Gallic acid_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.110087
APOB apolipoprotein B 0.097544
SAMD4A sterile alpha motif domain containing 4A 0.0950182
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0868814
FN1 fibronectin 1 0.0605482
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0452124
FAT1 FAT atypical cadherin 1 0.0433461
MYH9 myosin, heavy chain 9, non-muscle 0.0422333
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0416597
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0415463
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0393343
MACF1 microtubule-actin crosslinking factor 1 0.038596
ERRFI1 ERBB receptor feedback inhibitor 1 0.0368799
TRIO trio Rho guanine nucleotide exchange factor 0.0345509
YAP1 Yes-associated protein 1 0.0342117
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0329189
SVIL supervillin 0.0324951
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.032369
EIF4B eukaryotic translation initiation factor 4B 0.0319516
EEF2 eukaryotic translation elongation factor 2 0.0312498
CCNY cyclin Y 0.0306804
LCOR ligand dependent nuclear receptor corepressor 0.030559
PEG3 paternally expressed 3 0.0301424
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0294299
PAWR PRKC, apoptosis, WT1, regulator 0.0288866
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0285422
ITGAV integrin, alpha V 0.0265646
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0263217
RPL3 ribosomal protein L3 0.0257509
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0250526
FNBP1L formin binding protein 1-like 0.024538
ARHGAP9 Rho GTPase activating protein 9 0.0244634
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.024019
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0230077
POTEF POTE ankyrin domain family, member F 0.022842
RASA2 RAS p21 protein activator 2 0.0228045
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0227706
SDC4 syndecan 4 0.0223816
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0222456
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0221976
MBNL2 muscleblind-like splicing regulator 2 0.02218
PCBP2 poly(rC) binding protein 2 0.021797
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0214276
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0208678
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0207835
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0205582
RNF43 ring finger protein 43 0.0204086
FNDC3A fibronectin type III domain containing 3A 0.0203974
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0203361
GRB10 growth factor receptor-bound protein 10 0.0202968
ELL2 elongation factor, RNA polymerase II, 2 0.0201961
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0199011
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0194847
PDIA3 protein disulfide isomerase family A, member 3 0.0194795
PPARD peroxisome proliferator-activated receptor delta 0.0190662
NCKAP1 NCK-associated protein 1 0.0188013
OGA O-GlcNAcase 0.0183924
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0183378
SMAD3 SMAD family member 3 0.0183003
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0182769
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.018166
HSPA8 heat shock 70kDa protein 8 0.0181152
BCL2L1 BCL2-like 1 0.0179566
RPL4 ribosomal protein L4 0.0179006
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0178675
VMP1 vacuole membrane protein 1 0.0178549
ZEB1 zinc finger E-box binding homeobox 1 0.0178295
ENAH enabled homolog (Drosophila) 0.0177775
AFF1 AF4/FMR2 family, member 1 0.0175125
SPOPL speckle-type POZ protein-like 0.0175016
PCM1 pericentriolar material 1 0.0173668
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0173143
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0171952
KRT8 keratin 8, type II 0.0171723
CPE carboxypeptidase E 0.017144
FNIP1 folliculin interacting protein 1 0.0170863
MON2 MON2 homolog (S. cerevisiae) 0.017022
OSBPL10 oxysterol binding protein-like 10 0.0170143
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0168216
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.016804
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0165643
MYO5B myosin VB 0.0164508
ARHGAP32 Rho GTPase activating protein 32 0.0164424
WAC WW domain containing adaptor with coiled-coil 0.0164248
SEC23A Sec23 homolog A (S. cerevisiae) 0.0164107
SCAF8 SR-related CTD-associated factor 8 0.0161983
DOCK1 dedicator of cytokinesis 1 0.0160071
IGF1R insulin-like growth factor 1 receptor 0.0157439
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0155439
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0155394
ALPK2 alpha-kinase 2 0.0155383
TPM1 tropomyosin 1 (alpha) 0.0154811
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0153824
MAP2K4 mitogen-activated protein kinase kinase 4 0.0152813
MED13 mediator complex subunit 13 0.0152555
AFDN afadin, adherens junction formation factor 0.0152488
USP15 ubiquitin specific peptidase 15 0.0152378
MALT1 MALT1 paracaspase 0.0150218
MCL1 myeloid cell leukemia 1 0.0148474
DENND4A DENN/MADD domain containing 4A 0.0147667

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.309216
MT2A metallothionein 2A -0.16219
AKAP12 A kinase (PRKA) anchor protein 12 -0.112714
RPS12 ribosomal protein S12 -0.0933231
TPT1 tumor protein, translationally-controlled 1 -0.0929056
RPL37A ribosomal protein L37a -0.0885362
RPS6 ribosomal protein S6 -0.079944
NDRG1 N-myc downstream regulated 1 -0.0786073
RPS24 ribosomal protein S24 -0.071532
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0710898
RPLP1 ribosomal protein, large, P1 -0.067885
SLC38A2 solute carrier family 38, member 2 -0.0665717
RPS19 ribosomal protein S19 -0.0660624
TMSB10 thymosin beta 10 -0.0659685
RPL11 ribosomal protein L11 -0.0641723
GPC3 glypican 3 -0.0634267
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0630264
HMGA1 high mobility group AT-hook 1 -0.0619677
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0594407
RPL23 ribosomal protein L23 -0.0577568
RPL35A ribosomal protein L35a -0.0572082
RPL34 ribosomal protein L34 -0.0554279
RPS8 ribosomal protein S8 -0.0553585
RPL26 ribosomal protein L26 -0.0502817
RPL31 ribosomal protein L31 -0.0501216
RACK1 receptor for activated C kinase 1 -0.0496457
FTL ferritin, light polypeptide -0.0490907
RPL9 ribosomal protein L9 -0.0479275
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0471995
MARCKS myristoylated alanine-rich protein kinase C substrate -0.046235
RPLP2 ribosomal protein, large, P2 -0.046031
RPS3 ribosomal protein S3 -0.0419572
RPLP0 ribosomal protein, large, P0 -0.0412026
RPS21 ribosomal protein S21 -0.0409733
KLF6 Kruppel-like factor 6 -0.0383948
RPL12 ribosomal protein L12 -0.0369143
RPS27A ribosomal protein S27a -0.0364627
LOC112694756 uncharaterized LOC112694756 -0.0359536
EHBP1 EH domain binding protein 1 -0.0348673
CP ceruloplasmin (ferroxidase) -0.034824
RPS13 ribosomal protein S13 -0.0340734
GNAS GNAS complex locus -0.034065
APOA2 apolipoprotein A-II -0.0336912
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0331971
PTMA prothymosin, alpha -0.033189
TM4SF1 transmembrane 4 L six family member 1 -0.0328462
PTPRF protein tyrosine phosphatase, receptor type, F -0.0326595
ATP10A ATPase, class V, type 10A -0.0321619
NAP1L1 nucleosome assembly protein 1-like 1 -0.0318978
GMDS GDP-mannose 4,6-dehydratase -0.0312462
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0310454
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0310415
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0306649
RPS29 ribosomal protein S29 -0.0303565
RPL37 ribosomal protein L37 -0.0297081
RPS17 ribosomal protein S17 -0.0293527
RPS23 ribosomal protein S23 -0.0292596
B2M beta-2-microglobulin -0.0289719
RPS14 ribosomal protein S14 -0.0283189
EGR1 early growth response 1 -0.0281802
RPL28 ribosomal protein L28 -0.026969
APOE apolipoprotein E -0.0266752
IER3 immediate early response 3 -0.0263314
CMIP c-Maf inducing protein -0.0262863
RPL10A ribosomal protein L10a -0.0256776
RPL36 ribosomal protein L36 -0.0254546
NPR2 natriuretic peptide receptor 2 -0.0253999
S100A9 S100 calcium binding protein A9 -0.0244193
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0243434
RPL19 ribosomal protein L19 -0.0243122
RPL32 ribosomal protein L32 -0.0242837
PDGFB platelet-derived growth factor beta polypeptide -0.0241299
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.024005
RRBP1 ribosome binding protein 1 -0.0237651
AMBP alpha-1-microglobulin/bikunin precursor -0.023695
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0236924
RPS11 ribosomal protein S11 -0.0233981
RPL5 ribosomal protein L5 -0.0232305
RPS25 ribosomal protein S25 -0.023173
EIF1 eukaryotic translation initiation factor 1 -0.0228439
RPS10 ribosomal protein S10 -0.0227749
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0224432
IFITM1 interferon induced transmembrane protein 1 -0.0221887
ASPH aspartate beta-hydroxylase -0.0220968
MYL12B myosin, light chain 12B, regulatory -0.0220495
INTS6 integrator complex subunit 6 -0.021733
RPL27A ribosomal protein L27a -0.0217197
RPL27 ribosomal protein L27 -0.0213671
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0211136
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0209779
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0206194
RPS27 ribosomal protein S27 -0.0204275
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0204017
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0199903
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0199398
S100P S100 calcium binding protein P -0.0198276
SEC62 SEC62 homolog (S. cerevisiae) -0.0195803
ISG15 ISG15 ubiquitin-like modifier -0.0195327
APOA1 apolipoprotein A-I -0.019096
RPL38 ribosomal protein L38 -0.0188321