Gallic acid (hydrate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid (hydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid (hydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRIK1 glutamate receptor, ionotropic, kainate 1 0.107612
ENO1 enolase 1, (alpha) 0.0969196
RIT2 Ras-like without CAAX 2 0.0924251
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0869722
STC1 stanniocalcin 1 0.0826578
RIMS2 regulating synaptic membrane exocytosis 2 0.0626759
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0624237
IGFBP5 insulin-like growth factor binding protein 5 0.0617873
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0580781
TMSB4X thymosin beta 4, X-linked 0.0577504
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0552689
ELL2 elongation factor, RNA polymerase II, 2 0.0549082
DGKD diacylglycerol kinase, delta 130kDa 0.0483831
CHGB chromogranin B 0.0459885
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0445078
RAD21 RAD21 homolog (S. pombe) 0.0444957
SET SET nuclear proto-oncogene 0.0430827
SASH1 SAM and SH3 domain containing 1 0.0403973
PGK1 phosphoglycerate kinase 1 0.0401206
KIF26B kinesin family member 26B 0.0398055
DOCK5 dedicator of cytokinesis 5 0.0379277
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0377986
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0377918
ASCL1 achaete-scute family bHLH transcription factor 1 0.0372614
VGF VGF nerve growth factor inducible 0.0370759
TPR translocated promoter region, nuclear basket protein 0.0367316
SCG2 secretogranin II 0.0365739
SNTG1 syntrophin, gamma 1 0.0364323
RPL23 ribosomal protein L23 0.0360917
WWOX WW domain containing oxidoreductase 0.0353893
HMGB3 high mobility group box 3 0.0347058
CPE carboxypeptidase E 0.0342784
ASPH aspartate beta-hydroxylase 0.0340409
MACF1 microtubule-actin crosslinking factor 1 0.0336561
NBEA neurobeachin 0.033547
SINHCAF SIN3-HDAC complex associated factor 0.033488
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.0329124
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0327147
NCKAP5 NCK-associated protein 5 0.0323795
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0321051
RTN4 reticulon 4 0.0313255
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.031304
PDE4B phosphodiesterase 4B, cAMP-specific 0.0309291
GPC6 glypican 6 0.0308578
BZW1 basic leucine zipper and W2 domains 1 0.0300579
ARB2A ARB2 cotranscriptional regulator A 0.0299758
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0298205
AKAP12 A kinase (PRKA) anchor protein 12 0.029819
EIF3I eukaryotic translation initiation factor 3, subunit I 0.0294875
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0294837
CANX calnexin 0.0293613
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0292482
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0292426
CNKSR3 CNKSR family member 3 0.0290697
TPM3 tropomyosin 3 0.0290665
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0288978
RPL26 ribosomal protein L26 0.0287982
H1-0 H1.0 linker histone 0.0285301
NAMPT nicotinamide phosphoribosyltransferase 0.0283949
NSUN6 NOP2/Sun domain family, member 6 0.0280597
SOX4 SRY (sex determining region Y)-box 4 0.0278171
RPS3 ribosomal protein S3 0.0274671
NIPSNAP2 nipsnap homolog 2 0.0271114
TXNRD1 thioredoxin reductase 1 0.0267645
PEG10 paternally expressed 10 0.0265275
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0261112
SCG3 secretogranin III 0.0259046
MAP1B microtubule-associated protein 1B 0.0258437
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0255116
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0252585
PTMA prothymosin, alpha 0.0248866
TPT1 tumor protein, translationally-controlled 1 0.0245767
PTCHD4 patched domain containing 4 0.0245337
ADGRL2 adhesion G protein-coupled receptor L2 0.0244664
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.024378
LDHA lactate dehydrogenase A 0.0243171
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0241998
IFI6 interferon, alpha-inducible protein 6 0.0240642
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0233175
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.022938
PCDH9 protocadherin 9 0.0227439
RPS7 ribosomal protein S7 0.022698
FOXP1 forkhead box P1 0.0225554
DST dystonin 0.0224651
RAD51B RAD51 paralog B 0.022357
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0223048
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0220481
RPL12 ribosomal protein L12 0.0218652
DGKB diacylglycerol kinase, beta 90kDa 0.0217846
TOP2B topoisomerase (DNA) II beta 180kDa 0.0217402
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0216259
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0216213
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0216073
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0215957
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0215037
ARHGAP5 Rho GTPase activating protein 5 0.0214877
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0212688
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0212081
NPAS3 neuronal PAS domain protein 3 0.0211525
EXOC4 exocyst complex component 4 0.0210879

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133594
NALF1 NALCN channel auxiliary factor 1 -0.0855524
SNAP25 synaptosomal-associated protein, 25kDa -0.0702213
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0614549
EGR1 early growth response 1 -0.0590269
PDE10A phosphodiesterase 10A -0.0589154
TENT5A terminal nucleotidyltransferase 5A -0.0569147
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0518763
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0510041
ACTG1 actin gamma 1 -0.048138
POTEF POTE ankyrin domain family, member F -0.0481071
RPL8 ribosomal protein L8 -0.0473969
CALCA calcitonin-related polypeptide alpha -0.0470788
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0441336
DTNA dystrobrevin, alpha -0.0427086
RPL37A ribosomal protein L37a -0.0412642
LOC112694756 uncharaterized LOC112694756 -0.0404299
TTC19 tetratricopeptide repeat domain 19 -0.0400162
TENT4A terminal nucleotidyltransferase 4A -0.0393626
RPS29 ribosomal protein S29 -0.0376357
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0363653
PCM1 pericentriolar material 1 -0.0359954
RPLP1 ribosomal protein, large, P1 -0.0356109
RPS19 ribosomal protein S19 -0.0348396
ATP5F1B ATP synthase F1 subunit beta -0.0343633
FUS FUS RNA binding protein -0.0334675
PARD3 par-3 family cell polarity regulator -0.0328763
GATAD2B GATA zinc finger domain containing 2B -0.0325814
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0322842
ADNP activity-dependent neuroprotector homeobox -0.031698
RPS15 ribosomal protein S15 -0.0314066
RPL28 ribosomal protein L28 -0.0313742
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0302914
AUTS2 autism susceptibility candidate 2 -0.0301627
PKM pyruvate kinase, muscle -0.0293763
SIK3 SIK family kinase 3 -0.029095
NDRG1 N-myc downstream regulated 1 -0.029062
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0287725
KLHL24 kelch-like family member 24 -0.02864
NOP58 NOP58 ribonucleoprotein -0.0282791
ACTN4 actinin, alpha 4 -0.0273761
PCBP2 poly(rC) binding protein 2 -0.0271193
SCFD1 sec1 family domain containing 1 -0.0268464
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0267305
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0266941
PNISR PNN-interacting serine/arginine-rich protein -0.0265687
SREBF2 sterol regulatory element binding transcription factor 2 -0.0265435
CABIN1 calcineurin binding protein 1 -0.0264809
EP400 E1A binding protein p400 -0.0264496
MIS18BP1 MIS18 binding protein 1 -0.0263287
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0261868
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -0.0261561
GPHN gephyrin -0.0261007
NUP214 nucleoporin 214kDa -0.0258923
RPS11 ribosomal protein S11 -0.0257392
TMSB10 thymosin beta 10 -0.0257024
RPS23 ribosomal protein S23 -0.02541
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0251034
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0248698
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0246217
HLA-A major histocompatibility complex, class I, A -0.0242704
PRRC2B proline-rich coiled-coil 2B -0.0240482
MT2A metallothionein 2A -0.0240394
RPS21 ribosomal protein S21 -0.0237424
RPL13A ribosomal protein L13a -0.0237038
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0235628
RPS25 ribosomal protein S25 -0.023498
SLC38A2 solute carrier family 38, member 2 -0.0234329
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0234248
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0234215
PHIP pleckstrin homology domain interacting protein -0.0232393
BRD4 bromodomain containing 4 -0.0228982
PRELID2 PRELI domain containing 2 -0.0228956
RBM20 RNA binding motif protein 20 -0.0227542
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0226437
RPL7A ribosomal protein L7a -0.0225407
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0223653
RGS7 regulator of G-protein signaling 7 -0.0223323
PNN pinin, desmosome associated protein -0.0223034
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0222446
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0220538
FOXJ3 forkhead box J3 -0.0220209
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0220206
TP53 tumor protein p53 -0.0220049
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0219908
RPS5 ribosomal protein S5 -0.0218923
CAMTA1 calmodulin binding transcription activator 1 -0.0214596
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0213218
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0212401
RPL37 ribosomal protein L37 -0.0211841
RB1CC1 RB1-inducible coiled-coil 1 -0.0210982
MDK midkine (neurite growth-promoting factor 2) -0.0210837
DIDO1 death inducer-obliterator 1 -0.0210681
CCDC88A coiled-coil domain containing 88A -0.0209766
EEF2 eukaryotic translation elongation factor 2 -0.0209318
RPS13 ribosomal protein S13 -0.0208462
SRSF11 serine/arginine-rich splicing factor 11 -0.0206387
BIRC6 baculoviral IAP repeat containing 6 -0.0205144
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 -0.0204783
RFC3 replication factor C (activator 1) 3, 38kDa -0.0204231