Gallic acid_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.207303
PLAT plasminogen activator, tissue 0.152068
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.121267
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.117106
CD44 CD44 molecule (Indian blood group) 0.0931554
AKAP12 A kinase (PRKA) anchor protein 12 0.0867428
MYH9 myosin, heavy chain 9, non-muscle 0.0850495
EFNA5 ephrin-A5 0.0706356
APP amyloid beta (A4) precursor protein 0.0676851
SEPTIN9 septin 9 0.0658806
NAV1 neuron navigator 1 0.0631553
GLIS3 GLIS family zinc finger 3 0.0625252
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0620767
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0611952
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0597358
MCL1 myeloid cell leukemia 1 0.0519675
FLNA filamin A, alpha 0.0486805
CALR calreticulin 0.0476436
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0468299
COL3A1 collagen, type III, alpha 1 0.0466362
PKM pyruvate kinase, muscle 0.0444122
WWTR1 WW domain containing transcription regulator 1 0.0434851
DOCK5 dedicator of cytokinesis 5 0.0422883
TPM3 tropomyosin 3 0.0420547
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0408898
C1D C1D nuclear receptor corepressor 0.0403428
ERRFI1 ERBB receptor feedback inhibitor 1 0.0394184
RUNX1 runt-related transcription factor 1 0.0390615
FLNB filamin B, beta 0.0388946
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0386868
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0385377
FNDC3B fibronectin type III domain containing 3B 0.0384691
NFE2L1 nuclear factor, erythroid 2-like 1 0.0366986
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.03497
RNF144A ring finger protein 144A 0.0349344
MT2A metallothionein 2A 0.0338679
DNMBP dynamin binding protein 0.0334961
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0330576
MSN moesin 0.0324099
NOTCH2 notch 2 0.0322676
HDAC9 histone deacetylase 9 0.0321208
RRM2 ribonucleotide reductase M2 0.0318889
POTEF POTE ankyrin domain family, member F 0.031369
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0313608
SVIL supervillin 0.031127
ASPH aspartate beta-hydroxylase 0.0311196
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0310762
PLEC plectin 0.0300471
MACF1 microtubule-actin crosslinking factor 1 0.0299698
NAV2 neuron navigator 2 0.0299103
EGFR epidermal growth factor receptor 0.0296133
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0293433
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0292702
RNF213 ring finger protein 213 0.0289462
PICALM phosphatidylinositol binding clathrin assembly protein 0.0287565
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0287505
L1CAM L1 cell adhesion molecule 0.0287488
EEF2 eukaryotic translation elongation factor 2 0.0286997
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0286797
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0286746
AFF3 AF4/FMR2 family, member 3 0.028563
FSTL1 follistatin-like 1 0.0283816
SP3 Sp3 transcription factor 0.0278736
PRELID2 PRELI domain containing 2 0.0271944
FAT1 FAT atypical cadherin 1 0.0271192
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0269295
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0264192
SMAD3 SMAD family member 3 0.0261819
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0261657
MPRIP myosin phosphatase Rho interacting protein 0.0257218
LNPEP leucyl/cystinyl aminopeptidase 0.0256788
DST dystonin 0.0253912
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0249729
AHNAK2 AHNAK nucleoprotein 2 0.0249349
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0244294
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0240768
MKI67 marker of proliferation Ki-67 0.0235821
COL5A1 collagen, type V, alpha 1 0.0235251
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0229195
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0228599
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0226075
CDH13 cadherin 13 0.0223465
TGFBR1 transforming growth factor, beta receptor 1 0.0221963
RABGAP1L RAB GTPase activating protein 1-like 0.0214861
SLC22A23 solute carrier family 22, member 23 0.0214715
DGKG diacylglycerol kinase, gamma 90kDa 0.0212906
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0211305
ZNF148 zinc finger protein 148 0.0210248
NT5E 5'-nucleotidase, ecto (CD73) 0.0208932
LHFPL6 LHFPL tetraspan subfamily member 6 0.0208225
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0207633
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0207315
PSD3 pleckstrin and Sec7 domain containing 3 0.020693
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0205183
RFTN1 raftlin, lipid raft linker 1 0.0204548
SDCCAG8 serologically defined colon cancer antigen 8 0.0203073
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0203048
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0201421
ABTB3 ankyrin repeat and BTB domain containing 3 0.0200077
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0198749

decreased expression

Symbol Name Standardized Value
ABI3BP ABI family, member 3 (NESH) binding protein -0.176603
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.130556
FN1 fibronectin 1 -0.119852
NDRG1 N-myc downstream regulated 1 -0.110907
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.105389
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0913398
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0907061
CSTB cystatin B (stefin B) -0.0848932
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0794712
VIM vimentin -0.0746376
SAMD9 sterile alpha motif domain containing 9 -0.0737115
CCND1 cyclin D1 -0.0734554
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0716415
SLC38A1 solute carrier family 38, member 1 -0.0679514
LMNA lamin A/C -0.0666562
SPAG9 sperm associated antigen 9 -0.0656621
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0617042
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0567154
SUCNR1 succinate receptor 1 -0.05236
CAVIN1 caveolae associated protein 1 -0.0492848
DLG1 discs, large homolog 1 (Drosophila) -0.048881
RSAD2 radical S-adenosyl methionine domain containing 2 -0.048775
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.048142
SQSTM1 sequestosome 1 -0.0470637
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0469539
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0460972
COL8A1 collagen, type VIII, alpha 1 -0.0447343
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0440227
TPM4 tropomyosin 4 -0.0437846
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0427114
GOLGA4 golgin A4 -0.0424725
MEIS2 Meis homeobox 2 -0.0406898
S100A6 S100 calcium binding protein A6 -0.0403224
MAP1B microtubule-associated protein 1B -0.0401935
GARS1 glycyl-tRNA synthetase 1 -0.0399398
MSI2 musashi RNA-binding protein 2 -0.0387592
IFI16 interferon, gamma-inducible protein 16 -0.0373165
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0372157
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0369508
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0365382
HSPB1 heat shock 27kDa protein 1 -0.0358078
TMSB10 thymosin beta 10 -0.0352457
IL7R interleukin 7 receptor -0.034879
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0348723
S100A10 S100 calcium binding protein A10 -0.0347992
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0343807
VDAC1 voltage-dependent anion channel 1 -0.0341596
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0340516
PLAUR plasminogen activator, urokinase receptor -0.0340239
IARS1 isoleucyl-tRNA synthetase 1 -0.0331817
TNS3 tensin 3 -0.0321241
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.032111
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0315268
HLA-C major histocompatibility complex, class I, C -0.0313872
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0301816
RIGI RNA sensor RIG-I -0.029918
FGF13 fibroblast growth factor 13 -0.0298163
DDIT4 DNA-damage-inducible transcript 4 -0.0297353
NAP1L1 nucleosome assembly protein 1-like 1 -0.0296951
RRBP1 ribosome binding protein 1 -0.02945
PTMA prothymosin, alpha -0.0291674
TPM1 tropomyosin 1 (alpha) -0.0288821
KDM3A lysine (K)-specific demethylase 3A -0.0283165
SOD2 superoxide dismutase 2, mitochondrial -0.0281054
HILPDA hypoxia inducible lipid droplet-associated -0.0280921
ADM adrenomedullin -0.0280877
HLA-B major histocompatibility complex, class I, B -0.0278867
FNDC3A fibronectin type III domain containing 3A -0.0278276
H3-3B H3.3 histone B -0.0277888
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0276133
TPT1 tumor protein, translationally-controlled 1 -0.0274363
BHLHE40 basic helix-loop-helix family, member e40 -0.0274258
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0272776
FTL ferritin, light polypeptide -0.0272227
WARS1 tryptophanyl-tRNA synthetase 1 -0.0271648
ANKRD10 ankyrin repeat domain 10 -0.0270396
RAB7A RAB7A, member RAS oncogene family -0.0269762
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.026745
OASL 2'-5'-oligoadenylate synthetase-like -0.0264882
JUN jun proto-oncogene -0.0264776
TUBB tubulin, beta class I -0.0260516
KDM5B lysine (K)-specific demethylase 5B -0.0260309
MX2 MX dynamin-like GTPase 2 -0.0259378
PLCB4 phospholipase C, beta 4 -0.0259027
S100A4 S100 calcium binding protein A4 -0.0258657
TAGLN2 transgelin 2 -0.0258178
IFIH1 interferon induced with helicase C domain 1 -0.025351
ZMYND8 zinc finger, MYND-type containing 8 -0.0251283
THY1 Thy-1 cell surface antigen -0.0251146
IFITM3 interferon induced transmembrane protein 3 -0.0250616
WSB1 WD repeat and SOCS box containing 1 -0.0250592
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0244442
B2M beta-2-microglobulin -0.0243513
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0243159
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0240627
COL1A1 collagen, type I, alpha 1 -0.024058
ULK1 unc-51 like autophagy activating kinase 1 -0.0238355
MYL12B myosin, light chain 12B, regulatory -0.0238153
KLF6 Kruppel-like factor 6 -0.023651
AFF4 AF4/FMR2 family, member 4 -0.0235235