Gallic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.174489
TMSB10 thymosin beta 10 0.0903524
PTMA prothymosin, alpha 0.0879757
AHNAK AHNAK nucleoprotein 0.0615183
MSI2 musashi RNA-binding protein 2 0.0541409
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0535797
GARS1 glycyl-tRNA synthetase 1 0.0516632
RPL23 ribosomal protein L23 0.0498715
RPLP0 ribosomal protein, large, P0 0.0479858
EPS8 epidermal growth factor receptor pathway substrate 8 0.0466633
TPT1 tumor protein, translationally-controlled 1 0.0410222
RPL4 ribosomal protein L4 0.0388524
RPL13A ribosomal protein L13a 0.0381705
RPLP1 ribosomal protein, large, P1 0.0371243
RRBP1 ribosome binding protein 1 0.0363175
LAMB3 laminin, beta 3 0.033577
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0332138
ACTG1 actin gamma 1 0.0329598
PELI1 pellino E3 ubiquitin protein ligase 1 0.0325739
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.030751
HMGB2 high mobility group box 2 0.0291218
HDLBP high density lipoprotein binding protein 0.0290535
PLAC8 placenta-specific 8 0.0286931
DDIT4 DNA-damage-inducible transcript 4 0.0284548
FAT1 FAT atypical cadherin 1 0.0274647
OGA O-GlcNAcase 0.0272069
RPL35A ribosomal protein L35a 0.026975
IARS1 isoleucyl-tRNA synthetase 1 0.0268016
GDF15 growth differentiation factor 15 0.0263517
MARCHF6 membrane associated ring-CH-type finger 6 0.0248273
NFIA nuclear factor I/A 0.0247303
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0246224
CANX calnexin 0.0238573
RAD21 RAD21 homolog (S. pombe) 0.0237181
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0235007
KIF5B kinesin family member 5B 0.0233147
GSTP1 glutathione S-transferase pi 1 0.0228433
EIF4A1 eukaryotic translation initiation factor 4A1 0.0228051
KDM3A lysine (K)-specific demethylase 3A 0.022625
EIF1 eukaryotic translation initiation factor 1 0.0224492
DGKD diacylglycerol kinase, delta 130kDa 0.0221326
NRN1 neuritin 1 0.0219518
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0217601
USP3 ubiquitin specific peptidase 3 0.0214811
PPARG peroxisome proliferator-activated receptor gamma 0.0214045
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0211552
RPL14 ribosomal protein L14 0.0207918
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0206289
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0206057
YBX3 Y box binding protein 3 0.020523
UBE2H ubiquitin-conjugating enzyme E2H 0.0205039
EIF4B eukaryotic translation initiation factor 4B 0.0197598
MYL12B myosin, light chain 12B, regulatory 0.0197029
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0193632
GRB10 growth factor receptor-bound protein 10 0.0192825
LIN54 lin-54 DREAM MuvB core complex component 0.0191946
H1-0 H1.0 linker histone 0.0191219
NT5C2 5'-nucleotidase, cytosolic II 0.0190002
PRELID2 PRELI domain containing 2 0.018849
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0187994
RPL12 ribosomal protein L12 0.018585
ARF1 ADP-ribosylation factor 1 0.0185586
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.018404
PDIA4 protein disulfide isomerase family A, member 4 0.018294
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0182017
RPS9 ribosomal protein S9 0.018136
PYGB phosphorylase, glycogen; brain 0.0181306
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0180472
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0178981
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0177641
WDR45B WD repeat domain 45B 0.0175585
FRMD3 FERM domain containing 3 0.0175575
TOP1 topoisomerase (DNA) I 0.0174262
VDAC1 voltage-dependent anion channel 1 0.0170895
MAML3 mastermind-like 3 (Drosophila) 0.0168883
ZMYM2 zinc finger, MYM-type 2 0.0168766
DEK DEK proto-oncogene 0.0168233
SAFB2 scaffold attachment factor B2 0.0168161
NPEPPS aminopeptidase puromycin sensitive 0.0167642
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0167135
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0165967
RBM25 RNA binding motif protein 25 0.0164071
EIF3L eukaryotic translation initiation factor 3, subunit L 0.0163458
SBF2 SET binding factor 2 0.01631
SERINC5 serine incorporator 5 0.0161691
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0161157
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0161103
TKT transketolase 0.0160379
SEC61G Sec61 gamma subunit 0.0159697
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0158753
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0157753
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0156749
GSK3B glycogen synthase kinase 3 beta 0.0156326
OSBPL3 oxysterol binding protein-like 3 0.0155381
STRN3 striatin, calmodulin binding protein 3 0.0154901
PER2 period circadian clock 2 0.0154526
RPL23A ribosomal protein L23a 0.0153636
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0153475
HMGB1 high mobility group box 1 0.0152839
IQGAP2 IQ motif containing GTPase activating protein 2 0.0152452

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.173454
LMO7 LIM domain 7 -0.134291
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.13278
RPS2 ribosomal protein S2 -0.125437
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.121062
RPS12 ribosomal protein S12 -0.108446
RPS6 ribosomal protein S6 -0.103003
MYO1E myosin IE -0.100903
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.100477
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0999135
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0809378
PDE4D phosphodiesterase 4D, cAMP-specific -0.0777377
ITPRID2 ITPR interacting domain containing 2 -0.0750856
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0733759
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0696299
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.069511
POTEF POTE ankyrin domain family, member F -0.0645489
PTPRR protein tyrosine phosphatase, receptor type, R -0.0637486
F3 coagulation factor III (thromboplastin, tissue factor) -0.0576892
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0572107
PTPRB protein tyrosine phosphatase, receptor type, B -0.0565983
EZR ezrin -0.055495
SQSTM1 sequestosome 1 -0.0550634
MUC13 mucin 13, cell surface associated -0.0518951
RPL21 ribosomal protein L21 -0.0515191
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.050824
HLA-B major histocompatibility complex, class I, B -0.0497093
CALB1 calbindin 1, 28kDa -0.0474268
ANXA2 annexin A2 -0.0473791
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0469139
PDLIM5 PDZ and LIM domain 5 -0.046025
RPL26 ribosomal protein L26 -0.0456804
CCSER1 coiled-coil serine-rich protein 1 -0.0445237
KRT18 keratin 18, type I -0.0443985
EGFR epidermal growth factor receptor -0.0443811
KTN1 kinectin 1 (kinesin receptor) -0.0441159
FRMD5 FERM domain containing 5 -0.0431773
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0431208
MPRIP myosin phosphatase Rho interacting protein -0.0428502
TJP1 tight junction protein 1 -0.0423109
BRD2 bromodomain containing 2 -0.0418584
RPS13 ribosomal protein S13 -0.041689
DSG2 desmoglein 2 -0.0413447
SRRM2 serine/arginine repetitive matrix 2 -0.0412298
IFI6 interferon, alpha-inducible protein 6 -0.0411564
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0410485
PATJ PATJ crumbs cell polarity complex component -0.0409874
SVIL supervillin -0.0406894
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0402877
RPS17 ribosomal protein S17 -0.0395388
RPS8 ribosomal protein S8 -0.0387136
BACE2 beta-site APP-cleaving enzyme 2 -0.0385551
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.038548
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0383399
CAV2 caveolin 2 -0.0381358
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0376912
RPL37A ribosomal protein L37a -0.0373265
RIGI RNA sensor RIG-I -0.0369379
PKM pyruvate kinase, muscle -0.036716
RPL11 ribosomal protein L11 -0.0365082
MYH14 myosin, heavy chain 14, non-muscle -0.0364685
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0362214
RPL9 ribosomal protein L9 -0.0359277
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0354682
ASPH aspartate beta-hydroxylase -0.0354302
LAMC2 laminin, gamma 2 -0.0350767
SLC38A2 solute carrier family 38, member 2 -0.0347547
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0346983
ERBIN erbb2 interacting protein -0.034332
CATSPERB catsper channel auxiliary subunit beta -0.0339598
TSPAN8 tetraspanin 8 -0.0335855
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0324766
OSBPL8 oxysterol binding protein-like 8 -0.0324546
WWC1 WW and C2 domain containing 1 -0.0320856
RPL31 ribosomal protein L31 -0.0319515
EEF1G eukaryotic translation elongation factor 1 gamma -0.0317182
NPSR1 neuropeptide S receptor 1 -0.0313337
RPL3 ribosomal protein L3 -0.031287
SP100 SP100 nuclear antigen -0.0311465
LRRC23 leucine rich repeat containing 23 -0.03106
TMEM45B transmembrane protein 45B -0.0308224
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0307327
FLNB filamin B, beta -0.0305424
RABGAP1L RAB GTPase activating protein 1-like -0.0300351
CCDC91 coiled-coil domain containing 91 -0.0298891
CSNK1A1 casein kinase 1, alpha 1 -0.0293771
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0293548
ATXN1 ataxin 1 -0.0292697
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.029229
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0292241
LOC102724023 ES1 protein homolog, mitochondrial -0.0291601
UTRN utrophin -0.0290245
CLIC5 chloride intracellular channel 5 -0.0287307
INTS6 integrator complex subunit 6 -0.0286173
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0285077
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0283792
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0282465
RPS23 ribosomal protein S23 -0.0280438
PDIA3 protein disulfide isomerase family A, member 3 -0.0279764
SLTM SAFB-like, transcription modulator -0.0279358