Gallic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.143984
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.123079
SACK1A scaffolding CK1 anchoring protein A 0.0997175
MCL1 myeloid cell leukemia 1 0.0734616
TXNIP thioredoxin interacting protein 0.0715853
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0660596
POTEF POTE ankyrin domain family, member F 0.0619039
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.060586
APLP2 amyloid beta (A4) precursor-like protein 2 0.0594115
EXT1 exostosin glycosyltransferase 1 0.0589324
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0580678
KLK10 kallikrein-related peptidase 10 0.0572218
CLMP CXADR-like membrane protein 0.0487236
MSN moesin 0.0480805
PPARD peroxisome proliferator-activated receptor delta 0.047701
FMNL2 formin-like 2 0.0468786
BMP6 bone morphogenetic protein 6 0.0466209
MXD1 MAX dimerization protein 1 0.0464316
ABTB3 ankyrin repeat and BTB domain containing 3 0.0449073
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0425618
PMM2 phosphomannomutase 2 0.0420809
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0418058
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0404289
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0401938
THSD4 thrombospondin, type I, domain containing 4 0.0401312
ZSWIM6 zinc finger, SWIM-type containing 6 0.0388334
TPM3 tropomyosin 3 0.0358112
BLZF1 basic leucine zipper nuclear factor 1 0.0351666
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0349816
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.034327
TPM4 tropomyosin 4 0.0327606
TTC3 tetratricopeptide repeat domain 3 0.0320258
ZCCHC7 zinc finger, CCHC domain containing 7 0.0313992
AK1 adenylate kinase 1 0.0312359
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.031183
ANTXR2 anthrax toxin receptor 2 0.0305395
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0297553
PARD3 par-3 family cell polarity regulator 0.0291152
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0288947
ENO1 enolase 1, (alpha) 0.0283476
SRRM2 serine/arginine repetitive matrix 2 0.0269135
ZHX2 zinc fingers and homeoboxes 2 0.0268114
F3 coagulation factor III (thromboplastin, tissue factor) 0.0266082
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0261568
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0254951
FTL ferritin, light polypeptide 0.0252681
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0252417
HDAC9 histone deacetylase 9 0.0252351
DIAPH1 diaphanous-related formin 1 0.0250759
SCFD2 sec1 family domain containing 2 0.0246055
SND1 staphylococcal nuclease and tudor domain containing 1 0.0245055
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0243619
PICALM phosphatidylinositol binding clathrin assembly protein 0.024147
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0241428
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0240955
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0238893
TGFA transforming growth factor, alpha 0.0236815
TLN1 talin 1 0.0235545
MMP1 matrix metallopeptidase 1 0.0234655
BMAL2 basic helix-loop-helix ARNT like 2 0.023372
DENND2C DENN/MADD domain containing 2C 0.0231019
COPA coatomer protein complex, subunit alpha 0.0226996
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0226598
AKAP9 A kinase (PRKA) anchor protein 9 0.0223704
UBA6 ubiquitin-like modifier activating enzyme 6 0.022347
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0221594
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0221042
GOLGB1 golgin B1 0.0219091
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0218793
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0217875
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0216938
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0215026
SETX senataxin 0.0214504
CDK13 cyclin-dependent kinase 13 0.0214446
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0212578
UBE2H ubiquitin-conjugating enzyme E2H 0.0212481
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.021074
SRP54 signal recognition particle 54kDa 0.0207411
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0207184
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0206438
MACF1 microtubule-actin crosslinking factor 1 0.020448
INTS6 integrator complex subunit 6 0.0202661
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.020188
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0200053
SMC3 structural maintenance of chromosomes 3 0.0199492
UBAP2 ubiquitin associated protein 2 0.0198898
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0196714
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0195034
TRRAP transformation/transcription domain-associated protein 0.0193901
SEC31A SEC31 homolog A (S. cerevisiae) 0.0193826
MYO5B myosin VB 0.0191811
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0190773
PDLIM5 PDZ and LIM domain 5 0.0188872
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0187819
TBC1D15 TBC1 domain family, member 15 0.0187682
EVI5 ecotropic viral integration site 5 0.0187526
EGR1 early growth response 1 0.0187343
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0187053
AHRR aryl-hydrocarbon receptor repressor 0.0186212
RNF213 ring finger protein 213 0.0182585

decreased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 -0.147358
TMSB10 thymosin beta 10 -0.136898
LMTK2 lemur tyrosine kinase 2 -0.116108
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.105392
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.104727
AKAP12 A kinase (PRKA) anchor protein 12 -0.101147
SMAD3 SMAD family member 3 -0.0953266
PTPRR protein tyrosine phosphatase, receptor type, R -0.0940855
S100A10 S100 calcium binding protein A10 -0.0922261
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0906617
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0897144
PTMA prothymosin, alpha -0.0897008
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0877379
ITGA6 integrin, alpha 6 -0.0806806
SQSTM1 sequestosome 1 -0.0800021
VIM vimentin -0.0782837
MYOF myoferlin -0.0782498
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0780627
LMO7 LIM domain 7 -0.0777409
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0771237
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0750564
FNDC3B fibronectin type III domain containing 3B -0.0744138
TPT1 tumor protein, translationally-controlled 1 -0.0717783
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0716242
ASPH aspartate beta-hydroxylase -0.0711377
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0704251
VCAN versican -0.0692648
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0654738
EMP1 epithelial membrane protein 1 -0.0649785
ACTG1 actin gamma 1 -0.0618694
EPCAM epithelial cell adhesion molecule -0.0610563
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0607023
OSBPL3 oxysterol binding protein-like 3 -0.0604301
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.059016
TSC22D2 TSC22 domain family, member 2 -0.0587312
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0585814
NCOA3 nuclear receptor coactivator 3 -0.0582403
NEK7 NIMA-related kinase 7 -0.0562999
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.0560986
RBM39 RNA binding motif protein 39 -0.0559258
TRA2A transformer 2 alpha homolog (Drosophila) -0.0551637
VCL vinculin -0.0540091
S100A4 S100 calcium binding protein A4 -0.0537584
TOP1 topoisomerase (DNA) I -0.0527817
RTN4 reticulon 4 -0.0521648
JMJD1C jumonji domain containing 1C -0.0520138
RICTOR RPTOR independent companion of MTOR, complex 2 -0.051463
ADAM9 ADAM metallopeptidase domain 9 -0.0510565
HMGA1 high mobility group AT-hook 1 -0.0504032
MED13L mediator complex subunit 13-like -0.0498604
GLS2 glutaminase 2 (liver, mitochondrial) -0.0496357
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0496192
RAD21 RAD21 homolog (S. pombe) -0.0490002
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0487957
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0479303
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0465013
RPL11 ribosomal protein L11 -0.0464685
LOC112694756 uncharaterized LOC112694756 -0.0464181
RPL34 ribosomal protein L34 -0.0456762
KDM3A lysine (K)-specific demethylase 3A -0.0455307
RPS2 ribosomal protein S2 -0.045121
KRT8 keratin 8, type II -0.0448349
RPS24 ribosomal protein S24 -0.0442233
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0440833
ANLN anillin, actin binding protein -0.0431933
ARHGAP26 Rho GTPase activating protein 26 -0.0431909
TRIO trio Rho guanine nucleotide exchange factor -0.0430782
ZNF292 zinc finger protein 292 -0.042686
ARHGAP42 Rho GTPase activating protein 42 -0.0425167
RPL30 ribosomal protein L30 -0.0424432
SLMAP sarcolemma associated protein -0.0423935
SPAG9 sperm associated antigen 9 -0.0423682
RAB1A RAB1A, member RAS oncogene family -0.0423133
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0422675
ARHGAP5 Rho GTPase activating protein 5 -0.0421117
NAMPT nicotinamide phosphoribosyltransferase -0.0419254
FOXO3 forkhead box O3 -0.0416897
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0416878
H1-0 H1.0 linker histone -0.0414189
COL17A1 collagen, type XVII, alpha 1 -0.0412135
PPARG peroxisome proliferator-activated receptor gamma -0.0411864
NDRG1 N-myc downstream regulated 1 -0.041025
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0407693
RPL26 ribosomal protein L26 -0.0402488
CD2AP CD2-associated protein -0.0397351
RPL8 ribosomal protein L8 -0.0397263
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0396267
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0394028
WASF2 WAS protein family, member 2 -0.0390193
DSG2 desmoglein 2 -0.0386673
TMSB4X thymosin beta 4, X-linked -0.0385996
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0382137
HPCAL1 hippocalcin-like 1 -0.0381286
MYO6 myosin VI -0.0380953
PTK2 protein tyrosine kinase 2 -0.0380603
RPL12 ribosomal protein L12 -0.0380592
ZEB1 zinc finger E-box binding homeobox 1 -0.0379479
SLTM SAFB-like, transcription modulator -0.0377136
TUFT1 tuftelin 1 -0.0374844
SBF2 SET binding factor 2 -0.0368324