Gallic acid_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.40059
ENO1 enolase 1, (alpha) 0.15801
MYH9 myosin, heavy chain 9, non-muscle 0.147944
VEGFA vascular endothelial growth factor A 0.137647
MT2A metallothionein 2A 0.135007
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.122493
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.117866
COL5A1 collagen, type V, alpha 1 0.106923
AHNAK AHNAK nucleoprotein 0.0954953
NDRG1 N-myc downstream regulated 1 0.0861108
CALR calreticulin 0.0858964
CDH13 cadherin 13 0.0823388
ASPH aspartate beta-hydroxylase 0.0794486
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0789785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0709634
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0621144
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0611539
EEF2 eukaryotic translation elongation factor 2 0.0600484
JARID2 jumonji, AT rich interactive domain 2 0.0569387
APP amyloid beta (A4) precursor protein 0.0567302
ERRFI1 ERBB receptor feedback inhibitor 1 0.0565865
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0554007
MACF1 microtubule-actin crosslinking factor 1 0.0504316
PLEC plectin 0.0490749
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0489026
RUNX1 runt-related transcription factor 1 0.0477268
LOXL2 lysyl oxidase-like 2 0.0461146
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0459459
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0452309
NFE2L1 nuclear factor, erythroid 2-like 1 0.0443067
POTEF POTE ankyrin domain family, member F 0.0442584
RPL3 ribosomal protein L3 0.0430013
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0417685
MYO10 myosin X 0.0405851
NALF1 NALCN channel auxiliary factor 1 0.0402972
NAV1 neuron navigator 1 0.0399086
DOCK5 dedicator of cytokinesis 5 0.0387349
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.037948
EGFR epidermal growth factor receptor 0.037721
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0373226
TRIO trio Rho guanine nucleotide exchange factor 0.0371855
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0366685
NOTCH2 notch 2 0.0365328
EFNA5 ephrin-A5 0.0362575
ACTG1 actin gamma 1 0.0359503
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0347413
HSPA8 heat shock 70kDa protein 8 0.0346522
HYOU1 hypoxia up-regulated 1 0.0342304
HIPK2 homeodomain interacting protein kinase 2 0.0333068
PDIA6 protein disulfide isomerase family A, member 6 0.0331492
RPS12 ribosomal protein S12 0.0326387
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0313658
NAV2 neuron navigator 2 0.0308565
HAS2 hyaluronan synthase 2 0.0306929
FAT1 FAT atypical cadherin 1 0.0304452
RPS3 ribosomal protein S3 0.0302106
SFPQ splicing factor proline/glutamine-rich 0.0300459
PTPRG protein tyrosine phosphatase, receptor type, G 0.0299168
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0296924
DST dystonin 0.029173
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0291657
ANKRD11 ankyrin repeat domain 11 0.0290622
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0283656
MCL1 myeloid cell leukemia 1 0.0277909
ENO2 enolase 2 (gamma, neuronal) 0.0274405
COL4A1 collagen, type IV, alpha 1 0.0271218
EIF4A1 eukaryotic translation initiation factor 4A1 0.0270843
TNS1 tensin 1 0.0261114
RPL37A ribosomal protein L37a 0.0261
APLP2 amyloid beta (A4) precursor-like protein 2 0.0260645
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0260359
PTK2 protein tyrosine kinase 2 0.0258776
FMNL2 formin-like 2 0.025847
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0256261
PCBP2 poly(rC) binding protein 2 0.0255668
AKAP12 A kinase (PRKA) anchor protein 12 0.0254026
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0251574
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0246513
FAM219A family with sequence similarity 219, member A 0.0245822
TPM3 tropomyosin 3 0.0244558
SMYD3 SET and MYND domain containing 3 0.0241387
RPL23 ribosomal protein L23 0.0240014
B2M beta-2-microglobulin 0.0239779
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0231917
COL7A1 collagen, type VII, alpha 1 0.0229839
TLN1 talin 1 0.0229652
ANGPTL4 angiopoietin-like 4 0.0229198
MSN moesin 0.0228129
KTN1 kinectin 1 (kinesin receptor) 0.0227758
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0224249
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0223813
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0223411
DSPP dentin sialophosphoprotein 0.022175
SETBP1 SET binding protein 1 0.0220515
ANXA1 annexin A1 0.0218423
BACE2 beta-site APP-cleaving enzyme 2 0.021409
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.021177
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0211513
YBX1 Y box binding protein 1 0.0210067
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.020969

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.216623
COL1A1 collagen, type I, alpha 1 -0.215362
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158785
VIM vimentin -0.124796
FN1 fibronectin 1 -0.112741
IER3 immediate early response 3 -0.0916527
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0877662
CXCL8 chemokine (C-X-C motif) ligand 8 -0.083182
TM4SF1 transmembrane 4 L six family member 1 -0.0740768
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0674788
PALLD palladin, cytoskeletal associated protein -0.0665691
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0599746
DPYD dihydropyrimidine dehydrogenase -0.0581771
CALD1 caldesmon 1 -0.0567091
VCL vinculin -0.0549926
SPAG9 sperm associated antigen 9 -0.0506413
CLIC4 chloride intracellular channel 4 -0.0499835
EGR1 early growth response 1 -0.0481695
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0475648
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0460648
CD44 CD44 molecule (Indian blood group) -0.0460428
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0425287
STC1 stanniocalcin 1 -0.0421753
RRBP1 ribosome binding protein 1 -0.0419256
TMSB10 thymosin beta 10 -0.0407696
MBNL1 muscleblind-like splicing regulator 1 -0.0385336
POSTN periostin, osteoblast specific factor -0.0383609
OSMR oncostatin M receptor -0.0380882
LOX lysyl oxidase -0.0378213
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0377592
RAD21 RAD21 homolog (S. pombe) -0.0369582
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.036695
MAP1B microtubule-associated protein 1B -0.0354076
LMAN1 lectin, mannose-binding, 1 -0.0348664
COL1A2 collagen, type I, alpha 2 -0.0342643
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0327555
SQLE squalene epoxidase -0.0325959
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0313381
THY1 Thy-1 cell surface antigen -0.0310157
RIGI RNA sensor RIG-I -0.0309117
TMEM263 transmembrane protein 263 -0.030502
CAV1 caveolin 1, caveolae protein, 22kDa -0.0301764
ALCAM activated leukocyte cell adhesion molecule -0.0287874
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0285942
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0282511
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0281323
EXT1 exostosin glycosyltransferase 1 -0.0280638
ZFAND3 zinc finger, AN1-type domain 3 -0.0276756
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0274506
H1-0 H1.0 linker histone -0.0273575
NREP neuronal regeneration related protein -0.0273532
IL6ST interleukin 6 signal transducer -0.0270871
F3 coagulation factor III (thromboplastin, tissue factor) -0.0270862
PRRC1 proline-rich coiled-coil 1 -0.0267216
UBC ubiquitin C -0.0264958
PXDN peroxidasin -0.0264351
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0260259
WASF2 WAS protein family, member 2 -0.0258945
TRAM1 translocation associated membrane protein 1 -0.0258599
PDLIM5 PDZ and LIM domain 5 -0.0258401
SBF2 SET binding factor 2 -0.0257152
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0257142
TAPBP TAP binding protein (tapasin) -0.0257059
RAB2A RAB2A, member RAS oncogene family -0.0254178
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0252517
INHBA inhibin, beta A -0.0251865
ICAM1 intercellular adhesion molecule 1 -0.0249173
SOD2 superoxide dismutase 2, mitochondrial -0.0246812
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0245127
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.024458
EBF1 early B-cell factor 1 -0.0244455
WSB1 WD repeat and SOCS box containing 1 -0.024261
PIEZO2 piezo-type mechanosensitive ion channel component 2 -0.023875
TFG TRK-fused gene -0.023795
DPYSL3 dihydropyrimidinase-like 3 -0.0236098
JAK2 Janus kinase 2 -0.0235725
HMGA1 high mobility group AT-hook 1 -0.0233253
TMEM39A transmembrane protein 39A -0.0231668
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0226742
ARF1 ADP-ribosylation factor 1 -0.0225636
SRGN serglycin -0.0224717
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0222687
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0222518
TUBB tubulin, beta class I -0.0220967
GLIPR1 GLI pathogenesis-related 1 -0.0220951
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0217993
LOC112694756 uncharaterized LOC112694756 -0.0217725
TMEM123 transmembrane protein 123 -0.0216777
GOLT1B golgi transport 1B -0.0215482
FKBP10 FK506 binding protein 10, 65 kDa -0.0213656
HDLBP high density lipoprotein binding protein -0.0212888
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0211979
VDAC1 voltage-dependent anion channel 1 -0.0211453
CNTN5 contactin 5 -0.0210894
MORF4L2 mortality factor 4 like 2 -0.0210184
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0208994
RAP1B RAP1B, member of RAS oncogene family -0.0208143
RHEB Ras homolog enriched in brain -0.0208045
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0204149
RASA2 RAS p21 protein activator 2 -0.0202197