Gallic acid_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.201558
YAP1 Yes-associated protein 1 0.134861
ACTG1 actin gamma 1 0.123697
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0962897
AHNAK AHNAK nucleoprotein 0.0936327
RRM2 ribonucleotide reductase M2 0.0861075
MACF1 microtubule-actin crosslinking factor 1 0.080418
ENO1 enolase 1, (alpha) 0.0803271
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0722511
CALR calreticulin 0.0716516
ASPH aspartate beta-hydroxylase 0.0701012
NHSL1 NHS-like 1 0.0695046
PCBP2 poly(rC) binding protein 2 0.0689864
ANXA1 annexin A1 0.0658989
POTEF POTE ankyrin domain family, member F 0.065817
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0628539
EIF4B eukaryotic translation initiation factor 4B 0.061805
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0611345
MKI67 marker of proliferation Ki-67 0.0569306
SPATS2 spermatogenesis associated, serine-rich 2 0.0529804
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.052695
TPM3 tropomyosin 3 0.052323
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0515028
PTMA prothymosin, alpha 0.0508326
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.049566
PGK1 phosphoglycerate kinase 1 0.0492934
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0489782
RPL3 ribosomal protein L3 0.04883
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0467038
HSPA8 heat shock 70kDa protein 8 0.0460137
LRMDA leucine rich melanocyte differentiation associated 0.0459796
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0443688
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0435763
USP9X ubiquitin specific peptidase 9, X-linked 0.0427918
VMP1 vacuole membrane protein 1 0.0424244
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0419004
AKAP12 A kinase (PRKA) anchor protein 12 0.0416712
MYH9 myosin, heavy chain 9, non-muscle 0.0415053
WWOX WW domain containing oxidoreductase 0.0413455
FTL ferritin, light polypeptide 0.041332
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0409283
TPM4 tropomyosin 4 0.0408696
IPO7 importin 7 0.040319
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0385699
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.038209
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0370762
MCL1 myeloid cell leukemia 1 0.0369637
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365108
NLGN1 neuroligin 1 0.0357799
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0356609
PDIA6 protein disulfide isomerase family A, member 6 0.0350326
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0346916
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0340867
PKM pyruvate kinase, muscle 0.0336583
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0334816
PRKCE protein kinase C, epsilon 0.0329947
PDGFC platelet derived growth factor C 0.032914
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0327709
CEP192 centrosomal protein 192kDa 0.0326324
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0319499
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.031937
RPL4 ribosomal protein L4 0.0318355
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0314754
PDE4B phosphodiesterase 4B, cAMP-specific 0.0313933
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0313581
PRELID2 PRELI domain containing 2 0.0310752
RPL37A ribosomal protein L37a 0.0309907
CANX calnexin 0.0305471
ZEB1 zinc finger E-box binding homeobox 1 0.0296951
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.029246
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0292156
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0284751
KDM2A lysine (K)-specific demethylase 2A 0.028471
PDE4D phosphodiesterase 4D, cAMP-specific 0.0283203
EEF2 eukaryotic translation elongation factor 2 0.0281712
RPS29 ribosomal protein S29 0.028111
ANKRD11 ankyrin repeat domain 11 0.0279386
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0276856
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0275825
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0267469
RNF213 ring finger protein 213 0.026571
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0265126
PDIA3 protein disulfide isomerase family A, member 3 0.0264844
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.026283
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0261214
SMC1A structural maintenance of chromosomes 1A 0.025713
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0256402
FDPS farnesyl diphosphate synthase 0.0253025
ADAR adenosine deaminase, RNA-specific 0.0252064
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0246794
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0246163
DIAPH1 diaphanous-related formin 1 0.0245452
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0244766
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0242626
WNK1 WNK lysine deficient protein kinase 1 0.0241931
SDK1 sidekick cell adhesion molecule 1 0.0241291
DST dystonin 0.0240588
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0239954
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0239632
EZR ezrin 0.0239525

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.167038
SLC38A2 solute carrier family 38, member 2 -0.109534
AREG amphiregulin -0.0635937
TMSB10 thymosin beta 10 -0.0587997
ANKRD12 ankyrin repeat domain 12 -0.0558982
MYL12B myosin, light chain 12B, regulatory -0.0550572
KLF6 Kruppel-like factor 6 -0.054511
MGAT4C MGAT4 family, member C -0.0500863
ZBTB20 zinc finger and BTB domain containing 20 -0.0487944
EDN1 endothelin 1 -0.0482461
CELF2 CUGBP, Elav-like family member 2 -0.043788
EGR1 early growth response 1 -0.0432569
NAP1L1 nucleosome assembly protein 1-like 1 -0.0413069
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0404457
ZNF804A zinc finger protein 804A -0.0403167
CXADR coxsackie virus and adenovirus receptor -0.0392597
RAB7A RAB7A, member RAS oncogene family -0.0388548
TENM3 teneurin transmembrane protein 3 -0.0378346
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0359299
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0352308
NABP1 nucleic acid binding protein 1 -0.0350539
SYT1 synaptotagmin I -0.0347579
RPL26 ribosomal protein L26 -0.0344402
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0343912
VIM vimentin -0.0343214
ADGRG6 adhesion G protein-coupled receptor G6 -0.0327428
OXR1 oxidation resistance 1 -0.0327409
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0310768
PCNP PEST proteolytic signal containing nuclear protein -0.0305378
RPLP0 ribosomal protein, large, P0 -0.0305038
BIRC3 baculoviral IAP repeat containing 3 -0.0303475
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0303031
YBX3 Y box binding protein 3 -0.0299931
SEC62 SEC62 homolog (S. cerevisiae) -0.0299154
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0293289
HMGA1 high mobility group AT-hook 1 -0.0292847
PCDH7 protocadherin 7 -0.0291351
DLC1 DLC1 Rho GTPase activating protein -0.0291
GARS1 glycyl-tRNA synthetase 1 -0.0288118
CEP95 centrosomal protein 95kDa -0.0286291
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.028509
KLHL24 kelch-like family member 24 -0.0282424
DPYD dihydropyrimidine dehydrogenase -0.0279094
CLDN1 claudin 1 -0.0276551
WDR43 WD repeat domain 43 -0.0275314
RPS24 ribosomal protein S24 -0.0273564
TSC22D2 TSC22 domain family, member 2 -0.0272972
FSTL5 follistatin-like 5 -0.0269031
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0265746
ELP4 elongator acetyltransferase complex subunit 4 -0.0263885
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0263732
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0259868
TMEM123 transmembrane protein 123 -0.0258734
U2SURP U2 snRNP-associated SURP domain containing -0.0255387
ZNF217 zinc finger protein 217 -0.0254211
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0251823
MON2 MON2 homolog (S. cerevisiae) -0.0251627
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0251015
EPHA5 EPH receptor A5 -0.0242826
TXNRD1 thioredoxin reductase 1 -0.0242467
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0241665
ARL5B ADP-ribosylation factor-like 5B -0.023784
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0237164
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0236541
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.023169
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0231441
BRWD1 bromodomain and WD repeat domain containing 1 -0.0230648
TMEM41B transmembrane protein 41B -0.0224871
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0217623
RB1CC1 RB1-inducible coiled-coil 1 -0.0213084
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0212962
POU2F1 POU class 2 homeobox 1 -0.0208744
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0207466
ZFP91 ZFP91 zinc finger protein -0.0206568
RPS21 ribosomal protein S21 -0.0202499
RPL12 ribosomal protein L12 -0.0201154
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0200991
RPS6 ribosomal protein S6 -0.0200699
FBXL20 F-box and leucine-rich repeat protein 20 -0.0200531
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0199504
ARHGAP12 Rho GTPase activating protein 12 -0.0197379
ATG12 autophagy related 12 -0.0195771
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0194739
RAB1A RAB1A, member RAS oncogene family -0.0193875
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0192574
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0190764
CCNL1 cyclin L1 -0.0190397
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.0190392
PRR16 proline rich 16 -0.0189536
WASF2 WAS protein family, member 2 -0.0188841
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0188286
PFN1 profilin 1 -0.0187268
EHBP1 EH domain binding protein 1 -0.0183391
QKI QKI, KH domain containing, RNA binding -0.018204
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0181717
MDN1 MDN1, midasin homolog (yeast) -0.0181494
H1-0 H1.0 linker histone -0.0180895
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0180206
RNF13 ring finger protein 13 -0.017882
OSBPL8 oxysterol binding protein-like 8 -0.0177819