Gallic acid_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.161181
ASPH aspartate beta-hydroxylase 0.140986
EFNA5 ephrin-A5 0.122089
EXT1 exostosin glycosyltransferase 1 0.117386
MCL1 myeloid cell leukemia 1 0.098398
AHNAK AHNAK nucleoprotein 0.0932328
ERRFI1 ERBB receptor feedback inhibitor 1 0.0909503
RPS12 ribosomal protein S12 0.079048
ITGA6 integrin, alpha 6 0.078722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0786033
ENO1 enolase 1, (alpha) 0.0785448
EEF2 eukaryotic translation elongation factor 2 0.0761428
NALF1 NALCN channel auxiliary factor 1 0.0760706
MSN moesin 0.0747091
RPS3 ribosomal protein S3 0.0738228
MYO10 myosin X 0.0731825
PTPRG protein tyrosine phosphatase, receptor type, G 0.07089
PCBP2 poly(rC) binding protein 2 0.0702259
EIF4B eukaryotic translation initiation factor 4B 0.0701617
MYH9 myosin, heavy chain 9, non-muscle 0.0689406
ACTG1 actin gamma 1 0.0639902
PBX3 pre-B-cell leukemia homeobox 3 0.0631095
KIAA1549L KIAA1549-like 0.0610206
RPL3 ribosomal protein L3 0.059032
TXNIP thioredoxin interacting protein 0.0588116
POTEF POTE ankyrin domain family, member F 0.0561699
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0556041
RPL23 ribosomal protein L23 0.0541343
PRKG1 protein kinase, cGMP-dependent, type I 0.051414
HSPA8 heat shock 70kDa protein 8 0.0488942
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0487257
APLP2 amyloid beta (A4) precursor-like protein 2 0.0484072
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0476734
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0475381
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0461939
SDCCAG8 serologically defined colon cancer antigen 8 0.0459738
MACF1 microtubule-actin crosslinking factor 1 0.0454671
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0449957
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.044749
DST dystonin 0.0446644
PTPRD protein tyrosine phosphatase, receptor type, D 0.0445488
LIMCH1 LIM and calponin homology domains 1 0.0427472
TPM3 tropomyosin 3 0.042711
PKM pyruvate kinase, muscle 0.0426878
LSAMP limbic system-associated membrane protein 0.0425215
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0421511
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0417495
RPL4 ribosomal protein L4 0.0415947
FMNL2 formin-like 2 0.0410997
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0408431
ENO2 enolase 2 (gamma, neuronal) 0.0403222
SAMD3 sterile alpha motif domain containing 3 0.039817
RPL37A ribosomal protein L37a 0.0388319
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0376666
FAT1 FAT atypical cadherin 1 0.0370855
MARCHF4 membrane associated ring-CH-type finger 4 0.0370083
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0369559
DOCK4 dedicator of cytokinesis 4 0.0367793
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0364414
SET SET nuclear proto-oncogene 0.0361099
SFPQ splicing factor proline/glutamine-rich 0.0359252
JARID2 jumonji, AT rich interactive domain 2 0.0352522
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0351122
RPS2 ribosomal protein S2 0.034505
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0339242
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0330408
MT2A metallothionein 2A 0.032866
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0328302
LDHA lactate dehydrogenase A 0.0325552
BZW1 basic leucine zipper and W2 domains 1 0.031532
PLEC plectin 0.0314245
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0309196
SPATS2 spermatogenesis associated, serine-rich 2 0.0308486
HMGA2 high mobility group AT-hook 2 0.030754
EIF4A1 eukaryotic translation initiation factor 4A1 0.030418
RUNX1 runt-related transcription factor 1 0.0299574
ZNF638 zinc finger protein 638 0.0287616
RPS17 ribosomal protein S17 0.0283471
USP34 ubiquitin specific peptidase 34 0.0282407
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.027648
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.026892
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0268686
TLN1 talin 1 0.026739
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0264999
TRIO trio Rho guanine nucleotide exchange factor 0.0263339
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0261648
RPL27 ribosomal protein L27 0.0260209
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0258094
UBA6 ubiquitin-like modifier activating enzyme 6 0.0255661
SPATS2L spermatogenesis associated, serine-rich 2-like 0.025554
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0245816
LIMA1 LIM domain and actin binding 1 0.0245504
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0244977
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0243849
HIPK2 homeodomain interacting protein kinase 2 0.0243288
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0241385
SAMD4A sterile alpha motif domain containing 4A 0.0240325
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0238178
MAP2K1 mitogen-activated protein kinase kinase 1 0.023804
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0237315

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.502534
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0928871
KDM3A lysine (K)-specific demethylase 3A -0.065263
LOC112694756 uncharaterized LOC112694756 -0.0596209
RAD21 RAD21 homolog (S. pombe) -0.0565367
RPS6 ribosomal protein S6 -0.0536611
VCL vinculin -0.0523005
WSB1 WD repeat and SOCS box containing 1 -0.0515268
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0506601
DTNA dystrobrevin, alpha -0.0502746
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0495618
SPAG9 sperm associated antigen 9 -0.0487584
RTN4 reticulon 4 -0.0480022
PTCHD4 patched domain containing 4 -0.0453952
H1-0 H1.0 linker histone -0.0453441
ZFAND3 zinc finger, AN1-type domain 3 -0.0446201
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0443969
MCTP1 multiple C2 domains, transmembrane 1 -0.0431791
NUP58 nucleoporin 58 -0.0419508
GNAS GNAS complex locus -0.0409231
RPS24 ribosomal protein S24 -0.0406259
TSC22D2 TSC22 domain family, member 2 -0.0394275
RBM39 RNA binding motif protein 39 -0.0391045
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0373721
RAB1A RAB1A, member RAS oncogene family -0.0363433
TMSB10 thymosin beta 10 -0.0359998
EIF1 eukaryotic translation initiation factor 1 -0.0359471
CFAP251 cilia and flagella associated protein 251 -0.0357226
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0350469
NF1 neurofibromin 1 -0.0348659
MARCHF6 membrane associated ring-CH-type finger 6 -0.0336339
NABP1 nucleic acid binding protein 1 -0.0331795
WDR45B WD repeat domain 45B -0.0331168
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.032442
TPT1 tumor protein, translationally-controlled 1 -0.0320129
RLF rearranged L-myc fusion -0.0317739
YBX3 Y box binding protein 3 -0.0312587
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0312498
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0311368
OSMR oncostatin M receptor -0.030692
QKI QKI, KH domain containing, RNA binding -0.0306434
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0297935
RPL8 ribosomal protein L8 -0.0296849
CANX calnexin -0.0296099
BTG1 B-cell translocation gene 1, anti-proliferative -0.0295427
GPC6 glypican 6 -0.0292192
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0287965
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0285695
FBXO11 F-box protein 11 -0.0280897
HMGA1 high mobility group AT-hook 1 -0.0280754
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0280468
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0279205
FNDC3B fibronectin type III domain containing 3B -0.0277286
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0277274
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0276515
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0270269
RPL35A ribosomal protein L35a -0.0267958
KYNU kynureninase -0.0265135
VDAC1 voltage-dependent anion channel 1 -0.0261444
RAB7A RAB7A, member RAS oncogene family -0.0260728
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0260473
IER3 immediate early response 3 -0.0258315
PNISR PNN-interacting serine/arginine-rich protein -0.0257957
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0256872
CD109 CD109 molecule -0.0251796
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0251453
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0245633
TMEM263 transmembrane protein 263 -0.0245394
FUS FUS RNA binding protein -0.0244688
ZNF217 zinc finger protein 217 -0.0242895
RPL32 ribosomal protein L32 -0.0242637
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0241516
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0239651
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0238064
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0237624
NPR2 natriuretic peptide receptor 2 -0.0236844
LTN1 listerin E3 ubiquitin protein ligase 1 -0.023672
TMEM123 transmembrane protein 123 -0.0233964
RPL34 ribosomal protein L34 -0.0233651
MON2 MON2 homolog (S. cerevisiae) -0.0232783
HLA-E major histocompatibility complex, class I, E -0.023192
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0229764
ARF1 ADP-ribosylation factor 1 -0.0229387
NAMPT nicotinamide phosphoribosyltransferase -0.02277
WAC WW domain containing adaptor with coiled-coil -0.0226516
GLS2 glutaminase 2 (liver, mitochondrial) -0.0224344
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0220324
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0219959
WDR43 WD repeat domain 43 -0.0219622
PIBF1 progesterone immunomodulatory binding factor 1 -0.0218895
TFRC transferrin receptor -0.0218779
ZNF207 zinc finger protein 207 -0.0216369
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.021593
GLIPR1 GLI pathogenesis-related 1 -0.0214759
SEPTIN7 septin 7 -0.0213368
TEX10 testis expressed 10 -0.0212817
PDE4D phosphodiesterase 4D, cAMP-specific -0.0209741
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0209554
DLG1 discs, large homolog 1 (Drosophila) -0.020928