Gallic acid_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.235311
ENO1 enolase 1, (alpha) 0.182736
POTEF POTE ankyrin domain family, member F 0.130922
MYH9 myosin, heavy chain 9, non-muscle 0.116378
FAT1 FAT atypical cadherin 1 0.108661
PCBP2 poly(rC) binding protein 2 0.104501
EEF2 eukaryotic translation elongation factor 2 0.0914323
LDHA lactate dehydrogenase A 0.0859241
EZR ezrin 0.0776905
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0726791
APLP2 amyloid beta (A4) precursor-like protein 2 0.0703926
RPL3 ribosomal protein L3 0.0689528
MCL1 myeloid cell leukemia 1 0.0681518
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0590839
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0588679
ACTG1 actin gamma 1 0.0585743
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0568552
ANXA2 annexin A2 0.0553845
MT2A metallothionein 2A 0.0552454
EIF4A1 eukaryotic translation initiation factor 4A1 0.0544819
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0533357
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0510802
TPM3 tropomyosin 3 0.0504325
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0496962
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0466655
TXNIP thioredoxin interacting protein 0.0456039
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0455406
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0445483
DSPP dentin sialophosphoprotein 0.0443917
DSCAM Down syndrome cell adhesion molecule 0.0441353
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0425255
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0420445
HSPA8 heat shock 70kDa protein 8 0.0412457
SDC4 syndecan 4 0.041014
DIAPH1 diaphanous-related formin 1 0.0405353
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0404683
EIF4B eukaryotic translation initiation factor 4B 0.0400732
SFPQ splicing factor proline/glutamine-rich 0.0398034
TJP1 tight junction protein 1 0.0395405
IPO7 importin 7 0.0389846
YBX1 Y box binding protein 1 0.0381784
KRT8 keratin 8, type II 0.0363256
RPS12 ribosomal protein S12 0.0357348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0350961
ASPH aspartate beta-hydroxylase 0.0347772
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0342593
YAP1 Yes-associated protein 1 0.0324309
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0323921
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0322062
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0321392
BZW1 basic leucine zipper and W2 domains 1 0.0321003
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0309328
SRRM2 serine/arginine repetitive matrix 2 0.0307579
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0307183
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0305414
RPS3 ribosomal protein S3 0.0304655
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0296294
TIMP1 TIMP metallopeptidase inhibitor 1 0.029359
WWC1 WW and C2 domain containing 1 0.0290112
B2M beta-2-microglobulin 0.028717
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0286222
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0285528
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0285061
DOCK5 dedicator of cytokinesis 5 0.0284054
RPL4 ribosomal protein L4 0.0283813
BRD2 bromodomain containing 2 0.028298
PICALM phosphatidylinositol binding clathrin assembly protein 0.0278521
ENO2 enolase 2 (gamma, neuronal) 0.0274989
ZSWIM6 zinc finger, SWIM-type containing 6 0.027033
ATF4 activating transcription factor 4 0.0269202
ARCN1 archain 1 0.0267479
KTN1 kinectin 1 (kinesin receptor) 0.0261483
NFE2L1 nuclear factor, erythroid 2-like 1 0.0261081
ZC3H13 zinc finger CCCH-type containing 13 0.0258738
FLNA filamin A, alpha 0.0258341
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0257279
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0256564
PDIA4 protein disulfide isomerase family A, member 4 0.0255134
PNN pinin, desmosome associated protein 0.0253055
LOC102724023 ES1 protein homolog, mitochondrial 0.0252384
ATP13A3 ATPase type 13A3 0.0251321
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0251033
OGA O-GlcNAcase 0.025035
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0248312
GIGYF2 GRB10 interacting GYF protein 2 0.0246892
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0245669
RPL23 ribosomal protein L23 0.0242846
N4BP2L2 NEDD4 binding protein 2-like 2 0.0241255
EIF4H eukaryotic translation initiation factor 4H 0.0240813
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0237774
AFDN afadin, adherens junction formation factor 0.023681
TXNRD1 thioredoxin reductase 1 0.0236763
CSDE1 cold shock domain containing E1, RNA-binding 0.0236053
TOP2B topoisomerase (DNA) II beta 180kDa 0.0232528
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0231981
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0230367
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0229004
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0228347
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.022787
MYO5B myosin VB 0.0227397

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.180061
PTMA prothymosin, alpha -0.113551
TPT1 tumor protein, translationally-controlled 1 -0.109063
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0804975
TBC1D22A TBC1 domain family, member 22A -0.0701472
RPS6 ribosomal protein S6 -0.0693224
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0664027
RAD51B RAD51 paralog B -0.0627117
RPL35A ribosomal protein L35a -0.0593664
WSB1 WD repeat and SOCS box containing 1 -0.0573502
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0522171
DLG1 discs, large homolog 1 (Drosophila) -0.0518757
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0507462
CCND1 cyclin D1 -0.0489728
HMGA2 high mobility group AT-hook 2 -0.0489379
FHIT fragile histidine triad -0.0489186
HMGB1 high mobility group box 1 -0.04756
SERINC5 serine incorporator 5 -0.0471059
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0463172
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0453403
HMGA1 high mobility group AT-hook 1 -0.0441145
RPS24 ribosomal protein S24 -0.0439615
MKI67 marker of proliferation Ki-67 -0.0416327
FUS FUS RNA binding protein -0.0413793
RBM25 RNA binding motif protein 25 -0.041041
WASF2 WAS protein family, member 2 -0.0402515
TAS2R14 taste receptor, type 2, member 14 -0.0400459
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0392724
VDAC1 voltage-dependent anion channel 1 -0.0389678
RNF43 ring finger protein 43 -0.0387258
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.038295
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0381908
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0380437
EXOC4 exocyst complex component 4 -0.0376799
INTS6 integrator complex subunit 6 -0.0376278
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0371639
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0371518
TMSB10 thymosin beta 10 -0.0370571
TUBA1B tubulin, alpha 1b -0.0369775
GNAS GNAS complex locus -0.0367486
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0362264
LCORL ligand dependent nuclear receptor corepressor-like -0.0360143
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0357779
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0357228
CENPF centromere protein F, 350/400kDa -0.0357079
HOXB3 homeobox B3 -0.0356991
RRBP1 ribosome binding protein 1 -0.0356307
KPNB1 karyopherin (importin) beta 1 -0.0347705
LPP LIM domain containing preferred translocation partner in lipoma -0.0346854
SETD5 SET domain containing 5 -0.0346121
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0343953
APOLD1 apolipoprotein L domain containing 1 -0.0343598
TMEM123 transmembrane protein 123 -0.0343122
PATJ PATJ crumbs cell polarity complex component -0.0340882
LMAN1 lectin, mannose-binding, 1 -0.0331966
CUX1 cut-like homeobox 1 -0.033045
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0327731
SLC38A2 solute carrier family 38, member 2 -0.0325257
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0319757
TUBB tubulin, beta class I -0.0316409
ACBD6 acyl-CoA binding domain containing 6 -0.0310142
THOC2 THO complex 2 -0.0305536
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0302853
SCARB1 scavenger receptor class B, member 1 -0.0302468
MAP4 microtubule-associated protein 4 -0.0302102
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0299782
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297378
NF1 neurofibromin 1 -0.0294554
TPX2 TPX2, microtubule-associated -0.029234
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.029166
RPS15 ribosomal protein S15 -0.0288096
PIBF1 progesterone immunomodulatory binding factor 1 -0.0288049
SH3BP4 SH3-domain binding protein 4 -0.028469
TMEM263 transmembrane protein 263 -0.0281705
GCC2 GRIP and coiled-coil domain containing 2 -0.0281013
TNRC6B trinucleotide repeat containing 6B -0.0279929
NFIA nuclear factor I/A -0.0279817
RPL8 ribosomal protein L8 -0.0277056
RPS29 ribosomal protein S29 -0.0276536
H1-0 H1.0 linker histone -0.0274628
ANKRD17 ankyrin repeat domain 17 -0.0274363
NBEAL1 neurobeachin-like 1 -0.0273046
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0271689
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0271671
ZNF395 zinc finger protein 395 -0.0270855
NPEPPS aminopeptidase puromycin sensitive -0.0268163
ARF1 ADP-ribosylation factor 1 -0.026722
MSI2 musashi RNA-binding protein 2 -0.0267011
RERE arginine-glutamic acid dipeptide (RE) repeats -0.026534
S100A10 S100 calcium binding protein A10 -0.0264806
SBF2 SET binding factor 2 -0.026454
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0263491
YEATS2 YEATS domain containing 2 -0.026173
LMO7 LIM domain 7 -0.025889
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0258883
MXI1 MAX interactor 1, dimerization protein -0.0257409
ZFHX3 zinc finger homeobox 3 -0.0256918
ZFAND3 zinc finger, AN1-type domain 3 -0.0254309
ZMYND8 zinc finger, MYND-type containing 8 -0.0252835
UBE2I ubiquitin-conjugating enzyme E2I -0.0252333