Gallic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Gallic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Gallic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CAPRIN2 caprin family member 2 0.125491
ERRFI1 ERBB receptor feedback inhibitor 1 0.105977
STAT1 signal transducer and activator of transcription 1, 91kDa 0.104317
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.102415
BCAR3 breast cancer anti-estrogen resistance 3 0.0982222
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0920282
WWTR1 WW domain containing transcription regulator 1 0.0862415
PSD3 pleckstrin and Sec7 domain containing 3 0.0773364
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0764351
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0739649
POTEF POTE ankyrin domain family, member F 0.0735433
F2R coagulation factor II (thrombin) receptor 0.0700582
DST dystonin 0.0688705
ENO1 enolase 1, (alpha) 0.0687874
RAB27B RAB27B, member RAS oncogene family 0.0670132
KMT2E lysine (K)-specific methyltransferase 2E 0.0652893
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0566063
CENPF centromere protein F, 350/400kDa 0.0564457
EEF2 eukaryotic translation elongation factor 2 0.0552172
MKI67 marker of proliferation Ki-67 0.0550979
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0537956
BIRC3 baculoviral IAP repeat containing 3 0.0536667
ADAR adenosine deaminase, RNA-specific 0.0518732
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0511307
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0508603
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0507731
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.049064
VCL vinculin 0.0488693
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0487695
MACF1 microtubule-actin crosslinking factor 1 0.0473376
PDE10A phosphodiesterase 10A 0.0470383
TRIP12 thyroid hormone receptor interactor 12 0.0466632
KTN1 kinectin 1 (kinesin receptor) 0.0458665
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0451089
VMP1 vacuole membrane protein 1 0.0446119
PCBP2 poly(rC) binding protein 2 0.0441824
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0441144
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0437372
MYH9 myosin, heavy chain 9, non-muscle 0.0436177
TSC22D1 TSC22 domain family, member 1 0.0409724
EZR ezrin 0.0404566
TPM4 tropomyosin 4 0.0393743
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0387748
MT2A metallothionein 2A 0.0380898
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0378888
DPYD dihydropyrimidine dehydrogenase 0.0375419
CFLAR CASP8 and FADD-like apoptosis regulator 0.0371712
WAC WW domain containing adaptor with coiled-coil 0.036478
APP amyloid beta (A4) precursor protein 0.0358903
RAD51B RAD51 paralog B 0.0357514
ADAM17 ADAM metallopeptidase domain 17 0.0353253
ACTG1 actin gamma 1 0.0347102
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0342513
SLK STE20-like kinase 0.0337554
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0336928
RPL3 ribosomal protein L3 0.0334799
SFPQ splicing factor proline/glutamine-rich 0.0322227
NT5E 5'-nucleotidase, ecto (CD73) 0.0321644
MCL1 myeloid cell leukemia 1 0.0318384
TXNIP thioredoxin interacting protein 0.0312991
XPO1 exportin 1 0.0312819
CCNL1 cyclin L1 0.0312208
CKAP5 cytoskeleton associated protein 5 0.0312003
BARX2 BARX homeobox 2 0.0310837
MT1E metallothionein 1E 0.0297833
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0296504
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0296079
PRRC2B proline-rich coiled-coil 2B 0.0294736
WARS1 tryptophanyl-tRNA synthetase 1 0.0294699
SRRM2 serine/arginine repetitive matrix 2 0.0293636
STAG2 stromal antigen 2 0.0293098
UBXN4 UBX domain protein 4 0.0292447
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0288279
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.028575
SRSF11 serine/arginine-rich splicing factor 11 0.0285366
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0285192
SPRY4 sprouty homolog 4 (Drosophila) 0.0283623
RIGI RNA sensor RIG-I 0.0282441
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0282118
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.02793
SOCS6 suppressor of cytokine signaling 6 0.0276931
ENO2 enolase 2 (gamma, neuronal) 0.0275797
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0275506
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0275266
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0274296
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0271282
BZW1 basic leucine zipper and W2 domains 1 0.0271243
FOSL1 FOS-like antigen 1 0.0271197
MAT2A methionine adenosyltransferase II, alpha 0.0268586
ANTXR2 anthrax toxin receptor 2 0.0268127
TPM3 tropomyosin 3 0.0267073
IPO7 importin 7 0.0266542
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0266517
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0265267
VEGFC vascular endothelial growth factor C 0.0264425
SDK1 sidekick cell adhesion molecule 1 0.0264269
NIBAN2 niban apoptosis regulator 2 0.026349
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0263469
FXR1 fragile X mental retardation, autosomal homolog 1 0.0260967
FERMT1 fermitin family member 1 0.0259048

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.233932
TMSB10 thymosin beta 10 -0.141345
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132366
VIM vimentin -0.127385
DLG1 discs, large homolog 1 (Drosophila) -0.121845
RPL35A ribosomal protein L35a -0.0980234
TPT1 tumor protein, translationally-controlled 1 -0.0839419
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0773994
RPS6 ribosomal protein S6 -0.0685651
PTMA prothymosin, alpha -0.067912
EFNA5 ephrin-A5 -0.0644438
RPS24 ribosomal protein S24 -0.0574518
EPHA4 EPH receptor A4 -0.0567775
RAB7A RAB7A, member RAS oncogene family -0.0556673
RPS8 ribosomal protein S8 -0.053546
TNS3 tensin 3 -0.0522487
EHBP1 EH domain binding protein 1 -0.0499349
PTPRF protein tyrosine phosphatase, receptor type, F -0.0486469
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.043933
INTS6 integrator complex subunit 6 -0.0438316
RPL12 ribosomal protein L12 -0.0427291
HMGA1 high mobility group AT-hook 1 -0.0426999
MYOF myoferlin -0.0420091
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0414096
TRIO trio Rho guanine nucleotide exchange factor -0.0408057
RPL31 ribosomal protein L31 -0.0388129
RPLP1 ribosomal protein, large, P1 -0.0368274
RPS23 ribosomal protein S23 -0.0367818
CANX calnexin -0.0363957
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0357055
FTL ferritin, light polypeptide -0.0347004
NAP1L1 nucleosome assembly protein 1-like 1 -0.0346003
GNAS GNAS complex locus -0.0345157
RPS25 ribosomal protein S25 -0.0338432
RPS29 ribosomal protein S29 -0.0337596
RPL36A ribosomal protein L36a -0.0332838
RPL36 ribosomal protein L36 -0.033269
RPL7A ribosomal protein L7a -0.0332358
MORF4L2 mortality factor 4 like 2 -0.033145
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0331022
RPL37A ribosomal protein L37a -0.0330736
RPLP2 ribosomal protein, large, P2 -0.0330123
VDAC1 voltage-dependent anion channel 1 -0.0328733
KDM3A lysine (K)-specific demethylase 3A -0.0327257
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0320971
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0320155
RPL5 ribosomal protein L5 -0.0319419
RPS27A ribosomal protein S27a -0.0316903
RPL26 ribosomal protein L26 -0.0313486
CLIP2 CAP-GLY domain containing linker protein 2 -0.0311015
LOXL2 lysyl oxidase-like 2 -0.0310841
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0308383
DENND1A DENN/MADD domain containing 1A -0.0306786
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.030639
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0304119
USP34 ubiquitin specific peptidase 34 -0.0303488
RPL9 ribosomal protein L9 -0.0299054
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0296695
CSMD3 CUB and Sushi multiple domains 3 -0.0296428
EIF1 eukaryotic translation initiation factor 1 -0.0295112
RPL8 ribosomal protein L8 -0.0294213
ESYT2 extended synaptotagmin-like protein 2 -0.0293169
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0292648
TMSB4X thymosin beta 4, X-linked -0.0291192
RPS19 ribosomal protein S19 -0.0290626
RPL34 ribosomal protein L34 -0.029016
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0288269
TM4SF1 transmembrane 4 L six family member 1 -0.0286846
TTC3 tetratricopeptide repeat domain 3 -0.0284514
HSPG2 heparan sulfate proteoglycan 2 -0.0277176
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0276561
WSB1 WD repeat and SOCS box containing 1 -0.0274742
CMIP c-Maf inducing protein -0.0273416
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.027204
RPL19 ribosomal protein L19 -0.026895
RPLP0 ribosomal protein, large, P0 -0.026835
KDM4B lysine (K)-specific demethylase 4B -0.0268151
TFRC transferrin receptor -0.0266934
CLIP1 CAP-GLY domain containing linker protein 1 -0.0265033
DPYSL2 dihydropyrimidinase-like 2 -0.0260122
NPR2 natriuretic peptide receptor 2 -0.0259464
RPL38 ribosomal protein L38 -0.025773
LRRC49 leucine rich repeat containing 49 -0.0255805
MBD5 methyl-CpG binding domain protein 5 -0.0254864
FNIP1 folliculin interacting protein 1 -0.0254539
RPS13 ribosomal protein S13 -0.0252987
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0252132
RPS10 ribosomal protein S10 -0.025155
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.025143
CAVIN1 caveolae associated protein 1 -0.0251112
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0250963
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0250303
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0247198
RPS28 ribosomal protein S28 -0.024644
RPS3 ribosomal protein S3 -0.0244403
FUS FUS RNA binding protein -0.0244352
LYST lysosomal trafficking regulator -0.0243422
RPS15 ribosomal protein S15 -0.0240859
TAS2R14 taste receptor, type 2, member 14 -0.0240742
HDLBP high density lipoprotein binding protein -0.0240633