Gallic acid_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.0981044
AHNAK AHNAK nucleoprotein 0.0968763
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0921222
VMP1 vacuole membrane protein 1 0.091367
RPL23 ribosomal protein L23 0.0894241
ENO1 enolase 1, (alpha) 0.07233
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0694893
FNDC3A fibronectin type III domain containing 3A 0.0665801
CDK12 cyclin-dependent kinase 12 0.0620059
ANKRD36C ankyrin repeat domain 36C 0.0596772
LIMCH1 LIM and calponin homology domains 1 0.0587048
SRCIN1 SRC kinase signaling inhibitor 1 0.058477
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 0.0567667
DUSP16 dual specificity phosphatase 16 0.0564274
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0561011
VCP valosin containing protein 0.053924
FTH1 ferritin, heavy polypeptide 1 0.0494182
NTN4 netrin 4 0.049112
NRIP1 nuclear receptor interacting protein 1 0.0482312
MCL1 myeloid cell leukemia 1 0.0480137
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0479277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0473293
BZW1 basic leucine zipper and W2 domains 1 0.0464772
HSPA8 heat shock 70kDa protein 8 0.0456436
SP100 SP100 nuclear antigen 0.0449801
ANXA2 annexin A2 0.0445877
ZNFX1 zinc finger, NFX1-type containing 1 0.043789
THSD4 thrombospondin, type I, domain containing 4 0.0432933
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.041684
ASPH aspartate beta-hydroxylase 0.0413818
ADAR adenosine deaminase, RNA-specific 0.0406999
PGK1 phosphoglycerate kinase 1 0.0403732
SMYD3 SET and MYND domain containing 3 0.0397833
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0395811
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0393232
RIMS2 regulating synaptic membrane exocytosis 2 0.0374258
MLPH melanophilin 0.0373602
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0373504
MYOF myoferlin 0.0371036
IFI6 interferon, alpha-inducible protein 6 0.036946
CEP250 centrosomal protein 250kDa 0.0362595
DSPP dentin sialophosphoprotein 0.035448
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0346698
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.034503
APP amyloid beta (A4) precursor protein 0.0342989
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0340375
SGMS1 sphingomyelin synthase 1 0.0334566
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0333734
DOCK5 dedicator of cytokinesis 5 0.032796
AHR aryl hydrocarbon receptor 0.032349
DIAPH1 diaphanous-related formin 1 0.0318499
RNF213 ring finger protein 213 0.0317876
NEBL nebulette 0.031743
TPM3 tropomyosin 3 0.031679
YAP1 Yes-associated protein 1 0.0312211
SERINC3 serine incorporator 3 0.0309217
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.030884
SET SET nuclear proto-oncogene 0.0308717
NIBAN2 niban apoptosis regulator 2 0.0306267
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0302564
EEF2 eukaryotic translation elongation factor 2 0.0301628
CSDE1 cold shock domain containing E1, RNA-binding 0.0301354
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0298207
KIF1A kinesin family member 1A 0.0295103
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0290901
CANX calnexin 0.0289445
KRT7 keratin 7, type II 0.028856
POTEF POTE ankyrin domain family, member F 0.0286386
SRRM2 serine/arginine repetitive matrix 2 0.0285998
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0285755
SYTL2 synaptotagmin-like 2 0.02839
ZHX2 zinc fingers and homeoboxes 2 0.028128
DUSP4 dual specificity phosphatase 4 0.0272664
PAWR PRKC, apoptosis, WT1, regulator 0.0267519
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0266661
KRT8 keratin 8, type II 0.0266648
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0265977
NRP1 neuropilin 1 0.0262223
ARHGAP35 Rho GTPase activating protein 35 0.0260282
ATXN1 ataxin 1 0.0259705
ENAH enabled homolog (Drosophila) 0.0258678
INSR insulin receptor 0.0257662
MYH9 myosin, heavy chain 9, non-muscle 0.0255839
ADGRG6 adhesion G protein-coupled receptor G6 0.0255622
IQGAP1 IQ motif containing GTPase activating protein 1 0.0253425
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0252838
APLP2 amyloid beta (A4) precursor-like protein 2 0.0252008
PLSCR1 phospholipid scramblase 1 0.0244935
EPAS1 endothelial PAS domain protein 1 0.0244119
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0243437
ALCAM activated leukocyte cell adhesion molecule 0.0242941
EIF4A2 eukaryotic translation initiation factor 4A2 0.0241338
KRT18 keratin 18, type I 0.0241167
EFNA5 ephrin-A5 0.0240472
MYO1D myosin ID 0.0236819
FBXW11 F-box and WD repeat domain containing 11 0.0235141
FAM219A family with sequence similarity 219, member A 0.0234235
LDHA lactate dehydrogenase A 0.0233863
GSK3B glycogen synthase kinase 3 beta 0.0233809
RPL3 ribosomal protein L3 0.0232332

decreased expression

Symbol Name Standardized Value
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.119324
NDRG1 N-myc downstream regulated 1 -0.0833764
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0596207
IGFBP5 insulin-like growth factor binding protein 5 -0.0550307
GRB7 growth factor receptor-bound protein 7 -0.0547209
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0537806
MT2A metallothionein 2A -0.0534554
GRB10 growth factor receptor-bound protein 10 -0.0502496
PBX1 pre-B-cell leukemia homeobox 1 -0.0493443
DTNA dystrobrevin, alpha -0.0431404
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0419882
FASN fatty acid synthase -0.0376714
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0367093
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0363478
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0362586
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0339998
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0338435
ZMYND8 zinc finger, MYND-type containing 8 -0.0306501
TMEM123 transmembrane protein 123 -0.0289871
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0279499
TMEM41B transmembrane protein 41B -0.0277322
CCSER1 coiled-coil serine-rich protein 1 -0.0271348
ZFAND3 zinc finger, AN1-type domain 3 -0.0267277
VIPR2 vasoactive intestinal peptide receptor 2 -0.0266936
SLMAP sarcolemma associated protein -0.0256492
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.025528
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0254789
GNAS GNAS complex locus -0.0253149
KAZN kazrin, periplakin interacting protein -0.0251232
KMT2E lysine (K)-specific methyltransferase 2E -0.025115
CCNL1 cyclin L1 -0.0250166
RAB22A RAB22A, member RAS oncogene family -0.0250003
BCAS1 breast carcinoma amplified sequence 1 -0.0235211
SEC24A SEC24 family member A -0.0227495
SBF2 SET binding factor 2 -0.0227345
SEPTIN11 septin 11 -0.0226019
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0222693
TMEM165 transmembrane protein 165 -0.022067
S100A8 S100 calcium binding protein A8 -0.0220431
DHFR dihydrofolate reductase -0.0216622
TMSB10 thymosin beta 10 -0.0215231
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0214152
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0213578
LMNA lamin A/C -0.0213461
KIF16B kinesin family member 16B -0.0209706
FADS2 fatty acid desaturase 2 -0.0208293
ZNF292 zinc finger protein 292 -0.0206161
NAMPT nicotinamide phosphoribosyltransferase -0.0205497
ELOVL5 ELOVL fatty acid elongase 5 -0.0203858
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0201132
NCAM2 neural cell adhesion molecule 2 -0.0200141
MARK2 MAP/microtubule affinity-regulating kinase 2 -0.0199324
RAB6A RAB6A, member RAS oncogene family -0.0198248
GOLGA4 golgin A4 -0.0195105
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0194664
MSMO1 methylsterol monooxygenase 1 -0.0193489
KDM5B lysine (K)-specific demethylase 5B -0.0192641
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0191056
LRP1B low density lipoprotein receptor-related protein 1B -0.0189261
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0189104
AUTS2 autism susceptibility candidate 2 -0.018783
AHCTF1 AT hook containing transcription factor 1 -0.0187138
ITCH itchy E3 ubiquitin protein ligase -0.0186261
SCFD1 sec1 family domain containing 1 -0.0184505
PTMA prothymosin, alpha -0.0182513
MIDN midnolin -0.017727
CCNI cyclin I -0.0176396
SMC4 structural maintenance of chromosomes 4 -0.0176317
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0173009
RPS6 ribosomal protein S6 -0.0172764
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0171674
TAPBP TAP binding protein (tapasin) -0.0171454
ANLN anillin, actin binding protein -0.0171449
LMAN1 lectin, mannose-binding, 1 -0.0171251
TCEA2 transcription elongation factor A (SII), 2 -0.0170288
RAB7A RAB7A, member RAS oncogene family -0.017014
WSB1 WD repeat and SOCS box containing 1 -0.0169605
PIAS2 protein inhibitor of activated STAT, 2 -0.0169219
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0168735
PLSCR2 phospholipid scramblase 2 -0.016668
WWOX WW domain containing oxidoreductase -0.0165073
EXOC4 exocyst complex component 4 -0.0164103
PRR11 proline rich 11 -0.0162075
TUBA1B tubulin, alpha 1b -0.0161555
RPS24 ribosomal protein S24 -0.0161542
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0160813
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0160801
PTPRK protein tyrosine phosphatase, receptor type, K -0.0159607
CCNK cyclin K -0.0158821
SETD5 SET domain containing 5 -0.0157749
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0157334
POLD3 polymerase (DNA-directed), delta 3, accessory subunit -0.0156716
WASF2 WAS protein family, member 2 -0.0155707
TRA2B transformer 2 beta homolog (Drosophila) -0.0154743
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0154673
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0154497
RAB2A RAB2A, member RAS oncogene family -0.0154018
TENM4 teneurin transmembrane protein 4 -0.0152726
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0152213
FTL ferritin, light polypeptide -0.0150486