Gallic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.200192
MCL1 myeloid cell leukemia 1 0.136913
PDE10A phosphodiesterase 10A 0.120611
ARHGAP26 Rho GTPase activating protein 26 0.104096
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.103942
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0783953
KYNU kynureninase 0.0661691
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.062534
NRIP1 nuclear receptor interacting protein 1 0.0565214
SMAD3 SMAD family member 3 0.0556655
MYH9 myosin, heavy chain 9, non-muscle 0.0510834
FNDC3B fibronectin type III domain containing 3B 0.0495482
CEMIP cell migration inducing protein, hyaluronan binding 0.0494871
RPL4 ribosomal protein L4 0.0437471
ELL2 elongation factor, RNA polymerase II, 2 0.0434889
STC1 stanniocalcin 1 0.0432996
VMP1 vacuole membrane protein 1 0.040585
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0398517
AHNAK AHNAK nucleoprotein 0.039718
MSN moesin 0.0371234
GRAMD1B GRAM domain containing 1B 0.036456
RNF145 ring finger protein 145 0.0351496
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0336918
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.033577
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0333945
DGKD diacylglycerol kinase, delta 130kDa 0.0320578
TGM2 transglutaminase 2 0.031638
KANK1 KN motif and ankyrin repeat domains 1 0.0307282
WWC1 WW and C2 domain containing 1 0.0304006
BMP6 bone morphogenetic protein 6 0.0303504
DOCK4 dedicator of cytokinesis 4 0.029688
RPL3 ribosomal protein L3 0.0293436
ASPH aspartate beta-hydroxylase 0.0291952
WWTR1 WW domain containing transcription regulator 1 0.0289159
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0288332
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0285975
AXL AXL receptor tyrosine kinase 0.0273673
PCBP2 poly(rC) binding protein 2 0.027348
PDZD8 PDZ domain containing 8 0.0271323
WWOX WW domain containing oxidoreductase 0.0270319
AKAP13 A kinase (PRKA) anchor protein 13 0.0270304
TCIM transcriptional and immune response regulator 0.0268815
PDLIM5 PDZ and LIM domain 5 0.0267286
EIF4A1 eukaryotic translation initiation factor 4A1 0.0265013
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0258801
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0252686
VCL vinculin 0.024573
FAT1 FAT atypical cadherin 1 0.0245272
DOCK5 dedicator of cytokinesis 5 0.024462
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0243511
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0240836
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.024061
RIMKLB ribosomal modification protein rimK-like family member B 0.0240572
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0240525
EEF2 eukaryotic translation elongation factor 2 0.0239565
RASA2 RAS p21 protein activator 2 0.0237225
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0235766
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0231647
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0229054
UBASH3B ubiquitin associated and SH3 domain containing B 0.0223921
EIF4B eukaryotic translation initiation factor 4B 0.0223585
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.022247
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0219017
ITPRID2 ITPR interacting domain containing 2 0.0218188
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0213972
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0213218
ITGB5 integrin, beta 5 0.0211464
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0209089
POTEF POTE ankyrin domain family, member F 0.0206791
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0200424
TM4SF1 transmembrane 4 L six family member 1 0.0198441
IRAK2 interleukin-1 receptor-associated kinase 2 0.0195699
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0194907
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0192752
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.0188525
JAG1 jagged 1 0.0186444
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0181783
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0178215
SMOC1 SPARC related modular calcium binding 1 0.0177954
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0177597
ERRFI1 ERBB receptor feedback inhibitor 1 0.0176129
NPC1 Niemann-Pick disease, type C1 0.0175917
IPO7 importin 7 0.0174489
BCL2L1 BCL2-like 1 0.0174067
EPAS1 endothelial PAS domain protein 1 0.0173295
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0172341
CAPRIN2 caprin family member 2 0.0171025
SPRED1 sprouty-related, EVH1 domain containing 1 0.017051
RPL23 ribosomal protein L23 0.0170132
MPRIP myosin phosphatase Rho interacting protein 0.0167457
MLPH melanophilin 0.0166306
RPS3 ribosomal protein S3 0.0165734
PM20D1 peptidase M20 domain containing 1 0.0165652
SFPQ splicing factor proline/glutamine-rich 0.0163351
ACTN4 actinin, alpha 4 0.0162868
TOP1 topoisomerase (DNA) I 0.0162724
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0158138
ENO1 enolase 1, (alpha) 0.0156642
DPY19L1 dpy-19-like 1 (C. elegans) 0.0156295
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0155472

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.184445
TMSB10 thymosin beta 10 -0.174797
IGFBP3 insulin-like growth factor binding protein 3 -0.171201
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147888
VIM vimentin -0.101864
IGFBP4 insulin-like growth factor binding protein 4 -0.093173
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0830703
RPS6 ribosomal protein S6 -0.0694423
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0656514
RRBP1 ribosome binding protein 1 -0.0631017
CA12 carbonic anhydrase XII -0.0607755
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0572325
FTL ferritin, light polypeptide -0.0559207
GOLGA4 golgin A4 -0.0555567
FTH1 ferritin, heavy polypeptide 1 -0.0534155
ANXA2 annexin A2 -0.0533478
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0522499
S100A6 S100 calcium binding protein A6 -0.0503081
KRT81 keratin 81, type II -0.0496876
S100A10 S100 calcium binding protein A10 -0.0469633
ANXA4 annexin A4 -0.0467087
SPAG9 sperm associated antigen 9 -0.0464735
TXNRD1 thioredoxin reductase 1 -0.0454417
BTG1 B-cell translocation gene 1, anti-proliferative -0.045279
HMGA1 high mobility group AT-hook 1 -0.0448108
RAB1A RAB1A, member RAS oncogene family -0.0436555
ZMYND8 zinc finger, MYND-type containing 8 -0.0436132
EGFR epidermal growth factor receptor -0.0433129
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0431961
TNS3 tensin 3 -0.042439
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0423733
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0416724
PFN1 profilin 1 -0.0409894
KCTD9 potassium channel tetramerization domain containing 9 -0.0403306
MT1X metallothionein 1X -0.0391939
RPS19 ribosomal protein S19 -0.0389209
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0384848
MAP1B microtubule-associated protein 1B -0.0377674
TRIO trio Rho guanine nucleotide exchange factor -0.0372894
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0370416
TPT1 tumor protein, translationally-controlled 1 -0.0365071
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0350271
MYADM myeloid-associated differentiation marker -0.0345596
AUTS2 autism susceptibility candidate 2 -0.0338191
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0332783
MORF4L2 mortality factor 4 like 2 -0.0330857
CALU calumenin -0.0326916
CCDC88A coiled-coil domain containing 88A -0.0323158
NAP1L1 nucleosome assembly protein 1-like 1 -0.0323072
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0321245
PGK1 phosphoglycerate kinase 1 -0.0316682
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0316416
VDAC1 voltage-dependent anion channel 1 -0.0316135
BIRC6 baculoviral IAP repeat containing 6 -0.0314553
AKR1C2 aldo-keto reductase family 1, member C2 -0.0309299
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0309228
WSB1 WD repeat and SOCS box containing 1 -0.0308007
ACBD3 acyl-CoA binding domain containing 3 -0.0303047
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0300676
KLF6 Kruppel-like factor 6 -0.0293143
SBF2 SET binding factor 2 -0.0290391
LMAN1 lectin, mannose-binding, 1 -0.0290329
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0287142
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0284213
EHBP1 EH domain binding protein 1 -0.0282633
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0280012
HDLBP high density lipoprotein binding protein -0.0277669
RAI14 retinoic acid induced 14 -0.0277365
KDM3A lysine (K)-specific demethylase 3A -0.027602
GNAS GNAS complex locus -0.0275491
FBXL2 F-box and leucine-rich repeat protein 2 -0.0274874
LOC112694756 uncharaterized LOC112694756 -0.02737
H1-0 H1.0 linker histone -0.0269277
GPC6 glypican 6 -0.0265576
USP3 ubiquitin specific peptidase 3 -0.0264981
CANX calnexin -0.026366
SQSTM1 sequestosome 1 -0.0261991
SETD5 SET domain containing 5 -0.0258261
SEC31A SEC31 homolog A (S. cerevisiae) -0.0257968
MYO1E myosin IE -0.0252048
PRKCA protein kinase C, alpha -0.025109
TPM4 tropomyosin 4 -0.0251058
BASP1 brain abundant, membrane attached signal protein 1 -0.0250869
RAI1 retinoic acid induced 1 -0.0250867
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0250612
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0249232
SDCBP syndecan binding protein (syntenin) -0.0248959
MON2 MON2 homolog (S. cerevisiae) -0.0248498
CAVIN1 caveolae associated protein 1 -0.0248182
LMNA lamin A/C -0.0244797
RPL8 ribosomal protein L8 -0.0244348
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.024434
THOC2 THO complex 2 -0.0243946
WDR45B WD repeat domain 45B -0.0243617
RPLP1 ribosomal protein, large, P1 -0.0242647
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0240066
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0238193
RPL32 ribosomal protein L32 -0.0235017
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0232921
RAP1B RAP1B, member of RAS oncogene family -0.0232394