Gallic acid_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.353942
MYH9 myosin, heavy chain 9, non-muscle 0.1012
APP amyloid beta (A4) precursor protein 0.0932534
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0814691
AHNAK AHNAK nucleoprotein 0.0797411
CD44 CD44 molecule (Indian blood group) 0.0713189
FRMD4A FERM domain containing 4A 0.0700697
NRP2 neuropilin 2 0.0658124
RAI14 retinoic acid induced 14 0.0644272
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0613632
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0609146
RNF213 ring finger protein 213 0.0583206
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0572663
CA12 carbonic anhydrase XII 0.0556528
TXNRD1 thioredoxin reductase 1 0.0532259
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0516241
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0506992
SMAD3 SMAD family member 3 0.0506518
MX1 MX dynamin-like GTPase 1 0.0487227
LOXL2 lysyl oxidase-like 2 0.0485946
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0477223
FAT1 FAT atypical cadherin 1 0.0472951
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0465819
NAV2 neuron navigator 2 0.0453239
NRIP1 nuclear receptor interacting protein 1 0.0441968
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0433255
NFE2L1 nuclear factor, erythroid 2-like 1 0.0430639
IFI44L interferon-induced protein 44-like 0.0430526
ERRFI1 ERBB receptor feedback inhibitor 1 0.0418339
TPM3 tropomyosin 3 0.0413533
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.040783
EFNA5 ephrin-A5 0.0389684
ANXA2 annexin A2 0.0386984
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0383617
MYOF myoferlin 0.0383076
TRIO trio Rho guanine nucleotide exchange factor 0.0378247
PLIN2 perilipin 2 0.0376645
NAMPT nicotinamide phosphoribosyltransferase 0.0362331
RPL3 ribosomal protein L3 0.0356513
ENO1 enolase 1, (alpha) 0.0354373
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.035038
CALR calreticulin 0.0346464
EIF4A1 eukaryotic translation initiation factor 4A1 0.0331789
DST dystonin 0.0328052
COL4A1 collagen, type IV, alpha 1 0.0323082
DOCK5 dedicator of cytokinesis 5 0.0314137
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0313127
HIPK2 homeodomain interacting protein kinase 2 0.0305531
ANXA5 annexin A5 0.0294741
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0294425
JAK1 Janus kinase 1 0.028853
PBX1 pre-B-cell leukemia homeobox 1 0.0287822
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0284416
BZW1 basic leucine zipper and W2 domains 1 0.0282587
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0281595
PAX8 paired box 8 0.0281499
LDHA lactate dehydrogenase A 0.028025
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0274905
EGFR epidermal growth factor receptor 0.0273781
TLN1 talin 1 0.0268539
RRM2 ribonucleotide reductase M2 0.0268038
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.0258201
KLF7 Kruppel-like factor 7 (ubiquitous) 0.025452
PLK2 polo-like kinase 2 0.0251876
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0251863
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0251749
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0251309
MKI67 marker of proliferation Ki-67 0.0250823
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0248582
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0248433
EXOC4 exocyst complex component 4 0.0248104
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0247521
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0241532
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.024132
NRP1 neuropilin 1 0.0240926
RPL4 ribosomal protein L4 0.0235205
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0231103
EIF4H eukaryotic translation initiation factor 4H 0.0229355
COL4A2 collagen, type IV, alpha 2 0.0227869
PLEC plectin 0.0227546
SLTM SAFB-like, transcription modulator 0.022446
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0223948
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0220326
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0218001
FSTL1 follistatin-like 1 0.0214562
ADAR adenosine deaminase, RNA-specific 0.0213545
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0211458
CORO1C coronin, actin binding protein, 1C 0.0209624
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0203549
SLFN5 schlafen family member 5 0.0199729
ANXA1 annexin A1 0.0199482
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0197953
GOLM1 golgi membrane protein 1 0.019789
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0194365
TNIP1 TNFAIP3 interacting protein 1 0.0193879
ETV6 ets variant 6 0.019311
PFKP phosphofructokinase, platelet 0.019236
APLP2 amyloid beta (A4) precursor-like protein 2 0.0190275
MACF1 microtubule-actin crosslinking factor 1 0.0189414
EIF4B eukaryotic translation initiation factor 4B 0.0187858

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.174871
VIM vimentin -0.106601
TMSB10 thymosin beta 10 -0.0955622
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0938721
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0928502
RPS6 ribosomal protein S6 -0.0810728
FTL ferritin, light polypeptide -0.0804504
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0714248
HSPB1 heat shock 27kDa protein 1 -0.0671112
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0661638
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0657285
PFN1 profilin 1 -0.0594593
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0578719
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0550705
CTSD cathepsin D -0.0541941
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0533293
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0522268
TTC3 tetratricopeptide repeat domain 3 -0.0506913
COG5 component of oligomeric golgi complex 5 -0.0484595
RPL35A ribosomal protein L35a -0.0477013
PALLD palladin, cytoskeletal associated protein -0.041497
NUP98 nucleoporin 98kDa -0.0412252
SPAG9 sperm associated antigen 9 -0.0406583
RPL28 ribosomal protein L28 -0.0403012
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0370132
EXT1 exostosin glycosyltransferase 1 -0.0368219
SCFD2 sec1 family domain containing 2 -0.0359352
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0355053
RAB2A RAB2A, member RAS oncogene family -0.0347963
GOLGA4 golgin A4 -0.0347914
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0346767
MYADM myeloid-associated differentiation marker -0.0345562
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0344392
CADM1 cell adhesion molecule 1 -0.0343952
RPS5 ribosomal protein S5 -0.0324724
RND3 Rho family GTPase 3 -0.0324408
GDF15 growth differentiation factor 15 -0.0322692
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0319204
NOP58 NOP58 ribonucleoprotein -0.031865
RPL34 ribosomal protein L34 -0.0318404
INTS6 integrator complex subunit 6 -0.0318394
CYB5R3 cytochrome b5 reductase 3 -0.0316558
TRAM1 translocation associated membrane protein 1 -0.0310352
GNAS GNAS complex locus -0.030843
SUCO SUN domain containing ossification factor -0.0306071
RAB7A RAB7A, member RAS oncogene family -0.02991
MORF4L2 mortality factor 4 like 2 -0.0295183
RAP1B RAP1B, member of RAS oncogene family -0.0294376
RPS19 ribosomal protein S19 -0.0291725
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.028873
RAB1A RAB1A, member RAS oncogene family -0.0287461
UFM1 ubiquitin-fold modifier 1 -0.0286099
RPL8 ribosomal protein L8 -0.0285021
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0282413
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0281242
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0280896
RPS24 ribosomal protein S24 -0.0279984
MTDH metadherin -0.0278963
BIRC6 baculoviral IAP repeat containing 6 -0.0275699
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.0274717
FTH1 ferritin, heavy polypeptide 1 -0.0274153
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0273782
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0272432
UBAP2 ubiquitin associated protein 2 -0.027028
SDCBP syndecan binding protein (syntenin) -0.0270061
HM13 histocompatibility (minor) 13 -0.0268211
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0266741
COPA coatomer protein complex, subunit alpha -0.0266683
ELOVL5 ELOVL fatty acid elongase 5 -0.0265674
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0265181
RTN4 reticulon 4 -0.0261667
CDK13 cyclin-dependent kinase 13 -0.0259467
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259252
HLA-B major histocompatibility complex, class I, B -0.0259218
TPST1 tyrosylprotein sulfotransferase 1 -0.0258678
IARS1 isoleucyl-tRNA synthetase 1 -0.0258285
KYNU kynureninase -0.025396
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0253734
ZFAND3 zinc finger, AN1-type domain 3 -0.0253138
SBF2 SET binding factor 2 -0.025243
PTBP3 polypyrimidine tract binding protein 3 -0.0250723
FUS FUS RNA binding protein -0.0250078
ANKRD17 ankyrin repeat domain 17 -0.0247453
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -0.0247279
WDR43 WD repeat domain 43 -0.0246908
CCL2 chemokine (C-C motif) ligand 2 -0.0244192
EGR1 early growth response 1 -0.0244075
FOXO3 forkhead box O3 -0.024312
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0243006
AKAP9 A kinase (PRKA) anchor protein 9 -0.0242319
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0241898
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0241063
LIMA1 LIM domain and actin binding 1 -0.0239353
PNPLA8 patatin-like phospholipase domain containing 8 -0.0238921
TBC1D23 TBC1 domain family, member 23 -0.0238751
TSC22D2 TSC22 domain family, member 2 -0.0237863
TLE4 transducin-like enhancer of split 4 -0.0233752
ATP5F1B ATP synthase F1 subunit beta -0.02335
TPT1 tumor protein, translationally-controlled 1 -0.0231425
HMGA1 high mobility group AT-hook 1 -0.0228254