
ZBTB20 zinc finger and BTB domain containing 20 0.029984
NAP1L1 nucleosome assembly protein 1-like 1 0.0292523
PDIA3 protein disulfide isomerase family A, member 3 0.0292516
RPL5 ribosomal protein L5 0.028821
ALCAM activated leukocyte cell adhesion molecule 0.0286222
FTL ferritin, light polypeptide 0.0282671
PGK1 phosphoglycerate kinase 1 0.0281518
PKM pyruvate kinase, muscle 0.0280631
RPL11 ribosomal protein L11 0.0279521
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0278109
DENND1A DENN/MADD domain containing 1A 0.0271473
RPS25 ribosomal protein S25 0.0268859
RPL30 ribosomal protein L30 0.0268413
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0268281
TTR transthyretin 0.0268222
RPS27A ribosomal protein S27a 0.0265065
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0264163
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0260973
RPS13 ribosomal protein S13 0.0250376
RPL31 ribosomal protein L31 0.0250112
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0249738
RPLP0 ribosomal protein, large, P0 0.0249293
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0246177
RACK1 receptor for activated C kinase 1 0.0244394

decreased expression

Symbol Name Standardized Value
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0304956
ACTG1 actin gamma 1 -0.0296483
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0261664
NUP58 nucleoporin 58 -0.0254159
KDM3A lysine (K)-specific demethylase 3A -0.0222207
RAD21 RAD21 homolog (S. pombe) -0.0210791
USP3 ubiquitin specific peptidase 3 -0.0203121
SPRED2 sprouty-related, EVH1 domain containing 2 -0.018371
NAMPT nicotinamide phosphoribosyltransferase -0.0183084
ZFAND3 zinc finger, AN1-type domain 3 -0.0178743
BHLHE40 basic helix-loop-helix family, member e40 -0.0176958
RBM39 RNA binding motif protein 39 -0.0167868
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0165573
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0160879
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0160604
MIS18BP1 MIS18 binding protein 1 -0.0160346
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0154983
POU2F1 POU class 2 homeobox 1 -0.0152715
TSC22D2 TSC22 domain family, member 2 -0.0151821
MARCHF6 membrane associated ring-CH-type finger 6 -0.0145739
CDK17 cyclin-dependent kinase 17 -0.0145609
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.014403
CAMTA1 calmodulin binding transcription activator 1 -0.0143425
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0142916
PHIP pleckstrin homology domain interacting protein -0.0139361
FOXJ3 forkhead box J3 -0.013922
WDR45B WD repeat domain 45B -0.0139092
RLF rearranged L-myc fusion -0.0138809
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0138763
BRWD3 bromodomain and WD repeat domain containing 3 -0.0138683
FUBP3 far upstream element (FUSE) binding protein 3 -0.0138445
FOXO3 forkhead box O3 -0.0137739
TEX10 testis expressed 10 -0.0137448
NIPBL Nipped-B homolog (Drosophila) -0.0136527
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0131757
YAF2 YY1 associated factor 2 -0.0131274
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0129685
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0123687
RHEB Ras homolog enriched in brain -0.0123165
LCORL ligand dependent nuclear receptor corepressor-like -0.0122303
ECT2 epithelial cell transforming 2 -0.0120755
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0118976
IARS1 isoleucyl-tRNA synthetase 1 -0.0114199
AGO2 argonaute RISC catalytic component 2 -0.011121
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0110847
LATS2 large tumor suppressor kinase 2 -0.0110682
MON2 MON2 homolog (S. cerevisiae) -0.0110232
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0110108
RBM33 RNA binding motif protein 33 -0.0108796
PUM2 pumilio RNA-binding family member 2 -0.0108288
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0108121
ADAM9 ADAM metallopeptidase domain 9 -0.0107979
ADAM17 ADAM metallopeptidase domain 17 -0.0107969
CCNL1 cyclin L1 -0.0107448
ZNF654 zinc finger protein 654 -0.0105977
ABI1 abl-interactor 1 -0.0104044
AFF4 AF4/FMR2 family, member 4 -0.0103578
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0103532
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0102904
OLA1 Obg-like ATPase 1 -0.0102664
WAC WW domain containing adaptor with coiled-coil -0.0102629
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0102203
RYBP RING1 and YY1 binding protein -0.0101483
GLIPR1 GLI pathogenesis-related 1 -0.0100576
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.00999228
CHIC2 cysteine-rich hydrophobic domain 2 -0.00999164
NEK7 NIMA-related kinase 7 -0.0099586
USP15 ubiquitin specific peptidase 15 -0.00987488
MED13 mediator complex subunit 13 -0.00985033
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.00984707
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0098277
ATP13A3 ATPase type 13A3 -0.00982235
RNF145 ring finger protein 145 -0.00972421
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.00968061
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.00967589
NCOR1 nuclear receptor corepressor 1 -0.00953196
OGA O-GlcNAcase -0.00946799
YTHDC1 YTH domain containing 1 -0.00943621
ZFAND6 zinc finger, AN1-type domain 6 -0.00943301
NUP54 nucleoporin 54kDa -0.00938409
SPAG9 sperm associated antigen 9 -0.00933656
RTN4 reticulon 4 -0.0092824
MTF2 metal response element binding transcription factor 2 -0.00927761
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.00926746
PCNX1 pecanex 1 -0.00925533
RAB14 RAB14, member RAS oncogene family -0.00923736
PIAS1 protein inhibitor of activated STAT, 1 -0.00918095
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.00909828
TXNRD1 thioredoxin reductase 1 -0.00907459
SEC24A SEC24 family member A -0.00903021
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.00895278
FRS2 fibroblast growth factor receptor substrate 2 -0.00891585
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.00891201
CEP95 centrosomal protein 95kDa -0.00890111
STAU1 staufen double-stranded RNA binding protein 1 -0.00888949
CHD1 chromodomain helicase DNA binding protein 1 -0.00882182
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.00869949
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00862772
STRN3 striatin, calmodulin binding protein 3 -0.00861402
CUL3 cullin 3 -0.00860877